{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T07:21:18Z","timestamp":1794295278791,"version":"4.9.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"S & T Program of Hebei, China","award":["19277716D"],"award-info":[{"award-number":["19277716D"]}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.18013"],"award-info":[{"award-number":["320.6750.18013"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Updates Surg"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s13304-025-02330-x","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T19:56:24Z","timestamp":1752695784000},"page":"3247-3255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Indocyanine green fluorescence in pelvic lymph node dissection during laparoscopic radical prostatectomy: a randomized controlled trial"],"prefix":"10.1007","volume":"78","author":[{"given":"Si-qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-fan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"2330_CR1","first-page":"798","volume":"97","author":"S Brawley","year":"2018","unstructured":"Brawley S, Mohan R, Nein CD (2018) Localized prostate cancer: treatment options. Am Fam Phys 97:798\u2013805","journal-title":"Am Fam Phys"},{"issue":"1","key":"2330_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.eururo.2020.09.042","volume":"79","author":"N Mottet","year":"2021","unstructured":"Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M et al (2021) EAU-EANM-ESTRO-ESUR-SIOG Guidelines on prostate Cancer-2020 update part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol 79(1):243\u2013262","journal-title":"Eur Urol"},{"key":"2330_CR3","first-page":"1550","volume":"13","author":"A Ragusa","year":"2023","unstructured":"Ragusa A, Brassetti A, Prata F, Iannuzzi A, Call\u00e8 P, Tedesco F et al (2023) Predictors of urinary continence recovery after laparoscopic-assisted radical prostatectomy: Is surgical urethral length the only key factor? Life (Basel) 13:1550","journal-title":"Life (Basel)"},{"key":"2330_CR4","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.3390\/jpm13121634","volume":"13","author":"A Civitella","year":"2023","unstructured":"Civitella A, Prata F, Papalia R, Citriniti V, Tuzzolo P, Pascarella G et al (2023) Laparoscopic versus ultrasound-guided transversus abdominis plane block for postoperative analgesia management after radical prostatectomy: results from a single center study. J Pers Med 13:1634","journal-title":"J Pers Med"},{"key":"2330_CR5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.juro.2015.03.127","volume":"194","author":"S Hruby","year":"2015","unstructured":"Hruby S, Englberger C, Lusuardi L, Sch\u00e4tz T, Kunit T, Abdel-Aal AM et al (2015) Fluorescence guided targeted pelvic lymph node dissection for intermediate and high risk prostate cancer. J Urol 194:357\u2013363","journal-title":"J Urol"},{"key":"2330_CR6","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.2967\/jnumed.118.209171","volume":"59","author":"JA Doughton","year":"2018","unstructured":"Doughton JA, Hofman MS, Eu P, Hicks RJ, Williams S (2018) A First-in-human study of 68Ga-nanocolloid pet\/ct sentinel lymph node imaging in prostate cancer demonstrates aberrant lymphatic drainage pathways. J Nuclear Med 59:1837\u20131842","journal-title":"J Nuclear Med"},{"key":"2330_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11701-019-00951-0","volume":"14","author":"J Jayakumaran","year":"2020","unstructured":"Jayakumaran J, Pavlovic Z, Fuhrich D, Wiercinski K, Buffington C, Caceres A (2020) Robotic single-site endometriosis resection using near-infrared fluorescence imaging with indocyanine green: a prospective case series and review of literature. J Robot Surg 14:145\u2013154","journal-title":"J Robot Surg"},{"key":"2330_CR8","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.urology.2012.05.050","volume":"80","author":"S Jeschke","year":"2012","unstructured":"Jeschke S, Lusuardi L, Myatt A, Hruby S, Pirich C, Janetschek G (2012) Visualisation of the lymph node pathway in real time by laparoscopic radioisotope- and fluorescence-guided sentinel lymph node dissection in prostate cancer staging. Urology 80:1080\u20131087","journal-title":"Urology"},{"issue":"1","key":"2330_CR9","doi-asserted-by":"publisher","first-page":"254","DOI":"10.5489\/cuaj.10159","volume":"5","author":"S Inoue","year":"2011","unstructured":"Inoue S, Shiina H, Arichi N, Mitsui Y, Hiraoka T, Wake K et al (2011) Identification of lymphatic pathway involved in the spreading of prostate cancer by fluorescence navigation approach with intraoperatively injected indocyanine green. Canad Urol Ass J 5(1):254\u2013259","journal-title":"Canad Urol Ass J"},{"key":"2330_CR10","unstructured":"Prostate cancer nomograms: Dynamic prostate cancer nomogram: coefficients | memorial sloan kettering cancer center. https:\/\/www.mskcc.org\/nomograms\/prostate\/pre_op\/coefficients."},{"key":"2330_CR11","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1001\/jamasurg.2014.3502","volume":"150","author":"I Stoffels","year":"2015","unstructured":"Stoffels I, Dissemond J, P\u00f6ppel T, Schadendorf D, Klode J (2015) Intraoperative fluorescence imaging for sentinel lymph node detection: prospective clinical trial to compare the usefulness of indocyanine green vs technetium tc 99m for identification of sentinel lymph nodes. JAMA Surg 150:617\u2013623","journal-title":"JAMA Surg"},{"key":"2330_CR12","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1089\/lap.2021.0174","volume":"32","author":"A Y\u0131ld\u0131z","year":"2022","unstructured":"Y\u0131ld\u0131z A, An\u0131l H, Akdemir S, Aksaray EE, Ate\u015f M, Arslan M (2022) Extraperitoneal laparoscopic versus transperitoneal robot-assisted laparoscopic approaches for extended pelvic lymph node dissection during radical prostatectomy. J Laparoendosc Adv Surg Tech A 32:355\u2013359","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"2330_CR13","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011176","volume":"97","author":"K Wang","year":"2018","unstructured":"Wang K, Zhuang Q, Xu R, Lu H, Song G, Wang J et al (2018) Transperitoneal versus extraperitoneal approach in laparoscopic radical prostatectomy: a meta-analysis. Medicine (Baltimore) 97:e11176","journal-title":"Medicine (Baltimore)"},{"key":"2330_CR14","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.eururo.2013.11.017","volume":"65","author":"TB Manny","year":"2014","unstructured":"Manny TB, Patel M, Hemal AK (2014) Fluorescence-enhanced robotic radical prostatectomy using real-time lymphangiography and tissue marking with percutaneous injection of unconjugated indocyanine green: the initial clinical experience in 50 patients. Eur Urol 65:1162\u20131168","journal-title":"Eur Urol"},{"key":"2330_CR15","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1007\/s00259-021-05580-0","volume":"49","author":"EMK Wit","year":"2022","unstructured":"Wit EMK, van Beurden F, Kleinjan GH, Grivas N, de Korne CM, Buckle T et al (2022) The impact of drainage pathways on the detection of nodal metastases in prostate cancer: a phase II randomized comparison of intratumoral vs intraprostatic tracer injection for sentinel node detection. Eur J Nucl Med Mol Imaging 49:1743\u20131753","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2330_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.urology.2017.04.020","volume":"106","author":"L Xia","year":"2017","unstructured":"Xia L, Zeh R, Mizelle J, Newton A, Predina J, Nie S et al (2017) Near-infrared intraoperative molecular imaging can identify metastatic lymph nodes in prostate cancer. Urology 106:133\u2013138","journal-title":"Urology"},{"key":"2330_CR17","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.juro.2006.10.074","volume":"177","author":"D Weckermann","year":"2007","unstructured":"Weckermann D, Dorn R, Trefz M, Wagner T, Wawroschek F, Harzmann R (2007) Sentinel lymph node dissection for prostate cancer: experience with more than 1,000 patients. J Urol 177:916\u2013920","journal-title":"J Urol"},{"key":"2330_CR18","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/s00345-018-2330-7","volume":"36","author":"NN Harke","year":"2018","unstructured":"Harke NN, Godes M, Wagner C, Addali M, Fangmeyer B, Urbanova K et al (2018) Fluorescence-supported lymphography and extended pelvic lymph node dissection in robot-assisted radical prostatectomy: a prospective, randomized trial. World J Urol 36:1817\u20131823","journal-title":"World J Urol"},{"key":"2330_CR19","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00345-019-02870-z","volume":"38","author":"GE Cacciamani","year":"2020","unstructured":"Cacciamani GE, Shakir A, Tafuri A, Gill K, Han J, Ahmadi N et al (2020) Best practices in near-infrared fluorescence imaging with indocyanine green (NIRF\/ICG)-guided robotic urologic surgery: a systematic review-based expert consensus. World J Urol 38:883\u2013896","journal-title":"World J Urol"},{"key":"2330_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/MOU.0000000000000480","volume":"28","author":"A Winter","year":"2018","unstructured":"Winter A, Engels S, Wawroschek F (2018) Sentinel lymph node surgery in prostate cancer using magnetic particles. Curr Opin Urol 28:184\u2013190","journal-title":"Curr Opin Urol"},{"key":"2330_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.931867","volume":"9","author":"L Fumad\u00f3","year":"2022","unstructured":"Fumad\u00f3 L, Abascal JM, Mestre-Fusco A, Vidal-Sicart S, Aguilar G, Juanpere N et al (2022) Sentinel lymph node biopsy in prostate cancer patients: results from an injection technique targeting the index lesion in the prostate gland. Front Med 9:931867","journal-title":"Front Med"},{"key":"2330_CR22","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.eururo.2014.07.014","volume":"66","author":"GH KleinJan","year":"2014","unstructured":"KleinJan GH, van den Berg NS, Brouwer OR, de Jong J, Acar C, Wit EM et al (2014) Optimisation of fluorescence guidance during robot-assisted laparoscopic sentinel node biopsy for prostate cancer. Eur Urol 66:991\u2013998","journal-title":"Eur Urol"},{"key":"2330_CR23","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.eururo.2016.01.034","volume":"70","author":"DP Nguyen","year":"2016","unstructured":"Nguyen DP, Huber PM, Metzger TA, Genitsch V, Schudel HH, Thalmann GN (2016) A specific mapping study using fluorescence sentinel lymph node detection in patients with intermediate- and high-risk prostate cancer undergoing extended pelvic lymph node dissection. Eur Urol 70:734\u2013737","journal-title":"Eur Urol"},{"key":"2330_CR24","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/iju.14306","volume":"27","author":"M Shimbo","year":"2020","unstructured":"Shimbo M, Endo F, Matsushita K, Hattori K (2020) Impact of indocyanine green-guided extended pelvic lymph node dissection during robot-assisted radical prostatectomy. Intern J Urol 27:845\u2013850","journal-title":"Intern J Urol"},{"issue":"489","key":"2330_CR25","first-page":"e19","volume":"40","author":"F Claps","year":"2022","unstructured":"Claps F, de Pablos-Rodr\u00edguez P, G\u00f3mez-Ferrer \u00c1, Mascar\u00f3s JM, Marenco J, Collado Serra A et al (2022) Free-indocyanine green-guided pelvic lymph node dissection during radical prostatectomy. Urol Oncol 40(489):e19-489.e26","journal-title":"Urol Oncol"},{"issue":"466","key":"2330_CR26","first-page":"e1","volume":"19","author":"F Urabe","year":"2021","unstructured":"Urabe F, Kimura S, Yasue K, Yanagisawa T, Tsuzuki S, Kimura T et al (2021) Performance of indocyanine green fluorescence for detecting lymph node metastasis in prostate cancer: a systematic review and meta-analysis. Clin Genitourin Cancer 19(466):e1-466.e9","journal-title":"Clin Genitourin Cancer"},{"key":"2330_CR27","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/iju.14513","volume":"28","author":"F Claps","year":"2021","unstructured":"Claps F, Ram\u00edrez-Backhaus M, Mir Maresma MC, G\u00f3mez-Ferrer \u00c1, Mascar\u00f3s JM, Marenco J et al (2021) Indocyanine green guidance improves the efficiency of extended pelvic lymph node dissection during laparoscopic radical prostatectomy. Intern J Urol 28:566\u2013572","journal-title":"Intern J Urol"},{"key":"2330_CR28","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.2967\/jnumed.120.259788","volume":"62","author":"E Mazzone","year":"2021","unstructured":"Mazzone E, Dell\u2019Oglio P, Grivas N, Wit E, Donswijk M, Briganti A et al (2021) Diagnostic value, oncologic outcomes, and safety profile of image-guided surgery technologies during robot-assisted lymph node dissection with sentinel node biopsy for prostate cancer. J Nucl Med 62:1363\u20131371","journal-title":"J Nucl Med"},{"key":"2330_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100597","volume":"7","author":"M von Deimling","year":"2022","unstructured":"von Deimling M, Rajwa P, Tilki D, Heidenreich A, Pallauf M, Bianchi A et al (2022) The current role of precision surgery in oligometastatic prostate cancer. ESMO open 7:100597","journal-title":"ESMO open"},{"key":"2330_CR30","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/bju.15553","volume":"129","author":"S Buelens","year":"2022","unstructured":"Buelens S, Poelaert F, Claeys T, De Bleser E, Dhondt B, Verla W et al (2022) Multicentre, prospective study on local treatment of metastatic prostate cancer (LoMP study). BJU Int 129:699\u2013707","journal-title":"BJU Int"},{"key":"2330_CR31","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.euo.2018.10.010","volume":"2","author":"E Mazzone","year":"2019","unstructured":"Mazzone E, Preisser F, Nazzani S, Tian Z, Bandini M, Gandaglia G et al (2019) The effect of lymph node dissection in metastatic prostate cancer patients treated with radical prostatectomy: a contemporary analysis of survival and early postoperative outcomes. Europ Urol Oncol 2:541\u2013548","journal-title":"Europ Urol Oncol"},{"key":"2330_CR32","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ctrv.2016.09.020","volume":"50","author":"G Munbauhal","year":"2016","unstructured":"Munbauhal G, Seisen T, Gomez FD, Peyronnet B, Cussenot O, Shariat SF et al (2016) Current perspectives of sentinel lymph node dissection at the time of radical surgery for prostate cancer. Cancer Treat Rev 50:228\u2013239","journal-title":"Cancer Treat Rev"},{"key":"2330_CR33","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.2147\/IJN.S243548","volume":"15","author":"Y Wang","year":"2020","unstructured":"Wang Y, Lan M, Shen D, Fang K, Zhu L, Liu Y et al (2020) Targeted Nanobubbles carrying indocyanine green for ultrasound, photoacoustic and fluorescence imaging of prostate cancer. Int J Nanomed 15:4289\u20134309","journal-title":"Int J Nanomed"},{"key":"2330_CR34","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.3390\/cancers13051117","volume":"13","author":"S Engels","year":"2021","unstructured":"Engels S, Brautmeier L, Reinhardt L, Wasylow C, Hasselmann F, Henke RP et al (2021) Evaluation of fast molecular detection of lymph node metastases in prostate cancer patients using one-step nucleic acid amplification (OSNA). Cancers 13:1117","journal-title":"Cancers"}],"container-title":["Updates in Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-025-02330-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13304-025-02330-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-025-02330-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T06:24:24Z","timestamp":1794291864000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13304-025-02330-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["2330"],"URL":"https:\/\/doi.org\/10.1007\/s13304-025-02330-x","relation":{},"ISSN":["2038-131X","2038-3312"],"issn-type":[{"value":"2038-131X","type":"print"},{"value":"2038-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]},"assertion":[{"value":"8 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None of the authors have any conflicts of interest to report.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Hebei Yanda Hospital (19277716D). This study was registered at medicalresearch.org.cn on 20\/03\/2020 (ID: MR-13\u201322-016858). All participants were required to sign the informed consent form.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}