{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:00:33Z","timestamp":1793520033635,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Updates Surg"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s13304-023-01734-x","type":"journal-article","created":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T11:02:10Z","timestamp":1702810930000},"page":"589-593","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The unexpected effect of parathyroid adenoma on inflammation"],"prefix":"10.1007","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2888-7646","authenticated-orcid":false,"given":"Ahmet Tarik","family":"Harmantepe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9888-0661","authenticated-orcid":false,"given":"Belma","family":"Kocer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-7267","authenticated-orcid":false,"given":"Zulfu","family":"Bayhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-4414","authenticated-orcid":false,"given":"Emre","family":"Gonullu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-715X","authenticated-orcid":false,"given":"Ugur Can","family":"Dulger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,17]]},"reference":[{"key":"1734_CR1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0003-4975(00)02348-1","volume":"71","author":"RP Boushey","year":"2001","unstructured":"Boushey RP, Todd TR (2001) Middle mediastinal parathyroid: diagnosis and surgical approach. Ann Thorac Surg 71:699\u2013701","journal-title":"Ann Thorac Surg"},{"key":"1734_CR2","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1210\/jc.2012-4022","volume":"98","author":"MW Yeh","year":"2013","unstructured":"Yeh MW, Ituarte PHG, Zhou HC et al (2013) Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab 98:1122\u20131129","journal-title":"J Clin Endocrinol Metab"},{"key":"1734_CR3","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1210\/jc.2018-01225","volume":"103","author":"JP Bilezikian","year":"2018","unstructured":"Bilezikian JP (2018) Primary hyperparathyroidism. J Clin Endocrinol Metab 103:3993\u20134004","journal-title":"J Clin Endocrinol Metab"},{"key":"1734_CR4","first-page":"801","volume":"34","author":"BC Silva","year":"2011","unstructured":"Silva BC, Costa AG, Cusano NE et al (2011) Catabolic and anabolic actions of parathyroid hormone on the skeleton. J Endocrinol Invest 34:801\u2013810","journal-title":"J Endocrinol Invest"},{"key":"1734_CR5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1056\/NEJM199301213280304","volume":"328","author":"DS Rao","year":"1993","unstructured":"Rao DS, Shih MS, Mohini R (1993) Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia. N Engl J Med 328:171\u2013175","journal-title":"N Engl J Med"},{"key":"1734_CR6","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/j.1365-2257.2006.00877.x","volume":"29","author":"D-J Lim","year":"2007","unstructured":"Lim D-J, Oh EJ, Park C-W et al (2007) Pancytopenia and secondary myelofibrosis could be induced by primary hyperparathyroidism. Int J Lab Hematol 29:464\u2013468","journal-title":"Int J Lab Hematol"},{"key":"1734_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1055\/s-2004-817820","volume":"112","author":"B Kumbasar","year":"2004","unstructured":"Kumbasar B, Taylan I, Kazancioglu R et al (2004) Myelofibrosis secondary to hyperparathyroidism. Exp Clin Endocrinol Diabetes 112:127\u2013130","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1734_CR8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fonc.2018.00078","volume":"8","author":"JL Sylman","year":"2018","unstructured":"Sylman JL, Mitrugno A, Atallah M et al (2018) The predictive value of inflammation-related peripheral blood measurements in cancer staging and prognosis. Front Oncol 8:78","journal-title":"Front Oncol"},{"key":"1734_CR9","doi-asserted-by":"publisher","first-page":"16717","DOI":"10.1038\/s41598-017-16955-5","volume":"7","author":"RD Dolan","year":"2017","unstructured":"Dolan RD, Lim J, McSorley ST et al (2017) The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: systematic review and meta-analysis. Sci Rep 7:16717","journal-title":"Sci Rep"},{"key":"1734_CR10","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","volume":"20","author":"B Hu","year":"2014","unstructured":"Hu B, Yang X-R, Xu Y et al (2014) Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 20:6212\u20136222","journal-title":"Clin Cancer Res"},{"key":"1734_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/CEJ.0000000000000092","volume":"24","author":"S Kilincalp","year":"2015","unstructured":"Kilincalp S, \u00c7oban \u015e, Akinci H et al (2015) Neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma. Eur J Cancer Prev 24:328\u2013333","journal-title":"Eur J Cancer Prev"},{"key":"1734_CR12","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3233\/CBM-150534","volume":"15","author":"L Lian","year":"2015","unstructured":"Lian L, Xia Y-Y, Zhou C et al (2015) Application of platelet\/lymphocyte and neutrophil\/lymphocyte ratios in early diagnosis and prognostic prediction in patients with resectable gastric cancer. Cancer Biomark 15:899\u2013907","journal-title":"Cancer Biomark"},{"key":"1734_CR13","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10552-018-1031-2","volume":"29","author":"AC Vidal","year":"2018","unstructured":"Vidal AC, Howard LE, de Hoedt A et al (2018) Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database. Cancer Causes Control 29:581\u2013588","journal-title":"Cancer Causes Control"},{"key":"1734_CR14","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1097\/01.CCM.0000129975.26905.77","volume":"32","author":"R Taneja","year":"2004","unstructured":"Taneja R, Parodo J, Jia SH et al (2004) Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med 32:1460\u20131469","journal-title":"Crit Care Med"},{"key":"1734_CR15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014834","volume":"98","author":"C Kumarasamy","year":"2019","unstructured":"Kumarasamy C, Sabarimurugan S, Madurantakam RM et al (2019) Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer-A protocol for systematic review and meta-analysis. Medicine 98:e14834","journal-title":"Medicine"},{"key":"1734_CR16","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1097\/00003246-199904000-00026","volume":"27","author":"T Menges","year":"1999","unstructured":"Menges T, Engel J, Welters I et al (1999) Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications. Crit Care Med 27:733\u2013740","journal-title":"Crit Care Med"},{"key":"1734_CR17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.23736\/S0392-9590.17.03848-2","volume":"37","author":"Q Wang","year":"2018","unstructured":"Wang Q, Ma J, Jiang Z, Ming L (2018) Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute pulmonary embolism: a systematic review and meta-analysis. Int Angiol 37:4\u201311","journal-title":"Int Angiol"},{"key":"1734_CR18","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3343\/alm.2019.39.4.345","volume":"39","author":"AY Gasparyan","year":"2019","unstructured":"Gasparyan AY, Ayvazyan L, Mukanova U et al (2019) The Platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med 39:345\u2013357","journal-title":"Ann Lab Med"},{"key":"1734_CR19","first-page":"821","volume":"30","author":"S Zhang","year":"2021","unstructured":"Zhang S, Luan X, Zhang W, Jin Z (2021) Platelet-to-lymphocyte and neutrophil-to-lymphocyte ratio as predictive biomarkers for early-onset neonatal sepsis. J Coll Physicians Surg Pak 30:821\u2013824","journal-title":"J Coll Physicians Surg Pak"},{"key":"1734_CR20","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.lungcan.2017.07.024","volume":"111","author":"S Diem","year":"2017","unstructured":"Diem S, Schmid S, Krapf M et al (2017) Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab. Lung Cancer 111:176\u2013181","journal-title":"Lung Cancer"},{"key":"1734_CR21","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1186\/s12885-019-5903-y","volume":"19","author":"T Hirahara","year":"2019","unstructured":"Hirahara T, Arigami T, Yanagita S et al (2019) Combined neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts chemotherapy response and prognosis in patients with advanced gastric cancer. BMC Cancer 19:672","journal-title":"BMC Cancer"},{"key":"1734_CR22","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1186\/s12885-020-07482-0","volume":"20","author":"S Sun","year":"2020","unstructured":"Sun S, He C, Wang J et al (2020) The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy. BMC Cancer 20:981","journal-title":"BMC Cancer"},{"key":"1734_CR23","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3109\/14397595.2015.1091136","volume":"26","author":"B Qin","year":"2016","unstructured":"Qin B, Ma N, Tang Q et al (2016) Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol 26:372\u2013376","journal-title":"Mod Rheumatol"},{"key":"1734_CR24","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1089\/met.2012.0056","volume":"10","author":"R Alemzadeh","year":"2012","unstructured":"Alemzadeh R, Kichler J (2012) Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents. Metab Syndr Relat Disord 10:422\u2013429","journal-title":"Metab Syndr Relat Disord"},{"key":"1734_CR25","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1210\/jc.2013-4273","volume":"99","author":"K Stamatelopoulos","year":"2014","unstructured":"Stamatelopoulos K, Athanasouli F, Pappa T et al (2014) Hemodynamic markers and subclinical atherosclerosis in postmenopausal women with primary hyperparathyroidism. J Clin Endocrinol Metab 99:2704\u20132711","journal-title":"J Clin Endocrinol Metab"},{"key":"1734_CR26","doi-asserted-by":"publisher","first-page":"880","DOI":"10.5114\/aoms.2018.74758","volume":"15","author":"H-B Lam","year":"2019","unstructured":"Lam H-B, Yang P-S, Chien M-N et al (2019) Association between neutrophil-to-lymphocyte ratio and parathyroid hormone in patients with primary hyperparathyroidism. Arch Med Sci 15:880\u2013886","journal-title":"Arch Med Sci"},{"key":"1734_CR27","volume":"13","author":"H Alaku\u015f","year":"2021","unstructured":"Alaku\u015f H, G\u00f6ksu M (2021) Does parathyroidectomy affect the neutrophil\/lymphocyte ratio, a systemic inflammatory marker? Cureus 13:e13708","journal-title":"Cureus"},{"key":"1734_CR28","first-page":"29","volume":"91","author":"M Deska","year":"2018","unstructured":"Deska M, Romuk E, Segiet O et al (2018) Oxidative stress in proliferative lesions of parathyroid gland. Pol Przegl Chir 91:29\u201334","journal-title":"Pol Przegl Chir"},{"key":"1734_CR29","first-page":"395","volume":"47","author":"E Gulumsek","year":"2022","unstructured":"Gulumsek E, Yesilda LF, Koca H et al (2022) Native thiol decreases in patients with asymptomatic primary hyperparathyroidism, especially in the presence of surgery indication. Minerva Endocrinol. 47:395\u2013402","journal-title":"Minerva Endocrinol."},{"key":"1734_CR30","first-page":"CR628","volume":"14","author":"E Chertok-Shacham","year":"2008","unstructured":"Chertok-Shacham E, Ishay A, Lavi I, Luboshitzky R (2008) Biomarkers of hypercoagulability and inflammation in primary hyperparathyroidism. Med Sci Monit 14:CR628\u2013CR632","journal-title":"Med Sci Monit"},{"key":"1734_CR31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.aace.2020.11.018","volume":"7","author":"R Rajan","year":"2021","unstructured":"Rajan R, Paul I, Cherian KE et al (2021) Myelofibrosis and pancytopenia associated with primary hyperparathyroidism. AACE Clin Case Rep 7:69\u201371","journal-title":"AACE Clin Case Rep"},{"key":"1734_CR32","doi-asserted-by":"publisher","first-page":"925","DOI":"10.3803\/EnM.2020.725","volume":"35","author":"C Jeong","year":"2020","unstructured":"Jeong C, Kwon HI, Baek H et al (2020) Association of hyperparathyroidism and papillary thyroid cancer: a multicenter retrospective study. Endocrinol Metab (Seoul) 35:925\u2013932","journal-title":"Endocrinol Metab (Seoul)"},{"key":"1734_CR33","first-page":"42","volume":"19","author":"U Cinamon","year":"2015","unstructured":"Cinamon U, Levy D, Marom T (2015) Is primary hyperparathyroidism a risk factor for papillary thyroid cancer? An exemplar study and literature review. Int Arch Otorhinolaryngol 19:42\u201345","journal-title":"Int Arch Otorhinolaryngol"},{"key":"1734_CR34","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1017\/S002221511400108X","volume":"128","author":"L Cheung","year":"2014","unstructured":"Cheung L, Howlett D, El Teraifi H, Kirkland P (2014) Association of synchronous medullary and papillary thyroid carcinomas with primary hyperparathyroidism: first case report and literature review. J Laryngol Otol 128:565\u2013568","journal-title":"J Laryngol Otol"},{"key":"1734_CR35","doi-asserted-by":"publisher","first-page":"E1108","DOI":"10.1210\/jc.2011-0099","volume":"96","author":"M Fallah","year":"2011","unstructured":"Fallah M, Kharazmi E, Sundquist J, Hemminki K (2011) Nonendocrine cancers associated with benign and malignant parathyroid tumors. J Clin Endocrinol Metab 96:E1108\u2013E1114","journal-title":"J Clin Endocrinol Metab"},{"key":"1734_CR36","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3906\/sag-2012-18","volume":"51","author":"M Karak\u00f6se","year":"2021","unstructured":"Karak\u00f6se M, Kocaba\u015f M, Can M et al (2021) Increased incidence of malignancy in patients with primary hyperparathyroidism. Turk J Med Sci 51:2023\u20132028","journal-title":"Turk J Med Sci"},{"key":"1734_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/5584_2021_629","volume":"1369","author":"V Hasenmajer","year":"2022","unstructured":"Hasenmajer V, Puliani G, Minnetti M et al (2022) Beyond bone: infectious diseases and immunity in parathyroid disorders. Adv Exp Med Biol 1369:17\u201332","journal-title":"Adv Exp Med Biol"},{"key":"1734_CR38","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0026-0495(00)91247-2","volume":"49","author":"A Halabe","year":"2000","unstructured":"Halabe A, Shohat B (2000) Effect of parathyroid adenoma excision on interleukin-6 (IL-6) and IL-2 receptor levels. Metabolism 49:192\u2013194","journal-title":"Metabolism"},{"key":"1734_CR39","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1590\/S0004-27302010000200018","volume":"54","author":"VZC Borba","year":"2010","unstructured":"Borba VZC, Ma\u00f1as NCP (2010) The use of PTH in the treatment of osteoporosis. Arq Bras Endocrinol Metabol 54:213\u2013219","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"1734_CR40","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.tem.2020.04.004","volume":"31","author":"V Hasenmajer","year":"2020","unstructured":"Hasenmajer V, Sbardella E, Sciarra F et al (2020) The immune system in Cushing\u2019s Syndrome. Trends Endocrinol Metab 31:655\u2013669","journal-title":"Trends Endocrinol Metab"},{"key":"1734_CR41","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1530\/EJE-17-0986","volume":"178","author":"E Sbardella","year":"2018","unstructured":"Sbardella E, Minnetti M, D\u2019Aluisio D et al (2018) Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas. Eur J Endocrinol 178:501\u2013511","journal-title":"Eur J Endocrinol"}],"container-title":["Updates in Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-023-01734-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13304-023-01734-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-023-01734-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T07:13:47Z","timestamp":1712214827000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13304-023-01734-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,17]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["1734"],"URL":"https:\/\/doi.org\/10.1007\/s13304-023-01734-x","relation":{},"ISSN":["2038-131X","2038-3312"],"issn-type":[{"value":"2038-131X","type":"print"},{"value":"2038-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,17]]},"assertion":[{"value":"29 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Faculty of Medicine, Sakarya University Ethics Committee (No. 71522473\/050.01.04\/146289-195; date: 30.06.2022).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was not obtained because the study was retrospective.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent."}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human participants and\/or animals"}}]}}