{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:42:48Z","timestamp":1790433768987,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T00:00:00Z","timestamp":1294272000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s13311-010-0012-2","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T11:57:43Z","timestamp":1296475063000},"page":"82-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Neuroimaging in Dementia"],"prefix":"10.1016","volume":"8","author":[{"given":"Maria Carmela","family":"Tartaglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-010-0012-2_bib1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1212\/WNL.56.9.1143","article-title":"Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology.","volume":"56","author":"Knopman","year":"2001","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1007\/s13311-010-0012-2_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2009\/103123","article-title":"A comparative analysis of structural brain MRI in the diagnosis of Alzheimer's disease","volume":"21","author":"Appel","year":"2009","journal-title":"Behav Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib4","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/cercor\/bhj105","article-title":"Differential regional atrophy of the cingulate gyrus in Alzheimer disease: a volumetric MRI study","volume":"16","author":"Jones","year":"2006","journal-title":"Cereb Cortex"},{"key":"10.1007\/s13311-010-0012-2_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1148\/radiology.178.1.1984287","article-title":"Alzheimer disease: measuring loss of cerebral gray matter with MR imaging","volume":"178","author":"Rusinek","year":"1991","journal-title":"Radiology"},{"key":"10.1007\/s13311-010-0012-2_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/156720509788929273","article-title":"Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort","volume":"6","author":"Risacher","year":"2009","journal-title":"Curr Alzheimer Res"},{"key":"10.1007\/s13311-010-0012-2_bib7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1212\/01.WNL.0000044400.11317.EC","article-title":"Atrophy rates of entorhinal cortex in AD and normal aging","volume":"60","author":"Du","year":"2003","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.10424","article-title":"Assessing the onset of structural change in familial Alzheimer's disease","volume":"53","author":"Schott","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib9","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.neuroimage.2008.10.031","article-title":"Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI","volume":"44","author":"Misra","year":"2009","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-010-0012-2_bib10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1212\/WNL.58.2.198","article-title":"Patterns of brain atrophy in frontotemporal dementia and semantic dementia","volume":"58","author":"Rosen","year":"2002","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib11","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/brain\/awh628","article-title":"Neuroanatomical correlates of behavioural disorders in dementia","volume":"128","author":"Rosen","year":"2005","journal-title":"Brain"},{"key":"10.1007\/s13311-010-0012-2_bib12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuropsychologia.2005.06.012","article-title":"Neuroanatomical correlates of impaired recognition of emotion in dementia","volume":"44","author":"Rosen","year":"2006","journal-title":"Neuropsychologia"},{"key":"10.1007\/s13311-010-0012-2_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0022-510X(00)00261-6","article-title":"Volumetric study of lobar atrophy in Pick complex and Alzheimer's disease","volume":"174","author":"Fukui","year":"2000","journal-title":"J Neurol Sci"},{"key":"10.1007\/s13311-010-0012-2_bib14","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/S1355617798001064","article-title":"Structural MRI correlates of recognition memory in Alzheimer's disease","volume":"4","author":"Cahn","year":"1998","journal-title":"J Int Neuropsychol Soc"},{"key":"10.1007\/s13311-010-0012-2_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1212\/WNL.54.3.581","article-title":"Memory and MRI-based hippocampal volumes in aging and AD","volume":"54","author":"Petersen","year":"2000","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib16","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1162\/jocn.2006.18.10.1644","article-title":"The anatomy of category-specific object naming in neurodegenerative diseases","volume":"18","author":"Brambati","year":"2006","journal-title":"J Cogn Neurosci"},{"key":"10.1007\/s13311-010-0012-2_bib17","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1093\/brain\/awl254","article-title":"Structural anatomy of empathy in neurodegenerative disease","volume":"129","author":"Rankin","year":"2006","journal-title":"Brain"},{"key":"10.1007\/s13311-010-0012-2_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archneur.63.1.81","article-title":"Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy","volume":"63","author":"Boxer","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib19","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/01.wco.0000173141.74137.63","article-title":"An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism","volume":"18","author":"Seppi","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib20","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1212\/WNL.0b013e3181f736a1","article-title":"Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7\u2013T MRI","volume":"75","author":"Kerchner","year":"2010","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1007\/s13311-010-0012-2_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s004010050622","article-title":"Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn","volume":"93","author":"Braak","year":"1997","journal-title":"Acta Neuropathol"},{"key":"10.1007\/s13311-010-0012-2_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/exnr.2000.7380","article-title":"Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia","volume":"163","author":"Thal","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib24","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3940(97)13365-1","article-title":"Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia","volume":"222","author":"Mizutani","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1007\/s13311-010-0012-2_bib26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1474-4422(02)00190-4","article-title":"Subcortical ischaemic vascular dementia","volume":"1","author":"Roman","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1212\/WNL.59.6.867","article-title":"Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease","volume":"59","author":"Mungas","year":"2002","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib28","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1212\/01.wnl.0000210535.20297.ae","article-title":"Prevalence and severity of microbleeds in a memory clinic setting","volume":"66","author":"Cordonnier","year":"2006","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jns.2007.03.008","article-title":"Cortico-subcortical distribution of microbleeds is different between hypertension and cerebral amyloid angiopathy","volume":"258","author":"Lee","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.1007\/s13311-010-0012-2_bib30","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ncl.2007.04.001","article-title":"Rapidly progressive dementia","volume":"25","author":"Geschwind","year":"2007","journal-title":"Neurol Clin"},{"key":"10.1007\/s13311-010-0012-2_bib31","first-page":"1551","article-title":"Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis","volume":"26","author":"Young","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1007\/s13311-010-0012-2_bib32","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0140-6736(00)02140-1","article-title":"The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt-Jakob disease","volume":"355","author":"Zeidler","year":"2000","journal-title":"Lancet"},{"key":"10.1007\/s13311-010-0012-2_bib33","first-page":"356","article-title":"Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns","volume":"25","author":"Jellison","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1007\/s13311-010-0012-2_bib34","first-page":"1030","article-title":"Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load","volume":"22","author":"Bozzao","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1007\/s13311-010-0012-2_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1212\/01.wnl.0000250326.77323.01","article-title":"Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease","volume":"68","author":"Zhang","year":"2007","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pscychresns.2010.07.005","article-title":"MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging","volume":"184","author":"Sexton","year":"2010","journal-title":"Psychiatry Res"},{"key":"10.1007\/s13311-010-0012-2_bib37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pscychresns.2007.01.001","article-title":"Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease","volume":"155","author":"Firbank","year":"2007","journal-title":"Psychiatry Res"},{"key":"10.1007\/s13311-010-0012-2_bib38","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1093\/brain\/awp071","article-title":"White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI","volume":"132","author":"Zhang","year":"2009","journal-title":"Brain"},{"key":"10.1007\/s13311-010-0012-2_bib39","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1212\/WNL.0b013e3181d9edde","article-title":"Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia","volume":"74","author":"Whitwell","year":"2010","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp.2003.014910","article-title":"Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis","volume":"75","author":"O'Sullivan","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-010-0012-2_bib41","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1212\/01.WNL.0000113760.72706.D2","article-title":"Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia","volume":"62","author":"O'Sullivan","year":"2004","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib42","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1212\/WNL.58.6.928","article-title":"Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD","volume":"58","author":"Schuff","year":"2002","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib43","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1212\/01.WNL.0000078942.63360.22","article-title":"Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD","volume":"61","author":"Schuff","year":"2003","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib44","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.wnr.0000203353.52622.05","article-title":"Magnetic resonance spectroscopic study of Alzheimer's disease and frontotemporal dementia\/Pick complex","volume":"17","author":"Mihara","year":"2006","journal-title":"Neuroreport"},{"key":"10.1007\/s13311-010-0012-2_bib45","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1136\/jnnp.2006.094821","article-title":"Neuroimaging findings in human prion disease","volume":"78","author":"Macfarlane","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-010-0012-2_bib46","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1212\/01.wnl.0000257090.01107.2f","article-title":"Decreased frontal choline and neuropsychological performance in preclinical Huntington disease","volume":"68","author":"Gomez-Anson","year":"2007","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib47","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.conb.2003.09.017","article-title":"MR imaging in the non-human primate: studies of function and of dynamic connectivity","volume":"13","author":"Logothetis","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"10.1007\/s13311-010-0012-2_bib48","first-page":"1869","article-title":"Functional MR imaging in Alzheimer's disease during memory encoding","volume":"21","author":"Rombouts","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1007\/s13311-010-0012-2_bib49","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1212\/01.WNL.0000069462.11741.EC","article-title":"Loss of frontal fMRI activation in early frontotemporal dementia compared to early AD","volume":"60","author":"Rombouts","year":"2003","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib50","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/brain\/awl102","article-title":"Differences between Alzheimer's disease and dementia with Lewy bodies: an fMRI study of task-related brain activity","volume":"129","author":"Sauer","year":"2006","journal-title":"Brain"},{"key":"10.1007\/s13311-010-0012-2_bib51","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1073\/pnas.0604187103","article-title":"Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems","volume":"103","author":"Fox","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1007\/s13311-010-0012-2_bib52","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"Seeley","year":"2007","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-010-0012-2_bib53","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.0905267106","article-title":"Correspondence of the brain's functional architecture during activation and rest","volume":"106","author":"Smith","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1007\/s13311-010-0012-2_bib54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1007\/s13311-010-0012-2_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1073\/pnas.0135058100","article-title":"Functional connectivity in the resting brain: a network analysis of the default mode hypothesis","volume":"100","author":"Greicius","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1007\/s13311-010-0012-2_bib56","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s13311-010-0012-2_bib57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1474-4422(08)70019-X","article-title":"Current and future uses of neuroimaging for cognitively impaired patients","volume":"7","author":"Small","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1095-0397(99)00020-5","article-title":"Clinical value of neuroimaging in the diagnosis of dementia. Sensitivity and specificity of regional cerebral metabolic and other parameters for early identification of Alzheimer's Disease","volume":"2","author":"Silverman","year":"1999","journal-title":"Clin Positron Imaging"},{"key":"10.1007\/s13311-010-0012-2_bib59","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s00259-002-0967-2","article-title":"Functional brain imaging in the dementias: role in early detection, differential diagnosis, and longitudinal studies","volume":"29","author":"Devous","year":"2002","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s13311-010-0012-2_bib60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/snuc.2003.127294","article-title":"Positron emission tomography and single-photon emission computed tomography brain imaging in the evaluation of dementia","volume":"33","author":"Van Heertum","year":"2003","journal-title":"Semin Nucl Med"},{"key":"10.1007\/s13311-010-0012-2_bib61","first-page":"1920","article-title":"FDG PET imaging in patients with pathologically verified dementia","volume":"41","author":"Hoffman","year":"2000","journal-title":"J Nucl Med"},{"key":"10.1007\/s13311-010-0012-2_bib62","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1212\/WNL.56.7.950","article-title":"SPECT perfusion imaging in the diagnosis of Alzheimer's disease: a clinical-pathologic study","volume":"56","author":"Jagust","year":"2001","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib63","first-page":"2044","article-title":"Quantitative brain SPECT in Alzheimer's disease and normal aging","volume":"34","author":"Johnson","year":"1993","journal-title":"J Nucl Med"},{"key":"10.1007\/s13311-010-0012-2_bib64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/13554790490896938","article-title":"FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment","volume":"11","author":"Chetelat","year":"2005","journal-title":"Neurocase"},{"key":"10.1007\/s13311-010-0012-2_bib65","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1001\/jama.1995.03520360056039","article-title":"Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","volume":"273","author":"Small","year":"1995","journal-title":"JAMA"},{"key":"10.1007\/s13311-010-0012-2_bib66","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000017029","article-title":"Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease. X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies","volume":"9","author":"Tanaka","year":"1998","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1007\/s13311-010-0012-2_bib67","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJM199603213341202","article-title":"Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E","volume":"334","author":"Reiman","year":"1996","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.1007\/s13311-010-0012-2_bib68","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.expneurol.2004.06.017","article-title":"Differentiation of Alzheimer's disease from dementia with Lewy bodies utilizing positron emission tomography with [18F]fluorodeoxyglucose and neuropsychological testing","volume":"191","author":"Gilman","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib69","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1093\/brain\/awm177","article-title":"FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease","volume":"130","author":"Foster","year":"2007","journal-title":"Brain"},{"key":"10.1007\/s13311-010-0012-2_bib70","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/jcbfm.1985.25","article-title":"Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease","volume":"5","author":"Haxby","year":"1985","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1007\/s13311-010-0012-2_bib71","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neurobiolaging.2006.12.008","article-title":"Hippocampal hypometabolism predicts cognitive decline from normal aging","volume":"29","author":"Mosconi","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s13311-010-0012-2_bib72","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0925-4927(02)00003-3","article-title":"Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis","volume":"114","author":"Benoit","year":"2002","journal-title":"Psychiatry Res"},{"key":"10.1007\/s13311-010-0012-2_bib73","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2174\/156802607782507466","article-title":"Cerebral acetylcholinesterase imaging: development of the radioprobes","volume":"7","author":"Kikuchi","year":"2007","journal-title":"Curr Top Med Chem"},{"key":"10.1007\/s13311-010-0012-2_bib74","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00213-007-0725-z","article-title":"Changes in brain 11C-nicotine binding sites in patients with mild Alzheimer's disease following rivastigmine treatment as assessed by PET","volume":"191","author":"Kadir","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1007\/s13311-010-0012-2_bib75","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1212\/01.wnl.0000191154.78131.f6","article-title":"Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways","volume":"65","author":"Hilker","year":"2005","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib76","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1073\/pnas.91.1.33","article-title":"Quantitative magnetic resonance imaging of human brain perfusion at 1.5 T using steady-state inversion of arterial water","volume":"91","author":"Roberts","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1007\/s13311-010-0012-2_bib77","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/nimg.1995.1017","article-title":"Review: does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI","volume":"2","author":"Jueptner","year":"1995","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-010-0012-2_bib78","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/1531-8249(200001)47:1<93::AID-ANA15>3.0.CO;2-8","article-title":"Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging","volume":"47","author":"Alsop","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib79","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1148\/radiol.2343040197","article-title":"Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience","volume":"234","author":"Johnson","year":"2005","journal-title":"Radiology"},{"key":"10.1007\/s13311-010-0012-2_bib80","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-010-0012-2_bib81","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1093\/brain\/awm238","article-title":"Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease","volume":"130","author":"Pike","year":"2007","journal-title":"Brain"},{"key":"10.1007\/s13311-010-0012-2_bib82","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/01.wnl.0000219668.47116.e6","article-title":"Neuropathology of older persons without cognitive impairment from two community-based studies","volume":"66","author":"Bennett","year":"2006","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib83","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/01.wnl.0000260969.94695.56","article-title":"PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment","volume":"68","author":"Kemppainen","year":"2007","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib84","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1212\/01.wnl.0000259035.98480.ed","article-title":"11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration","volume":"68","author":"Rabinovici","year":"2007","journal-title":"Neurology"},{"key":"10.1007\/s13311-010-0012-2_bib85","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2967\/jnumed.109.069088","article-title":"In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)","volume":"51","author":"Wong","year":"2010","journal-title":"J Nucl Med"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-010-0012-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13311-010-0012-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923015544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923015544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-010-0012-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-010-0012-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:03:52Z","timestamp":1761807832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923015544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1878747923015544"],"URL":"https:\/\/doi.org\/10.1007\/s13311-010-0012-2","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroimaging in Dementia","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-010-0012-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 The authors. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}