{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T06:27:34Z","timestamp":1794292054393,"version":"4.9.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":959,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s13311-020-00955-x","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T16:03:01Z","timestamp":1604505781000},"page":"81-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sleep-Related Breathing Disorders: When CPAP Is Not Enough"],"prefix":"10.1016","volume":"18","author":[{"given":"Bernardo","family":"Selim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Ramar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8225","key":"10.1007\/s13311-020-00955-x_bib1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0140-6736(81)92140-1","article-title":"Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares","volume":"1","author":"Sullivan","year":"1981","journal-title":"Lancet"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1399-6576.2010.02337.x","article-title":"End-expiratory lung volume and ventilation distribution with different continuous positive airway pressure systems in volunteers","volume":"55","author":"Andersson","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1378\/chest.98.2.317","article-title":"Obstructive sleep apnea treated by independently adjusted inspiratory and expiratory positive airway pressures via nasal mask. Physiologic and clinical implications","volume":"98","author":"Sanders","year":"1990","journal-title":"Chest."},{"issue":"1","key":"10.1007\/s13311-020-00955-x_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.chest.2017.06.036","article-title":"Initiation of noninvasive ventilation for sleep related hypoventilation disorders: advanced modes and devices","volume":"153","author":"Selim","year":"2018","journal-title":"Chest."},{"key":"10.1007\/s13311-020-00955-x_bib5","unstructured":"International Classification of Sleep Disorders, 3rd ed. American Academy of Sleep Medicine, Darien, IL 2014. 2014(3rd ed)."},{"issue":"5","key":"10.1007\/s13311-020-00955-x_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11940-012-0188-3","article-title":"Therapy for sleep hypoventilation and central apnea syndromes","volume":"14","author":"Selim","year":"2012","journal-title":"Curr Treat Options Neurol"},{"issue":"9","key":"10.1007\/s13311-020-00955-x_bib7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1080\/17434440.2016.1218759","article-title":"Advanced positive airway pressure modes: adaptive servo ventilation and volume assured pressure support","volume":"13","author":"Selim","year":"2016","journal-title":"Expert Rev Med Devices"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ccm.2010.02.013","article-title":"Central sleep apnea","volume":"31","author":"Javaheri","year":"2010","journal-title":"Clin Chest Med"},{"issue":"3","key":"10.1007\/s13311-020-00955-x_bib9","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1164\/rccm.201905-1071ST","article-title":"Evaluation and management of obesity hypoventilation syndrome. An Official American Thoracic Society Clinical Practice Guideline","volume":"200","author":"Mokhlesi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1007\/s13311-020-00955-x_bib10","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1152\/japplphysiol.01082.2001","article-title":"Postevent ventilation as a function of CO(2) load during respiratory events in obstructive sleep apnea","volume":"93","author":"Berger","year":"2002","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1007\/s13311-020-00955-x_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S2213-2600(16)00054-0","article-title":"Prevention and care of respiratory failure in obese patients","volume":"4","author":"P\u00e9pin","year":"2016","journal-title":"Lancet Respir Med"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5664\/jcsm.2398","article-title":"Morbidity prior to a diagnosis of sleep-disordered breathing: a controlled national study","volume":"9","author":"Jennum","year":"2013","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/crj.12054","article-title":"Comparison of clinical characteristics in patients with obesity hypoventilation syndrome and obese obstructive sleep apnea syndrome: a case-control study","volume":"8","author":"Basoglu","year":"2014","journal-title":"Clin Respir J"},{"issue":"1","key":"10.1007\/s13311-020-00955-x_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.amjmed.2003.08.022","article-title":"Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome","volume":"116","author":"Nowbar","year":"2004","journal-title":"Am J Med"},{"issue":"3","key":"10.1007\/s13311-020-00955-x_bib15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1513\/AnnalsATS.201907-528OC","article-title":"The role of positive airway pressure therapy in adults with obesity hypoventilation syndrome. A systematic review and meta-analysis","volume":"17","author":"Afshar","year":"2020","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"10.1007\/s13311-020-00955-x_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/thx.2007.081315","article-title":"Randomised trial of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation","volume":"63","author":"Piper","year":"2008","journal-title":"Thorax."},{"issue":"10182","key":"10.1007\/s13311-020-00955-x_bib17","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/S0140-6736(18)32978-7","article-title":"Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive ventilation therapy in patients with obesity hypoventilation syndrome: a multicentre, open-label, randomised controlled trial","volume":"393","author":"Masa","year":"2019","journal-title":"Lancet"},{"key":"10.1007\/s13311-020-00955-x_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.sleep.2018.09.016","article-title":"Efficacy of bilevel ventilatory support in the treatment of stable patients with obesity hypoventilation syndrome: systematic review and meta-analysis","volume":"53","author":"Royer","year":"2019","journal-title":"Sleep Med"},{"issue":"3","key":"10.1007\/s13311-020-00955-x_bib19","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1378\/chest.130.3.815","article-title":"Average volume-assured pressure support in obesity hypoventilation: a randomized crossover trial","volume":"130","author":"Storre","year":"2006","journal-title":"Chest."},{"issue":"1","key":"10.1007\/s13311-020-00955-x_bib20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1164\/rccm.201410-1900OC","article-title":"Efficacy of different treatment alternatives for obesity hypoventilation syndrome. Pickwick study","volume":"192","author":"Masa","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1007\/s13311-020-00955-x_bib21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF03339872","article-title":"Sleep disordered breathing in the elderly","volume":"12","author":"Janssens","year":"2000","journal-title":"Aging Clin Exp Res"},{"key":"10.1007\/s13311-020-00955-x_bib22","doi-asserted-by":"crossref","unstructured":"Masa JF, Mokhlesi B, Ben\u00edtez I, S\u00e1nchez-Quiroga M, Gomez de Terreros FJ, Corral J, Romero A, et al. Spanish Sleep Network. Cost-effectiveness of positive airway pressure modalities in obesity hypoventilation syndrome with severe obstructive sleep apnoea. Thorax. 2020;75(6):459-467. https:\/\/doi.org\/10.1136\/thoraxjnl-2019-213622.","DOI":"10.1136\/thoraxjnl-2019-213622"},{"issue":"1","key":"10.1007\/s13311-020-00955-x_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1378\/chest.11-2848","article-title":"Impact of different backup respiratory rates on the efficacy of noninvasive positive pressure ventilation in obesity hypoventilation syndrome: a randomized trial","volume":"143","author":"Contal","year":"2013","journal-title":"Chest."},{"issue":"10","key":"10.1007\/s13311-020-00955-x_bib24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/thoraxjnl-2016-208501","article-title":"Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea","volume":"71","author":"Masa","year":"2016","journal-title":"Thorax."},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(05)70326-4","article-title":"Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial","volume":"5","author":"Bourke","year":"2006","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.1007\/s13311-020-00955-x_bib26","article-title":"Mechanical ventilation for amyotrophic lateral sclerosis\/motor neuron disease","volume":"10","author":"Radunovic","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"15","key":"10.1007\/s13311-020-00955-x_bib27","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1212\/WNL.0b013e3181bc0141","article-title":"Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"73","author":"Miller","year":"2009","journal-title":"Neurology."},{"issue":"12","key":"10.1007\/s13311-020-00955-x_bib28","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.5664\/jcsm.7530","article-title":"Practical implementation of a single-night split-titration protocol with BPAP-ST and AVAPS in patients with neuromuscular disease","volume":"14","author":"Patel","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"7","key":"10.1007\/s13311-020-00955-x_bib29","first-page":"1139","article-title":"Respiratory pattern and tidal volumes differ for pressure support and volume-assured pressure support in amyotrophic lateral sclerosis","volume":"14","author":"Nicholson","year":"2017","journal-title":"Ann Am Thorac Soc"},{"issue":"4","key":"10.1007\/s13311-020-00955-x_bib30","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1440-1843.2011.01962.x","article-title":"Efficacy and comfort of volume-guaranteed pressure support in patients with chronic ventilatory failure of neuromuscular origin","volume":"16","author":"Crescimanno","year":"2011","journal-title":"Respirology"},{"issue":"1","key":"10.1007\/s13311-020-00955-x_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5665\/sleep.1580","article-title":"The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses","volume":"35","author":"Aurora","year":"2012","journal-title":"Sleep."},{"issue":"8","key":"10.1007\/s13311-020-00955-x_bib32","first-page":"1298","article-title":"Respiratory sleep disorders in patients with congestive heart failure","volume":"7","author":"Naughton","year":"2015","journal-title":"J Thorac Dis"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5664\/jcsm.27760","article-title":"Frequency of sleep apnea in stroke and TIA patients: a meta-analysis","volume":"6","author":"Johnson","year":"2010","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib34","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.hlc.2012.08.006","article-title":"Sleep disordered breathing in heart failure patients with reduced versus preserved ejection fraction","volume":"22","author":"Sekizuka","year":"2013","journal-title":"Heart Lung Circ"},{"issue":"6","key":"10.1007\/s13311-020-00955-x_bib35","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.chest.2019.12.020","article-title":"Update on apneas of heart failure with reduced ejection fraction: emphasis on the physiology of treatment: part 2: central sleep apnea","volume":"57","author":"Javaheri","year":"2020","journal-title":"Chest."},{"issue":"19","key":"10.1007\/s13311-020-00955-x_bib36","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1056\/NEJMoa051001","article-title":"Continuous positive airway pressure for central sleep apnea and heart failure","volume":"353","author":"Bradley","year":"2005","journal-title":"N Engl J Med"},{"issue":"25","key":"10.1007\/s13311-020-00955-x_bib37","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1161\/CIRCULATIONAHA.106.683482","volume":"115","author":"Arzt","year":"2007","journal-title":"Circulation."},{"issue":"6","key":"10.1007\/s13311-020-00955-x_bib38","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.sleep.2007.09.008","article-title":"Bi-level positive pressure ventilation and adaptive servo ventilation in patients with heart failure and Cheyne-Stokes respiration","volume":"9","author":"Fietze","year":"2008","journal-title":"Sleep Med"},{"issue":"12","key":"10.1007\/s13311-020-00955-x_bib39","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1506459","article-title":"Adaptive servo-ventilation for central sleep apnea in systolic heart failure","volume":"373","author":"Cowie","year":"2015","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib40","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01692-2016","article-title":"Adaptive servo ventilation for central sleep apnoea in heart failure: SERVE-HF on-treatment analysis","volume":"50","author":"Woehrle","year":"2017","journal-title":"Eur Respir J."},{"issue":"5","key":"10.1007\/s13311-020-00955-x_bib41","doi-asserted-by":"crossref","first-page":"757","DOI":"10.5664\/jcsm.5812","article-title":"Updated adaptive servo-ventilation recommendations for the 2012 AASM guideline: \u201cthe treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses\u201d","volume":"12","author":"Aurora","year":"2016","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1007\/s13311-020-00955-x_bib42","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1523\/JNEUROSCI.4611-10.2011","article-title":"PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression","volume":"31","author":"Montandon","year":"2011","journal-title":"J Neurosci"},{"issue":"3","key":"10.1007\/s13311-020-00955-x_bib43","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1378\/chest.128.3.1339","article-title":"Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients","volume":"128","author":"Teichtahl","year":"2005","journal-title":"Chest."},{"issue":"Pt 11","key":"10.1007\/s13311-020-00955-x_bib44","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1113\/jphysiol.2009.171678","article-title":"Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo","volume":"587","author":"Hajiha","year":"2009","journal-title":"J Physiol"},{"issue":"5","key":"10.1007\/s13311-020-00955-x_bib45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5664\/jcsm.26908","article-title":"Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing.[Erratum appears in J Clin Sleep Med. 2007 Oct 15;3(6):table of contents]","volume":"3","author":"Walker","year":"2007","journal-title":"J Clin Sleep Med"},{"issue":"8","key":"10.1007\/s13311-020-00955-x_bib46","doi-asserted-by":"crossref","first-page":"847","DOI":"10.5664\/jcsm.3950","article-title":"Sleep disordered breathing and chronic respiratory failure in patients with chronic pain on long term opioid therapy","volume":"10","author":"Rose","year":"2014","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"10.1007\/s13311-020-00955-x_bib47","doi-asserted-by":"crossref","first-page":"637","DOI":"10.5664\/jcsm.3788","article-title":"Adaptive servoventilation for treatment of opioid-associated central sleep apnea","volume":"10","author":"Javaheri","year":"2014","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1007\/s13311-020-00955-x_bib48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.5664\/jcsm.27230","article-title":"Adaptive servoventilation (ASV) in patients with sleep disordered breathing associated with chronic opioid medications for non-malignant pain","volume":"4","author":"Farney","year":"2008","journal-title":"J Clin Sleep Med"},{"issue":"5","key":"10.1007\/s13311-020-00955-x_bib49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.5664\/jcsm.2160","article-title":"Adaptive servoventilation in patients with central or complex sleep apnea related to chronic opioid use and congestive heart failure","volume":"8","author":"Ramar","year":"2012","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1007\/s13311-020-00955-x_bib50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5664\/jcsm.27229","article-title":"Adaptive pressure support servoventilation: a novel treatment for sleep apnea associated with use of opioids","volume":"4","author":"Javaheri","year":"2008","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1007\/s13311-020-00955-x_bib51","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.chest.2017.06.010","article-title":"Trajectories of Emergent Central Sleep Apnea During CPAP Therapy","volume":"152","author":"Liu","year":"2017","journal-title":"Chest."},{"issue":"6","key":"10.1007\/s13311-020-00955-x_bib52","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1164\/ajrccm.163.6.pc1201a","article-title":"Apnea following mechanical ventilation may be caused by nonchemical neuromechanical influences","volume":"163","author":"Dempsey","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1007\/s13311-020-00955-x_bib53","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1183\/09031936.00162009","article-title":"A prospective polysomnographic study on the evolution of complex sleep apnoea","volume":"38","author":"Cassel","year":"2011","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1007\/s13311-020-00955-x_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5664\/jcsm.6880","article-title":"Adherence to positive airway therapy after switching from CPAP to ASV: a big data analysis","volume":"14","author":"P\u00e9pin","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"5","key":"10.1007\/s13311-020-00955-x_bib55","doi-asserted-by":"crossref","first-page":"927","DOI":"10.5665\/sleep.3662","article-title":"The complex sleep apnea resolution study: a prospective randomized controlled trial of continuous positive airway pressure versus adaptive servoventilation therapy","volume":"37","author":"Morgenthaler","year":"2014","journal-title":"Sleep."},{"issue":"8","key":"10.1007\/s13311-020-00955-x_bib56","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.5665\/sleep.2878","article-title":"Randomized controlled trial of noninvasive positive pressure ventilation (NPPV) versus servoventilation in patients with CPAP-induced central sleep apnea (complex sleep apnea)","volume":"36","author":"Dellweg","year":"2013","journal-title":"Sleep."}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00955-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-020-00955-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923011819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923011819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00955-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:51:09Z","timestamp":1761807069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923011819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1878747923011819"],"URL":"https:\/\/doi.org\/10.1007\/s13311-020-00955-x","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep-Related Breathing Disorders: When CPAP Is Not Enough","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-020-00955-x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}