{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:40:39Z","timestamp":1787319639587,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Updates Surg"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2\u201320% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.<\/jats:p>","DOI":"10.1007\/s13304-022-01315-4","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T14:02:26Z","timestamp":1657980146000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer"],"prefix":"10.1007","volume":"75","author":[{"given":"Eider","family":"Talavera-Urquijo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas P. L.","family":"Wijnhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"1315_CR1","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1186\/s12885-019-5922-8","volume":"19","author":"WH Han","year":"2019","unstructured":"Han WH, Eom BW, Yoon HM, Reim D, Kim YW, Kim MS et al (2019) The optimal extent of lymph node dissection in gastroesophageal junctional cancer: retrospective case control study. BMC Cancer 19:719. https:\/\/doi.org\/10.1186\/s12885-019-5922-8","journal-title":"BMC Cancer"},{"issue":"4 suppl","key":"1315_CR2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1200\/JCO.2019.37.4_suppl.40","volume":"37","author":"M Bartel","year":"2019","unstructured":"Bartel M, Brahmbhatt B, Bhurwal A (2019) Incidence of gastroesophageal junction cancer continues to rise: analysis of surveillance, epidemiology, and end results (SEER) database. J Clin Oncol 37(4 suppl):40\u201340. https:\/\/doi.org\/10.1200\/JCO.2019.37.4_suppl.40","journal-title":"J Clin Oncol"},{"issue":"3","key":"1315_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/00000658-200009000-00007","volume":"232","author":"J R\u00fcdiger Siewert","year":"2000","unstructured":"R\u00fcdiger Siewert J, Feith M, Werner M, Stein HJ (2000) Adenocarcinoma of the esophagogastric junction: results of surgical therapy based on anatomical\/topographic classification in 1,002 consecutive patients. Ann Surg 232(3):353\u2013361. https:\/\/doi.org\/10.1097\/00000658-200009000-00007","journal-title":"Ann Surg"},{"key":"1315_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004303","author":"YS Suh","year":"2020","unstructured":"Suh YS, Na D, Lee JS et al (2020) Comprehensive molecular characterization of adenocarcinoma of the gastroesophageal junction between esophageal and gastric adenocarcinomas. Ann Surg. https:\/\/doi.org\/10.1097\/SLA.0000000000004303","journal-title":"Ann Surg"},{"key":"1315_CR5","doi-asserted-by":"publisher","first-page":"e88","DOI":"10.1200\/EDBK_236827","volume":"39","author":"D Lin","year":"2019","unstructured":"Lin D, Khan U, Goetze TO, Reizine N, Goodman KA, Shah MA et al (2019) Gastroesophageal junction adenocarcinoma: is there an optimal management? Am Soc Clin Oncol Educ Book 39:e88\u2013e95. https:\/\/doi.org\/10.1200\/EDBK_236827","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"3","key":"1315_CR6","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/S1470-2045(10)70125-X","volume":"12","author":"C Mariette","year":"2011","unstructured":"Mariette C, Piessen G, Briez N, Gronnier C, Triboulet JP (2011) Oesophagogastric junction adenocarcinoma: which therapeutic approach? Lancet Oncol 12(3):296\u2013305. https:\/\/doi.org\/10.1016\/S1470-2045(10)70125-X","journal-title":"Lancet Oncol"},{"issue":"16","key":"1315_CR7","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1016\/j.ejca.2012.07.029","volume":"48","author":"MP Lutz","year":"2012","unstructured":"Lutz MP, Zalcberg JR, Ducreux M, Ajani JA, Allum W, Aust D et al (2012) First St Gallen EORTC gastrointestinal cancer conference 2012 expert panel. Highlights of the EORTC St. Gallen international expert consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - differential treatment strategies for subtypes of early gastroesophageal cancer. Eur J Cancer 48(16):2941\u201353. https:\/\/doi.org\/10.1016\/j.ejca.2012.07.029","journal-title":"Eur J Cancer"},{"issue":"1","key":"1315_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/dote.12480","volume":"30","author":"L Haverkamp","year":"2017","unstructured":"Haverkamp L, Seesing MF, Ruurda JP, Boone J, Hillegersberg VR (2017) Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer. Dis Esophagus 30(1):1\u20137. https:\/\/doi.org\/10.1111\/dote.12480","journal-title":"Dis Esophagus"},{"issue":"4","key":"1315_CR9","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.suronc.2014.10.004","volume":"23","author":"L Haverkamp","year":"2014","unstructured":"Haverkamp L, Ruurda JP, van Leeuwen MS, Siersema PD, van Hillegersberg R (2014) Systematic review of the surgical strategies of adenocarcinomas of the gastroesophageal junction. Surg Oncol 23(4):222\u2013228. https:\/\/doi.org\/10.1016\/j.suronc.2014.10.004","journal-title":"Surg Oncol"},{"issue":"1","key":"1315_CR10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s10120-015-0466-3","volume":"19","author":"H Fuchs","year":"2016","unstructured":"Fuchs H, H\u00f6lscher AH, Leers J, Bludau M, Brinkmann S, Schr\u00f6der W et al (2016) Long-term quality of life after surgery for adenocarcinoma of the esophagogastric junction: extended gastrectomy or transthoracic esophagectomy? Gastric Cancer 19(1):312\u2013317. https:\/\/doi.org\/10.1007\/s10120-015-0466-3","journal-title":"Gastric Cancer"},{"issue":"8","key":"1315_CR11","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s00423-017-1610-9","volume":"402","author":"AM Brown","year":"2017","unstructured":"Brown AM, Giugliano DN, Berger AC, Pucci MJ, Palazzo F (2017) Surgical approaches to adenocarcinoma of the gastroesophageal junction: the Siewert II conundrum. Langenbecks Arch Surg 402(8):1153\u20131158. https:\/\/doi.org\/10.1007\/s00423-017-1610-9 (Epub 2017 Aug 12)","journal-title":"Langenbecks Arch Surg"},{"issue":"1","key":"1315_CR12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/ags3.12406","volume":"5","author":"Y Imamura","year":"2020","unstructured":"Imamura Y, Watanabe M, Oki E, Morita M, Baba H (2020) Esophagogastric junction adenocarcinoma shares characteristics with gastric adenocarcinoma: literature review and retrospective multicenter cohort study. Ann Gastroenterol Surg 5(1):46\u201359. https:\/\/doi.org\/10.1002\/ags3.12406","journal-title":"Ann Gastroenterol Surg"},{"issue":"6","key":"1315_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/jso.20731","volume":"95","author":"BC Cho","year":"2007","unstructured":"Cho BC, Jeung HC, Choi HJ, Rha SY, Hyung WJ, Cheong JH et al (2007) Prognostic impact of resection margin involvement after extended (D2\/D3) gastrectomy for advanced gastric cancer: a 15-year experience at a single institute. J Surg Oncol 95(6):461\u2013468. https:\/\/doi.org\/10.1002\/jso.20731","journal-title":"J Surg Oncol"},{"issue":"1","key":"1315_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s10120-015-0589-6","volume":"20","author":"M Bissolati","year":"2017","unstructured":"Bissolati M, Desio M, Rosa F, Rausei S, Marrelli D, Baiocchi GL et al (2017) Risk factor analysis for involvement of resection margins in gastric and esophagogastric junction cancer: an Italian multicenter study. Gastric Cancer 20(1):70\u201382. https:\/\/doi.org\/10.1007\/s10120-015-0589-6","journal-title":"Gastric Cancer"},{"issue":"1","key":"1315_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10120-020-01042-y","volume":"24","author":"Japanese Gastric Cancer Association","year":"2021","unstructured":"Japanese Gastric Cancer Association (2021) Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer 24(1):1\u201321. https:\/\/doi.org\/10.1007\/s10120-020-01042-y","journal-title":"Gastric Cancer"},{"issue":"5","key":"1315_CR16","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ejso.2013.09.020","volume":"40","author":"T Waddell","year":"2014","unstructured":"Waddell T, Verheij M, Allum W, Cunningham D, Cervantes A, Arnold D (2014) Gastric cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Eur J Surg Oncol 40(5):584\u2013591. https:\/\/doi.org\/10.1016\/j.ejso.2013.09.020","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"1315_CR17","doi-asserted-by":"publisher","first-page":"378","DOI":"10.6004\/jnccn.2010.0030","volume":"8","author":"JA Ajani","year":"2010","unstructured":"Ajani JA, Barthel JS, Bekaii-Saab T, Bentrem DJ, D\u2019Amico TA, Das P et al (2010) NCCN gastric cancer panel. Gastric Cancer J Natl Compr Canc Netw 8(4):378\u2013409. https:\/\/doi.org\/10.6004\/jnccn.2010.0030","journal-title":"Gastric Cancer J Natl Compr Canc Netw"},{"issue":"11","key":"1315_CR18","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1136\/gut.2010.228254","volume":"60","author":"WH Allum","year":"2011","unstructured":"Allum WH, Blazeby JM, Griffin SM, Cunningham D, Jankowski JA, Wong R (2011) Association of upper gastrointestinal surgeons of great britain and Ireland, the British society of gastroenterology and the British association of surgical oncology. Guidelines for the management of oesophageal and gastric cancer. Gut 60(11):1449\u201372. https:\/\/doi.org\/10.1136\/gut.2010.228254","journal-title":"Gut"},{"key":"1315_CR19","unstructured":"Landelijke werkgroep Gastro-intestinale Tumoren. Richtlijn: Maagcarcinoom (2.2) - richtlijnendatabase. 2017 [cited 2022 Jan 24]. Available from: https:\/\/richtlijnendatabase.nl\/gerelateerde_documenten\/f\/16316\/IKNL%20richtlijn%20Maagcarcinoom.pdf"},{"issue":"4","key":"1315_CR20","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1055\/s-0031-1273201","volume":"49","author":"M Moehler","year":"2011","unstructured":"Moehler M, Al-Batran SE, Andus T, Anthuber M, Arends J, Arnold D et al (2011) AWMF; AWMF S3-Leitlinie \u201cMagenkarzinom\u201d - Diagnostik und Therapie der Adenokarzinome des Magens und \u00f6sophagogastralen \u00dcbergangs (AWMF-Regist-Nr 032\u2013009-OL) [German S3-guideline \u201cDiagnosis and treatment of esophagogastric cancer\u201d]. Z Gastroenterol 49(4):461\u2013531. https:\/\/doi.org\/10.1055\/s-0031-1273201","journal-title":"Z Gastroenterol"},{"key":"1315_CR21","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 (HAS) and Institut National du Cancer (2011) Guide\u2014Affection de longue dur\u00e9e (ALD). Tumeur maligne, affection maligne du tissue lymphatique ou h\u00e9matopoi\u00e9tique. Cancer de l\u2019estomac. http:\/\/www.has-sante.fr, http:\/\/www.e-cancer.fr. Accessed date 24 Jan 2022"},{"issue":"1","key":"1315_CR22","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s10120-016-0615-3","volume":"20","author":"G De Manzoni","year":"2017","unstructured":"De Manzoni G, Marrelli D, Baiocchi GL, Morgagni P, Saragoni L, Degiuli M et al (2017) The Italian research group for gastric cancer (GIRCG) guidelines for gastric cancer staging and treatment: 2015. Gastric Cancer 20(1):20\u201330. https:\/\/doi.org\/10.1007\/s10120-016-0615-3","journal-title":"Gastric Cancer"},{"issue":"11","key":"1315_CR23","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1046\/j.1365-2168.2002.02220.x","volume":"89","author":"HH Hartgrink","year":"2022","unstructured":"Hartgrink HH, Putter H, Klein Kranenbarg E, Bonenkamp JJ, van de Velde CJ (2022) Dutch gastric cancer group. Value of palliative resection in gastric cancer. Br J Surg 89(11):1438\u201343. https:\/\/doi.org\/10.1046\/j.1365-2168.2002.02220.x","journal-title":"Br J Surg"},{"issue":"3","key":"1315_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S1470-2045(15)00553-7","volume":"17","author":"K Fujitani","year":"2016","unstructured":"Fujitani K, Yang HK, Mizusawa J, Kim YW, Terashima M, Han SU et al (2016) REGATTA study investigators. Gastrectomy plus chemotherapy versus chemotherapy alone for advanced gastric cancer with a single non-curable factor (REGATTA): a phase 3, randomised controlled trial. Lancet Oncol 17(3):309\u2013318. https:\/\/doi.org\/10.1016\/S1470-2045(15)00553-7","journal-title":"Lancet Oncol"},{"key":"1315_CR25","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1002\/jso.23123","volume":"106","author":"JH Lee","year":"2012","unstructured":"Lee JH, Ahn SH, Park Do J, Kim HH, Lee HJ, Yang HK (2012) Clinical impact of tumor infiltration at the transected surgical margin during gastric cancer surgery. J Surg Oncol 106:772\u2013776","journal-title":"J Surg Oncol"},{"key":"1315_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5230\/jgc.2012.12.2.113","volume":"12","author":"SY Kim","year":"2012","unstructured":"Kim SY, Hwang YS, Sohn TS, Oh SJ, Choi MG, Noh JH et al (2012) The predictors and clinical impact of positive resection margins on frozen section in gastric cancer surgery. J Gastric Cancer 12:113\u2013119","journal-title":"J Gastric Cancer"},{"issue":"13","key":"1315_CR27","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1245\/s10434-014-3834-z","volume":"21","author":"MH Squires 3rd","year":"2014","unstructured":"Squires MH 3rd, Kooby DA, Pawlik TM, Weber SM, Poultsides G, Schmidt C et al (2014) Utility of the proximal margin frozen section for resection of gastric adenocarcinoma: a 7-institution study of the US gastric cancer collaborative. Ann Surg Oncol 21(13):4202\u20134210. https:\/\/doi.org\/10.1245\/s10434-014-3834-z","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"1315_CR28","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1245\/s10434-019-07381-0","volume":"26","author":"LR van der Werf","year":"2019","unstructured":"van der Werf LR, Cords C, Arntz I, Belt EJT, Cherepanin IM, Coene PLO et al (2019) Population-based study on risk factors for tumor-positive resection margins in patients with gastric cancer. Ann Surg Oncol 26(7):2222\u20132233. https:\/\/doi.org\/10.1245\/s10434-019-07381-0","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"1315_CR29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12893-020-00744-5","volume":"20","author":"Y Kumazu","year":"2020","unstructured":"Kumazu Y, Hayashi T, Yoshikawa T, Yamada T, Hara K, Shimoda Y et al (2020) Risk factors analysis and stratification for microscopically positive resection margin in gastric cancer patients. BMC Surg 20(1):95. https:\/\/doi.org\/10.1186\/s12893-020-00744-5","journal-title":"BMC Surg"},{"key":"1315_CR30","doi-asserted-by":"publisher","DOI":"10.1177\/10732748211043665","author":"Z Jiang","year":"2021","unstructured":"Jiang Z, Liu C, Cai Z, Shen C, Yin Y, Yin X et al (2021) Impact of surgical margin status on survival in gastric cancer: a systematic review and meta-analysis. Cancer Control. https:\/\/doi.org\/10.1177\/10732748211043665","journal-title":"Cancer Control"},{"key":"1315_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-021-01238-w","author":"Y Muneoka","year":"2021","unstructured":"Muneoka Y, Ohashi M, Ishizuka N, Hayami M, Makuuchi R, Ida S et al (2021) Risk factors and oncological impact of positive resection margins in gastrectomy for cancer: are they salvaged by an additional resection? Gastric Cancer. https:\/\/doi.org\/10.1007\/s10120-021-01238-w","journal-title":"Gastric Cancer"},{"issue":"7","key":"1315_CR32","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.ejso.2013.02.026","volume":"39","author":"J Stiekema","year":"2013","unstructured":"Stiekema J, Cats A, Kuijpers A, van Coevorden F, Boot H, Jansen EP et al (2013) Surgical treatment results of intestinal and diffuse type gastric cancer. Implications for a differentiated therapeutic approach? Eur J Surg Oncol 39(7):686\u201393. https:\/\/doi.org\/10.1016\/j.ejso.2013.02.026","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"1315_CR33","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1245\/s10434-015-4947-8","volume":"23","author":"AU Blackham","year":"2016","unstructured":"Blackham AU, Swords DS, Levine EA, Fino NF, Squires MH, Poultsides G et al (2016) Is linitis plastica a contraindication for surgical resection: a multi-institution study of the U.S. gastric cancer collaborative. Ann Surg Oncol 23(4):1203\u201311. https:\/\/doi.org\/10.1245\/s10434-015-4947-8","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"1315_CR34","doi-asserted-by":"publisher","first-page":"356","DOI":"10.21037\/jgo.2020.03.03","volume":"11","author":"LX Ma","year":"2020","unstructured":"Ma LX, Espin-Garcia O, Lim CH, Jiang DM, Sim HW, Natori A et al (2020) Impact of adjuvant therapy in patients with a microscopically positive margin after resection for gastric and esophageal cancers. J Gastrointest Oncol 11(2):356\u2013365. https:\/\/doi.org\/10.21037\/jgo.2020.03.03","journal-title":"J Gastrointest Oncol"},{"key":"1315_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009944.pub2","author":"S Mocellin","year":"2015","unstructured":"Mocellin S, Pasquali S (2015) Diagnostic accuracy of endoscopic ultrasonography (EUS) for the preoperative locoregional staging of primary gastric cancer. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD009944.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"1315_CR36","doi-asserted-by":"publisher","first-page":"e201","DOI":"10.1097\/RLU.0000000000000661","volume":"40","author":"D Fuster","year":"2015","unstructured":"Fuster D, Mayoral M, Rubello D, Pineda E, Fern\u00e1ndez-Esparrach G, Pag\u00e8s M et al (2015) Is there a role for PET\/CT with esophagogastric junction adenocarcinoma? Clin Nucl Med 40(3):e201\u2013e207. https:\/\/doi.org\/10.1097\/RLU.0000000000000661","journal-title":"Clin Nucl Med"},{"issue":"2","key":"1315_CR37","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1700\/1491.16415","volume":"100","author":"K Park","year":"2014","unstructured":"Park K, Jang G, Baek S, Song H (2014) Usefulness of combined PET\/CT to assess regional lymph node involvement in gastric cancer. Tumori 100(2):201\u20136. https:\/\/doi.org\/10.1700\/1491.16415","journal-title":"Tumori"},{"issue":"10184","key":"1315_CR38","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1016\/S0140-6736(18)32557-1","volume":"393","author":"SE Al-Batran","year":"2019","unstructured":"Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S et al (2019) Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2\/3 trial. Lancet 393(10184):1948\u20131957. https:\/\/doi.org\/10.1016\/S0140-6736(18)32557-1","journal-title":"Lancet"},{"issue":"9","key":"1315_CR39","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/S1470-2045(15)00040-6","volume":"16","author":"J Shapiro","year":"2015","unstructured":"Shapiro J, van Lanschot JJB, Hulshof MCCM, van Hagen P, van Berge Henegouwen MI, Wijnhoven BPL et al (2015) Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol 16(9):1090\u20131098. https:\/\/doi.org\/10.1016\/S1470-2045(15)00040-6","journal-title":"Lancet Oncol"},{"issue":"2","key":"1315_CR40","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s13304-018-0552-2","volume":"70","author":"P Morgagni","year":"2018","unstructured":"Morgagni P, La Barba G, Colciago E, Vittimberga G, Ercolani G (2018) Resection line involvement after gastric cancer treatment: handle with care. Updates Surg 70(2):213\u2013223. https:\/\/doi.org\/10.1007\/s13304-018-0552-2","journal-title":"Updates Surg"},{"issue":"1","key":"1315_CR41","doi-asserted-by":"publisher","first-page":"142","DOI":"10.21037\/jgo-20-277","volume":"12","author":"P Yuan","year":"2021","unstructured":"Yuan P, Yan Y, Jia Y, Wang J, Li Z, Wu Q (2021) Intraoperative gastroscopy to determine proximal resection margin during totally laparoscopic gastrectomy for patients with upper third gastric cancer. J Gastrointest Oncol 12(1):142\u2013152. https:\/\/doi.org\/10.21037\/jgo-20-277","journal-title":"J Gastrointest Oncol"},{"issue":"13","key":"1315_CR42","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1002\/bjs.10618","volume":"104","author":"S Kawakatsu","year":"2017","unstructured":"Kawakatsu S, Ohashi M, Hiki N, Nunobe S, Nagino M, Sano T (2017) Use of endoscopy to determine the resection margin during laparoscopic gastrectomy for cancer. Br J Surg 104(13):1829\u20131836. https:\/\/doi.org\/10.1002\/bjs.10618","journal-title":"Br J Surg"},{"issue":"8","key":"1315_CR43","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1245\/s10434-014-3669-7","volume":"21","author":"J Spicer","year":"2014","unstructured":"Spicer J, Benay C, Lee L, Rousseau M, Andalib A, Kushner Y et al (2014) Diagnostic accuracy and utility of intraoperative microscopic margin analysis of gastric and esophageal adenocarcinoma. Ann Surg Oncol 21(8):2580\u20132586. https:\/\/doi.org\/10.1245\/s10434-014-3669-7","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"1315_CR44","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1097\/SLA.0000000000004266","volume":"272","author":"F Berlth","year":"2020","unstructured":"Berlth F, Kim WH, Choi JH, Park SH, Kong SH, Lee HJ et al (2020) Prognostic impact of frozen section investigation and extent of proximal safety margin in gastric cancer resection. Ann Surg 272(5):871\u2013878. https:\/\/doi.org\/10.1097\/SLA.0000000000004266","journal-title":"Ann Surg"},{"issue":"6","key":"1315_CR45","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/jjco\/29.6.291","volume":"29","author":"S Cascinu","year":"1999","unstructured":"Cascinu S, Giordani P, Catalano V, Agostinelli R, Catalano G (1999) Resection-line involvement in gastric cancer patients undergoing curative resections: implications for clinical management. Jpn J Clin Oncol 29(6):291\u2013293. https:\/\/doi.org\/10.1093\/jjco\/29.6.291","journal-title":"Jpn J Clin Oncol"},{"issue":"1","key":"1315_CR46","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/s1091-255x(99)80004-3","volume":"3","author":"SH Kim","year":"1999","unstructured":"Kim SH, Karpeh MS, Klimstra DS, Leung D, Brennan MF (1999) Effect of microscopic resection line disease on gastric cancer survival. J Gastrointest Surg 3(1):24\u201333. https:\/\/doi.org\/10.1016\/s1091-255x(99)80004-3","journal-title":"J Gastrointest Surg"},{"issue":"11","key":"1315_CR47","first-page":"6283","volume":"34","author":"P Aurello","year":"2014","unstructured":"Aurello P, Magistri P, Nigri G, Petrucciani N, Novi L, Antolino L et al (2014) Surgical management of microscopic positive resection margin after gastrectomy for gastric cancer: a systematic review of gastric R1 management. Anticancer Res 34(11):6283\u20136288","journal-title":"Anticancer Res"},{"issue":"8","key":"1315_CR48","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1245\/s10434-013-2950-5","volume":"20","author":"KA Bickenbach","year":"2013","unstructured":"Bickenbach KA, Gonen M, Strong V, Brennan MF, Coit DG (2013) Association of positive transection margins with gastric cancer survival and local recurrence. Ann Surg Oncol 20(8):2663\u20132668. https:\/\/doi.org\/10.1245\/s10434-013-2950-5","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"1315_CR49","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1245\/s10434-014-4032-8","volume":"22","author":"J Stiekema","year":"2015","unstructured":"Stiekema J, Trip AK, Jansen EP, Aarts MJ, Boot H, Cats A et al (2015) Does adjuvant chemoradiotherapy improve the prognosis of gastric cancer after an r1 resection? Results from a dutch cohort study. Ann Surg Oncol 22(2):581\u2013588. https:\/\/doi.org\/10.1245\/s10434-014-4032-8","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"1315_CR50","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1245\/s10434-013-3397-4","volume":"21","author":"J Stiekema","year":"2014","unstructured":"Stiekema J, Trip AK, Jansen EP, Boot H, Cats A, Ponz OB et al (2014) The prognostic significance of an R1 resection in gastric cancer patients treated with adjuvant chemoradiotherapy. Ann Surg Oncol 21(4):1107\u20131114. https:\/\/doi.org\/10.1245\/s10434-013-3397-4","journal-title":"Ann Surg Oncol"},{"issue":"14","key":"1315_CR51","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1200\/JCO.2009.26.9654","volume":"28","author":"JL Dikken","year":"2010","unstructured":"Dikken JL, Jansen EP, Cats A, Bakker B, Hartgrink HH, Kranenbarg EM et al (2010) Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer. J Clin Oncol 28(14):2430\u20132436. https:\/\/doi.org\/10.1200\/JCO.2009.26.9654","journal-title":"J Clin Oncol"},{"issue":"1089","key":"1315_CR52","doi-asserted-by":"publisher","first-page":"20180276","DOI":"10.1259\/bjr.20180276","volume":"91","author":"ML Zhou","year":"2018","unstructured":"Zhou ML, Li GC, Yang W, Deng WJ, Hu R, Wang Y et al (2018) Adjuvant chemoradiotherapy versus adjuvant chemotherapy for R1 resected gastric cancer: a retrospective cohort study. Br J Radiol 91(1089):20180276. https:\/\/doi.org\/10.1259\/bjr.20180276","journal-title":"Br J Radiol"}],"container-title":["Updates in Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-022-01315-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13304-022-01315-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-022-01315-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T16:20:59Z","timestamp":1674145259000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13304-022-01315-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,16]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1315"],"URL":"https:\/\/doi.org\/10.1007\/s13304-022-01315-4","relation":{},"ISSN":["2038-131X","2038-3312"],"issn-type":[{"value":"2038-131X","type":"print"},{"value":"2038-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,16]]},"assertion":[{"value":"26 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}