{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:50:48Z","timestamp":1763538648123,"version":"3.45.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["82473210"],"award-info":[{"award-number":["82473210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Shanghai","award":["24ZR1464400"],"award-info":[{"award-number":["24ZR1464400"]}]},{"name":"Development Center for Medical Science & Technology National Health Commission of the People\u2019s Republic of China","award":["WA2021RW27"],"award-info":[{"award-number":["WA2021RW27"]}]},{"name":"Zhejiang Province Medical and Health Project","award":["2022KY296"],"award-info":[{"award-number":["2022KY296"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Updates Surg"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s13304-025-02289-9","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T14:03:04Z","timestamp":1750514584000},"page":"2601-2610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lobar versus sub-lobar resection for clinical stage IA (\u2264\u20092\u00a0cm) lung neuroendocrine tumor with spread through air spaces: a multi-center study"],"prefix":"10.1007","volume":"77","author":[{"given":"Hanbo","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weicheng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhuo","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guomo","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guodong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-9477","authenticated-orcid":false,"given":"Qingquan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"issue":"1","key":"2289_CR1","first-page":"12","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74(1):12\u201349","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"2289_CR2","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.jtho.2019.05.009","volume":"14","author":"RG Aly","year":"2019","unstructured":"Aly RG et al (2019) Spread through air spaces (STAS) is prognostic in atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma of the lung. J Thorac Oncol 14(9):1583\u20131593","journal-title":"J Thorac Oncol"},{"issue":"9","key":"2289_CR3","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","volume":"10","author":"WD Travis","year":"2015","unstructured":"Travis WD et al (2015) The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol 10(9):1243\u20131260","journal-title":"J Thorac Oncol"},{"issue":"Suppl 1","key":"2289_CR4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41379-021-00943-2","volume":"35","author":"N Rekhtman","year":"2022","unstructured":"Rekhtman N (2022) Lung neuroendocrine neoplasms: recent progress and persistent challenges. Mod Pathol 35(Suppl 1):36\u201350","journal-title":"Mod Pathol"},{"issue":"11","key":"2289_CR5","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1097\/PAS.0000000000001788","volume":"45","author":"DJ Gross","year":"2021","unstructured":"Gross DJ et al (2021) Spread through air spaces (STAS) in non-small cell lung carcinoma: evidence supportive of an in vivo phenomenon. Am J Surg Pathol 45(11):1509\u20131515","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"2289_CR6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/JTO.0000000000000486","volume":"10","author":"K Kadota","year":"2015","unstructured":"Kadota K et al (2015) Tumor spread through air spaces is an important pattern of invasion and impacts the frequency and location of recurrences after limited resection for small stage I lung adenocarcinomas. J Thorac Oncol 10(5):806\u2013814","journal-title":"J Thorac Oncol"},{"issue":"4","key":"2289_CR7","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.athoracsur.2024.03.007","volume":"118","author":"H Si","year":"2024","unstructured":"Si H et al (2024) Spread through air spaces in residual tumor classification for clinical IA lung adenocarcinoma. Ann Thorac Surg 118(4):825\u2013833","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"2289_CR8","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.athoracsur.2018.02.076","volume":"106","author":"S Shiono","year":"2018","unstructured":"Shiono S et al (2018) Spread through air spaces is a prognostic factor in sublobar resection of non-small cell lung cancer. Ann Thorac Surg 106(2):354\u2013360","journal-title":"Ann Thorac Surg"},{"key":"2289_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.lungcan.2020.04.026","volume":"146","author":"MI Toki","year":"2020","unstructured":"Toki MI, Harrington K, Syrigos KN (2020) The role of spread through air spaces (STAS) in lung adenocarcinoma prognosis and therapeutic decision making. Lung Cancer 146:127\u2013133","journal-title":"Lung Cancer"},{"issue":"2","key":"2289_CR10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.athoracsur.2024.01.002","volume":"118","author":"S Wan","year":"2024","unstructured":"Wan S et al (2024) Spread through air spaces in stage I pulmonary large cell neuroendocrine carcinoma. Ann Thorac Surg 118(2):385\u2013393","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"2289_CR11","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00428-019-02596-8","volume":"475","author":"S Altinay","year":"2019","unstructured":"Altinay S et al (2019) Spread through air spaces (STAS) is a predictor of poor outcome in atypical carcinoids of the lung. Virchows Arch 475(3):325\u2013334","journal-title":"Virchows Arch"},{"issue":"8","key":"2289_CR12","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1097\/PAS.0000000000001285","volume":"43","author":"K Kadota","year":"2019","unstructured":"Kadota K et al (2019) Limited resection is associated with a higher risk of locoregional recurrence than lobectomy in stage I lung adenocarcinoma with tumor spread through air spaces. Am J Surg Pathol 43(8):1033\u20131041","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2289_CR13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jtho.2018.09.005","volume":"14","author":"T Eguchi","year":"2019","unstructured":"Eguchi T et al (2019) Lobectomy is associated with better outcomes than sublobar resection in spread through air spaces (STAS)-positive T1 lung adenocarcinoma: a propensity score-matched analysis. J Thorac Oncol 14(1):87\u201398","journal-title":"J Thorac Oncol"},{"key":"2289_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.lungcan.2023.01.009","volume":"177","author":"Y Lv","year":"2023","unstructured":"Lv Y et al (2023) Impact of surgery and adjuvant chemotherapy on the survival of stage I lung adenocarcinoma patients with tumor spread through air spaces. Lung Cancer 177:51\u201358","journal-title":"Lung Cancer"},{"issue":"7","key":"2289_CR15","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jtho.2024.02.011","volume":"19","author":"R Rami-Porta","year":"2024","unstructured":"Rami-Porta R et al (2024) The International Association for the Study of Lung Cancer lung cancer staging project: proposals for revision of the TNM stage groups in the forthcoming (ninth) edition of the TNM classification for lung cancer. J Thorac Oncol 19(7):1007\u20131027","journal-title":"J Thorac Oncol"},{"issue":"3","key":"2289_CR16","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jtcvs.2023.11.030","volume":"168","author":"S Tasnim","year":"2024","unstructured":"Tasnim S et al (2024) Preoperative predictors of spread through air spaces in lung cancer. J Thorac Cardiovasc Surg 168(3):660-669.e4","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"2289_CR17","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.jtcvs.2018.04.126","volume":"156","author":"G Toyokawa","year":"2018","unstructured":"Toyokawa G et al (2018) Computed tomography features of resected lung adenocarcinomas with spread through air spaces. J Thorac Cardiovasc Surg 156(4):1670-1676.e4","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"2289_CR18","doi-asserted-by":"publisher","first-page":"624","DOI":"10.21037\/tcr-22-2593","volume":"12","author":"Y Wang","year":"2023","unstructured":"Wang Y et al (2023) Advances in the prediction of spread through air spaces with imaging in lung cancer: a narrative review. Transl Cancer Res 12(3):624\u2013630","journal-title":"Transl Cancer Res"},{"issue":"1","key":"2289_CR19","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12890-022-02002-1","volume":"22","author":"S Wang","year":"2022","unstructured":"Wang S et al (2022) An individual nomogram can reliably predict tumor spread through air spaces in non-small-cell lung cancer. BMC Pulm Med 22(1):209","journal-title":"BMC Pulm Med"},{"key":"2289_CR20","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.xjon.2024.07.018","volume":"21","author":"S Dou","year":"2024","unstructured":"Dou S et al (2024) Improving prediction accuracy of spread through air spaces in clinical-stage T1N0 lung adenocarcinoma using computed tomography imaging models. JTCVS Open 21:290\u2013303","journal-title":"JTCVS Open"},{"issue":"11","key":"2289_CR21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.diii.2022.06.002","volume":"103","author":"J Tao","year":"2022","unstructured":"Tao J et al (2022) 3D convolutional neural network model from contrast-enhanced CT to predict spread through air spaces in non-small cell lung cancer. Diagn Interv Imaging 103(11):535\u2013544","journal-title":"Diagn Interv Imaging"},{"issue":"1","key":"2289_CR22","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s40364-023-00539-9","volume":"11","author":"W Jin","year":"2023","unstructured":"Jin W et al (2023) Improving the prediction of spreading through air spaces (STAS) in primary lung cancer with a dynamic dual-delta hybrid machine learning model: a multicenter cohort study. Biomark Res 11(1):102","journal-title":"Biomark Res"},{"issue":"6","key":"2289_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00281-015-0518-0","volume":"37","author":"M Gold","year":"2015","unstructured":"Gold M, El Khoury J (2015) \u03b2-amyloid, microglia, and the inflammasome in Alzheimer\u2019s disease. Semin Immunopathol 37(6):607\u2013611","journal-title":"Semin Immunopathol"},{"issue":"5","key":"2289_CR24","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.jtcvs.2023.01.030","volume":"166","author":"HA Khalil","year":"2023","unstructured":"Khalil HA et al (2023) Analysis of recurrence in lung adenocarcinoma with spread through air spaces. J Thorac Cardiovasc Surg 166(5):1317-1328.e4","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"2289_CR25","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jtho.2019.10.019","volume":"15","author":"JG Edwards","year":"2020","unstructured":"Edwards JG et al (2020) The IASLC lung cancer staging project: analysis of resection margin status and proposals for residual tumor descriptors for non-small cell lung cancer. J Thorac Oncol 15(3):344\u2013359","journal-title":"J Thorac Oncol"},{"issue":"7","key":"2289_CR26","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.jtho.2022.03.015","volume":"17","author":"J Lee","year":"2022","unstructured":"Lee J et al (2022) Reclassifying the International Association for the Study of Lung Cancer residual tumor classification according to the extent of nodal dissection for NSCLC: one size does not fit all. J Thorac Oncol 17(7):890\u2013899","journal-title":"J Thorac Oncol"},{"issue":"1","key":"2289_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jtho.2023.09.1443","volume":"19","author":"C Jiang","year":"2024","unstructured":"Jiang C et al (2024) A shift in paradigm: selective lymph node dissection for minimizing oversurgery in early stage lung cancer. J Thorac Oncol 19(1):25\u201335","journal-title":"J Thorac Oncol"},{"issue":"7","key":"2289_CR28","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.jtho.2024.03.021","volume":"19","author":"FC Detterbeck","year":"2024","unstructured":"Detterbeck FC et al (2024) The International Association for the Study of Lung Cancer lung cancer staging project: proposals for revision of the classification of residual tumor after resection for the forthcoming (ninth) edition of the TNM classification of lung cancer. J Thorac Oncol 19(7):1052\u20131072","journal-title":"J Thorac Oncol"}],"container-title":["Updates in Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-025-02289-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13304-025-02289-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-025-02289-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:49:20Z","timestamp":1763538560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13304-025-02289-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,21]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2289"],"URL":"https:\/\/doi.org\/10.1007\/s13304-025-02289-9","relation":{},"ISSN":["2038-131X","2038-3312"],"issn-type":[{"type":"print","value":"2038-131X"},{"type":"electronic","value":"2038-3312"}],"subject":[],"published":{"date-parts":[[2025,6,21]]},"assertion":[{"value":"25 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of Shanghai Chest Hospital (approval No. IS24111) and admitted by all participating institutions. All procedures involving human participants in this study adhere to the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and Human and animal Rights"}},{"value":"For this type of study, consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}