{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:01:24Z","timestamp":1789603284498,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Collaborative Research Program of SNU Boramae Medical Center and Basic Medical Science from Seoul National University College of Medicine","award":["800-20180004 & 800-20180005"],"award-info":[{"award-number":["800-20180004 & 800-20180005"]}]},{"name":"Seoul National University Bundang Hospital Research Fund","award":["02-2019-004"],"award-info":[{"award-number":["02-2019-004"]}]},{"name":"Basic Science Research Program of the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology","award":["NRF-2018R1D1A1B07050517"],"award-info":[{"award-number":["NRF-2018R1D1A1B07050517"]}]},{"name":"Korea Association of Health Promotion Fund","award":["2020-06"],"award-info":[{"award-number":["2020-06"]}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s13311-020-00957-9","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T14:02:30Z","timestamp":1605621750000},"page":"430-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Chronic Toxoplasma gondii Infection Alleviates Experimental Autoimmune Encephalomyelitis by the Immune Regulation Inducing Reduction in IL-17A\/Th17 Via Upregulation of SOCS3"],"prefix":"10.1016","volume":"18","author":[{"given":"Do-Won","family":"Ham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Gyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hwan","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-1079","authenticated-orcid":false,"given":"Eun-Hee","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-020-00957-9_bib1","series-title":"Inhibition of IL-6 family cytokines by SOCS3","first-page":"13","author":"Babon","year":"2014"},{"key":"10.1007\/s13311-020-00957-9_bib2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.it.2009.07.001","article-title":"SOCS1 and SOCS3 in the control of CNS immunity","volume":"30","author":"Baker","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1007\/s13311-020-00957-9_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/pim.12173","article-title":"Persistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune system","volume":"37","author":"Blanchard","year":"2015","journal-title":"Parasite Immunol"},{"key":"10.1007\/s13311-020-00957-9_bib4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/intimm\/dxh095","article-title":"Toxoplasma gondii infection inhibits the development of lupus-like syndrome in autoimmune (New Zealand Black\u00d7 New Zealand White) F1 mice","volume":"16","author":"Chen","year":"2004","journal-title":"Int Immunol"},{"key":"10.1007\/s13311-020-00957-9_bib5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1007\/s13311-020-00957-9_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fimmu.2018.00158","article-title":"Characteristics of infection immunity regulated by Toxoplasma gondii to maintain chronic infection in the brain","volume":"9","author":"Hwang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1007\/s13311-020-00957-9_bib7","doi-asserted-by":"crossref","first-page":"e33312","DOI":"10.1371\/journal.pone.0033312","article-title":"Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of Alzheimer's disease","volume":"7","author":"Jung","year":"2012","journal-title":"PLoS One"},{"key":"10.1007\/s13311-020-00957-9_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fgene.2015.00236","article-title":"Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs","volume":"6","author":"Khan","year":"2015","journal-title":"Front Genet"},{"key":"10.1007\/s13311-020-00957-9_bib9","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.2174\/1389450117666160307144027","article-title":"IL-17A and multiple sclerosis: signaling pathways, producing cells and target cells in the central nervous system","volume":"17","author":"Kolbinger","year":"2016","journal-title":"Curr Drug Targets"},{"key":"10.1007\/s13311-020-00957-9_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.msard.2017.04.004","article-title":"Is Toxoplasma gondii infection protective against multiple sclerosis risk?","volume":"15","author":"Koskderelioglu","year":"2017","journal-title":"Multiple Sclerosis Related Disorders"},{"key":"10.1007\/s13311-020-00957-9_bib11","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/ijms19030730","article-title":"The balance of Th17 versus Treg cells in autoimmunity","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1007\/s13311-020-00957-9_bib12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.pt.2011.08.001","article-title":"Toxoplasma gondii effectors are master regulators of the inflammatory response","volume":"27","author":"Melo","year":"2011","journal-title":"Trends Parasitol"},{"key":"10.1007\/s13311-020-00957-9_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006351","article-title":"Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system","volume":"13","author":"Mendez","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1007\/s13311-020-00957-9_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41577-020-0286-5","article-title":"IL-17A brings new recruits to EAE","volume":"20","author":"Minton","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1007\/s13311-020-00957-9_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/MMBR.00027-15","article-title":"Long-term relationships: the complicated interplay between the host and the developmental stages of Toxoplasma gondii during acute and chronic infections","volume":"79","author":"Pittman","year":"2015","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1007\/s13311-020-00957-9_bib16","series-title":"The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handbook of clinical neurology","first-page":"173","author":"Robinson","year":"2014"},{"key":"10.1007\/s13311-020-00957-9_bib17","first-page":"58","article-title":"SOCS3, a major regulator of infection and inflammation","volume":"5","author":"Rottenberg","year":"2014","journal-title":"Front Immunol"},{"key":"10.1007\/s13311-020-00957-9_bib18","doi-asserted-by":"crossref","first-page":"ii43","DOI":"10.1093\/rheumatology\/kex513","article-title":"Physiological effects of modulating the interleukin-6 axis","volume":"57","author":"Schett","year":"2018","journal-title":"Rheumatology"},{"key":"10.1007\/s13311-020-00957-9_bib19","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1073\/pnas.0802218105","article-title":"IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis","volume":"105","author":"Serada","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"10.1007\/s13311-020-00957-9_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1590\/S0074-02762009000200013","article-title":"Advances in understanding immunity to Toxoplasma gondii","volume":"104","author":"Tait","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1007\/s13311-020-00957-9_bib21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1474-4422(18)30443-5","article-title":"Global, regional, and national burden of multiple sclerosis 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Wallin","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-020-00957-9_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.chom.2011.07.009","article-title":"A critical role for SOCS3 in innate resistance to Toxoplasma gondii","volume":"10","author":"Whitmarsh","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1007\/s13311-020-00957-9_bib23","doi-asserted-by":"crossref","unstructured":"Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B. M., Tato, C., \u2026 & O'Shea, J. J. (2006). Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci, 103(21), 8137-8142","DOI":"10.1073\/pnas.0600666103"},{"issue":"2","key":"10.1007\/s13311-020-00957-9_bib24","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4049\/jimmunol.167.2.902","article-title":"IFN-\u03b3 overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection","volume":"167","author":"Gavrilescu","year":"2001","journal-title":"J Immunol"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00957-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-020-00957-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923012072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923012072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00957-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:58:07Z","timestamp":1761807487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923012072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1878747923012072"],"URL":"https:\/\/doi.org\/10.1007\/s13311-020-00957-9","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic Toxoplasma gondii Infection Alleviates Experimental Autoimmune Encephalomyelitis by the Immune Regulation Inducing Reduction in IL-17A\/Th17 Via Upregulation of SOCS3","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-020-00957-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The authors. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}