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The genetic basis of the disease is still unclear. Vitamin D receptor (VDR) is involved in parathormone regulation. The aim of this study is to evaluate Vitamin D receptor expression in sporadic parathyroid adenoma. Fifty-one patients with parathyroid adenoma and 51 healthy volunteers were enrolled in the study and genetic and immunohistochemical studies were conducted. VDR polymorphism TaqI was correlated with parathyroid adenoma development, while VDR stained positive in immunohistochemical study. Our study suggests VDR as a major contributor to sporadic parathyroid adenoma formation in Greek population.<\/jats:p>","DOI":"10.1007\/s13304-025-02182-5","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:42:53Z","timestamp":1743889373000},"page":"1201-1204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D receptor: a possible biomarker for sporadic parathyroid adenoma?"],"prefix":"10.1007","volume":"77","author":[{"given":"Angeliki","family":"Chorti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki","family":"Cheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kassiani","family":"Boulogeorgou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthoula","family":"Chatzikyriakidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charoula","family":"Achilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despoina","family":"Tsalkatidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despoina","family":"Krokou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohail","family":"Bakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Papavramidis","family":"Theodossis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"2182_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12022-022-09709-1","volume":"33","author":"LA Erickson","year":"2022","unstructured":"Erickson LA, Mete O, Juhlin CC et al (2022) Overview of the 2022 WHO classification of parathyroid tumors. 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