{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T08:33:29Z","timestamp":1768120409734,"version":"3.49.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":959,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY019014"],"award-info":[{"award-number":["EY019014"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY030163"],"award-info":[{"award-number":["EY030163"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["Physician Scientist Award"],"award-info":[{"award-number":["Physician Scientist Award"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001205","name":"F.M. Kirby Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001205","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","award":["Harold Amos Faculty Development Award"],"award-info":[{"award-number":["Harold Amos Faculty Development Award"]}],"id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Noveome Biotherapeutics, Inc"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s13311-020-00949-9","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T14:02:45Z","timestamp":1602856965000},"page":"448-459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis"],"prefix":"10.1016","volume":"18","author":[{"given":"Reas S.","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmara G.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keirnan","family":"Willett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Dine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Banas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-258X","authenticated-orcid":false,"given":"Kenneth S.","family":"Shindler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-020-00949-9_bib1","first-page":"175","article-title":"Multiple sclerosis review","volume":"37","author":"Goldenberg","year":"2012","journal-title":"Phar & Therap"},{"key":"10.1007\/s13311-020-00949-9_bib2","doi-asserted-by":"crossref","first-page":"e11168","DOI":"10.2196\/11168","article-title":"The Impact of Disease Modifying Therapy Access Barriers on People With Multiple Sclerosis: Mixed-Methods Study","volume":"20","author":"Simacek","year":"2018","journal-title":"J Med Internet Res"},{"key":"10.1007\/s13311-020-00949-9_bib3","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1056\/NEJMra052130","article-title":"Multiple sclerosis-the plaque and its pathogenesis","volume":"354","author":"Frohman","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1007\/s13311-020-00949-9_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/EB.S54131","article-title":"Optic neuritis as an early sign of multiple sclerosis","volume":"8","author":"Kale","year":"2016","journal-title":"Eye Brain"},{"key":"10.1007\/s13311-020-00949-9_bib5","doi-asserted-by":"crossref","first-page":"e700","DOI":"10.1212\/NXI.0000000000000700","article-title":"Chronic demyelination exacerbates neuroaxonal loss in patients with MS with unilateral optic neuritis","volume":"7","author":"You","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1007\/s13311-020-00949-9_bib6","doi-asserted-by":"crossref","first-page":"11664","DOI":"10.1038\/s41598-019-48087-3","article-title":"Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis","volume":"9","author":"Khan","year":"2019","journal-title":"Sci Rep"},{"key":"10.1007\/s13311-020-00949-9_bib7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4103\/0972-2327.58283","article-title":"Management of acute exacerbations in multiple sclerosis","volume":"12","author":"Ontaneda","year":"2009","journal-title":"Ann Indian Acad Neurol"},{"key":"10.1007\/s13311-020-00949-9_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/135245850100700109","article-title":"Interferon beta-1b and intravenous methylprednisolone promote lesion recovery in multiple sclerosis","volume":"7","author":"Richert","year":"2001","journal-title":"Mult Scler"},{"key":"10.1007\/s13311-020-00949-9_bib9","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJM199312093292403","article-title":"The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group","volume":"329","author":"Beck","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1007\/s13311-020-00949-9_bib10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s004150070172","article-title":"Steroids for multiple sclerosis and optic neuritis: a meta-analysis of randomized controlled clinical trials","volume":"247","author":"Brusaferri","year":"2000","journal-title":"J Neurol"},{"key":"10.1007\/s13311-020-00949-9_bib11","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1016\/S0140-6736(05)75165-5","article-title":"Interferon beta treatment for multiple sclerosis","volume":"353","author":"Goodin","year":"1999","journal-title":"Lancet."},{"key":"10.1007\/s13311-020-00949-9_bib12","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1001\/archopht.126.7.994","article-title":"Treatment of acute optic neuritis: a summary of findings from the optic neuritis treatment trial","volume":"126","author":"Beck","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"10.1007\/s13311-020-00949-9_bib13","first-page":"727","article-title":"Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up","volume":"65","author":"Optic Neuritis Study Group","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1007\/s13311-020-00949-9_bib14","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.1523\/JNEUROSCI.23-18-06993.2003","article-title":"Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway","volume":"23","author":"Diem","year":"2003","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00949-9_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/biomedicines7020026","article-title":"Stem Cell-Based Therapies for Multiple Sclerosis: Current Perspectives","volume":"7","author":"Cuascut","year":"2019","journal-title":"Biomedicines."},{"key":"10.1007\/s13311-020-00949-9_bib16","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1093\/brain\/awx154","article-title":"Cell-based therapeutic strategies for multiple sclerosis: International Conference on Cell-Based Therapies for Multiple Sclerosis","volume":"140","author":"Scolding","year":"2017","journal-title":"Brain."},{"key":"10.1007\/s13311-020-00949-9_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.21037\/sci.2019.10.06","article-title":"Saftey and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis","volume":"6","author":"Jafarzadeh-Bejargafshe","year":"2019","journal-title":"Stem Cell Investig"},{"key":"10.1007\/s13311-020-00949-9_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12974-015-0322-8","article-title":"Immunosuppressive potential of human amnion epithelial cells in the treatment of experimental autoimmune encephalomyelitis","volume":"12","author":"McDonald","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1007\/s13311-020-00949-9_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.humimm.2008.04.007","article-title":"Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells","volume":"69","author":"Banas","year":"2008","journal-title":"Hum Immunol"},{"key":"10.1007\/s13311-020-00949-9_bib20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3727\/096368913X670165","article-title":"Amnion derived multipotent progenitor cells inhibit blood monocyte differentiation into mature dendritic cells","volume":"23","author":"Banas","year":"2014","journal-title":"Cell Transplant"},{"key":"10.1007\/s13311-020-00949-9_bib21","doi-asserted-by":"crossref","first-page":"41768","DOI":"10.1038\/srep41768","article-title":"Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model","volume":"7","author":"Khan","year":"2017","journal-title":"Sci Rep"},{"key":"10.1007\/s13311-020-00949-9_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7180632","article-title":"Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis","volume":"2017","author":"Khan","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1007\/s13311-020-00949-9_bib23","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1167\/iovs.14-14672","article-title":"HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis","volume":"55","author":"Khan","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1007\/s13311-020-00949-9_bib24","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1007\/s13311-020-00949-9_bib25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fneur.2011.00050","article-title":"Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis","volume":"2","author":"Quinn","year":"2011","journal-title":"Front Neurol"},{"key":"10.1007\/s13311-020-00949-9_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/WNO.0b013e3181f7f833","article-title":"Oral resveratrol reduces neuronal damage in a model of multiple sclerosis","volume":"30","author":"Shindler","year":"2010","journal-title":"J Neuroophthalmol"},{"key":"10.1007\/s13311-020-00949-9_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fneur.2012.00084","article-title":"Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis","volume":"3","author":"Fonseca-Kelly","year":"2012","journal-title":"Front Neurol"},{"key":"10.1007\/s13311-020-00949-9_bib28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fcimb.2018.00311","article-title":"Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis","volume":"8","author":"Singh","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1007\/s13311-020-00949-9_bib29","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1007\/s13311-020-00949-9_bib30","doi-asserted-by":"crossref","unstructured":"Day M. Histopathology of EAE. Experimental Models of Multiple Sclerosis. L E and C C. New York, Springer, 2005; pp. 25-43.","DOI":"10.1007\/0-387-25518-4_3"},{"key":"10.1007\/s13311-020-00949-9_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2012.01126.x","article-title":"Mechanisms regulating regional localization of inflammation during CNS autoimmunity","volume":"248","author":"Pierson","year":"2012","journal-title":"Immunol Rev"},{"key":"10.1007\/s13311-020-00949-9_bib32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nm1197","article-title":"Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis","volume":"11","author":"Greter","year":"2005","journal-title":"Nat Med"},{"key":"10.1007\/s13311-020-00949-9_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12974-015-0325-5","article-title":"Inhibition of NADPH oxidase reduces EAE-induced white matter damage in mice","volume":"12","author":"Choi","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1007\/s13311-020-00949-9_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/1573395511666150707181644","article-title":"Optic Neuritis: A Model for the Immuno-pathogenesis of Central Nervous System Inflammatory Demyelinating Diseases","volume":"11","author":"Wu","year":"2015","journal-title":"Curr Immunol Rev"},{"key":"10.1007\/s13311-020-00949-9_bib35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s40478-019-0768-5","article-title":"Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis","volume":"7","author":"Manogaran","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1007\/s13311-020-00949-9_bib36","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000119879","article-title":"Optic nerve degeneration in experimental autoimmune encephalomyelitis","volume":"40","author":"Guy","year":"2008","journal-title":"Ophthalmic Res"},{"key":"10.1007\/s13311-020-00949-9_bib37","first-page":"869","article-title":"Alteration of T helper cell subsets in the optic nerve of experimental autoimmune encephalomyelitis","volume":"25","author":"Tian","year":"2010","journal-title":"Int J Mol Med"},{"key":"10.1007\/s13311-020-00949-9_bib38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneuroim.2016.06.008","article-title":"Microglia response in retina and optic nerve in chronic experimental autoimmune encephalomyelitis","volume":"298","author":"Horstmann","year":"2016","journal-title":"J Neuroimmunol"},{"key":"10.1007\/s13311-020-00949-9_bib39","first-page":"1539","article-title":"Immunogenicity of human amniotic membrane in experimental xenotransplatation","volume":"42","author":"Kubo","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1007\/s13311-020-00949-9_bib40","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0198-8859(00)00192-0","article-title":"Modulation of HLA-G expression in human thymic and amniotic epithelial cells","volume":"61","author":"Lefebvre","year":"2000","journal-title":"Hum Immunol"},{"key":"10.1007\/s13311-020-00949-9_bib41","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.4049\/jimmunol.154.11.5665","article-title":"The human amnion is a site of MHC class Ib expression: Evidence for the expression of HLA-E and HLA-G","volume":"154","author":"Houlihan","year":"1995","journal-title":"J Immunol"},{"key":"10.1007\/s13311-020-00949-9_bib42","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/eji.200324266","article-title":"Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients","volume":"34","author":"Le Rond","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1007\/s13311-020-00949-9_bib43","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.4049\/jimmunol.176.5.3266","article-title":"Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive\/ regulatory T cells","volume":"176","author":"Le Rond","year":"2006","journal-title":"J Immunol"},{"key":"10.1007\/s13311-020-00949-9_bib44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.humimm.2006.10.017","article-title":"Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2\/ILT-4\/FasL-mediated pathways","volume":"68","author":"Naji","year":"2007","journal-title":"Hum Immunol"},{"key":"10.1007\/s13311-020-00949-9_bib45","doi-asserted-by":"crossref","first-page":"e35758","DOI":"10.1371\/journal.pone.0035758","article-title":"Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1007\/s13311-020-00949-9_bib46","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fimmu.2019.00238","volume":"10","author":"Abbasi-Kangevari","year":"2019","journal-title":"Front Immunol"},{"key":"10.1007\/s13311-020-00949-9_bib47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.192.1.123","article-title":"Failure to suppress the expansion of the activated cd4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis","volume":"192","author":"Chu","year":"2000","journal-title":"J Exp Med"},{"key":"10.1007\/s13311-020-00949-9_bib48","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/978-1-60761-720-4_19","article-title":"Mouse models of multiple sclerosis: Experimental autoimmune encephalomyelitis and Theiler's virus-induced demyelinating disease","volume":"900","author":"McCarthy","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1007\/s13311-020-00949-9_bib49","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s001090050101","article-title":"Role of macrophages\/microglia in multiple sclerosis and experimental allergic encephalomyelitis","volume":"75","author":"Benveniste","year":"1997","journal-title":"J Mol Med"},{"key":"10.1007\/s13311-020-00949-9_bib50","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1309\/AJCP7UBK8IBVMVNR","article-title":"Analysis of proinflammatory and anti-inflammatory cytokine serum concentrations in patients with multiple sclerosis by using a multiplexed immunoassay","volume":"136","author":"Martins","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1007\/s13311-020-00949-9_bib51","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/neup.12612","article-title":"Serum pro-inflammatory and anti-inflammatory cytokines and the pathogenesis of experimental autoimmune encephalomyelitis","volume":"40","author":"Jahan-Abad","year":"2020","journal-title":"Neuropathology."},{"key":"10.1007\/s13311-020-00949-9_bib52","article-title":"The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice","volume":"24","author":"Shu","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1007\/s13311-020-00949-9_bib53","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1167\/iovs.04-0495","article-title":"Immunosuppressive Factors Secreted by Human Amniotic Epithelial Cells","volume":"46","author":"Li","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1007\/s13311-020-00949-9_bib54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-3940(96)12599-4","article-title":"Expression of markers for both neuronal and glial cells in human amniotic epithelial cells","volume":"209","author":"Sakuragawa","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1007\/s13311-020-00949-9_bib55","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10561-013-9401-1","article-title":"In toto differentiation of human amniotic membrane towards the Schwann cell lineage","volume":"15","author":"Banerjee","year":"2014","journal-title":"Cell Tissue Bank"},{"key":"10.1007\/s13311-020-00949-9_bib56","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/jnr.22302","article-title":"Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved","volume":"88","author":"Zheng","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1007\/s13311-020-00949-9_bib57","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF- induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia","volume":"111","author":"Sun","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1007\/s13311-020-00949-9_bib58","doi-asserted-by":"crossref","first-page":"15095","DOI":"10.1074\/jbc.RA119.008491","article-title":"Angiogenin activates the astrocytic Nrf2\/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress","volume":"294","author":"Hoang","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1007\/s13311-020-00949-9_bib59","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1471-4159.2009.06117.x","article-title":"Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2","volume":"110","author":"Polazzi","year":"2009","journal-title":"J Neurochem"},{"key":"10.1007\/s13311-020-00949-9_bib60","doi-asserted-by":"crossref","first-page":"e332","DOI":"10.1038\/cddis.2012.54","article-title":"Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia","volume":"3","author":"Ashutosh","year":"2012","journal-title":"Cell Death Dis"},{"key":"10.1007\/s13311-020-00949-9_bib61","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2008.02.040","article-title":"Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease mice","volume":"1205","author":"Kong","year":"2008","journal-title":"Brain Res"},{"key":"10.1007\/s13311-020-00949-9_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15283\/ijsc.2014.7.1.1","article-title":"Comparative Study between Intravenous and Intraperitoneal Stem Cell Therapy in Amiodarone Induced Lung Injury in Rat","volume":"7","author":"Zickri","year":"2014","journal-title":"Int J Stem Cells"},{"key":"10.1007\/s13311-020-00949-9_bib63","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00383-009-2504-x","article-title":"Amniotic fluid stem cell migration after intraperitoneal injection in pup rats: implication for therapy","volume":"26","author":"Ghionzoli","year":"2010","journal-title":"Pediatr Surg Int"},{"key":"10.1007\/s13311-020-00949-9_bib64","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1182\/blood-2006-03-013433","article-title":"Clinical trials with adult stem\/progenitor cells for tissue repair: let's not overlook some essential precautions","volume":"109","author":"Prockop","year":"2007","journal-title":"Blood."},{"key":"10.1007\/s13311-020-00949-9_bib65","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5432301","article-title":"Therapeutic Potential of Human Amniotic Epithelial Cells on Injuries and Disorders in the Central Nervous System","volume":"2019","author":"Xu","year":"2019","journal-title":"Stem Cells Int"},{"key":"10.1007\/s13311-020-00949-9_bib66","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/aps.2018.22","article-title":"Biological characterization of human amniotic epithelial cells in a serum-free system and their safety evaluation","volume":"39","author":"Yang","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"10.1007\/s13311-020-00949-9_bib67","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1095\/biolreprod.106.055244","article-title":"Stem cells derived from human fetal membranes display multilineage differentiation potential","volume":"77","author":"Ilancheran","year":"2007","journal-title":"Biol Reprod"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00949-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-020-00949-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923012084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923012084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00949-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:01:52Z","timestamp":1761807712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923012084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1878747923012084"],"URL":"https:\/\/doi.org\/10.1007\/s13311-020-00949-9","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-020-00949-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}