{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:12:17Z","timestamp":1780776737679,"version":"3.54.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s13311-020-00849-y","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T13:02:32Z","timestamp":1586955752000},"page":"1075-1086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6\/2 Mouse Model of Huntington's Disease"],"prefix":"10.1016","volume":"17","author":[{"given":"Szilvia","family":"Vas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie M.","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will T.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Kalmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Jennifer","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-020-00849-y_bib1","doi-asserted-by":"crossref","unstructured":"Bates and Tabrizi and J. Huntington's Disease, 4th ed. https:\/\/doi.org\/10.1093\/med\/9780199929146.001.0001","DOI":"10.1093\/med\/9780199929146.001.0001"},{"key":"10.1007\/s13311-020-00849-y_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1189","article-title":"Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire","volume":"2","author":"Goodman","year":"2010","journal-title":"PLoS Curr"},{"key":"10.1007\/s13311-020-00849-y_bib3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.24495","article-title":"Sleep deficits but no metabolic deficits in premanifest Huntington's disease","volume":"78","author":"Lazar","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-020-00849-y_bib4","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.5665\/sleep.4996","article-title":"Polysomnographic Findings and Clinical Correlates in Huntington Disease: A Cross-Sectional Cohort Study","volume":"38","author":"Piano","year":"2015","journal-title":"Sleep"},{"key":"10.1007\/s13311-020-00849-y_bib5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archneur.65.4.482","article-title":"Rapid eye movement sleep disturbances in Huntington disease","volume":"65","author":"Arnulf","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1007\/s13311-020-00849-y_bib6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.parkreldis.2008.10.002","article-title":"Daytime somnolence and nocturnal sleep disturbances in Huntington disease","volume":"5","author":"Videnovic","year":"2009","journal-title":"Park Relat Disord"},{"key":"10.1007\/s13311-020-00849-y_bib7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/1550059416632413","article-title":"Wake and Sleep EEG in Patients with Huntington Disease","volume":"48","author":"Piano","year":"2017","journal-title":"Clin EEG Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.parkreldis.2010.02.009","article-title":"Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease","volume":"16","author":"Aziz","year":"2010","journal-title":"Park Relat Disord"},{"key":"10.1007\/s13311-020-00849-y_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.expneurol.2012.10.014","article-title":"Circadian and sleep disorder in Huntington's disease","volume":"243","author":"Morton","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1007\/s13311-020-00849-y_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainresrev.2010.03.004","article-title":"Electrophysiological measures as potential biomarkers in Huntington's disease: Review and future directions","volume":"64","author":"Nguyen","year":"2010","journal-title":"Brain Res Rev"},{"key":"10.1007\/s13311-020-00849-y_bib11","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1093\/brain\/awt128","article-title":"Progressive sleep and electroencephalogram changes in mice carrying the Huntington's disease mutation","volume":"136","author":"Kantor","year":"2013","journal-title":"Brain"},{"key":"10.1007\/s13311-020-00849-y_bib12","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/brain\/awt132","article-title":"Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6\/2 mouse model of Huntington's disease","volume":"136","author":"Fisher","year":"2013","journal-title":"Brain"},{"key":"10.1007\/s13311-020-00849-y_bib13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.nbd.2012.07.015","article-title":"\u201cEctopic\u201d theta oscillations and interictal activity during slow-wave state in the R6\/1 mouse model of Huntington's disease","volume":"48","author":"Pignatelli","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1007\/s13311-020-00849-y_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126972","article-title":"Sleep physiology alterations precede plethoric phenotypic changes in R6\/1 Huntington's disease mice","volume":"10","author":"Lebreton","year":"2015","journal-title":"PLoS One"},{"key":"10.1007\/s13311-020-00849-y_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069993","article-title":"The Q175 Mouse Model of Huntington's Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep","volume":"8","author":"Loh","year":"2013","journal-title":"PLoS One"},{"key":"10.1007\/s13311-020-00849-y_bib16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neuroscience.2015.10.039","article-title":"Pathological gamma oscillations, impaired dopamine release, synapse loss and reduced dynamic range of unitary glutamatergic synaptic transmission in the striatum of hypokinetic Q175 Huntington mice","volume":"311","author":"Rothe","year":"2015","journal-title":"Neuroscience"},{"key":"10.1007\/s13311-020-00849-y_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5665\/sleep.5448","article-title":"Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease","volume":"39","author":"Fisher","year":"2016","journal-title":"Sleep"},{"key":"10.1007\/s13311-020-00849-y_bib18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon I of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1007\/s13311-020-00849-y_bib19","doi-asserted-by":"crossref","first-page":"10428","DOI":"10.1523\/JNEUROSCI.19-23-10428.1999","article-title":"Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation","volume":"19","author":"Lione","year":"1999","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib20","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2009.03.072","article-title":"Management of sleep\/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease","volume":"1279","author":"Pallier","year":"2009","journal-title":"Brain Res"},{"key":"10.1007\/s13311-020-00849-y_bib22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrn2868","article-title":"Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease","volume":"11","author":"Wulff","year":"2010","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jns.2016.03.021","article-title":"Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function","volume":"364","author":"Baker","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.1007\/s13311-020-00849-y_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00213-008-1068-0","article-title":"The effects of modafinil on mood and cognition in Huntington's disease","volume":"199","author":"Blackwell","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1007\/s13311-020-00849-y_bib25","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.euroneuro.2015.07.028","article-title":"Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review","volume":"25","author":"Battleday","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1007\/s13311-020-00849-y_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fpsyt.2019.00221","article-title":"Sleep Disorders in Huntington's Disease","volume":"10","author":"Herzog-Krzywoszanska","year":"2019","journal-title":"Front Psychiatry"},{"key":"10.1007\/s13311-020-00849-y_bib27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11940-015-0347-4","article-title":"Update on Therapy for Narcolepsy","volume":"17","author":"Thorpy","year":"2015","journal-title":"Curr Treat Options Neurol"},{"key":"10.1007\/s13311-020-00849-y_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.parkreldis.2016.03.002","article-title":"Pharmacological interventions for daytime sleepiness and sleep disorders in Parkinson's disease: Systematic review and meta-analysis","volume":"27","author":"Rodrigues","year":"2016","journal-title":"Park Relat Disord"},{"key":"10.1007\/s13311-020-00849-y_bib29","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/sj.npp.1301534","article-title":"Modafinil: A review of neurochemical actions and effects on cognition","volume":"33","author":"Minzenberg","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1007\/s13311-020-00849-y_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1021\/acschemneuro.7b00374","article-title":"An Overview of the Clinical Uses, Pharmacology, and Safety of Modafinil","volume":"9","author":"Murillo-Rodr\u00edguez","year":"2018","journal-title":"ACS Chem Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pbb.2005.07.019","article-title":"Cognitive effects of modafinil in student volunteers may depend on IQ","volume":"82","author":"Randall","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1007\/s13311-020-00849-y_bib32","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neuropharm.2012.07.009","article-title":"Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers","volume":"64","author":"M\u00fcller","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1007\/s13311-020-00849-y_bib33","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/npp.2015.271","article-title":"Sustained Modafinil Treatment Effects on Control-Related Gamma Oscillatory Power in Schizophrenia","volume":"41","author":"Minzenberg","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1007\/s13311-020-00849-y_bib34","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1017\/S0033291717000885","article-title":"Modafinil and cognitive enhancement in schizophrenia and healthy volunteers: The effects of test battery in a randomised controlled trial","volume":"47","author":"Lees","year":"2017","journal-title":"Psychol Med"},{"key":"10.1007\/s13311-020-00849-y_bib35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1586\/14737175.6.4.455","article-title":"A review of the use of modafinil for attention-deficit hyperactivity disorder","volume":"6","author":"Turner","year":"2006","journal-title":"Expert Rev Neurother"},{"key":"10.1007\/s13311-020-00849-y_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/da.20801","article-title":"Double-blind randomized parallel-group clinical trial of efficacy of the combination fluoxetine plus modafinil versus fluoxetine plus placebo in the treatment of major depression","volume":"28","author":"Abolfazli","year":"2011","journal-title":"Depress Anxiety"},{"key":"10.1007\/s13311-020-00849-y_bib37","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/npp.2010.83","article-title":"Modulatory effects of modafinil on neural circuits regulating emotion and cognition","volume":"35","author":"Rasetti","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1007\/s13311-020-00849-y_bib38","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1176\/jnp.17.4.496","article-title":"Depression and stages of Huntington's disease","volume":"17","author":"Paulsen","year":"2005","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib39","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuroscience.2004.10.005","article-title":"Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates","volume":"130","author":"Willie","year":"2005","journal-title":"Neuroscience"},{"key":"10.1007\/s13311-020-00849-y_bib40","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.neuroscience.2005.02.003","article-title":"Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil","volume":"132","author":"Wisor","year":"2005","journal-title":"Neuroscience"},{"key":"10.1007\/s13311-020-00849-y_bib41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.nbd.2011.02.005","article-title":"\u201cBrain training\u201d improves cognitive performance and survival in a transgenic mouse model of Huntington's disease","volume":"42","author":"Wood","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1007\/s13311-020-00849-y_bib42","first-page":"195","article-title":"A two process model of sleep regulation","volume":"1","author":"Borbely","year":"1982","journal-title":"Hum Neurobiol"},{"key":"10.1007\/s13311-020-00849-y_bib43","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0166-2236(00)02002-6","article-title":"The sleep switch: Hypothalamic control of sleep and wakefulness","volume":"24","author":"Saper","year":"2001","journal-title":"Trends Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib44","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythms","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"key":"10.1007\/s13311-020-00849-y_bib45","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2017.01.014","article-title":"Neural Circuitry of Wakefulness and Sleep","volume":"93","author":"Scammell","year":"2017","journal-title":"Neuron"},{"key":"10.1007\/s13311-020-00849-y_bib46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1007\/s13311-020-00849-y_bib47","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1196\/annals.1427.034","article-title":"Complexity and heterogeneity: What drives the ever-changing brain in Huntington's disease?","volume":"1147","author":"Rosas","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1007\/s13311-020-00849-y_bib48","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0013-4694(98)00051-0","article-title":"Electrophysiological correlates of sleep delta waves","volume":"107","author":"Amzica","year":"1998","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1007\/s13311-020-00849-y_bib49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0028-3932(94)90001-9","article-title":"EEG power spectra in huntington's disease: Clinical and neuropsychological correlates","volume":"32","author":"Bylsma","year":"1994","journal-title":"Neuropsychologia"},{"key":"10.1007\/s13311-020-00849-y_bib50","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00702-010-0491-7","article-title":"Comparative EEG mapping studies in Huntington's disease patients and controls","volume":"117","author":"Painold","year":"2010","journal-title":"J Neural Transm"},{"key":"10.1007\/s13311-020-00849-y_bib51","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1523\/JNEUROSCI.1592-09.2009","article-title":"Alterations in Cortical Excitation and Inhibition in Genetic Mouse Models of Huntington's Disease","volume":"29","author":"Cummings","year":"2009","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib52","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/npp.2009.3","article-title":"How to keep the brain awake the complex molecular pharmacogenetics of wake promotion","volume":"34","author":"Hasan","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1007\/s13311-020-00849-y_bib53","article-title":"Roles of Adrenergic \u03b11 and Dopamine D1 and D2 Receptors in the Mediation of the Desynchronization Effects of Modafinil in a Mouse EEG Synchronization Model","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1007\/s13311-020-00849-y_bib54","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00415-018-8880-1","article-title":"Pallidal deep brain stimulation in juvenile Huntington's disease: local field potential oscillations and clinical data","volume":"265","author":"Ferrea","year":"2018","journal-title":"J Neurol"},{"key":"10.1007\/s13311-020-00849-y_bib55","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tins.2011.09.003","article-title":"New insights into the relationship between dopamine, beta oscillations and motor function","volume":"34","author":"Jenkinson","year":"2011","journal-title":"Trends Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib56","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3389\/fnhum.2014.00485","article-title":"EEG beta suppression and low gamma modulation are different elements of human upright walking","volume":"8","author":"Seeber","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib57","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0010-9452(08)70874-8","article-title":"The role of theta-range oscillations in synchronising and integrating activity in distributed mnemonic networks","volume":"39","author":"Kirk","year":"2003","journal-title":"Cortex"},{"key":"10.1007\/s13311-020-00849-y_bib58","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0301-0082(94)00051-I","article-title":"Expression, control, and probable functional significance of the neuronal theta-rhythm","volume":"45","author":"Vinogradova","year":"1995","journal-title":"Prog Neurobiol"},{"key":"10.1007\/s13311-020-00849-y_bib59","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1523\/JNEUROSCI.21-09-03175.2001","article-title":"Gating of Human Theta Oscillations by a Working Memory Task","volume":"21","author":"Raghavachari","year":"2001","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib60","first-page":"37","article-title":"Topographic classification of EEG patterns in Huntington's disease","volume":"2004","author":"Bellotti","year":"2004","journal-title":"Neurol Clin Neurophysiol"},{"key":"10.1007\/s13311-020-00849-y_bib61","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/1550059416632413","article-title":"Wake and Sleep EEG in Patients With Huntington Disease An eLORETA Study and Review of the Literature","volume":"48","author":"Piano","year":"2016","journal-title":"Clin EEG Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainresrev.2006.06.003","article-title":"EEG alpha oscillations: The inhibition-timing hypothesis","volume":"53","author":"Klimesch","year":"2007","journal-title":"Brain Res Rev"},{"key":"10.1007\/s13311-020-00849-y_bib63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fncel.2018.00049","article-title":"Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation","volume":"12","author":"Wadhwa","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"10.1007\/s13311-020-00849-y_bib64","doi-asserted-by":"crossref","unstructured":"Staal RGW, M\u00f6ller T. Neuroinflammation in Huntington's disease. In: Neuroinflammation Neurodegener. Springer New York, pp 179\u2013197","DOI":"10.1007\/978-1-4939-1071-7_10"},{"key":"10.1007\/s13311-020-00849-y_bib65","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroscience.2014.08.014","article-title":"Short- and long-term treatment with modafinil differentially affects adult hippocampal neurogenesis","volume":"278","author":"Brandt","year":"2014","journal-title":"Neuroscience"},{"key":"10.1007\/s13311-020-00849-y_bib66","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1172\/JCI32829","article-title":"Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin\/orexin neurons","volume":"117","author":"Rao","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1007\/s13311-020-00849-y_bib67","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuropharm.2010.03.010","article-title":"The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus","volume":"59","author":"Tsanov","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1007\/s13311-020-00849-y_bib68","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12640-014-9493-9","article-title":"Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil's Actions Against Methamphetamine-Induced Striatal Toxicity in Mice","volume":"27","author":"Raineri","year":"2015","journal-title":"Neurotox Res"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00849-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-020-00849-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923013259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923013259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00849-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:56:22Z","timestamp":1761807382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923013259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1878747923013259"],"URL":"https:\/\/doi.org\/10.1007\/s13311-020-00849-y","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6\/2 Mouse Model of Huntington's Disease","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-020-00849-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 The authors. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}