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A comparative study was conducted, including patients who underwent PD with a-RHA or with normal RHA anatomy. The primary endpoints were R1 resection in all margins (pancreatic, anterior, posterior, superior mesenteric artery, and portal groove), overall survival (OS), and disease-free survival (DFS). The secondary endpoints were morbidity, mortality, biliary leak (BL), postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), post pancreatectomy hemorrhage (PPH), length of stay (LOS), and operative time (OT). The selection bias was measured using the <jats:italic>d<\/jats:italic>-value and limited using entropy balancing analysis. Patients with arterial variants were 84 (37.5%), 39 (17.4%) of whom had a-RHA from SMA. The patients with a-RHA were more frequently symptomatic (<jats:italic>d<\/jats:italic>\u2009=\u20090.652), often affected by PDAC (<jats:italic>d<\/jats:italic>\u2009=\u20090.369), and judged borderline resectable (<jats:italic>d<\/jats:italic>\u2009=\u20090.588). Neoadjuvant therapy was more frequently proposed for patients with a-RHA (<jats:italic>d<\/jats:italic>\u2009=\u20090.465). The patients with a-RHA often had the Wirsung dilated compared to those without a-RHA (<jats:italic>d<\/jats:italic>\u2009=\u20090.336). After bias correction, the R1 resection rate on the superior mesenteric artery (SMA) margin was higher in the a-RHA group than in patients with normal RHA anatomy (OR 2.3; 1.1\u20135.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.045). OS, DFS, morbidity, mortality, biliary leak (BL), postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), post pancreatectomy hemorrhage (PPH), length of stay (LOS), and operative time (OT) were similar in unmatched and matched population. The presence of a-RHA seems to increase the risk of R1 resection in the SMA margin.<\/jats:p>","DOI":"10.1007\/s13304-025-02079-3","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T19:06:00Z","timestamp":1738177560000},"page":"511-521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical and oncological implications of the presence of hepatic artery anatomical variations in patients undergoing pancreaticoduodenectomy: a single center experience"],"prefix":"10.1007","volume":"77","author":[{"given":"Laura","family":"Alberici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-4479","authenticated-orcid":false,"given":"Claudio","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"D\u2019Ambra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ingaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Minghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Mazzucchelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Casadei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"2079_CR1","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.ijsu.2013.08.009","volume":"11","author":"M Bouassida","year":"2013","unstructured":"Bouassida M, Mighri MM, Chtourou MF, Sassi S, Touinsi H, Hajji H, Sassi S (2013) Retroportal lamina or mesopancreas? 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