{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:31:34Z","timestamp":1763479894988,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":4069,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s13311-012-0121-1","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T15:57:48Z","timestamp":1332863868000},"page":"635-638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor"],"prefix":"10.1016","volume":"9","author":[{"given":"Fatta B.","family":"Nahab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Handforth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnulfo","family":"Quesada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Haubenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hallett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-012-0121-1_bib1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/mds.23579","article-title":"Milestones in tremor research","volume":"26","author":"Elble","year":"2011","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-012-0121-1_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/brain\/awr301","article-title":"Defective dentate nucleus GABA receptors in essential tremor","volume":"135","author":"Paris-Robidas","year":"2012","journal-title":"Brain"},{"key":"10.1007\/s13311-012-0121-1_bib3","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.2967\/jnumed.109.074120","article-title":"GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study","volume":"51","author":"Boecker","year":"2010","journal-title":"J Nucl Med"},{"key":"10.1007\/s13311-012-0121-1_bib4","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1212\/WNL.0b013e318236f0fd","article-title":"Evidence-based guideline update: Treatment of essential tremor: Report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"77","author":"Zesiewicz","year":"2011","journal-title":"Neurology"},{"key":"10.1007\/s13311-012-0121-1_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1474-4422(10)70322-7","article-title":"Treatment of patients with essential tremor","volume":"10","author":"Deuschl","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-012-0121-1_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/ana.410350613","article-title":"The relationship of essential tremor to other movement disorders: report on 678 patients. Essential Tremor Study Group","volume":"35","author":"Koller","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-012-0121-1_bib7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1212\/WNL.34.2.221","article-title":"Effect of alcohol on tremors: comparison with propranolol","volume":"34","author":"Koller","year":"1984","journal-title":"Neurology"},{"key":"10.1007\/s13311-012-0121-1_bib8","first-page":"174","article-title":"Specific blockade of the low threshold calcium channel by high molecular weight alcohols","volume":"12","author":"Llinas","year":"1986","journal-title":"Soc Neurosci"},{"key":"10.1007\/s13311-012-0121-1_bib9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1113\/jphysiol.1981.sp013764","article-title":"Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro","volume":"315","author":"Llinas","year":"1981","journal-title":"J Physiol"},{"key":"10.1007\/s13311-012-0121-1_bib10","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1007\/BF00585623","article-title":"The effectiveness of different isomers of octanol as blockers of harmaline induced tremor","volume":"414","author":"Sinton","year":"1989","journal-title":"Pflugers Arch"},{"key":"10.1007\/s13311-012-0121-1_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1212\/01.WNL.0000101722.95137.19","article-title":"Pilot trial of 1-octanol in essential tremor","volume":"62","author":"Bushara","year":"2004","journal-title":"Neurology"},{"key":"10.1007\/s13311-012-0121-1_bib12","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1212\/WNL.62.12.2320","article-title":"Open label dose escalation study of oral 1octanol in patients with essential tremor","volume":"62","author":"Shill","year":"2004","journal-title":"Neurology"},{"key":"10.1007\/s13311-012-0121-1_bib13","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13311-011-0045-1","article-title":"An open-label, single-dose, crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremor","volume":"8","author":"Nahab","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1007\/s13311-012-0121-1_bib14","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/mds.23808","article-title":"Validation of digital spiral analysis as outcome parameter for clinical trials in essential tremor","volume":"26","author":"Haubenberger","year":"2011","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-012-0121-1_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/mds.20331","article-title":"Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications","volume":"20","author":"Martin","year":"2005","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-012-0121-1_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s002130050809","article-title":"Positive allosteric modulators of the GABAA receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol","volume":"141","author":"Vanover","year":"1999","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-012-0121-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13311-012-0121-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923017361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923017361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-012-0121-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:09:38Z","timestamp":1761808178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923017361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S1878747923017361"],"URL":"https:\/\/doi.org\/10.1007\/s13311-012-0121-1","relation":{},"ISSN":["1878-7479"],"issn-type":[{"type":"print","value":"1878-7479"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-012-0121-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}