{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:50:44Z","timestamp":1792795844198,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":2150,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U54 HD079125"],"award-info":[{"award-number":["U54 HD079125"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of the Assistant Secretary of Defense for Health Affairs","award":["W81XWH-09-1-0746"],"award-info":[{"award-number":["W81XWH-09-1-0746"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG04825"],"award-info":[{"award-number":["R01 AG04825"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Private donations"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s13311-017-0555-6","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T09:26:01Z","timestamp":1499937961000},"page":"1073-1083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor\/Ataxia Syndrome"],"prefix":"10.1016","volume":"14","author":[{"given":"J.Y.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.R.","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Giulivi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lubarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.W.","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Brinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Olichney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Rogawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Hagerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1007\/s13311-017-0555-6_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.57.1.127","article-title":"Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X","volume":"57","author":"Hagerman","year":"2001","journal-title":"Neurology"},{"issue":"14","key":"10.1007\/s13311-017-0555-6_bib2","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/mds.21493","article-title":"Fragile X-associated tremor\/ataxia syndrome: clinical features, genetics, and testing guidelines","volume":"22","author":"Berry-Kravis","year":"2007","journal-title":"Mov Disord"},{"issue":"4","key":"10.1007\/s13311-017-0555-6_bib3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1086\/374321","article-title":"Fragile X premutation tremor\/ataxia syndrome: molecular, clinical, and neuroimaging correlates","volume":"72","author":"Jacquemont","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1007\/s13311-017-0555-6_bib4","series-title":"Fragile X-associated tremor ataxia syndrome (FXTAS)","year":"2010"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/jmg.2007.054171","article-title":"A low symptomatic form of neurodegeneration in younger carriers of the FMR1 premutation, manifesting typical radiological changes","volume":"45","author":"Loesch","year":"2008","journal-title":"J Med Genet"},{"issue":"8","key":"10.1007\/s13311-017-0555-6_bib6","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1212\/01.wnl.0000239837.57475.3a","article-title":"Molecular and imaging correlates of the fragile X-associated tremor\/ataxia syndrome","volume":"67","author":"Cohen","year":"2006","journal-title":"Neurology"},{"issue":"10","key":"10.1007\/s13311-017-0555-6_bib7","first-page":"1757","article-title":"Fragile X premutation carriers: characteristic MR imaging findings of adult male patients with progressive cerebellar and cognitive dysfunction","volume":"23","author":"Brunberg","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"issue":"Pt 3","key":"10.1007\/s13311-017-0555-6_bib8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/brain\/awq368","article-title":"A voxel-based morphometry study of grey matter loss in fragile X-associated tremor\/ataxia syndrome","volume":"134","author":"Hashimoto","year":"2011","journal-title":"Brain"},{"issue":"9","key":"10.1007\/s13311-017-0555-6_bib9","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1002\/hbm.22491","article-title":"Altered structural brain connectome in young adult fragile X premutation carriers","volume":"35","author":"Leow","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1007\/s13311-017-0555-6_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2017.03.018","article-title":"Abnormal trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation","volume":"55","author":"Wang","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s13311-017-0555-6_bib11","series-title":"FXTAS, FXPOI, and Other Premutation Disorders","first-page":"181","article-title":"Treatment and management of FXTAS","author":"Hall","year":"2016"},{"issue":"8","key":"10.1007\/s13311-017-0555-6_bib12","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.neurobiolaging.2011.06.008","article-title":"Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice","volume":"33","author":"Singh","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"4","key":"10.1007\/s13311-017-0555-6_bib13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrendo.2013.31","article-title":"Neurosteroids as regenerative agents in the brain: therapeutic implications","volume":"9","author":"Brinton","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"10.1007\/s13311-017-0555-6_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuroscience.2003.09.023","article-title":"Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex","volume":"123","author":"Djebaili","year":"2004","journal-title":"Neuroscience"},{"issue":"1","key":"10.1007\/s13311-017-0555-6_bib15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/neu.2005.22.106","article-title":"The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats","volume":"22","author":"Djebaili","year":"2005","journal-title":"J Neurotrauma"},{"issue":"13","key":"10.1007\/s13311-017-0555-6_bib16","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1093\/hmg\/dds118","article-title":"Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone","volume":"21","author":"Cao","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib17","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00213-005-0148-7","article-title":"Pharmacokinetic and behavioral effects of allopregnanolone in healthy women","volume":"186","author":"Timby","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"10.1007\/s13311-017-0555-6_bib18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/ana.24295","article-title":"Pediatric super-refractory status epilepticus treated with allopregnanolone","volume":"76","author":"Broomall","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-017-0555-6_bib19","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/acn3.408","article-title":"First-in-man allopregnanolone use in super-refractory status epilepticus","volume":"4","author":"Vaitkevicius","year":"2017","journal-title":"Ann Clin Transl Neurol"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1373\/clinchem.2009.136101","article-title":"A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome","volume":"56","author":"Filipovic-Sadic","year":"2010","journal-title":"Clin Chem"},{"issue":"21","key":"10.1007\/s13311-017-0555-6_bib21","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1001\/jama.2010.1706","article-title":"Mitochondrial dysfunction in autism","volume":"304","author":"Giulivi","year":"2010","journal-title":"JAMA"},{"key":"10.1007\/s13311-017-0555-6_bib22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4088\/JCP.13m08546","article-title":"Memantine for fragile X-associated tremor\/ataxia syndrome: a randomized, double-blind, placebo-controlled trial","volume":"75","author":"Seritan","year":"2014","journal-title":"J Clin Psychiatry"},{"key":"10.1007\/s13311-017-0555-6_bib23","series-title":"California verbal learning test-second edition","author":"Delis","year":"2000"},{"key":"10.1007\/s13311-017-0555-6_bib24","series-title":"Wechsler Memory Scale-Fourth Edition","author":"Wechsler","year":"2009"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1007\/s13311-017-0555-6_bib26","series-title":"The Behavioral Dyscontrol Scale: Manual","author":"Grigsby","year":"1996"},{"issue":"12","key":"10.1007\/s13311-017-0555-6_bib27","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1532-5415.1990.tb03452.x","article-title":"Prediction of independent functioning and behavior problems in geriatric patients","volume":"38","author":"Kaye","year":"1990","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"10.1007\/s13311-017-0555-6_bib28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0892-0362(96)00027-X","article-title":"CANTAB battery: proposed utility in neurotoxicology","volume":"18","author":"Fray","year":"1996","journal-title":"Neurotoxicol Teratol"},{"key":"10.1007\/s13311-017-0555-6_bib29","series-title":"A compendium of neuropsychological tests: administration, norms and commentary","author":"Spreen","year":"1998"},{"key":"10.1007\/s13311-017-0555-6_bib30","series-title":"Symptom Checklist-90-R: administration, scoring and procedures manual","author":"Derogatis","year":"1994"},{"issue":"6","key":"10.1007\/s13311-017-0555-6_bib31","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: psychometric properties","volume":"56","author":"Beck","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"10.1007\/s13311-017-0555-6_bib32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ajmg.a.32211","article-title":"A quantitative assessment of tremor and ataxia in FMR1 premutation carriers using CATSYS","volume":"146A","author":"Aguilar","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1007\/s13311-017-0555-6_bib33","doi-asserted-by":"crossref","first-page":"484713","DOI":"10.1155\/2011\/484713","article-title":"A quantitative assessment of tremor and ataxia in female FMR1 premutation carriers using CATSYS","volume":"2011","author":"Narcisa","year":"2011","journal-title":"Curr Gerontol Geriatr Res"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuroimage.2009.02.030","article-title":"Model-based automatic detection of the anterior and posterior commissures on MRI scans","volume":"46","author":"Ardekani","year":"2009","journal-title":"Neuroimage"},{"issue":"2","key":"10.1007\/s13311-017-0555-6_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3","article-title":"Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging","volume":"45","author":"Mori","year":"1999","journal-title":"Ann Neurol"},{"issue":"6","key":"10.1007\/s13311-017-0555-6_bib36","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"Suppl. 1","key":"10.1007\/s13311-017-0555-6_bib37","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-017-0555-6_bib38","first-page":"548","article-title":"Multi-atlas segmentation with robust label transfer and label fusion","volume":"23","author":"Wang","year":"2013","journal-title":"Inform Process Med Imaging"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib39","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2011.01.006","article-title":"A learning-based wrapper method to correct systematic errors in automatic image segmentation: consistently improved performance in hippocampus, cortex and brain segmentation","volume":"55","author":"Wang","year":"2011","journal-title":"Neuroimage"},{"issue":"5","key":"10.1007\/s13311-017-0555-6_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156123","article-title":"Robust Machine learning-based correction on automatic segmentation of the cerebellum and brainstem","volume":"11","author":"Wang","year":"2016","journal-title":"PLOS ONE"},{"issue":"9","key":"10.1007\/s13311-017-0555-6_bib41","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/mds.25473","article-title":"A multimodal imaging analysis of subcortical gray matter in fragile X premutation carriers","volume":"28","author":"Wang","year":"2013","journal-title":"Mov Disord"},{"issue":"1","key":"10.1007\/s13311-017-0555-6_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"Neuroimage"},{"issue":"4","key":"10.1007\/s13311-017-0555-6_bib43","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-017-0555-6_bib44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroimage.2016.07.018","article-title":"BIANCA (Brain Intensity AbNormality Classification Algorithm): a new tool for automated segmentation of white matter hyperintensities","volume":"141","author":"Griffanti","year":"2016","journal-title":"Neuroimage"},{"issue":"Pt 5","key":"10.1007\/s13311-017-0555-6_bib45","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/brain\/awq077","article-title":"Abnormal N400 word repetition effects in fragile X-associated tremor\/ataxia syndrome","volume":"133","author":"Olichney","year":"2010","journal-title":"Brain"},{"key":"10.1007\/s13311-017-0555-6_bib46","series-title":"R: a language and environment for statistical computing","author":"Team RDC","year":"2014"},{"key":"10.1007\/s13311-017-0555-6_bib47","unstructured":"Winter B. Linear models and linear mixed effects models in R with linguistic applications. Available at: http:\/\/arxiv.org\/pdf\/1308.5499.pdf. Accessed June 14, 2017."},{"issue":"1","key":"10.1007\/s13311-017-0555-6_bib48","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pain.2010.10.015","article-title":"Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: multi-parametric assessment and direct evidence","volume":"152","author":"Meyer","year":"2011","journal-title":"Pain"},{"key":"10.1007\/s13311-017-0555-6_bib49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pneurobio.2013.07.004","article-title":"Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain","volume":"113","author":"Patte-Mensah","year":"2014","journal-title":"Prog Neurobiol"},{"issue":"1","key":"10.1007\/s13311-017-0555-6_bib50","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1866-1955-6-28","article-title":"The cognitive neuropsychological phenotype of carriers of the FMR1 premutation","volume":"6","author":"Grigsby","year":"2014","journal-title":"J Neurodevelop Disord"},{"key":"10.1007\/s13311-017-0555-6_bib51","first-page":"127","article-title":"Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory","volume":"2016","author":"Lieberwirth","year":"1644","journal-title":"Brain Res"},{"issue":"1-2","key":"10.1007\/s13311-017-0555-6_bib52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0166-4328(99)00101-1","article-title":"The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat","volume":"106","author":"Akwa","year":"1999","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.1007\/s13311-017-0555-6_bib53","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2007.01.004","article-title":"Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors","volume":"415","author":"Wang","year":"2007","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib54","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/ajmg.b.31046","article-title":"Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers","volume":"153B","author":"Adams","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"Pt 2","key":"10.1007\/s13311-017-0555-6_bib55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/brain\/awl338","article-title":"Amygdala dysfunction in men with the fragile X premutation","volume":"130","author":"Hessl","year":"2007","journal-title":"Brain"},{"issue":"2","key":"10.1007\/s13311-017-0555-6_bib56","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11682-008-9020-9","article-title":"Reduced hippocampal activation during recall is associated with elevated FMR1 mRNA and psychiatric symptoms in men with the Fragile X premutation","volume":"2","author":"Koldewyn","year":"2008","journal-title":"Brain Imaging Behav"},{"issue":"4","key":"10.1007\/s13311-017-0555-6_bib57","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archneurol.2011.2023","article-title":"Age-dependent structural connectivity effects in fragile x premutation","volume":"69","author":"Wang","year":"2012","journal-title":"Arch Neurol"},{"issue":"8","key":"10.1007\/s13311-017-0555-6_bib58","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/jamaneurol.2013.2934","article-title":"Fragile X-associated tremor\/ataxia syndrome: influence of the FMR1 gene on motor fiber tracts in males with normal and premutation alleles","volume":"70","author":"Wang","year":"2013","journal-title":"JAMA Neurol"},{"issue":"Pt 1","key":"10.1007\/s13311-017-0555-6_bib59","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/brain\/awh683","article-title":"Neuropathology of fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"129","author":"Greco","year":"2006","journal-title":"Brain"},{"key":"10.1007\/s13311-017-0555-6_bib60","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuropsychologia.2014.08.001","article-title":"ERP abnormalities elicited by word repetition in fragile X-associated tremor\/ataxia syndrome (FXTAS) and amnestic MCI","volume":"63","author":"Yang","year":"2014","journal-title":"Neuropsychologia"},{"issue":"12","key":"10.1007\/s13311-017-0555-6_bib61","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1038\/npp.2014.122","article-title":"Memantine effects on verbal memory in fragile X-associated tremor\/ataxia syndrome (FXTAS): a double-blind brain potential study","volume":"39","author":"Yang","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1007\/s13311-017-0555-6_bib62","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1006\/nimg.2002.1268","article-title":"N400-like magnetoencephalography responses modulated by semantic context, word frequency, and lexical class in sentences","volume":"17","author":"Halgren","year":"2002","journal-title":"Neuroimage"},{"issue":"6503","key":"10.1007\/s13311-017-0555-6_bib63","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/372260a0","article-title":"Word recognition in the human inferior temporal lobe","volume":"372","author":"Nobre","year":"1994","journal-title":"Nature"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13311-017-0555-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-017-0555-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923014265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923014265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-017-0555-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:58:42Z","timestamp":1761807522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923014265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1878747923014265"],"URL":"https:\/\/doi.org\/10.1007\/s13311-017-0555-6","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor\/Ataxia Syndrome","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-017-0555-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}