{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:33:39Z","timestamp":1762868019866,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Updates Surg"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s13304-019-00700-w","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T12:55:43Z","timestamp":1577969743000},"page":"335-340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Kono-S anastomosis after intestinal resection for Crohn\u2019s disease"],"prefix":"10.1007","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-2269","authenticated-orcid":false,"given":"Roberto","family":"Peltrini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Antonella","family":"Greco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Manfreda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Luglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"700_CR1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/ibd.21506","volume":"17","author":"B Pariente","year":"2011","unstructured":"Pariente B, Cosnes J, Danese S et al (2011) Development of the Crohn\u2019s disease digestive damage score, the L\u00e9mann score. Inflamm Bowel Dis 17:1415\u20131422","journal-title":"Inflamm Bowel Dis"},{"key":"700_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ecco-jcc\/jjy056","volume":"12","author":"WA Bemelman","year":"2018","unstructured":"Bemelman WA, Warusavitarne J, Sampietro GM et al (2018) ECCO-ESCP consensus on surgery for Crohn\u2019s disease. J Crohns Colitis 12:1\u201316","journal-title":"J Crohns Colitis"},{"key":"700_CR3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1136\/gut.2010.234617","volume":"60","author":"G Bouguen","year":"2011","unstructured":"Bouguen G, Peyrin-biroulet L (2011) Surgery for adult Crohn\u2019s disease: what is the actual risk? Gut 60:1178\u20131181","journal-title":"Gut"},{"key":"700_CR4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ajg.2009.579","volume":"105","author":"L Peyrin-biroulet","year":"2009","unstructured":"Peyrin-biroulet L, Loft EV Jr, Colombel JF, Sandborn WJ (2009) The natural history of adult Crohn\u2019s disease in population-based cohorts. Am J Gastroenterol 105:289\u2013297","journal-title":"Am J Gastroenterol"},{"key":"700_CR5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1365-2036.2012.05002.x","volume":"35","author":"A Buisson","year":"2012","unstructured":"Buisson A, Chevaux J, Allen PB, Bommelaer G, Peyrin-Biroulet L (2012) Review article: the natural history of postoperative Crohn\u2019s disease recurrence. Aliment Pharmacol Ther 35:625\u2013633","journal-title":"Aliment Pharmacol Ther"},{"key":"700_CR6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0016-5085(94)90697-1","volume":"106","author":"M Cottone","year":"1994","unstructured":"Cottone M, Rosselli M, Orlando A, Oliva L, Puleo A, Cappello M, Traina M, Tonelli F, Pagliaro L (1994) Smoking habits and recurrence in Crohn\u2019s disease. Gastroenterology 106:643\u2013648","journal-title":"Gastroenterology"},{"key":"700_CR7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.gtc.2017.05.011","volume":"46","author":"S Singh","year":"2017","unstructured":"Singh S, Nguyen GC (2017) Management of Crohn\u2019s disease after surgical resection. Gastroenterol Clin N Am 46:563\u2013575","journal-title":"Gastroenterol Clin N Am"},{"key":"700_CR8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/DCR.0b013e3181b7bfb0","volume":"53","author":"C Simillis","year":"2010","unstructured":"Simillis C, Jacovides M, Reese GE, Yamamoto T, Tekkis PP (2010) Meta-analysis of the role of granulomas in the recurrence of Crohn disease. Dis Colon Rectum 53:177\u2013185","journal-title":"Dis Colon Rectum"},{"key":"700_CR9","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.dld.2016.02.023","volume":"48","author":"S Decousus","year":"2016","unstructured":"Decousus S, Boucher AL, Joubert J, Pereira B, Dubois A, Goutorbe F, D\u00e9chelotte PJ, Bommelaer G, Buisson A (2016) Myenteric plexitis is a risk factor for endoscopic and clinical postoperative recurrence after ileocolonic resection in Crohn\u2019s disease. Dig Liver Dis 48:753\u2013758","journal-title":"Dig Liver Dis"},{"key":"700_CR10","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.3748\/wjg.v18.i32.4391","volume":"18","author":"M Aguas","year":"2012","unstructured":"Aguas M, Bastida G, Cerrillo E, Beltr\u00e1n B, Iborra M, S\u00e1nchez-Montes C, Mu\u00f1oz F, Barrio J, Riestra S, Nos P (2012) Adalimumab in prevention of postoperative recurrence of Crohn\u2019s disease in high-risk patients. World J Gastroenterol 18:4391\u20134398","journal-title":"World J Gastroenterol"},{"key":"700_CR11","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/ajg.2013.287","volume":"108","author":"E Savarino","year":"2013","unstructured":"Savarino E, Bodini G, Dulbecco P, Assandri L, Bruzzone L, Mazza F, Frigo AC, Fazio V, Marabotto E, Savarino V (2013) Adalimumab is more effective than azathioprine and mesalamine at preventing postoperative recurrence of Crohn\u2019s disease: a randomized controlled trial. Am J Gastroenterol 108:1731\u20131742","journal-title":"Am J Gastroenterol"},{"key":"700_CR12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1053\/j.gastro.2008.10.051","volume":"136","author":"M Regueiro","year":"2009","unstructured":"Regueiro M, Schraut W, Baidoo L, Kip KE, Sepulveda AR, Pesci M, Harrison J, Plevy SE (2009) Infliximab prevents Crohn\u2019s disease recurrence after ileal resection. Gastroenterology 136:441\u2013450","journal-title":"Gastroenterology"},{"key":"700_CR13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/gut.25.6.665","volume":"25","author":"P Rutgeerts","year":"1984","unstructured":"Rutgeerts P, Geboes K, Vantrappen G, Kerremans R, Coenegrachts JL, Coremans G (1984) Natural history of recurrent Crohn\u2019s disease at the ileocolonic anastomosis after curative surgery. Gut 25:665\u2013672","journal-title":"Gut"},{"key":"700_CR14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ecco-jcc\/jjw169","volume":"11","author":"P Gionchetti","year":"2017","unstructured":"Gionchetti P, Dignass A, Danese S et al (2017) 3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: part 2: surgical management and special situations. J Crohn\u2019s Colitis 11:135\u2013149","journal-title":"J Crohn\u2019s Colitis"},{"key":"700_CR15","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/DCR.0b013e318208b90f","volume":"54","author":"T Kono","year":"2011","unstructured":"Kono T, Ashida T, Ebisawa Y, Chisato N, Okamoto K, Katsuno H, Maeda K, Fujiya M, Kohgo Y, Furukawa H (2011) A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic recurrence in Crohn\u2019s disease. Dis Colon Rectum 54:586\u2013592","journal-title":"Dis Colon Rectum"},{"key":"700_CR16","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","volume":"73","author":"K Slim","year":"2003","unstructured":"Slim K, Nini E, Forestier D et al (2003) Methodological index for non-randomized studies (Minors): development and validation of a new instrument. ANZ J Surg 73:712\u2013716","journal-title":"ANZ J Surg"},{"key":"700_CR17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bmjebm-2017-110853","volume":"23","author":"MH Murad","year":"2018","unstructured":"Murad MH, Sultan S, Haffar S, Bazerbachi F (2018) Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med 23:60\u201363","journal-title":"BMJ Evid Based Med"},{"key":"700_CR18","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/s11605-012-1905-7","volume":"16","author":"A Fichera","year":"2012","unstructured":"Fichera A, Zoccali M, Kono T (2012) Antimesenteric functional end-to-end handsewn (Kono-S) anastomosis. J Gastrointest Surg 16:1412\u20131416","journal-title":"J Gastrointest Surg"},{"key":"700_CR19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s11605-015-3061-3","volume":"20","author":"T Kono","year":"2016","unstructured":"Kono T, Fichera A, Maeda K, Sakai Y, Ohge H, Krane M, Katsuno H, Fujiya M (2016) Kono-S anastomosis for surgical prophylaxis of anastomotic recurrence in Crohn\u2019s disease: an international multicenter study. J Gastrointest Surg 20:783\u2013790","journal-title":"J Gastrointest Surg"},{"key":"700_CR20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000371857","volume":"32","author":"H Katsuno","year":"2015","unstructured":"Katsuno H, Maeda K, Hanai T, Masumori K, Koide Y, Kono T (2015) Novel antimesenteric functional end-to-end handsewn (Kono-s) anastomoses for Crohn\u2019s disease: a report of surgical procedure and short-term outcomes. Dig Surg 32:39\u201344","journal-title":"Dig Surg"},{"key":"700_CR21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00104-018-0668-4","volume":"90","author":"S Seyfried","year":"2019","unstructured":"Seyfried S, Post S, Kienle P, Galata CL (2019) The Kono-S anastomosis in surgery for Crohn\u2019s disease: first results of a new functional end-to-end anastomotic technique after intestinal resection in patients with Crohn\u2019s disease in Germany. Chirurg 90:131\u2013136","journal-title":"Chirurg"},{"key":"700_CR22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11605-018-4012-6","volume":"23","author":"N Shimada","year":"2018","unstructured":"Shimada N, Ohge H, Kono T, Sugitani A, Yano R, Watadani Y, Uemura K, Murakami Y, Sueda T (2018) Surgical recurrence at anastomotic site after bowel resection in Crohn\u2019s disease: comparison of Kono-S and end-to-end anastomosis. J Gastrointest Surg 23:312\u2013319","journal-title":"J Gastrointest Surg"},{"key":"700_CR23","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/ibd.21825","volume":"18","author":"P De Cruz","year":"2012","unstructured":"De Cruz P, Kamm MA, Prideaux L, Allen PB, Desmond PV (2012) Postoperative recurrent luminal Crohn\u2019s disease: a systematic review. Inflamm Bowel Dis 18:758\u2013777","journal-title":"Inflamm Bowel Dis"},{"key":"700_CR24","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/gut.2005.084061","volume":"55","author":"FL Wolters","year":"2006","unstructured":"Wolters FL, Russel MG, Sijbrandij J et al (2006) Phenotype at diagnosis predicts recurrence rates in Crohn\u2019s disease. Gut 55:1124\u20131130","journal-title":"Gut"},{"key":"700_CR25","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.crohns.2014.07.010","volume":"8","author":"MK Vester-Andersen","year":"2014","unstructured":"Vester-Andersen MK, Vind I, Prosberg MV, Bengtsson BG, Blixt T, Munkholm P, Andersson M, Jess T, Bendtsen F (2014) Hospitalisation, surgical and medical recurrence rates in inflammatory bowel disease 2003\u20132011\u2014a Danish population-based cohort study. J Crohn\u2019s Colitis 8:1675\u20131683","journal-title":"J Crohn\u2019s Colitis"},{"key":"700_CR26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ibd.21671","volume":"18","author":"T Watanabe","year":"2012","unstructured":"Watanabe T, Sasaki I, Sugita A, Fukushima K, Futami K, Hibi T, Watanabe M (2012) Interval of less than 5\u00a0years between the first and second operation is a risk factor for a third operation for Crohn\u2019s disease. Inflamm Bowel Dis 18:17\u201324","journal-title":"Inflamm Bowel Dis"},{"key":"700_CR27","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00000658-199205000-00018","volume":"215","author":"JL Cameron","year":"1992","unstructured":"Cameron JL, Hamilton SR, Coleman J, Sitzmann JV, Bayless TM (1992) Patterns of ileal recurrence in Crohn\u2019s disease. A prospective randomized study. Ann Surg 215:546\u2013551","journal-title":"Ann Surg"},{"key":"700_CR28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00268-013-1928-6","volume":"37","author":"Z Guo","year":"2013","unstructured":"Guo Z, Li Y, Zhu W, Gong J, Li N, Li J (2013) Comparing outcomes between side-to-side anastomosis and other anastomotic configurations after intestinal resection for patients with Crohn\u2019s disease: a meta-analysis. World J Surg 37:893\u2013901","journal-title":"World J Surg"},{"key":"700_CR29","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s10620-014-3039-0","volume":"59","author":"X He","year":"2014","unstructured":"He X, Chen Z, Huang J, Lian L, Rouniyar S, Wu X, Lan P (2014) Stapled side-to-side anastomosis might be better than handsewn end-to-end anastomosis in ileocolic resection for Crohn\u2019s disease: a meta-analysis. Dig Dis Sci 59:1544\u20131551","journal-title":"Dig Dis Sci"},{"key":"700_CR30","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00423-012-0904-1","volume":"398","author":"U Zurbuchen","year":"2013","unstructured":"Zurbuchen U, Kroesen AJ, Knebel P, Betzler MH, Becker H, Bruch HP, Senninger N, Post S, Buhr HJ, Ritz JP, German Advanced Surgical Treatment Study Group (2013) Complications after end-to-end vs. side-to-side anastomosis in ileocecal Crohn\u2019s disease\u2014early postoperative results from a randomized controlled multi-center trial (ISRCTN-45665492). Langenbeck\u2019s Arch Surg 398:467\u2013474","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"700_CR31","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/DCR.0b013e3181a4fa58","volume":"52","author":"RS McLeod","year":"2009","unstructured":"McLeod RS, Wolff BG, Ross S, Parkes R, McKenzie M, Investigators of the CAST Trial (2009) Recurrence of Crohn\u2019s disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial. Dis Colon Rectum 52:919\u2013927","journal-title":"Dis Colon Rectum"},{"key":"700_CR32","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/BF02258231","volume":"41","author":"M Hashemi","year":"1998","unstructured":"Hashemi M, Novell JR, Lewis AA (1998) Side-to side stapled anastomosis may delay recurrence in Crohn\u2019s disease. Dis Colon Rectum 41:1293\u20131296","journal-title":"Dis Colon Rectum"},{"key":"700_CR33","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/003655299750025921","volume":"34","author":"T Yamamoto","year":"1999","unstructured":"Yamamoto T, Bain IM, Mylonakis E, Allan RN, Keighley MR (1999) Stapled functional end-to-end anastomosis versus sutured end-to-end anastomosis after ileocolonic resection in Crohn disease. Scand J Gastroenterol 34:708\u2013713","journal-title":"Scand J Gastroenterol"},{"key":"700_CR34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF02234814","volume":"44","author":"M Mu\u00f1oz-Ju\u00e1rez","year":"2001","unstructured":"Mu\u00f1oz-Ju\u00e1rez M, Yamamoto T, Wolff BG, Keighley MR (2001) Wide-lumen stapled anastomosis vs. conventional end-to-end anastomosis in the treatment of Crohn\u2019s disease. Dis Colon Rectum 44:20\u201326","journal-title":"Dis Colon Rectum"},{"key":"700_CR35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S2468-1253(16)30026-7","volume":"1","author":"JC Coffey","year":"2016","unstructured":"Coffey JC, O\u2019Leary DP (2016) The mesentery: structure, function, and role in disease. Lancet Gastroenterol Hepatol 1:238\u2013247","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"700_CR36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/MOG.0000000000000280","volume":"32","author":"JC Coffey","year":"2016","unstructured":"Coffey JC, O\u2019Leary DP, Kiernan MG, Faul P (2016) The mesentery in Crohn\u2019s disease: friend or foe? Curr Opin Gastroenterol 32:267\u2013273","journal-title":"Curr Opin Gastroenterol"},{"key":"700_CR37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/ecco-jcc\/jjx187","volume":"12","author":"CJ Coffey","year":"2018","unstructured":"Coffey CJ, Kiernan MG, Sahebally SM (2018) Inclusion of the mesentery in ileocolic resection for Crohn\u2019s disease is associated with reduced surgical recurrence. J Crohn\u2019s Colitis 12:1139\u20131150","journal-title":"J Crohn\u2019s Colitis"},{"key":"700_CR38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00384-018-3197-1","volume":"34","author":"R Peltrini","year":"2019","unstructured":"Peltrini R, Bucci L (2019) \u201cMesentery-based surgery\u201d to prevent surgical recurrence in Crohn\u2019s disease: from basics to surgical practice. Int J Colorectal Dis 34:353\u2013354","journal-title":"Int J Colorectal Dis"},{"key":"700_CR39","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s00595-015-1110-x","volume":"45","author":"H Ojima","year":"2015","unstructured":"Ojima H, Sohda M, Ando H, Sano A, Fukai Y, Ogawa A, Mochida Y, Kuwano H (2015) Relationship between functional end-to-end anastomosis for colon cancer and surgical site infections. Surg Today 45:1489\u20131492","journal-title":"Surg Today"},{"key":"700_CR40","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00384-016-2567-9","volume":"31","author":"G Luglio","year":"2016","unstructured":"Luglio G, Rispo A, Castiglione F, Imperatore N, Giglio MC, De Palma GD, Bucci L (2016) Kono-type anastomosis in a patient with severe multi-recurrent Crohn\u2019s disease. Int J Colorectal Dis 31:1565\u20131566","journal-title":"Int J Colorectal Dis"},{"issue":"Suppl 1","key":"700_CR41","first-page":"S398","volume":"10","author":"G Luglio","year":"2016","unstructured":"Luglio G, Giglio MC, Rispo A, Peltrini R, Sacco M, Sollazzo V, Bucci C, Spadarella E, Terracciano F, De Palma GD, Bucci L (2016) SuPREMe-CD study: surgical prevention of anastomotic recurrence by excluding mesentery in Crohn\u2019s disease-preliminary results and trial protocol. J Crohn\u2019s Colitis 10(Suppl 1):S398","journal-title":"J Crohn\u2019s Colitis"}],"container-title":["Updates in Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-019-00700-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13304-019-00700-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-019-00700-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:29:20Z","timestamp":1609460960000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13304-019-00700-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["700"],"URL":"https:\/\/doi.org\/10.1007\/s13304-019-00700-w","relation":{},"ISSN":["2038-131X","2038-3312"],"issn-type":[{"type":"print","value":"2038-131X"},{"type":"electronic","value":"2038-3312"}],"subject":[],"published":{"date-parts":[[2020,1,2]]},"assertion":[{"value":"23 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"The informed consent does not apply since this is a review study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}