{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:21:45Z","timestamp":1793186505335,"version":"4.5.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K01014X\/1"],"award-info":[{"award-number":["MR\/K01014X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s13311-016-0484-9","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T09:15:11Z","timestamp":1476695711000},"page":"11-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Neuroimaging Endpoints in Amyotrophic Lateral Sclerosis"],"prefix":"10.1016","volume":"14","author":[{"given":"Ricarda A.L.","family":"Menke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Agosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Grosskreutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-016-0484-9_bib1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Kiernan","year":"2011","journal-title":"Lancet"},{"key":"10.1007\/s13311-016-0484-9_bib2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/jnnp-2014-308946","article-title":"The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey","volume":"86","author":"Turner","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib3","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1212\/WNL.0b013e31826e9b1d","article-title":"Presymptomatic studies in ALS: rationale, challenges, and approach","volume":"79","author":"Benatar","year":"2012","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/17482960903420140","article-title":"Pattern of spread and prognosis in lower limb-onset ALS","volume":"11","author":"Turner","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0b013e3181b6bbbd","article-title":"ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration","volume":"73","author":"Ravits","year":"2009","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1007\/s13311-016-0484-9_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archneurpsyc.1943.02290140011001","article-title":"Amyotrophic lateral sclerosis and related conditions: a clinical analysis","volume":"49","author":"Swank","year":"1943","journal-title":"Arch Neurol Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/jnnp.74.7.995","article-title":"Prolonged survival in motor neuron disease: a descriptive study of the King\u2019s database 1990\u20132002","volume":"74","author":"Turner","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jnnp.2010.235952","article-title":"Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study","volume":"82","author":"Chio","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib10","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1212\/WNL.0b013e31828f18ac","article-title":"Cognitive changes predict functional decline in ALS: A population-based longitudinal study","volume":"80","author":"Elamin","year":"2013","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"key":"10.1007\/s13311-016-0484-9_bib12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3109\/21678421.2016.1140786","article-title":"The ALSFRS as an outcome measure in therapeutic trials and its relationship to symptom onset","volume":"17","author":"Proudfoot","year":"2016","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1007\/s13311-016-0484-9_bib13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1474-4422(15)00014-9","article-title":"Sensitivity and specificity of threshold tracking transcranial magnetic stimulation for diagnosis of amyotrophic lateral sclerosis: a prospective study","volume":"14","author":"Menon","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib14","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1212\/WNL.0000000000001642","article-title":"Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis","volume":"84","author":"Lu","year":"2015","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1212\/WNL.0b013e318225aabf","article-title":"Multipoint incremental motor unit number estimation as an outcome measure in ALS","volume":"77","author":"Shefner","year":"2011","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/17482968.2012.688837","article-title":"Electrical impedance myography as a biomarker to assess ALS progression","volume":"13","author":"Rutkove","year":"2012","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib18","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cell.2011.10.011","article-title":"The seeds of neurodegeneration: prion-like spreading in ALS","volume":"147","author":"Polymenidou","year":"2011","journal-title":"Cell"},{"key":"10.1007\/s13311-016-0484-9_bib19","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrneurol.2013.221","article-title":"Amyotrophic lateral sclerosis\u2014a model of corticofugal axonal spread","volume":"9","author":"Braak","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2217\/bmm.12.26","article-title":"Neuroimaging in amyotrophic lateral sclerosis","volume":"6","author":"Turner","year":"2012","journal-title":"Biomark Med"},{"key":"10.1007\/s13311-016-0484-9_bib21","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.neuroimage.2009.05.029","article-title":"An evaluation of four automatic methods of segmenting the subcortical structures in the brain","volume":"47","author":"Babalola","year":"2009","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1007\/s13311-016-0484-9_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib24","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2014the methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104894","article-title":"Voxel-based MRI intensitometry reveals extent of cerebral white matter pathology in amyotrophic lateral sclerosis","volume":"9","author":"Hartung","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1007\/s13311-016-0484-9_bib26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1148\/radiology.161.2.3763909","article-title":"Mr Imaging of intravoxel incoherent motions\u2014application to diffusion and perfusion in neurologic disorders","volume":"161","author":"Lebihan","year":"1986","journal-title":"Radiology."},{"key":"10.1007\/s13311-016-0484-9_bib27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/jmrb.1994.1037","article-title":"Estimation of the effective self-diffusion tensor from the NMR spin echo","volume":"103","author":"Basser","year":"1994","journal-title":"J Magn Reson Ser B"},{"key":"10.1007\/s13311-016-0484-9_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system\u2014a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed"},{"key":"10.1007\/s13311-016-0484-9_bib29","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.neuroimage.2010.12.008","article-title":"DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease","volume":"55","author":"Douaud","year":"2011","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib30","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1385\/NI:2:2:145","article-title":"The small world of the cerebral cortex","volume":"2","author":"Sporns","year":"2004","journal-title":"Neuroinformatics"},{"key":"10.1007\/s13311-016-0484-9_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuroimage.2007.02.012","article-title":"Characterizing brain anatomical connections using diffusion weighted MRI and graph theory","volume":"36","author":"Iturria-Medina","year":"2007","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib33","doi-asserted-by":"crossref","first-page":"13848","DOI":"10.1073\/pnas.0601417103","article-title":"Consistent resting-state networks across healthy subjects","volume":"103","author":"Damoiseaux","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1007\/s13311-016-0484-9_bib34","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.0905267106","article-title":"Correspondence of the brain's functional architecture during activation and rest","volume":"106","author":"Smith","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1007\/s13311-016-0484-9_bib35","first-page":"8","article-title":"Advances and pitfalls in the analysis and interpretation of resting-state FMRI data","volume":"4","author":"Cole","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"10.1007\/s13311-016-0484-9_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1109\/TMI.2003.822821","article-title":"Probabilistic independent component analysis for functional magnetic resonance imaging","volume":"23","author":"Beckmann","year":"2004","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1007\/s13311-016-0484-9_bib37","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1098\/rstb.2005.1634","article-title":"Investigations into resting-state connectivity using independent component analysis","volume":"360","author":"Beckmann","year":"2005","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"Suppl. 2","key":"10.1007\/s13311-016-0484-9_bib38","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1080\/54-14660820050515665","article-title":"Positron emission tomography (PET)\u2014its potential to provide surrogate markers in ALS","volume":"1","author":"Turner","year":"2000","journal-title":"Amyotroph Lateral Scle rOther Motor Neuron Disord"},{"key":"10.1007\/s13311-016-0484-9_bib39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mcn.2012.10.008","article-title":"Inflammation and neurovascular changes in amyotrophic lateral sclerosis","volume":"53","author":"Evans","year":"2012","journal-title":"Mol Cell Neurosci"},{"key":"10.1007\/s13311-016-0484-9_bib40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mus.24470","article-title":"Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis","volume":"51","author":"Turner","year":"2015","journal-title":"Muscle Nerve"},{"key":"10.1007\/s13311-016-0484-9_bib41","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.clinph.2016.04.025","article-title":"Assessment of the upper motor neuron in amyotrophic lateral sclerosis","volume":"127","author":"Huynh","year":"2016","journal-title":"Clin Neurophysiol"},{"key":"10.1007\/s13311-016-0484-9_bib42","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/nbm.907","article-title":"Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysis","volume":"17","author":"Abe","year":"2004","journal-title":"NMR Biomed"},{"key":"10.1007\/s13311-016-0484-9_bib43","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/brain\/awh041","article-title":"Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis","volume":"127","author":"Sach","year":"2004","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib44","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1148\/radiol.2371041506","article-title":"Diffusion-tensor MR imaging of corticospinal tract in amyotrophic lateral sclerosis and progressive muscular atrophy","volume":"237","author":"Cosottini","year":"2005","journal-title":"Radiology"},{"key":"10.1007\/s13311-016-0484-9_bib45","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuroimage.2006.09.025","article-title":"Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis","volume":"34","author":"Sage","year":"2007","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib46","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/jnnp.2006.101758","article-title":"Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability","volume":"78","author":"Thivard","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib47","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1212\/01.wnl.0000299186.72374.19","article-title":"Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation","volume":"70","author":"Iwata","year":"2008","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib48","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3174\/ajnr.A2105","article-title":"Assessment of white matter tract damage in patients with amyotrophic lateral sclerosis: a diffusion tensor MR imaging tractography study","volume":"31","author":"Agosta","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1007\/s13311-016-0484-9_bib49","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/brain\/awr016","article-title":"Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging study","volume":"134","author":"van der Graaff","year":"2011","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib50","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1093\/brain\/awu162","article-title":"Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis","volume":"137","author":"Menke","year":"2014","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib51","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/jnnp.2010.236018","article-title":"Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALS","volume":"82","author":"Blain","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3109\/21678421.2013.844168","article-title":"Multimodal tract-based analysis in ALS patients at 7T: a specific white matter profile?","volume":"15","author":"Verstraete","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1007\/s13311-016-0484-9_bib53","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1212\/WNL.0b013e3181fb84d1","article-title":"Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis","volume":"75","author":"Filippini","year":"2010","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib54","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jmri.24218","article-title":"Diffusion tensor MRI of the corpus callosum in amyotrophic lateral sclerosis","volume":"39","author":"Chapman","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"10.1007\/s13311-016-0484-9_bib55","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/brain\/awr178","article-title":"White matter alterations differ in primary lateral sclerosis and amyotrophic lateral sclerosis","volume":"134","author":"Iwata","year":"2011","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/17482968.2010.517850","article-title":"Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study","volume":"12","author":"Senda","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082017","article-title":"Extramotor damage is associated with cognition in primary lateral sclerosis patients","volume":"8","author":"Canu","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1007\/s13311-016-0484-9_bib58","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/hbm.23124","article-title":"Structural brain correlates of cognitive and behavioral impairment in MND","volume":"37","author":"Agosta","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"10.1007\/s13311-016-0484-9_bib59","doi-asserted-by":"crossref","unstructured":"Ng MC, Ho JT, Ho SL, Lee R, Li G, Cheng TS, et al. Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation. J Magn Reson Imaging 2008;27(1):8-13.","DOI":"10.1002\/jmri.21217"},{"key":"10.1007\/s13311-016-0484-9_bib60","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.clinph.2010.02.164","article-title":"Corticomotoneuronal function in asymptomatic SOD-1 mutation carriers","volume":"121","author":"Vucic","year":"2010","journal-title":"Clin Neurophysiol"},{"key":"10.1007\/s13311-016-0484-9_bib61","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.acra.2012.04.012","article-title":"Diagnostic accuracy using diffusion tensor imaging in the diagnosis of ALS: a meta-analysis","volume":"19","author":"Foerster","year":"2012","journal-title":"Acad Radiol"},{"key":"10.1007\/s13311-016-0484-9_bib62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2377-6-17","article-title":"Widespread sensorimotor and frontal cortical atrophy in amyotrophic lateral sclerosis","volume":"6","author":"Grosskreutz","year":"2006","journal-title":"BMC Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib63","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/hbm.20364","article-title":"Voxel-based morphometry study of brain volumetry and diffusivity in amyotrophic lateral sclerosis patients with mild disability","volume":"28","author":"Agosta","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"10.1007\/s13311-016-0484-9_bib64","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/17482960802267530","article-title":"Detection of motor cortex thinning and corticospinal tract involvement by quantitative MRI in amyotrophic lateral sclerosis","volume":"10","author":"Roccatagliata","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib65","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/ene.12615","article-title":"Prose memory impairment in amyotrophic lateral sclerosis patients is related to hippocampus volume","volume":"22","author":"Raaphorst","year":"2015","journal-title":"Eur J Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib66","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fnagi.2016.00064","article-title":"Voxel-wise meta-analysis of gray matter changes in amyotrophic lateral sclerosis","volume":"8","author":"Shen","year":"2016","journal-title":"Front Aging Neurosci"},{"key":"10.1007\/s13311-016-0484-9_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042816","article-title":"The cortical signature of amyotrophic lateral sclerosis","volume":"7","author":"Agosta","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1007\/s13311-016-0484-9_bib68","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/jnnp-2011-300909","article-title":"Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis","volume":"83","author":"Verstraete","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib69","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1007\/s00415-013-7083-z","article-title":"Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study","volume":"260","author":"Schuster","year":"2013","journal-title":"J Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib70","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/jnnp-2013-306839","article-title":"Cortical thickness in ALS: towards a marker for upper motor neuron involvement","volume":"86","author":"Walhout","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib71","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1093\/brain\/awr279","article-title":"Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis","volume":"134","author":"Douaud","year":"2011","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib72","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/acn3.212","article-title":"CSF neurofilament light chain reflects corticospinal tract degeneration in ALS","volume":"2","author":"Menke","year":"2015","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib74","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1212\/WNL.0000000000002135","article-title":"Brain morphologic changes in asymptomatic C9orf72 repeat expansion carriers","volume":"85","author":"Walhout","year":"2015","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib75","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s00415-005-0787-y","article-title":"Functional motor compensation in amyotrophic lateral sclerosis","volume":"252","author":"Schoenfeld","year":"2005","journal-title":"J Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib76","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/hbm.21064","article-title":"Functional neuroimaging at different disease stages reveals distinct phases of neuroplastic changes in amyotrophic lateral sclerosis","volume":"32","author":"Mohammadi","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"10.1007\/s13311-016-0484-9_bib77","doi-asserted-by":"crossref","first-page":"14260","DOI":"10.1523\/JNEUROSCI.1111-14.2014","article-title":"Cognitive deterioration and functional compensation in ALS measured with fMRI using an inhibitory task","volume":"34","author":"Witiuk","year":"2014","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-016-0484-9_bib78","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1212\/WNL.0000000000000745","article-title":"Prefrontal involvement related to cognitive impairment in progressive muscular atrophy","volume":"83","author":"Raaphorst","year":"2014","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib79","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.expneurol.2009.01.025","article-title":"Changes of resting state brain networks in amyotrophic lateral sclerosis","volume":"217","author":"Mohammadi","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib80","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fnsys.2010.00158","article-title":"Reduced interhemispheric functional connectivity in the motor cortex during rest in limb-onset amyotrophic lateral sclerosis","volume":"4","author":"Jelsone-Swain","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"10.1007\/s13311-016-0484-9_bib81","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neurobiolaging.2010.07.011","article-title":"Interaction between aging and neurodegeneration in amyotrophic lateral sclerosis","volume":"33","author":"Tedeschi","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s13311-016-0484-9_bib82","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/cercor\/bhr002","article-title":"Sensorimotor functional connectivity changes in amyotrophic lateral sclerosis","volume":"21","author":"Agosta","year":"2011","journal-title":"Cereb Cortex"},{"key":"10.1007\/s13311-016-0484-9_bib83","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neurobiolaging.2012.04.015","article-title":"Divergent brain network connectivity in amyotrophic lateral sclerosis","volume":"34","author":"Agosta","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s13311-016-0484-9_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157443","article-title":"Investigating default mode and sensorimotor network connectivity in amyotrophic lateral sclerosis","volume":"11","author":"Chenji","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1007\/s13311-016-0484-9_bib85","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1002\/hbm.22481","article-title":"Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis","volume":"35","author":"Schmidt","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1007\/s13311-016-0484-9_bib86","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/jnnp-2015-311945","article-title":"Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk","volume":"87","author":"Menke","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib87","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/ana.410220504","article-title":"Lowered cerebral glucose-utilization in amyotrophic-lateral-sclerosis","volume":"22","author":"Dalakas","year":"1987","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib88","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/brain\/116.3.655","article-title":"Cortical function in amyotrophic lateral sclerosis. A positron emission tomography study","volume":"116","author":"Kew","year":"1993","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib89","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.nbd.2003.12.012","article-title":"Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [C-11](R)-PK11195 positron emission tomography study","volume":"15","author":"Turner","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1007\/s13311-016-0484-9_bib90","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.nicl.2015.01.009","article-title":"Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [(11)C]-PBR28","volume":"7","author":"Zurcher","year":"2015","journal-title":"Neuroimage Clin"},{"key":"10.1007\/s13311-016-0484-9_bib91","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/brain\/123.11.2289","article-title":"Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil","volume":"123","author":"Lloyd","year":"2000","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib92","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/brain\/awh509","article-title":"Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET","volume":"128","author":"Turner","year":"2005","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib93","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/brain\/awh428","article-title":"[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS","volume":"28","author":"Turner","year":"2005","journal-title":"Brain"},{"key":"10.1007\/s13311-016-0484-9_bib94","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pscychresns.2007.07.003","article-title":"Serotonin-1A receptors in frontotemporal dementia compared with controls","volume":"156","author":"Lanctot","year":"2007","journal-title":"Psychiatry Res"},{"key":"10.1007\/s13311-016-0484-9_bib95","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.drudis.2012.10.004","article-title":"PET and SPECT tracers for glutamate receptors","volume":"18","author":"Majo","year":"2013","journal-title":"Drug Discov Today"},{"key":"10.1007\/s13311-016-0484-9_bib96","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12974-015-0439-9","article-title":"PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene","volume":"12","author":"Brownell","year":"2015","journal-title":"J Neuroinflamm"},{"key":"10.1007\/s13311-016-0484-9_bib97","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1212\/WNL.44.10.1933","article-title":"Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo","volume":"44","author":"Pioro","year":"1994","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib98","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1212\/WNL.0b013e318281ccec","article-title":"Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS","volume":"80","author":"Stagg","year":"2013","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib99","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1212\/WNL.0b013e3182563b57","article-title":"Decreased motor cortex gamma-aminobutyric acid in amyotrophic lateral sclerosis","volume":"78","author":"Foerster","year":"2012","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1212\/WNL.53.1.71","article-title":"1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla","volume":"53","author":"Pioro","year":"1999","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib101","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/17482960802566824","article-title":"Prognostic factors in ALS: A critical review","volume":"10","author":"Chio","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib102","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3109\/17482968.2011.653571","article-title":"Neuroanatomical patterns of cerebral white matter involvement in different motor neuron diseases as studied by diffusion tensor imaging analysis","volume":"13","author":"Muller","year":"2012","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib103","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/hbm.22286","article-title":"Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS","volume":"35","author":"Agosta","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1007\/s13311-016-0484-9_bib104","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s00415-014-7434-4","article-title":"Central white matter degeneration in bulbar- and limb-onset amyotrophic lateral sclerosis","volume":"261","author":"Cardenas-Blanco","year":"2014","journal-title":"J Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib105","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/archneurol.2012.1122","article-title":"Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis","volume":"69","author":"Menke","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib106","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/17482960701548139","article-title":"A longitudinal study of diffusion tensor MRI in ALS","volume":"8","author":"Blain","year":"2007","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib107","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/jnnp.2008.154252","article-title":"A longitudinal diffusion tensor MRI study of the cervical cord and brain in amyotrophic lateral sclerosis patients","volume":"80","author":"Agosta","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095516","article-title":"Multi-parametric spinal cord MRI as potential progression marker in amyotrophic lateral sclerosis","volume":"9","author":"El Mendili","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1007\/s13311-016-0484-9_bib109","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1460-9568.2010.07445.x","article-title":"MRI predictors of long-term evolution in amyotrophic lateral sclerosis","volume":"32","author":"Agosta","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1007\/s13311-016-0484-9_bib110","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/17482968.2011.593036","article-title":"Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study","volume":"12","author":"Zhang","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib111","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2202-13-141","article-title":"Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis","volume":"13","author":"Keil","year":"2012","journal-title":"BMC Neurosci"},{"key":"10.1007\/s13311-016-0484-9_bib112","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/hbm.22258","article-title":"Structural brain network imaging shows expanding disconnection of the motor system in amyotrophic lateral sclerosis","volume":"35","author":"Verstraete","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1007\/s13311-016-0484-9_bib113","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/17482960802603841","article-title":"Longitudinal assessment of grey matter contraction in amyotrophic lateral sclerosis: a tensor based morphometry study","volume":"10","author":"Agosta","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib114","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00415-014-7426-4","article-title":"Longitudinal course of cortical thickness decline in amyotrophic lateral sclerosis","volume":"261","author":"Schuster","year":"2014","journal-title":"J Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib115","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.neurobiolaging.2014.09.002","article-title":"Subcortical structures in amyotrophic lateral sclerosis","volume":"36","author":"Westeneng","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s13311-016-0484-9_bib116","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.nicl.2012.12.003","article-title":"Structural imaging differences and longitudinal changes in primary lateral sclerosis and amyotrophic lateral sclerosis","volume":"2","author":"Kwan","year":"2012","journal-title":"Neuroimage Clin"},{"key":"10.1007\/s13311-016-0484-9_bib117","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.nicl.2016.03.011","article-title":"Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis","volume":"11","author":"Cardenas-Blanco","year":"2016","journal-title":"Neuroimage Clin"},{"key":"10.1007\/s13311-016-0484-9_bib118","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1212\/WNL.58.5.773","article-title":"Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI","volume":"58","author":"Suhy","year":"2002","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib119","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/14660820410017109","article-title":"Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study","volume":"5","author":"Rule","year":"2004","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1007\/s13311-016-0484-9_bib120","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00415-006-0495-2","article-title":"Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study","volume":"254","author":"Unrath","year":"2007","journal-title":"J Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib121","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jalz.2015.04.005","article-title":"Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014","volume":"11","author":"Weiner","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1007\/s13311-016-0484-9_bib122","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/alzrt276","article-title":"Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?","volume":"6","author":"Merlo Pich","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.1007\/s13311-016-0484-9_bib123","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1212\/WNL.0000000000002985","article-title":"Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes","volume":"87","author":"Burciu","year":"2016","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib124","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1212\/WNL.0000000000000187","article-title":"PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease","volume":"82","author":"Rosas","year":"2014","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib125","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/17482968.2011.593036","article-title":"Progression of white matter degeneration in amyotrophic lateral sclerosis: a diffusion tensor imaging study","volume":"12","author":"Zhang","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1007\/s13311-016-0484-9_bib126","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.clinimag.2015.09.002","article-title":"MRI safety: a report of current practice and advancements in patient preparation and screening","volume":"39","author":"Weidman","year":"2015","journal-title":"Clin Imaging"},{"key":"10.1007\/s13311-016-0484-9_bib127","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1118\/1.3116776","article-title":"Measurement of MRI scanner performance with the ADNI phantom","volume":"36","author":"Gunter","year":"2009","journal-title":"Med Phys"},{"key":"10.1007\/s13311-016-0484-9_bib128","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/jmri.22186","article-title":"Intercenter differences in diffusion tensor MRI acquisition","volume":"31","author":"Pagani","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"10.1007\/s13311-016-0484-9_bib129","doi-asserted-by":"crossref","unstructured":"Brueggen K, Grothe MJ, Dyrba M, et al. The European DTI Study on Dementia\u2014a multicenter DTI and MRI study on Alzheimer\u2019s disease and mild cognitive impairment. Neuroimage 2016 Apr 2.","DOI":"10.1016\/j.neuroimage.2016.03.067"},{"key":"10.1007\/s13311-016-0484-9_bib130","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/jnnp-2015-311952","article-title":"A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis","volume":"87","author":"Muller","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-016-0484-9_bib131","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1212\/01.WNL.0000150542.16969.CC","article-title":"Dehydration confounds the assessment of brain atrophy","volume":"64","author":"Duning","year":"2005","journal-title":"Neurology"},{"key":"10.1007\/s13311-016-0484-9_bib132","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust, and automated longitudinal and cross-sectional brain change analysis","volume":"17","author":"Smith","year":"2002","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib133","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/practneurol-2013-000768","article-title":"Magnetoencephalography","volume":"14","author":"Proudfoot","year":"2014","journal-title":"Pract Neurol"},{"key":"10.1007\/s13311-016-0484-9_bib134","doi-asserted-by":"crossref","unstructured":"Proudfoot M, Rohenkohl G, Quinn A, et al. Altered cortical beta-band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis. Hum Brain Mapp 2016 Sep 13.","DOI":"10.1002\/hbm.23357"},{"key":"10.1007\/s13311-016-0484-9_bib135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroimage.2011.03.070","article-title":"Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner","volume":"57","author":"Miller","year":"2011","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-016-0484-9_bib136","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/brain\/awu090","article-title":"Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology","volume":"137","author":"Kassubek","year":"2014","journal-title":"Brain"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-016-0484-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13311-016-0484-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792301509X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792301509X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-016-0484-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:07:06Z","timestamp":1761808026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187874792301509X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":136,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S187874792301509X"],"URL":"https:\/\/doi.org\/10.1007\/s13311-016-0484-9","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroimaging Endpoints in Amyotrophic Lateral Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-016-0484-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 The authors. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}