{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:00:51Z","timestamp":1782954051215,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100020912","name":"King Faisal University","doi-asserted-by":"publisher","award":["KFU252851"],"award-info":[{"award-number":["KFU252851"]}],"id":[{"id":"10.13039\/501100020912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Updates Surg"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s13304-025-02410-y","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:47:32Z","timestamp":1760474852000},"page":"1155-1166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of tranexamic acid in patients undergoing liver surgeries: an updated meta-analysis of randomized-controlled trials"],"prefix":"10.1007","volume":"78","author":[{"given":"Mahmoud","family":"Kandeel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2713-3233","authenticated-orcid":false,"given":"Mohamed Saad","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noof K.","family":"Binashikhbubkr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"2410_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11393","author":"A Shah","year":"2020","unstructured":"Shah A, Palmer AJR, Klein AA (2020) Strategies to minimize intraoperative blood loss during major surgery. Br J Surg. https:\/\/doi.org\/10.1002\/bjs.11393","journal-title":"Br J Surg"},{"key":"2410_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-017-1194-y","author":"I Pabinger","year":"2017","unstructured":"Pabinger I, Fries D, Sch\u00f6chl H, Streif W, Toller W (2017) Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis. Wien Klin Wochenschr. https:\/\/doi.org\/10.1007\/s00508-017-1194-y","journal-title":"Wien Klin Wochenschr"},{"key":"2410_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01313-6","author":"M Delaney","year":"2016","unstructured":"Delaney M et al (2016) Transfusion reactions: prevention, diagnosis, and treatment. Lancet. https:\/\/doi.org\/10.1016\/S0140-6736(15)01313-6","journal-title":"Lancet"},{"key":"2410_CR4","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkt042","author":"B Clevenger","year":"2014","unstructured":"Clevenger B, Kelleher A (2014) Hazards of blood transfusion in adults and children. Contin Educ Anaesth Crit Care Pain. https:\/\/doi.org\/10.1093\/bjaceaccp\/mkt042","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"key":"2410_CR5","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000711","author":"SA Lang","year":"2023","unstructured":"Lang SA (2023) Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study. Int J Surg. https:\/\/doi.org\/10.1097\/JS9.0000000000000711","journal-title":"Int J Surg"},{"key":"2410_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2016.12.008","author":"S Bennett","year":"2017","unstructured":"Bennett S et al (2017) The impact of perioperative red blood cell transfusions in patients undergoing liver resection: a systematic review. HPB. https:\/\/doi.org\/10.1016\/j.hpb.2016.12.008","journal-title":"HPB"},{"key":"2410_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-021-06355-2","author":"A Koh","year":"2022","unstructured":"Koh A, Adiamah A, Gomez D, Sanyal S (2022) Safety and efficacy of tranexamic acid to minimise perioperative bleeding in hepatic surgery: a systematic review and meta-analysis. World J Surg. https:\/\/doi.org\/10.1007\/s00268-021-06355-2","journal-title":"World J Surg"},{"key":"2410_CR8","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363130-00008","author":"K Wellington","year":"2003","unstructured":"Wellington K, Wagstaff AJ (2003) Tranexamic acid: a review of its use in the management of menorrhagia. Drugs. https:\/\/doi.org\/10.2165\/00003495-200363130-00008","journal-title":"Drugs"},{"key":"2410_CR9","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957060-00017","author":"CJ Dunn","year":"1999","unstructured":"Dunn CJ, Goa KL (1999) Tranexamic acid: a review of its use in surgery and other indications. Drugs. https:\/\/doi.org\/10.2165\/00003495-199957060-00017","journal-title":"Drugs"},{"key":"2410_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20868","author":"SA McCluskey","year":"2006","unstructured":"McCluskey SA et al (2006) Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation. Liver Transpl. https:\/\/doi.org\/10.1002\/lt.20868","journal-title":"Liver Transpl"},{"key":"2410_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010245.pub2","author":"P Perel","year":"2013","unstructured":"Perel P, Ker K, Morales-Uribe CH, Roberts I (2013) Tranexamic acid for reducing mortality in emergency and urgent surgery. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD010245.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"2410_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60835-5","author":"F Olldashi","year":"2010","unstructured":"Olldashi F et al (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet. https:\/\/doi.org\/10.1016\/S0140-6736(10)60835-5","journal-title":"Lancet"},{"key":"2410_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.10.001","author":"BL Houston","year":"2020","unstructured":"Houston BL et al (2020) Efficacy and safety of tranexamic acid in major non-cardiac surgeries at high risk for transfusion: a systematic review and meta-analysis. Transfus Med Rev. https:\/\/doi.org\/10.1016\/j.tmrv.2019.10.001","journal-title":"Transfus Med Rev"},{"key":"2410_CR14","volume-title":"NICE guideline NG24-blood transfusion","author":"National Institute for Health and Care Excellence","year":"2023","unstructured":"National Institute for Health and Care Excellence (2023) NICE guideline NG24-blood transfusion. NIHCE"},{"key":"2410_CR15","volume-title":"National Clinical Guideline Centre, no Appendices M-N","author":"National Institute for Health and Care Excellence","year":"2020","unstructured":"National Institute for Health and Care Excellence (2020) 2020 Surveillance of blood transfusion (NICE guideline NG24). National Clinical Guideline Centre, no Appendices M-N. NIHCE"},{"key":"2410_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","author":"MJ Page","year":"2021","unstructured":"Page MJ et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"2410_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"JPT Higgins","year":"2019","unstructured":"Higgins JPT et al (2019) Cochrane handbook for systematic reviews of interventions. Wiley. https:\/\/doi.org\/10.1002\/9781119536604"},{"key":"2410_CR18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"2410_CR19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.11783","author":"PJ Karanicolas","year":"2024","unstructured":"Karanicolas PJ et al (2024) Tranexamic acid in patients undergoing liver resection the HeLiX randomized clinical trial. JAMA. https:\/\/doi.org\/10.1001\/jama.2024.11783","journal-title":"JAMA"},{"key":"2410_CR20","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000197561.70972.73","author":"CC Wu","year":"2006","unstructured":"Wu CC et al (2006) Perioperative parenteral tranexamic acid in liver tumor resection: A prospective randomized trial toward \u2018blood transfusion\u2019-free hepatectomy. Ann Surg. https:\/\/doi.org\/10.1097\/01.sla.0000197561.70972.73","journal-title":"Ann Surg"},{"key":"2410_CR21","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199708000-00007","author":"M Kaspar","year":"1997","unstructured":"Kaspar M, Ramsay MAE, Nguyen AT, Cogswell M, Hurst G, Ramsay KJ (1997) Continuous small-dose tranexamic acid reduces fibrinolysis but not transfusion requirements during orthotopic liver transplantation. Anesth Analg. https:\/\/doi.org\/10.1097\/00000539-199708000-00007","journal-title":"Anesth Analg"},{"key":"2410_CR22","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199611000-00012","author":"JF Boylan","year":"1996","unstructured":"Boylan JF et al (1996) Tranexamic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation. Anesthesiology. https:\/\/doi.org\/10.1097\/00000542-199611000-00012","journal-title":"Anesthesiology"},{"key":"2410_CR23","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200007000-00006","author":"A Dalmau","year":"2000","unstructured":"Dalmau A et al (2000) Tranexamic acid reduces red cell transfusion better than \u03b5-aminocaproic acid or placebo in liver transplantation. Anesth Analg. https:\/\/doi.org\/10.1213\/00000539-200007000-00006","journal-title":"Anesth Analg"},{"key":"2410_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2016.09.005","author":"PJ Karanicolas","year":"2016","unstructured":"Karanicolas PJ et al (2016) Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid. HPB. https:\/\/doi.org\/10.1016\/j.hpb.2016.09.005","journal-title":"HPB"},{"key":"2410_CR25","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003896","author":"WY Teoh","year":"2021","unstructured":"Teoh WY et al (2021) Prophylactic topical tranexamic acid versus placebo in surgical patients: a systematic review and meta-analysis. Ann Surg. https:\/\/doi.org\/10.1097\/SLA.0000000000003896","journal-title":"Ann Surg"},{"key":"2410_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009052.pub2","author":"KS Gurusamy","year":"2011","unstructured":"Gurusamy KS, Pissanou T, Pikhart H, Vaughan J, Burroughs AK, Davidson BR (2011) Methods to decrease blood loss and transfusion requirements for liver transplantation. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD009052.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"2410_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010683.pub3","author":"E Moggia","year":"2016","unstructured":"Moggia E et al (2016) Methods to decrease blood loss during liver resection: a network meta-analysis. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD010683.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"2410_CR28","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15030","author":"J Yates","year":"2019","unstructured":"Yates J et al (2019) Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta-analysis. Transfusion. https:\/\/doi.org\/10.1111\/trf.15030","journal-title":"Transfusion"},{"key":"2410_CR29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4583","author":"S Sweetland","year":"2009","unstructured":"Sweetland S et al (2009) Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ (Online). https:\/\/doi.org\/10.1136\/bmj.b4583","journal-title":"BMJ (Online)."}],"container-title":["Updates in Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-025-02410-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13304-025-02410-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13304-025-02410-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:37:16Z","timestamp":1780983436000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13304-025-02410-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["2410"],"URL":"https:\/\/doi.org\/10.1007\/s13304-025-02410-y","relation":{},"ISSN":["2038-131X","2038-3312"],"issn-type":[{"value":"2038-131X","type":"print"},{"value":"2038-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}