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All authors meet the criteria for authorship and have participated in writing this manuscript. There was no conflict of interest for any of the author. Moreover, none of the authors of the study have received subsidies from Public Bodies or from any other sources for the execution of this study.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. The research protocol has been notified to the local IRB. 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