{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:26:30Z","timestamp":1793834790669,"version":"4.6.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Aristotle University of Thessaloniki","id":[{"id":"https:\/\/ror.org\/02j61yw88","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Updates Surg"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Postoperative hypoparathyroidism is the most frequent complication after thyroid surgery. Parathyroid autofluorescence ability serves as a useful tool for localizing parathyroid glands intraoperatively. The aim of this study is to evaluate the efficacy of intra-operative autofluorescence imaging concerning the unintentional excision rate of parathyroids during total thyroidectomy with central lymph node compartment dissection. This s a prospective randomized study enrolling patients with thyroid cancer that underwent total thyroidectomy with therapeutic bilateral central lymph node compartment dissection in a high-volume center during a two-year period. Patients were separated in two groups [without (A) or with FLUOBEAM\n                    <jats:sup>\u00ae<\/jats:sup>\n                    LX (B)] and the number of identified parathyroid glands intraoperatively was recorded and correlated with postoperative levels of parathyroid hormone and serum calcium. One-hundred eighty patients were included in this study. A higher number of parathyroid glands were identified and distinguished from lymph nodes in the central compartment with autofluorescence compared to naked eye visualization (3.84\u2009\u00b1\u20090.51 vs. 3.69\u2009\u00b1\u20090.78,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). The number of parathyroid glands found in specimen were lower in Group B (17 vs. 8,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.06). Group B had lower incidence of transient postoperative hypoparathyroidism (16.1% vs. 9.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.058, odds ratio 0.54, 95% CI 0.28\u20131.02). Moreover, the autofluorescence score had influence on postoperative transient hypoparathyroidism rates (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Parathyroid autofluorescence is a safe and efficient tool in experienced hands during central compartment neck dissection, improving postoperative hypoparathyroidism rates and quality of lymph node dissection.\n                  <\/jats:p>","DOI":"10.1007\/s13304-026-02762-z","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:59:28Z","timestamp":1784131168000},"page":"2629-2635","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does parathyroid autofluorescence reduces unintentional parathyroidectomy during total thyroidectomy with central lymph node compartment dissection?"],"prefix":"10.1007","volume":"78","author":[{"given":"Angeliki","family":"Chorti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Pliakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moysis","family":"Moysidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Bakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodossis","family":"Papavramidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2762_CR1","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1089\/thy.2017.0309","volume":"28","author":"LA Orloff","year":"2018","unstructured":"Orloff LA, Wiseman SM, Bernet VJ et al (2018) American thyroid association statement on postoperative hypoparathyroidism: diagnosis, prevention, and management in adults. Thyroid 28:830\u2013841. https:\/\/doi.org\/10.1089\/thy.2017.0309","journal-title":"Thyroid"},{"key":"2762_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12020-021-02663-8","volume":"73","author":"GD Koimtzis","year":"2021","unstructured":"Koimtzis GD, Stefanopoulos L, Giannoulis K, Papavramidis TS (2021) What are the real rates of temporary hypoparathyroidism following thyroidectomy? It is a matter of definition: a systematic review. Endocrine 73:1\u20137. https:\/\/doi.org\/10.1007\/s12020-021-02663-8","journal-title":"Endocrine"},{"key":"2762_CR3","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1210\/jc.2012-1170","volume":"97","author":"OE Anastasiou","year":"2012","unstructured":"Anastasiou OE, Yavropoulou MP, Papavramidis TS et al (2012) Secretory capacity of the parathyroid glands after total thyroidectomy in normocalcemic subjects. 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Gland Surg 9:S136\u2013S146. https:\/\/doi.org\/10.21037\/gs.2020.01.04","journal-title":"Gland Surg"},{"key":"2762_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12020-024-04011-y","volume":"87","author":"G Koimtzis","year":"2024","unstructured":"Koimtzis G, Stefanopoulos L, Geropoulos G, Papavramidis T (2024) The outcomes of parathyroid gland autotransplantation during thyroid surgery: a systematic review, meta-analysis and trial sequential analysis. Endocrine 87:27\u201338. https:\/\/doi.org\/10.1007\/s12020-024-04011-y","journal-title":"Endocrine"},{"key":"2762_CR7","doi-asserted-by":"publisher","first-page":"067012","DOI":"10.1117\/1.3583571","volume":"16","author":"C Paras","year":"2011","unstructured":"Paras C, Keller M, White L et al (2011) Near-infrared autofluorescence for the detection of parathyroid glands. J Biomed Opt 16:067012. https:\/\/doi.org\/10.1117\/1.3583571","journal-title":"J Biomed Opt"},{"key":"2762_CR8","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.jamcollsurg.2018.12.044","volume":"228","author":"F Dip","year":"2019","unstructured":"Dip F, Falco J, Verna S et al (2019) Randomized controlled trial comparing white light with near-infrared autofluorescence for parathyroid gland identification during total thyroidectomy. J Am Coll Surg 228:744\u2013751. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2018.12.044","journal-title":"J Am Coll Surg"},{"key":"2762_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s12070-022-03309-5","volume":"75","author":"R Tjahjono","year":"2023","unstructured":"Tjahjono R, Phung D, Elliott MS et al (2023) The utility of near-infrared autofluorescence for parathyroid gland identification during thyroid surgery: a single-center experience. 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