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In this single-center, retrospective, observational cohort study. All patients treated with above-the-knee amputation (AKA) or below-the-knee amputation (BKA) between January 1st, 2010 and June 30th, 2018 were identified. The primary outcome of interest was early (\u2264\u200930\u00a0days) mortality. Secondary outcomes were postoperative complications and freedom from amputation stump revision\/failure. We identified 310 (77.7%) mLEAs performed on 286 patients. There were 188 (65.7%) men and 98 (34.3%) women with a median age of 79\u00a0years (IQR, 69\u201383\u00a0years). We performed 257 (82.9%) AKA and 53 (17.1%) BKA. There were 49 (15.8%) early deaths, which did not differ among the age quartiles of this cohort (15.4% vs. 14.3% vs. 15.4% vs. 19.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.826). Binary logistic regression analysis identified age\u2009&gt;\u200980\u00a0years (OR 2.24, 95% CI 1.17\u20134.31;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.015), chronic obstructive pulmonary disease (OR 2.12, 95% CI 1.11\u20134.06;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.023), and hemodialysis (OR 2.52, 95% CI 1.15\u20135.52;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.021) to be associated with early mortality. The final score (range 0\u201310) identified two subgroups with different mortality at 30\u00a0days: lower-risk (score\u2009&lt;\u20094, 10.8%), and higher-risk (score\u2009\u2265\u20094: 28.7%; OR 3.2, 95% CI 1.63\u20136.32;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). In our experience, mLEAs still have a 14% mortality rate over the years. Our lower-risk group (score\u2009&lt;\u20094) is characterized by a lower rate of perioperative death and longer survival.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphic abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s13304-021-01085-5","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:02:30Z","timestamp":1623542550000},"page":"1989-2000","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A predictive score for 30-day survival for patients undergoing major lower limb amputation for peripheral arterial obstructive disease"],"prefix":"10.1007","volume":"73","author":[{"given":"Marco","family":"Franchin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Iannuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Rivolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaddiel","family":"Mozzetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Tozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth L.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-4658","authenticated-orcid":false,"given":"Gabriele","family":"Piffaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"1085_CR1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.avsg.2016.12.015","volume":"42","author":"JR Stern","year":"2017","unstructured":"Stern JR, Wong CK, Yerovinkina M, Spindler SJ, See AS, Panjaki S et al (2017) A meta-analysis of long-term mortality and associated risk factors following lower extremity amputation. 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