{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:45:57Z","timestamp":1790880357558,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":1143,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"This research was funded by the Italian Ministry of Instruction, University and Research (MIUR) and by the University of Florence"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s13311-020-00873-y","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T11:03:47Z","timestamp":1592823827000},"page":"1005-1015","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity"],"prefix":"10.1016","volume":"17","author":[{"given":"Laura","family":"Micheli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-4432","authenticated-orcid":false,"given":"Lorenzo","family":"Di Cesare Mannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Del Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Giannella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Piergentili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Quaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatello","family":"Carrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ghelardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-020-00873-y_bib1","unstructured":"International Association for the Study of Pain. IASP Taxonomy. Pain terms. Neuropathic pain. Updated 2017. www.iasp-pain.org\/Taxonomy#Neuropathicpain"},{"key":"10.1007\/s13311-020-00873-y_bib2","doi-asserted-by":"crossref","unstructured":"Andr\u00e9 T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350:2343\u201351.","DOI":"10.1056\/NEJMoa032709"},{"key":"10.1007\/s13311-020-00873-y_bib3","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","article-title":"Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial","volume":"14","author":"Nordlinger","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1007\/s13311-020-00873-y_bib4","first-page":"1999","article-title":"A systematic review on chronic oxaliplatin-induced peripheral neuropathy and the relation with oxaliplatin administration","volume":"22","author":"Beijers","year":"2014","journal-title":"Support Care Cancer."},{"key":"10.1007\/s13311-020-00873-y_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1517\/14740338.2011.543417","article-title":"Chemotherapy-induced peripheral neuropathies: from clinical relevance to preclinical evidence","volume":"10","author":"Balayssac","year":"2011","journal-title":"Expert Opin Drug Saf."},{"key":"10.1007\/s13311-020-00873-y_bib6","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.ejca.2007.09.008","article-title":"The pain with platinum: oxaliplatin and neuropathy","volume":"43","author":"Kiernan","year":"2007","journal-title":"Eur J Cancer."},{"issue":"2","key":"10.1007\/s13311-020-00873-y_bib7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/cncr.27732","article-title":"Clinical pattern and associations of oxaliplatin acute neurotoxicity: a prospective study in 170 patients with colorectal cancer","volume":"119","author":"Argyriou","year":"2013","journal-title":"Cancer."},{"key":"10.1007\/s13311-020-00873-y_bib8","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuro.2006.04.010","article-title":"Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding","volume":"27","author":"Ta","year":"2006","journal-title":"Neurotoxicol."},{"key":"10.1007\/s13311-020-00873-y_bib9","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jpain.2013.08.002","article-title":"Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain","volume":"14","author":"Di Cesare","year":"2013","journal-title":"J Pain."},{"key":"10.1007\/s13311-020-00873-y_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.expneurol.2014.06.016","article-title":"Glial role in oxaliplatin-induced neuropathic pain","volume":"261","author":"Di Cesare","year":"2014","journal-title":"Exp Neurol."},{"key":"10.1007\/s13311-020-00873-y_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuropharm.2013.10.034","article-title":"Involvement of \u03b17 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation","volume":"79","author":"Di Cesare","year":"2014","journal-title":"Neuropharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuropharm.2015.05.037","article-title":"Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1","volume":"97","author":"Di Cesare","year":"2015","journal-title":"Neuropharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib13","doi-asserted-by":"crossref","first-page":"102831","DOI":"10.1016\/j.critrevonc.2019.102831","article-title":"Prevention of chemotherapy-induced peripheral neuropathy: A review of recent findings","volume":"145","author":"Ibrahim","year":"2020","journal-title":"Crit Rev Oncol Hematol."},{"issue":"6","key":"10.1007\/s13311-020-00873-y_bib14","doi-asserted-by":"crossref","first-page":"e421","DOI":"10.1200\/JOP.2014.001776","article-title":"Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline Summary","volume":"10","author":"Hershman","year":"2014","journal-title":"J Oncol Pract."},{"issue":"7","key":"10.1007\/s13311-020-00873-y_bib15","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.ctrv.2014.04.004","article-title":"Chemotherapy-induced neuropathy: A comprehensive survey","volume":"40","author":"Miltenburg","year":"2014","journal-title":"Cancer Treat Rev."},{"key":"10.1007\/s13311-020-00873-y_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/PL00005026","article-title":"Labelling I-2B-imidazoline receptors by [H-3]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes","volume":"356","author":"Alemany","year":"1997","journal-title":"Naunyn-Schmied. Arch Pharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2006.09.031","article-title":"Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects","volume":"553","author":"Gentili","year":"2006","journal-title":"Eur J Pharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib18","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/bph.12555","article-title":"Antihyperalgesic effects of imidazoline I2 receptor ligands in rat models of inflammatory and neuropathic pain","volume":"171","author":"Li","year":"2014","journal-title":"Br J Pharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4103\/0253-7613.165196","article-title":"The imidazoline receptors and ligands in pain modulation","volume":"47","author":"Bektas","year":"2015","journal-title":"Indian J Pharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib20","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00213-017-4599-4","article-title":"Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I2 receptor agonist phenyzoline in adult male rats","volume":"234","author":"Thorn","year":"2017","journal-title":"Psychopharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib21","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.2174\/138955712803832636","article-title":"Pharmacophore development and SAR studies of imidazoline receptor ligands","volume":"12","author":"Nikolic","year":"2012","journal-title":"Mini-Rev Med Chem."},{"issue":"2","key":"10.1007\/s13311-020-00873-y_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1871529X18666180629170336","article-title":"Cardiovascular Effects Mediated by Imidazoline Drugs: An Update","volume":"19","author":"Cobos-Puc","year":"2019","journal-title":"Cardiovasc Hematol Disord Drug Targets."},{"key":"10.1007\/s13311-020-00873-y_bib23","doi-asserted-by":"crossref","first-page":"89S","DOI":"10.1016\/S0895-7061(00)00224-7","article-title":"I1 imidazoline receptors in cardiovascular regulation: the place of rilmenidine","volume":"13","author":"Head","year":"2000","journal-title":"Am J Hypertens."},{"key":"10.1007\/s13311-020-00873-y_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1749-6632.1999.tb09339.x","article-title":"The I1-imidazoline receptor and its cellular signaling pathways","volume":"881","author":"Ernsberger","year":"1999","journal-title":"Ann N Y Acad Sci."},{"key":"10.1007\/s13311-020-00873-y_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1749-6632.1999.tb09375.x","article-title":"1999. Novel targets and techniques in imidazoline receptor research","volume":"881","author":"Musgrave","year":"1999","journal-title":"Ann N Y Acad Sci."},{"key":"10.1007\/s13311-020-00873-y_bib26","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/S0026-895X(24)23223-5","article-title":"Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline","volume":"57","author":"Greney","year":"2000","journal-title":"Mol Pharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib27","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/HJH.0b013e3282f5ed44","article-title":"G-protein inwardly rectifying potassium channels are involved in the hypotensive effect of I1-imidazoline receptor selective ligands","volume":"26","author":"Yoro","year":"2008","journal-title":"J Hypertens."},{"key":"10.1007\/s13311-020-00873-y_bib28","doi-asserted-by":"crossref","unstructured":"Kim YH, Nam TS, Ahn DS, Chung S. Modulation of N-type Ca(2)(+) currents by moxonidine via imidazoline I(1) receptor activation in rat superior cervical ganglion neurons. Biochem Biophys Res Commun. 2011;409:645\u2013650.","DOI":"10.1016\/j.bbrc.2011.05.058"},{"key":"10.1007\/s13311-020-00873-y_bib29","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1016\/j.fct.2012.05.015","article-title":"Adenosinergic modulation of the imidazoline I(1)- receptor-dependent hypotensive effect of ethanol in acute renal failure","volume":"50","author":"Harraz OF","year":"2012","journal-title":"Food Chem Toxicol."},{"key":"10.1007\/s13311-020-00873-y_bib30","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/157018005774717325","article-title":"Rational design of the new antihypertensive I1-receptor ligand 2-(2-biphenyl-2-yl-1-methyl-ethyl)-4,5-dihydro-1H-imidazole","volume":"2","author":"Gentili","year":"2005","journal-title":"Lett Drug Des Discov."},{"key":"10.1007\/s13311-020-00873-y_bib31","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/acsmedchemlett.5b00115","article-title":"Antagonism\/agonism modulation to build novel antihypertensives selectively triggering I1-imidazoline receptor activation","volume":"6","author":"Del Bello","year":"2015","journal-title":"ACS Med Chem Lett."},{"key":"10.1007\/s13311-020-00873-y_bib32","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1021\/jm021113r","article-title":"Imidazoline Binding Sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues","volume":"46","author":"Gentili","year":"2003","journal-title":"J Med Chem."},{"key":"10.1007\/s13311-020-00873-y_bib33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0165-6147(98)01244-9","article-title":"\u201cSeeing through a glass darkly\u201d: casting light on imidazoline \u201cI\u201d sites","volume":"19","author":"Eglen","year":"1998","journal-title":"Trends Pharmacol Sci."},{"key":"10.1007\/s13311-020-00873-y_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1749-6632.1999.tb09344.x","article-title":"Novel selective compounds for the investigation of imidazoline receptors","volume":"881","author":"Hudson","year":"1999","journal-title":"Ann N Y Acad Sci."},{"key":"10.1007\/s13311-020-00873-y_bib35","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br J Pharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib36","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/S0959-8049(01)00300-8","article-title":"Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat","volume":"37","author":"Cavaletti","year":"2001","journal-title":"Eur. J. Cancer."},{"key":"10.1007\/s13311-020-00873-y_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2015.10.005","article-title":"2015. Intrathecal administration of nociceptin\/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity","volume":"766","author":"Micheli","year":"2015","journal-title":"Eur J Pharmacol."},{"issue":"15","key":"10.1007\/s13311-020-00873-y_bib38","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1002\/jnr.21786","article-title":"Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury","volume":"86","author":"Tanabe","year":"2008","journal-title":"J Neurosci Res."},{"issue":"1","key":"10.1007\/s13311-020-00873-y_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.peptides.2012.08.005","article-title":"Central administration of oxytocin reduces hyperalgesia in mice: implication for cannabinoid and opioid systems","volume":"38","author":"Russo","year":"2012","journal-title":"Peptides."},{"key":"10.1007\/s13311-020-00873-y_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejphar.2014.04.028","article-title":"Serotonergic modulation in neuropathy induced by oxaliplatin: effect on the 5HT2C receptor","volume":"735","author":"Baptista-De-Souza","year":"2014","journal-title":"Eur J Pharmacol."},{"key":"10.1007\/s13311-020-00873-y_bib41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pain.2009.09.003","article-title":"Oxaliplatin-induced neuropathy in the rat: involvement of oxalate in cold hyperalgesia but not mechanical allodynia","volume":"147","author":"Sakurai","year":"2009","journal-title":"Pain."},{"key":"10.1007\/s13311-020-00873-y_bib42","doi-asserted-by":"crossref","unstructured":"Di Cesare Mannelli L, Micheli L, Maresca M, et al. Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors. Sci Rep. 2016;6:34832","DOI":"10.1038\/srep34832"},{"key":"10.1007\/s13311-020-00873-y_bib43","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1021\/jm901262f","article-title":"Might adrenergic \u03b12C-agonists\/\u03b12A-antagonists become novel therapeutic tools for pain treatment with Morphine?","volume":"52","author":"Cardinaletti","year":"2009","journal-title":"J Med Chem."},{"key":"10.1007\/s13311-020-00873-y_bib44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1021\/ml300064v","article-title":"Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit antidepressant-like effect","volume":"3","author":"Del Bello","year":"2012","journal-title":"ACS Med Chem Lett."},{"key":"10.1007\/s13311-020-00873-y_bib45","first-page":"1","article-title":"The 2-substituted imidazoline ring linked to an aromatic moiety by a biatomic bridge: a bioversatile scaffold","volume":"1","author":"Del Bello","year":"2016","journal-title":"Glob Drugs Therap."},{"key":"10.1007\/s13311-020-00873-y_bib46","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1021\/acsmedchemlett.6b00290","article-title":"Combined interactions with I1-, I2-imidazoline binding sites and \u03b12-adrenoceptors to manage opioid addiction","volume":"7","author":"Giusepponi","year":"2016","journal-title":"ACS Med Chem Lett."},{"key":"10.1007\/s13311-020-00873-y_bib47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/jm0110082","article-title":"\u03b12-Adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole","volume":"45","author":"Gentili","year":"2002","journal-title":"J Med Chem."},{"key":"10.1007\/s13311-020-00873-y_bib48","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/cmdc.201600383","article-title":"The versatile 2-substituted imidazoline nucleus as a structural motif of ligands directed to the serotonin 5-HT1A receptor","volume":"11","author":"Del Bello","year":"2016","journal-title":"Chem Med Chem."},{"key":"10.1007\/s13311-020-00873-y_bib49","first-page":"128","article-title":"Synergic stimulation of serotonin 5-HT1A receptor and \u03b12-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives","volume":"810","author":"Di Cesare","year":"2017","journal-title":"Eur J Med Chem."},{"key":"10.1007\/s13311-020-00873-y_bib50","first-page":"391","article-title":"Epidural clonidine analgesia for intractable cancer pain","volume":"61","author":"Eisenach","year":"1995","journal-title":"The Epidural Clonidine Study Group. Pain."},{"key":"10.1007\/s13311-020-00873-y_bib51","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1097\/00000542-199812000-00031","article-title":"Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats","volume":"89","author":"Pan","year":"1998","journal-title":"Anesthesiology."},{"issue":"1","key":"10.1007\/s13311-020-00873-y_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(01)00170-X","article-title":"Imidazoline antihypertensive drugs: a critical review on their mechanism of action","volume":"93","author":"Szabo","year":"2002","journal-title":"Pharmacol Ther."},{"key":"10.1007\/s13311-020-00873-y_bib53","first-page":"CD010967","article-title":"Topical clonidine for neuropathic pain","volume":"318","author":"Wrzosek","year":"2015","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1007\/s13311-020-00873-y_bib54","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1124\/jpet.107.125526","article-title":"ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors","volume":"323","author":"Stone","year":"2007","journal-title":"J Pharmacol Exp Ther."},{"key":"10.1007\/s13311-020-00873-y_bib55","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1124\/pr.118.016311","article-title":"Imidazoline Receptor System: The Past, the Present, and the Future","volume":"72","author":"Bousquet","year":"2020","journal-title":"Pharmacol Rev."},{"key":"10.1007\/s13311-020-00873-y_bib56","doi-asserted-by":"crossref","unstructured":"Ernsberger P, Shen IH. Membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites. Neurochem Int. 1997;30:17\u201323.","DOI":"10.1016\/S0197-0186(96)00033-2"},{"key":"10.1007\/s13311-020-00873-y_bib57","doi-asserted-by":"crossref","unstructured":"Edwards L, Ernsberger P. The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase. Brain Res. 2003;980:71\u201379.","DOI":"10.1016\/S0006-8993(03)02893-2"},{"key":"10.1007\/s13311-020-00873-y_bib58","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1124\/pr.117.014399","article-title":"Etiology and Pharmacology of Neuropathic Pain","volume":"70","author":"Alles","year":"2018","journal-title":"Pharmacol Rev."},{"key":"10.1007\/s13311-020-00873-y_bib59","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/j.pain.0000000000001488","article-title":"Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons","volume":"160","author":"Coppi","year":"2019","journal-title":"Pain."},{"key":"10.1007\/s13311-020-00873-y_bib60","doi-asserted-by":"crossref","unstructured":"Tanabe M, Kino Y, Honda M, Ono H. Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons. J Neurosci. 2006;26:1795\u20131802.","DOI":"10.1523\/JNEUROSCI.4642-05.2006"},{"key":"10.1007\/s13311-020-00873-y_bib61","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4103\/jnsbm.JNSBM_239_17","article-title":"Neuroprotective effect of agmatine in mouse spinal cord injury model: Modulation by imidazoline receptors","volume":"9","author":"Dixit","year":"2018","journal-title":"J Nat Sci Biol Med."},{"key":"10.1007\/s13311-020-00873-y_bib62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresbull.2014.02.007","article-title":"Pharmacological benefit of I(1)-imidazoline receptors activation and nuclear factor kappa-B (NF-\u03baB) modulation in experimental Huntington's disease","volume":"102","author":"Gupta","year":"2014","journal-title":"Brain Res Bull."},{"issue":"1","key":"10.1007\/s13311-020-00873-y_bib63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat Rev Neurosci."},{"issue":"4","key":"10.1007\/s13311-020-00873-y_bib64","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms","volume":"73","author":"Von Hehn","year":"2012","journal-title":"Neuron."},{"issue":"6","key":"10.1007\/s13311-020-00873-y_bib65","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1096\/fj.09-138834","article-title":"C5a alters blood-brain barrier integrity in experimental lupus","volume":"24","author":"Jacob","year":"2010","journal-title":"FASEB J."},{"key":"10.1007\/s13311-020-00873-y_bib66","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/1386207311316040004","article-title":"Imidazoline-1 receptor ligands as apoptotic agents: pharmacophore modeling and virtual docking study","volume":"16","author":"Nikolic","year":"2013","journal-title":"Comb Chem High Throughput Screen."},{"key":"10.1007\/s13311-020-00873-y_bib67","doi-asserted-by":"crossref","first-page":"9137","DOI":"10.1021\/ja060273f","article-title":"Sensitization of cancer cells to DNA damaging agents by imidazolines","volume":"128","author":"Sharma","year":"2006","journal-title":"J Am Chem Soc."},{"key":"10.1007\/s13311-020-00873-y_bib68","doi-asserted-by":"crossref","unstructured":"Seretny M, Currie GL, Sena ES, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain. 2014;155:2461\u20132470.","DOI":"10.1016\/j.pain.2014.09.020"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00873-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-020-00873-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792301320X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792301320X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00873-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:55:04Z","timestamp":1761807304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187874792301320X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S187874792301320X"],"URL":"https:\/\/doi.org\/10.1007\/s13311-020-00873-y","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-020-00873-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}