{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:08:48Z","timestamp":1787162928935,"version":"build-2736575974"},"reference-count":227,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["207799\/Z\/17\/Z"],"award-info":[{"award-number":["207799\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Asssociation of British Neurologists","award":["G104701"],"award-info":[{"award-number":["G104701"]}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["RROU.GAAB"],"award-info":[{"award-number":["RROU.GAAB"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s13311-020-00959-7","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:02:50Z","timestamp":1605096170000},"page":"202-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Treatment of Sleep Dysfunction in Neurodegenerative Disorders"],"prefix":"10.1016","volume":"18","author":[{"given":"Zanna J.","family":"Voysey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-8229","authenticated-orcid":false,"given":"Alpar S.","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-020-00959-7_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1300\/J018v16n02_04","article-title":"Sleep Disturbances in Community-Dwelling Patients with Alzheimer's Disease","volume":"16","author":"Carpenter","year":"1996","journal-title":"Clin Gerontol"},{"key":"10.1007\/s13311-020-00959-7_bib2","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/mds.22643","article-title":"The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease","volume":"24","author":"Barone","year":"2009","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/mds.870130606","article-title":"A community-based study of sleep disorders in patients with Parkinson's disease","volume":"13","author":"Tandberg","year":"1998","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000335363","article-title":"Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: A multicenter Italian clinical cross-sectional study on 431 patients","volume":"33","author":"Guarnieri","year":"2012","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1007\/s13311-020-00959-7_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.smrv.2016.08.001","article-title":"A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015","volume":"35","author":"Chahine","year":"2017","journal-title":"Sleep Med Rev"},{"key":"10.1007\/s13311-020-00959-7_bib6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1513\/AnnalsATS.201608-625OC","article-title":"Insomnia, sleep quality, and quality of life in mild to moderate parkinson's disease","volume":"14","author":"Shafazand","year":"2017","journal-title":"Ann Am Thorac Soc"},{"issue":"SUPPL. 1","key":"10.1007\/s13311-020-00959-7_bib7","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S1389-9457(08)70012-1","article-title":"Sleep, insomnia and falls in elderly patients","volume":"9","author":"Stone","year":"2008","journal-title":"Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01321316","article-title":"Sleep problems in the community elderly as predictors of death and nursing home placement","volume":"15","author":"Pollak","year":"1990","journal-title":"J Community Health"},{"key":"10.1007\/s13311-020-00959-7_bib9","first-page":"204","article-title":"Sleep Problems and Institutionalization of the Elderly","volume":"4","author":"Pollak","year":"1991","journal-title":"Top.Geriatr."},{"key":"10.1007\/s13311-020-00959-7_bib10","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/(SICI)1099-1166(1998100)13:10<682::AID-GPS847>3.0.CO;2-Y","article-title":"Predictors of institutionalization for people with dementia living at home with a carer","volume":"13","author":"Hope","year":"1998","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000106930","article-title":"Predictors of mortality and institutionalization in Alzheimer disease patients 1 year after discharge from an Alzheimer dementia unit","volume":"6","author":"Bianchetti","year":"1995","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1007\/s13311-020-00959-7_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.gerinurse.2017.06.003","article-title":"Impact of Alzheimer disease patients' sleep disturbances on their caregivers","volume":"39","author":"Gehrman","year":"2018","journal-title":"Geriatr Nurs (Minneap)"},{"key":"10.1007\/s13311-020-00959-7_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1017\/S1041610209991153","article-title":"Sleep and physical functioning in family caregivers of older adults with memory impairment","volume":"22","author":"Spira","year":"2010","journal-title":"Int Psychogeriatr"},{"key":"10.1007\/s13311-020-00959-7_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.smrv.2006.09.002","article-title":"Sleep disturbances in caregivers of persons with dementia: Contributing factors and treatment implications","volume":"11","author":"McCurry","year":"2007","journal-title":"Sleep Med Rev"},{"key":"10.1007\/s13311-020-00959-7_bib15","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.chest.2017.01.002","article-title":"Sleep and Neurodegeneration: A Critical Appraisal","volume":"151","author":"Pillai","year":"2017","journal-title":"Chest."},{"key":"10.1007\/s13311-020-00959-7_bib16","first-page":"553","article-title":"Sleep deprivation: Impact on cognitive performance","volume":"3","author":"Alhola","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1007\/s13311-020-00959-7_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/acp.3463","article-title":"Effects of sleep deprivation on executive functioning, cognitive abilities, metacognitive confidence, and decision making","volume":"33","author":"Aidman","year":"2019","journal-title":"Appl Cogn Psychol"},{"key":"10.1007\/s13311-020-00959-7_bib18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.5665\/sleep.5552","article-title":"Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study","volume":"39","author":"Lo","year":"2016","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5665\/sleep.3302","article-title":"Sustained Attention Performance during Sleep Deprivation Associates with Instability in Behavior and Physiologic Measures at Baseline","volume":"37","author":"Chua","year":"2014","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.smrv.2014.12.005","article-title":"Social interactions, emotion and sleep: A systematic review and research agenda","volume":"24","author":"Beattie","year":"2015","journal-title":"Sleep Med Rev"},{"key":"10.1007\/s13311-020-00959-7_bib21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib23","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.aax5440","article-title":"Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep","volume":"366","author":"Fultz","year":"2019","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1007\/s13311-020-00959-7_bib25","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3020-14.2014","article-title":"Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury","volume":"34","author":"Iliff","year":"2014","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.brainres.2013.07.010","article-title":"Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical A\u03b2 and pTau in a mouse model of Alzheimer's disease","volume":"1529","author":"Rothman","year":"2013","journal-title":"Brain Res"},{"key":"10.1007\/s13311-020-00959-7_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.aav2546","article-title":"The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans","volume":"363","author":"Holth","year":"2019","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ana.25117","article-title":"Effect of sleep on overnight cerebrospinal fluid amyloid \u03b2 kinetics","volume":"83","author":"Lucey","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib29","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1073\/pnas.1721694115","article-title":"\u03b2-Amyloid accumulation in the human brain after one night of sleep deprivation","volume":"115","author":"Shokri-Kojori","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1007\/s13311-020-00959-7_bib30","first-page":"e1181","article-title":"Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men","volume":"94","author":"Benedict","year":"2020","journal-title":"Randomized Controlled Trial"},{"key":"10.1007\/s13311-020-00959-7_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-018-3343-7","article-title":"Low-grade neuroinflammation due to chronic sleep deprivation results in anxiety and learning and memory impairments","volume":"449","author":"Manchanda","year":"2018","journal-title":"Mol Cell Biochem"},{"key":"10.1007\/s13311-020-00959-7_bib32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1152\/physrev.00032.2012","article-title":"About sleep's role in memory","volume":"93","author":"Rasch","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1007\/s13311-020-00959-7_bib33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1126\/science.aay0616","article-title":"Isolated cortical computations during delta waves support memory consolidation","volume":"366","author":"Todorova","year":"2019","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib34","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.aao0702","article-title":"Hippocampal ripples down-regulate synapses","volume":"359","author":"Norimoto","year":"2018","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jsmc.2017.09.006","article-title":"Neurodegenerative Disorders and Sleep","volume":"13","author":"Malhotra","year":"2018","journal-title":"Sleep Med Clin"},{"key":"10.1007\/s13311-020-00959-7_bib36","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.parkreldis.2015.09.025","article-title":"Subjective sleep dysfunction and insomnia symptoms in Parkinson's disease: Insights from a cross-sectional evaluation of the French CoPark cohort","volume":"21","author":"Ratti","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1007\/s13311-020-00959-7_bib37","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrneurol.2014.206","article-title":"\u2018The clocks that time us' - Circadian rhythms in neurodegenerative disorders","volume":"10","author":"Videnovic","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nbscr.2016.11.001","article-title":"Circadian dysregulation in Parkinson's disease","volume":"2","author":"Videnovic","year":"2017","journal-title":"Neurobio Sleep and Circadian Rhythms"},{"key":"10.1007\/s13311-020-00959-7_bib39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/sleep\/16.1.40","article-title":"Sleep in normal aging and dementia","volume":"16","author":"Bliwise","year":"1993","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/sleep\/zsz154","article-title":"Sleep in Huntington's disease: a systematic review and meta-analysis of polysomongraphic findings","volume":"42","author":"Zhang","year":"2019","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib41","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.ncl.2005.05.001","article-title":"Parkinson's Disease and Sleep","volume":"23","author":"Thorpy","year":"2005","journal-title":"Neurol Clin"},{"key":"10.1007\/s13311-020-00959-7_bib42","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.5665\/sleep.2802","article-title":"Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons","volume":"36","author":"Lim","year":"2013","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib43","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.24495","article-title":"Sleep deficits but no metabolic deficits in premanifest Huntington's disease","volume":"78","author":"Lazar","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1474-4422(13)70078-4","article-title":"REM sleep behaviour disorder: A marker of synucleinopathy","volume":"12","author":"Mahowald","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib45","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nrneurol.2017.157","article-title":"Idiopathic REM sleep behaviour disorder and neurodegeneration - An update","volume":"14","author":"H\u00f6gl","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib46","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/sleep\/14.6.486","article-title":"Sleep-disordered breathing in community-dwelling elderly","volume":"14","author":"Ancoli-Israel","year":"1991","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib47","first-page":"257","article-title":"Sleep apnea in Alzheimer's dementia: Correlation with mental deterioration","volume":"46","author":"Reynolds","year":"1985","journal-title":"J Clin Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib48","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11940-016-0424-3","article-title":"Treatment of Sleep Disorders in Dementia","volume":"18","author":"Ooms","year":"2016","journal-title":"Curr Treat Options Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fneur.2017.00042","article-title":"The treatment of sleep disorders in Parkinson's disease: From research to clinical practice","volume":"8","author":"Loddo","year":"2017","journal-title":"Front Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jama.287.4.455","article-title":"Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: A survey by the Canadian Movement Disorders Group","volume":"287","author":"Hobson","year":"2002","journal-title":"J Am Med Assoc"},{"key":"10.1007\/s13311-020-00959-7_bib51","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archneur.65.4.482","article-title":"Rapid eye movement sleep disturbances in Huntington disease","volume":"65","author":"Arnulf","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib52","doi-asserted-by":"crossref","first-page":"004","DOI":"10.1126\/science.aah4968","article-title":"Mechanisms linking circadian clocks, sleep, and neurodegeneration","volume":"354","author":"Musiek","year":"2016","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib53","doi-asserted-by":"crossref","first-page":"682","DOI":"10.12998\/wjcc.v3.i8.682","article-title":"Depressive symptoms in neurodegenerative diseases","volume":"3","author":"Baquero","year":"2015","journal-title":"World J Clin Cases"},{"key":"10.1007\/s13311-020-00959-7_bib54","doi-asserted-by":"crossref","first-page":"329","DOI":"10.31887\/DCNS.2008.10.3\/dnutt","article-title":"Sleep disorders as core symptoms of depression","volume":"10","author":"Nutt","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib55","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/mds.23168","article-title":"Treatment of insomnia in Parkinson's disease: A controlled trial of eszopiclone and placebo","volume":"25","author":"Menza","year":"2010","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib56","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/JGP.0b013e3181e448f7","article-title":"Depression in Parkinson's disease: Symptom improvement and residual symptoms after acute pharmacologic management","volume":"19","author":"Dobkin","year":"2011","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib57","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/1531-8257(199905)14:3<507::AID-MDS1021>3.0.CO;2-8","article-title":"Melatonin as a therapy in REM sleep behavior disorder patients: An open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation","volume":"14","author":"Kunz","year":"1999","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib58","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1389-9457(03)00072-8","article-title":"Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: Results in 14 patients","volume":"4","author":"Boeve","year":"2003","journal-title":"Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib59","first-page":"267","article-title":"Melatonin therapy for REM sleep behavior disorder","volume":"55","author":"Takeuchi","year":"2001","journal-title":"In: Psychiatry and Clinical Neurosciences"},{"key":"10.1007\/s13311-020-00959-7_bib60","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.sleep.2013.03.010","article-title":"Subjectively impaired bed mobility in Parkinson disease affects sleep efficiency","volume":"14","author":"Louter","year":"2013","journal-title":"Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1468-1331.2011.03442.x","article-title":"Improvements in nocturnal symptoms with ropinirole prolonged release in patients with advanced Parkinson's disease","volume":"19","author":"Ray Chaudhuri","year":"2012","journal-title":"Eur J Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib62","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1007\/PL00007731","article-title":"Sleep disorders in Parkinson's disease","volume":"245","author":"Stocchi","year":"1998","journal-title":"J Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib63","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1468-1331.2010.03213.x","article-title":"Effect of controlled-release levodopa on the microstructure of sleep in Parkinson's disease","volume":"18","author":"Wailke","year":"2011","journal-title":"Eur J Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib64","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.parkreldis.2014.04.020","article-title":"Rasagiline effect on bladder disturbances in early mild Parkinson's disease patients","volume":"20","author":"Brusa","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1007\/s13311-020-00959-7_bib65","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/nau.1930120302","article-title":"Effects of apomorphine and L-dopa on the parkinsonian bladder","volume":"12","author":"Aranda","year":"1993","journal-title":"Neurourol Urodyn"},{"key":"10.1007\/s13311-020-00959-7_bib66","article-title":"Rotigotine Objectively Improves Sleep in Parkinson's Disease: An Open-Label Pilot Study with Actigraphic Recording","volume":"2016","author":"Calandra-Buonaura","year":"2016","journal-title":"Parkinsons Dis"},{"key":"10.1007\/s13311-020-00959-7_bib67","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.psychres.2017.02.039","article-title":"Effects of donepezil on sleep disturbances in patients with dementia with Lewy bodies: An open-label study with actigraphy","volume":"251","author":"Kazui","year":"2017","journal-title":"Psychiatry Res"},{"key":"10.1007\/s13311-020-00959-7_bib68","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1017\/neu.2015.61","article-title":"The effect of memantine on sleep architecture and psychiatric symptoms in patients with Alzheimer's disease","volume":"28","author":"Ishikawa","year":"2016","journal-title":"Acta Neuropsychiatr"},{"issue":"5","key":"10.1007\/s13311-020-00959-7_bib69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.9740\/mhc.n222761","article-title":"Impact of nighttime donepezil administration on sleep in the older adult population: A retrospective study","volume":"4","author":"Agboton","year":"2014","journal-title":"Ment Heal Clin"},{"key":"10.1007\/s13311-020-00959-7_bib70","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/mds.23441","article-title":"Rotigotine effects on early morning motor function and sleep in Parkinson's disease: A double-blind, randomized, placebo-controlled study (RECOVER)","volume":"26","author":"Trenkwalder","year":"2011","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib71","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.sleep.2016.01.016","article-title":"Rotigotine may improve sleep architecture in Parkinson's disease: A double-blind, Randomized, Placebo-controlled polysomnographic study","volume":"21","author":"Pierantozzi","year":"2016","journal-title":"Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib72","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/fampra\/cmn065","article-title":"Drinking alcohol for medicinal purposes by people aged over 75: A community-based interview study","volume":"25","author":"Aira","year":"2008","journal-title":"Fam Pract"},{"key":"10.1007\/s13311-020-00959-7_bib73","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.smrv.2005.12.003","article-title":"Periodic leg movements in sleep and periodic limb movement disorder: Prevalence, clinical significance and treatment","volume":"10","author":"Hornyak","year":"2006","journal-title":"Sleep Med Rev"},{"key":"10.1007\/s13311-020-00959-7_bib74","first-page":"608","article-title":"Excessive daytime sleepiness in sleep disorders","volume":"4","author":"Slater","year":"2012","journal-title":"Journal of Thoracic Disease"},{"key":"10.1007\/s13311-020-00959-7_bib75","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1532-5415.2006.00694.x","article-title":"Continuous Positive Airway Pressure Reduces Subjective Daytime Sleepiness in Patients with Mild to Moderate Alzheimer's Disease with Sleep Disordered Breathing","volume":"54","author":"Chong","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib76","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1136\/jnnp-2013-307544","article-title":"Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer's disease","volume":"85","author":"Troussi\u00e8re","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib77","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1111\/j.1532-5415.2008.01934.x","article-title":"Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: A randomized controlled study","volume":"56","author":"Ancoli-Israel","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib78","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5664\/jcsm.27538","article-title":"Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: A preliminary study","volume":"5","author":"Cooke","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib79","doi-asserted-by":"crossref","first-page":"125","DOI":"10.7326\/M15-2175","article-title":"Management of chronic insomnia disorder in adults: A clinical practice guideline from the American college of physicians","volume":"165","author":"Qaseem","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1007\/s13311-020-00959-7_bib80","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF02244252","article-title":"Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil","volume":"103","author":"Curran","year":"1991","journal-title":"Psychopharmacology"},{"key":"10.1007\/s13311-020-00959-7_bib81","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2869.2009.00746.x","article-title":"Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem","volume":"18","author":"Leufkens","year":"2009","journal-title":"J Sleep Res"},{"key":"10.1007\/s13311-020-00959-7_bib82","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2165\/00023210-200418010-00004","article-title":"Cognitive Effects of Long-Term Benzodiazepine Use: A Meta-Analysis","volume":"18","author":"Barker","year":"2004","journal-title":"CNS Drugs"},{"key":"10.1007\/s13311-020-00959-7_bib83","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00213-005-2228-0","article-title":"Zolpidem and triazolam do not affect the nocturnal sleep-induced memory improvement","volume":"181","author":"Mel\u00e9ndez","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1007\/s13311-020-00959-7_bib84","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1523\/JNEUROSCI.3127-12.2013","article-title":"The critical role of sleep spindles in hippocampal-dependent memory: A pharmacology study","volume":"33","author":"Mednick","year":"2013","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib85","doi-asserted-by":"crossref","unstructured":"Zhang J, Yetton B, Whitehurst LN, Naji M, Mednick SC. The effect of zolpidem on memory consolidation over a night of sleep. Sleep. 2020.","DOI":"10.1093\/sleep\/zsaa084"},{"key":"10.1007\/s13311-020-00959-7_bib86","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/hup.980","article-title":"Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers","volume":"23","author":"Otmani","year":"2008","journal-title":"Hum Psychopharmacol"},{"key":"10.1007\/s13311-020-00959-7_bib87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5664\/jcsm.3352","article-title":"The effect of two benzodiazepine receptor agonist hypnotics on sleep-dependent memory consolidation","volume":"10","author":"Hall-Porter","year":"2014","journal-title":"J Clin Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib88","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/B978-0-444-53817-8.00005-0","article-title":"Effects of the use of hypnotics on cognition","volume":"190","author":"Vermeeren","year":"2011","journal-title":"Prog Brain Res"},{"key":"10.1007\/s13311-020-00959-7_bib89","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/0269881115581963","article-title":"Randomised clinical trial of the effects of prolonged-release melatonin, temazepam and zolpidem on slow-wave activity during sleep in healthy people","volume":"29","author":"Arbon","year":"2015","journal-title":"J Psychopharmacol"},{"key":"10.1007\/s13311-020-00959-7_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02244546","article-title":"Effect of zolpidem on sleep and sleep EEG spectra in healthy young men","volume":"104","author":"Brunner","year":"1991","journal-title":"Psychopharmacology"},{"key":"10.1007\/s13311-020-00959-7_bib91","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM199503233321202","article-title":"Risk Factors for Hip Fracture in White Women","volume":"332","author":"Cummings","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1007\/s13311-020-00959-7_bib92","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0740-5472(91)90025-6","article-title":"Benzodiazepines and the elderly a review of potential problems","volume":"8","author":"Closser","year":"1991","journal-title":"J Subst Abus Treat"},{"key":"10.1007\/s13311-020-00959-7_bib93","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00004714-200206000-00009","article-title":"Long-term benzodiazepine use and cognitive decline in the elderly: The epidemiology of vascular aging study","volume":"22","author":"Paterniti","year":"2002","journal-title":"J Clin Psychopharmacol"},{"key":"10.1007\/s13311-020-00959-7_bib94","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/jnnp.2006.104034","article-title":"The effects of commonly prescribed drugs in patients with Alzheimer's disease on the rate or deterioration","volume":"78","author":"Ellul","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib95","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.brainresrev.2010.04.008","article-title":"Cognitive domains affected by histamine H1-antagonism in humans: A literature review","volume":"64","author":"Van Ruitenbeek","year":"2010","journal-title":"Brain Res Rev"},{"key":"10.1007\/s13311-020-00959-7_bib96","first-page":"225","article-title":"The cognitive impact of anticholinergics: a clinical review","volume":"4","author":"Campbell","year":"2009","journal-title":"Clin Interv Aging"},{"key":"10.1007\/s13311-020-00959-7_bib97","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1111\/jgs.13702","article-title":"American Geriatrics Society 2015 updated beers criteria for potentially inappropriate medication use in older adults","volume":"63","author":"Samuel","year":"2015","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib98","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/brain\/awx074","article-title":"Repurposed drugs targeting eIF2\u03b1-P-mediated translational repression prevent neurodegeneration in mice","volume":"140","author":"Halliday","year":"2017","journal-title":"Brain."},{"key":"10.1007\/s13311-020-00959-7_bib99","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1345\/aph.1Q589","article-title":"Psychotropic related hip fractures: meta-analysis of first generation and second generation antidepressant and antipsychotic drugs","volume":"46","author":"Oderda","year":"2012","journal-title":"Ann Pharmacother"},{"key":"10.1007\/s13311-020-00959-7_bib100","doi-asserted-by":"crossref","first-page":"d4551","DOI":"10.1136\/bmj.d4551","article-title":"Antidepressant use and risk of adverse outcomes in older people: Population based cohort study","volume":"343","author":"Coupland","year":"2011","journal-title":"BMJ"},{"key":"10.1007\/s13311-020-00959-7_bib101","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.jagp.2013.12.174","article-title":"Trazodone improves sleep parameters in Alzheimer disease patients: A randomized, double-blind, and placebo-controlled study","volume":"22","author":"Camargos","year":"2014","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib102","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2869.2011.00928.x","article-title":"Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs","volume":"20","author":"Roth","year":"2011","journal-title":"J Sleep Res"},{"key":"10.1007\/s13311-020-00959-7_bib103","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/psyg.12191","article-title":"Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study","volume":"17","author":"Scoralick","year":"2017","journal-title":"Psychogeriatrics."},{"key":"10.1007\/s13311-020-00959-7_bib104","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/sleep\/33.11.1553","article-title":"Efficacy and safety of doxepin 1 mg and 3 mg in a 12-week sleep laboratory and outpatient trial of elderly subjects with chronic primary insomnia","volume":"33","author":"Krystal","year":"2010","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib105","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.parkreldis.2013.03.003","article-title":"Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease - A randomized study","volume":"19","author":"Rios Romenets","year":"2013","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1007\/s13311-020-00959-7_bib106","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/0891988704264535","article-title":"Risperidone is effective for wandering and disturbed sleep\/wake patterns in Alzheimer's disease","volume":"17","author":"Meguro","year":"2004","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib107","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000435889","article-title":"Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's Disease Patients with Sleep Disturbances","volume":"96","author":"Yin","year":"2015","journal-title":"Pharmacology."},{"key":"10.1007\/s13311-020-00959-7_bib108","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/1533317510390351","article-title":"Risk of cerebrovascular adverse events and death in elderly patients with dementia when treated with antipsychotic medications: A literature review of evidence","volume":"26","author":"Mittal","year":"2011","journal-title":"Am J Alzheimers Dis Other Dement"},{"key":"10.1007\/s13311-020-00959-7_bib109","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1474-4422(08)70295-3","article-title":"The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial","volume":"8","author":"Ballard","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib110","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.healthpol.2015.02.014","article-title":"A literature review of clinical outcomes associated with antipsychotic medication use in North American nursing home residents","volume":"119","author":"Chiu","year":"2015","journal-title":"Health Policy"},{"key":"10.1007\/s13311-020-00959-7_bib111","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2147\/NDT.S163842","article-title":"Treatment of behavioral and psychological symptoms of dementias with psychopharmaceuticals: A review","volume":"14","author":"Masopust","year":"2018","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1007\/s13311-020-00959-7_bib112","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/sleep\/33.9.1217","article-title":"Enhancing slow wave sleep with sodium oxybate reduces the behavioral and physiological impact of sleep loss","volume":"33","author":"Walsh","year":"2010","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib113","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13195-016-0205-y","article-title":"A proposed preventive role for Gamma-hydroxybutyrate (XyremR) in Alzheimer's disease","volume":"8","author":"Maitre","year":"2016","journal-title":"Alzheimer's Research and Therapy"},{"key":"10.1007\/s13311-020-00959-7_bib114","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1001\/archneur.65.10.1337","article-title":"Sodium oxybate for excessive daytime sleepiness in Parkinson disease: An open-label polysomnographic study","volume":"65","author":"Ondo","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1001\/jamaneurol.2017.3171","article-title":"Sodium oxybate for excessive daytime sleepiness and sleep disturbance in Parkinson disease: A randomized clinical trial","volume":"75","author":"B\u00fcchele","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib116","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/WNF.0b013e3181aa916a","article-title":"Using modafinil to treat fatigue in parkinson disease: A double-blind, placebo-controlled pilot study","volume":"32","author":"Lou","year":"2009","journal-title":"Clin Neuropharmacol"},{"key":"10.1007\/s13311-020-00959-7_bib117","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1136\/jnnp.2005.065870","article-title":"Modafinil for daytime somnolence in Parkinson's disease: Double blind, placebo controlled parallel trial","volume":"76","author":"Ondo","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib118","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/sleep\/25.8.62","article-title":"Modafinil for the treatment of daytime sleepiness in Parkinson's disease: A double-blind, randomized, crossover, placebo-controlled polygraphic trial","volume":"25","author":"H\u00f6gl","year":"2002","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib119","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4088\/JCP.10m06708","article-title":"A randomized, double-blind, placebo-controlled trial of modafinil for the treatment of apathy in individuals with mild-to-moderate Alzheimer's disease","volume":"73","author":"Frakey","year":"2012","journal-title":"J Clin Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00213-008-1068-0","article-title":"The effects of modafinil on mood and cognition in Huntington's disease","volume":"199","author":"Blackwell","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1007\/s13311-020-00959-7_bib121","series-title":"Clinical Use of Melatonin in the Treatment of Sleep Disorders","author":"Zakharov","year":"2020"},{"key":"10.1007\/s13311-020-00959-7_bib122","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3389\/fendo.2019.00480","article-title":"Melatonin: Clinical perspectives in neurodegeneration","volume":"10","author":"Cardinali","year":"2019","journal-title":"Front Endocrinol"},{"issue":"7","key":"10.1007\/s13311-020-00959-7_bib123","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2174\/1567205015666180411092551","article-title":"Melatonin Treatment Enhances A\u03b2 Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis","volume":"15","author":"Pappolla","year":"2018","journal-title":"Curr Alzheimer Res"},{"key":"10.1007\/s13311-020-00959-7_bib124","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S0011-393X(97)80066-5","article-title":"Effects of melatonin in elderly patients with sleep disturbance: A pilot study","volume":"58","author":"Fainstein","year":"1997","journal-title":"Curr Ther Res - Clin Exp"},{"key":"10.1007\/s13311-020-00959-7_bib125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-4943(00)00068-6","article-title":"Melatonin for treatment of sundowning in elderly persons with dementia - A preliminary study","volume":"31","author":"Cohen-Mansfield","year":"2000","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1007\/s13311-020-00959-7_bib126","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1081\/CBI-100101055","article-title":"Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons","volume":"17","author":"Mishima","year":"2000","journal-title":"Chronobiol Int"},{"key":"10.1007\/s13311-020-00959-7_bib127","first-page":"20","article-title":"The use of melatonin in Alzheimer's disease","volume":"23","author":"Cardinali","year":"2002","journal-title":"Neuroendocrinol Lett"},{"key":"10.1007\/s13311-020-00959-7_bib128","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/gps.760","article-title":"Double blind randodmised placebo controlled trial of low dose melatonin for sleep disorders in dementia","volume":"17","author":"Serfaty","year":"2002","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib129","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/JGP.0b013e318187de18","article-title":"Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with alzheimer disease","volume":"17","author":"Gehrman","year":"2009","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib130","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/sleep\/26.7.893","article-title":"A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease","volume":"26","author":"Singer","year":"2003","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib131","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1272\/jnms.70.334","article-title":"Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia","volume":"70","author":"Asayama","year":"2003","journal-title":"J Nippon Med Sch"},{"key":"10.1007\/s13311-020-00959-7_bib132","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1532-5415.2007.01543.x","article-title":"Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease","volume":"56","author":"Dowling","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib133","first-page":"947","article-title":"Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: A 6-month, randomized, placebo-controlled, multicenter trial","volume":"9","author":"Wade","year":"2014","journal-title":"Clin Interv Aging"},{"key":"10.1007\/s13311-020-00959-7_bib134","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1600-079X.1998.tb00557.x","article-title":"Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment","volume":"25","author":"Jean-Louis","year":"1998","journal-title":"J Pineal Res"},{"key":"10.1007\/s13311-020-00959-7_bib135","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.sleep.2005.04.004","article-title":"Melatonin for sleep disturbances in Parkinson's disease","volume":"6","author":"Dowling","year":"2005","journal-title":"Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib136","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00415-006-0390-x","article-title":"Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease: A randomized, double blind, placebo-controlled study","volume":"254","author":"Medeiros","year":"2007","journal-title":"J Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib137","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/mds.27602","article-title":"Update on treatments for nonmotor symptoms of Parkinson's disease\u2014an evidence-based medicine review","volume":"34","author":"Seppi","year":"2019","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib138","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10072-015-2357-0","article-title":"Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials","volume":"37","author":"Zhang","year":"2016","journal-title":"Neurol Sci"},{"key":"10.1007\/s13311-020-00959-7_bib139","article-title":"Pharmacotherapies for sleep disturbances in dementia. Vol. 2016","volume":"11","author":"Mccleery","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1007\/s13311-020-00959-7_bib140","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/1533317514568005","article-title":"Melatonin for Sleep Disorders and Cognition in Dementia: A Meta-Analysis of Randomized Controlled Trials","volume":"30","author":"Xu","year":"2015","journal-title":"Am J Alzheimers Dis Other Dement"},{"key":"10.1007\/s13311-020-00959-7_bib141","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/gps.4571","article-title":"Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer's disease","volume":"32","author":"Wang","year":"2017","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib142","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2869.2010.00848.x","article-title":"A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder","volume":"19","author":"Kunz","year":"2010","journal-title":"J Sleep Res"},{"key":"10.1007\/s13311-020-00959-7_bib143","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.smrv.2016.02.002","article-title":"Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease","volume":"31","author":"Cedernaes","year":"2017","journal-title":"Sleep Med Rev"},{"issue":"5955","key":"10.1007\/s13311-020-00959-7_bib144","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-\u03b2 dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib145","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.5664\/jcsm.6116","article-title":"Suvorexant in patients with insomnia: Pooled analyses of three-month data from phase-3 randomized controlled clinical trials","volume":"12","author":"Herring","year":"2016","journal-title":"J Clin Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib146","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1474-4422(14)70053-5","article-title":"Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: A phase 3 randomised, double-blind, placebo-controlled trial","volume":"13","author":"Michelson","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib147","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.18254","article-title":"Comparison of Lemborexant With Placebo and Zolpidem Tartrate Extended Release for the Treatment of Older Adults With Insomnia Disorder: A Phase 3 Randomized Clinical Trial","volume":"2","author":"Rosenberg","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1007\/s13311-020-00959-7_bib148","doi-asserted-by":"crossref","unstructured":"Neylan TC, Richards A, Metzler TJ, et al. Acute cognitive effects of the hypocretin receptor antagonist almorexant relative to zolpidem and placebo: a randomized clinical trial. Sleep. 2020.","DOI":"10.1093\/sleep\/zsaa080"},{"key":"10.1007\/s13311-020-00959-7_bib149","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.sleep.2017.05.009","article-title":"Efficacy and safety of almorexant in adult chronic insomnia: a randomized placebo-controlled trial with an active reference","volume":"36","author":"Black","year":"2017","journal-title":"Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib150","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jagp.2017.03.004","article-title":"Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials","volume":"25","author":"Herring","year":"2017","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib151","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/alz.12035","article-title":"Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial","volume":"16","author":"Herring","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1007\/s13311-020-00959-7_bib152","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/brain\/awm090","article-title":"Hypocretin (orexin) loss in Parkinson's disease","volume":"130","author":"Fronczek","year":"2007","journal-title":"Brain."},{"key":"10.1007\/s13311-020-00959-7_bib153","doi-asserted-by":"crossref","unstructured":"Fronczek R, van Geest S, Fr\u00f6lich M, et al. Hypocretin (orexin) loss in Alzheimer's disease. Neurobiol Aging 2012;33:1642\u20131650.","DOI":"10.1016\/j.neurobiolaging.2011.03.014"},{"key":"10.1007\/s13311-020-00959-7_bib154","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1126\/science.3726555","article-title":"Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle","volume":"233","author":"Czeisler","year":"1986","journal-title":"Science."},{"key":"10.1007\/s13311-020-00959-7_bib155","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fnins.2020.00359","article-title":"Bright Light Therapy and Circadian Cycles in Institutionalized Elders","volume":"14","author":"Rubi\u00f1o","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib156","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1113\/jphysiol.2003.040477","article-title":"A phase response curve to single bright light pulses in human subjects","volume":"549","author":"Khalsa","year":"2003","journal-title":"J Physiol"},{"key":"10.1007\/s13311-020-00959-7_bib157","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1440-1819.1999.00486.x","article-title":"Effects of morning bright light on sleep in healthy elderly women","volume":"53","author":"Kobayashi","year":"1999","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib158","first-page":"25","article-title":"Light as Therapy for Sleep Disorders and Depression in Older Adults","volume":"16","author":"Sloane","year":"2008","journal-title":"Clin Geriatr"},{"key":"10.1007\/s13311-020-00959-7_bib159","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2147\/CIA.S68557","article-title":"Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer's disease and related dementia living in long-term care facilities","volume":"9","author":"Gfigueiro","year":"2014","journal-title":"Clin Interv Aging"},{"key":"10.1007\/s13311-020-00959-7_bib160","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0006-3223(97)89928-3","article-title":"Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients","volume":"41","author":"Van Someren","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib161","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/gps.852","article-title":"Bright light treatment improves sleep in institutionalised elderly - An open trial","volume":"18","author":"Fetveit","year":"2003","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib162","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3109\/07420529808993200","article-title":"Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of alzheimer's type","volume":"15","author":"Mishima","year":"1998","journal-title":"Chronobiol Int"},{"key":"10.1007\/s13311-020-00959-7_bib163","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/gps.1352","article-title":"Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease","volume":"20","author":"Dowling","year":"2005","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib164","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1532-5415.2002.50060.x","article-title":"Effect of light treatment on sleep and circadian rhythms in demented nursing home patients","volume":"50","author":"Ancoli-Israel","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1207\/S15402010BSM0101_4","article-title":"Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's disease patients","volume":"1","author":"Ancoli-Israel","year":"2003","journal-title":"Behav Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib166","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1017\/S1041610209008886","article-title":"Bright light therapy for agitation in dementia: A randomized controlled trial","volume":"21","author":"Burns","year":"2009","journal-title":"Int Psychogeriatr"},{"key":"10.1007\/s13311-020-00959-7_bib167","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0531-5565(02)00164-X","article-title":"Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly","volume":"38","author":"Fontana Gasio","year":"2003","journal-title":"Exp Gerontol"},{"key":"10.1007\/s13311-020-00959-7_bib168","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0006-3223(01)01178-7","article-title":"The effects of light therapy on mini-mental state examination scores in demented patients","volume":"50","author":"Graf","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib169","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1046\/j.1440-1819.2000.00711.x","article-title":"Effects of bright light on cognitive and sleep\u2013wake (circadian) rhythm disturbances in Alzheimer-type dementia","volume":"54","author":"Yamadera","year":"2000","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib170","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1001\/jama.299.22.2642","article-title":"Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: A randomized controlled trial","volume":"299","author":"Riemersma-van Der Lek","year":"2008","journal-title":"JAMA - J Am Med Assoc"},{"key":"10.1007\/s13311-020-00959-7_bib171","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/gps.2453","article-title":"Impact of ambient bright light on agitation in dementia","volume":"25","author":"Barrick","year":"2010","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib172","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/07420520701420717","article-title":"Primary and secondary features of Parkinson's disease improve with strategic exposure to bright light: a case series study","volume":"24","author":"Willis","year":"2007","journal-title":"Chronobiol Int"},{"key":"10.1007\/s13311-020-00959-7_bib173","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1515\/revneuro-2011-0072","article-title":"A historical justification for and retrospective analysis of the systematic application of light therapy in Parkinson's disease","volume":"23","author":"Willis","year":"2012","journal-title":"Rev Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib174","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/mds.21542","article-title":"Bright light therapy in Parkinson's disease: A pilot study","volume":"22","author":"Paus","year":"2007","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib175","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1001\/jamaneurol.2016.5192","article-title":"Timed light therapy for sleep and daytime sleepiness associated with Parkinson disease a randomized clinical trial","volume":"74","author":"Videnovic","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1007\/s13311-020-00959-7_bib176","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.maturitas.2019.06.007","article-title":"Non-pharmacological treatments for sleep disturbance in mild cognitive impairment and dementia: A systematic review and meta-analysis","volume":"127","author":"O'Caoimh","year":"2019","journal-title":"Maturitas."},{"key":"10.1007\/s13311-020-00959-7_bib177","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000494921","article-title":"Effects of light treatment on sleep, cognition, mood, and behavior in Alzheimer's disease: A systematic review","volume":"46","author":"Mitolo","year":"2018","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1007\/s13311-020-00959-7_bib178","article-title":"Light therapy for improving cognition, activities of daily living, sleep, challenging behaviour, and psychiatric disturbances in dementia","volume":"2","author":"Forbes","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1007\/s13311-020-00959-7_bib179","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.smrv.2015.08.009","article-title":"The effects of light therapy on sleep problems: A systematic review and meta-analysis","volume":"29","author":"van Maanen","year":"2016","journal-title":"Sleep Med Rev"},{"key":"10.1007\/s13311-020-00959-7_bib180","article-title":"Blue Light Therapy Glasses in Parkinson's Disease: Patients' Experience","volume":"2019","author":"Smilowska","year":"2019","journal-title":"Parkinsons Dis"},{"key":"10.1007\/s13311-020-00959-7_bib181","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smrv.2017.02.001","article-title":"Cognitive and behavioral therapies in the treatment of insomnia: A meta-analysis","volume":"38","author":"van Straten","year":"2018","journal-title":"Sleep Med Rev"},{"key":"10.1007\/s13311-020-00959-7_bib182","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1532-5415.2005.53251.x","article-title":"Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep\/wake patterns in nursing home residents","volume":"53","author":"Alessi","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib183","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1532-5415.2005.00562.x","article-title":"A Nonpharmacological Intervention to Improve Sleep in Nursing Home Patients: Results of a Controlled Clinical Trial","volume":"54","author":"Ouslander","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib184","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1532-5415.2005.53460.x","article-title":"Effect of individualized social activity on sleep in nursing home residents with dementia","volume":"53","author":"Richards","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib185","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1300\/J081v21n03_10","article-title":"Therapeutic effects of an outdoor activity program on nursing home residents with Dementia","volume":"21","author":"Connell","year":"2007","journal-title":"J Hous Elder"},{"key":"10.1007\/s13311-020-00959-7_bib186","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/sleep\/23.1.1f","article-title":"Daily social and physical activity increases slow-wave sleep and daytime neuropsychological performance in the elderly","volume":"23","author":"Naylor","year":"2000","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib187","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1532-5415.2010.03246.x","article-title":"Strength training, walking, and social activity improve sleep in nursing home and assisted living residents: Randomized controlled trial","volume":"59","author":"Richards","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib188","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1532-5415.1999.tb03833.x","article-title":"A randomized trial of a combined physical activity and environmental intervention in nursing home residents: Do sleep and agitation improve?","volume":"47","author":"Alessi","year":"1999","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib189","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/JGP.0b013e318248ae79","article-title":"Development and evaluation of a sleep education program for older adults with dementia living in adult family homes","volume":"20","author":"McCurry","year":"2012","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1007\/s13311-020-00959-7_bib190","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1532-5415.2005.53252.x","article-title":"Nighttime Insomnia Treatment and Education for Alzheimer's Disease: A randomized, controlled trial","volume":"53","author":"McCurry","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib191","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1532-5415.2011.03519.x","article-title":"Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: Results of a randomized, controlled trial","volume":"59","author":"McCurry","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib192","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/07317115.2017.1384777","article-title":"Neuropsychological Functioning in Older Adults with Mild Cognitive Impairment and Insomnia Randomized to CBT-I or Control Group","volume":"41","author":"Cassidy-Eagle","year":"2018","journal-title":"Clin Gerontol"},{"key":"10.1007\/s13311-020-00959-7_bib193","doi-asserted-by":"crossref","unstructured":"Frazzitta G, Maestri R, Ferrazzoli D, et al. Multidisciplinary intensive rehabilitation treatment improves sleep quality in Parkinson's disease. J Clin Mov Disord. 2015;2(1):11.","DOI":"10.1186\/s40734-015-0020-9"},{"key":"10.1007\/s13311-020-00959-7_bib194","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/ggi.12082","article-title":"Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients","volume":"14","author":"Nascimento","year":"2014","journal-title":"Geriatr Gerontol Int"},{"key":"10.1007\/s13311-020-00959-7_bib195","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/ggi.12571","article-title":"Effect of health Baduanjin Qigong for mild to moderate Parkinson's disease","volume":"16","author":"Xiao","year":"2016","journal-title":"Geriatr Gerontol Int"},{"key":"10.1007\/s13311-020-00959-7_bib196","doi-asserted-by":"crossref","unstructured":"Osawa C, Kamei Y, Nozaki K, Furusawa Y, Murata M. Brief Cognitive Behavioral Therapy for Insomnia in Parkinson's Disease: A Case Series Study. Jpn Psychol Res 2020;4.","DOI":"10.1111\/jpr.12287"},{"key":"10.1007\/s13311-020-00959-7_bib197","article-title":"Physical Activity, Fatigue, and Sleep in People with Parkinson's Disease: A Secondary per Protocol Analysis from an Intervention Trial","volume":"2018","author":"Coe","year":"2018","journal-title":"Parkinsons Dis"},{"key":"10.1007\/s13311-020-00959-7_bib198","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/mds.28009","article-title":"Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease","volume":"35","author":"Amara","year":"2020","journal-title":"Mov Disord"},{"key":"10.1007\/s13311-020-00959-7_bib199","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/1471301215625821","article-title":"Non-pharmacological interventions for managing dementia-related sleep problems within community dwelling pairs: A mixed-method approach","volume":"16","author":"Gibson","year":"2017","journal-title":"Dementia."},{"key":"10.1007\/s13311-020-00959-7_bib200","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1046\/j.1532-5415.2003.51466.x","article-title":"Training caregivers to change the sleep hygiene practices of patients with dementia: The NITE-AD project","volume":"51","author":"McCurry","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"10.1007\/s13311-020-00959-7_bib201","first-page":"75","article-title":"Age-related changes in the cognitive function of sleep","volume":"191","author":"Pace-Schott","year":"2011","journal-title":"In: Progress in Brain Research"},{"key":"10.1007\/s13311-020-00959-7_bib202","doi-asserted-by":"crossref","unstructured":"Cordone S, Annarumma L, Rossini PM, De Gennaro L. Sleep and \u03b2-amyloid deposition in Alzheimer disease: Insights on mechanisms and possible innovative treatments. Frontiers in Pharmacology. Frontiers Media S.A. 2019; 10:695.","DOI":"10.3389\/fphar.2019.00695"},{"key":"10.1007\/s13311-020-00959-7_bib203","doi-asserted-by":"crossref","first-page":"104865","DOI":"10.1016\/j.nbd.2020.104865","article-title":"Neurostimulation techniques to enhance sleep and improve cognition in aging","volume":"141","author":"Grimaldi","year":"2020","journal-title":"Neurobiology of Disease Academic Press Inc"},{"key":"10.1007\/s13311-020-00959-7_bib204","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fnsys.2014.00208","article-title":"Enhancement of sleep slow waves: Underlying mechanisms and practical consequences","volume":"8","author":"Bellesi","year":"2014","journal-title":"Front Syst Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib205","doi-asserted-by":"crossref","first-page":"9985","DOI":"10.1523\/JNEUROSCI.2725-04.2004","article-title":"Transcranial direct current stimulation during sleep improves declarative memory","volume":"24","author":"Marshall","year":"2004","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib206","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nature05278","article-title":"Boosting slow oscillations during sleep potentiates memory","volume":"444","author":"Marshall","year":"2006","journal-title":"Nature."},{"key":"10.1007\/s13311-020-00959-7_bib207","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fnhum.2019.00123","article-title":"Short Duration Repetitive Transcranial Electrical Stimulation During Sleep Enhances Declarative Memory of Facts","volume":"13","author":"Cellini","year":"2019","journal-title":"Front Hum Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib208","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1016\/j.neurobiolaging.2015.05.014","article-title":"Memory improvement via slow-oscillatory stimulation during sleep in older adults","volume":"36","author":"Westerberg","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s13311-020-00959-7_bib209","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuroimage.2016.06.057","article-title":"Brain stimulation during an afternoon nap boosts slow oscillatory activity and memory consolidation in older adults","volume":"142","author":"Ladenbauer","year":"2016","journal-title":"Neuroimage."},{"key":"10.1007\/s13311-020-00959-7_bib210","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.brs.2015.01.414","article-title":"Oscillating square wave transcranial direct current stimulation (tDCS) delivered during slow wave sleep does not improve declarative memory more than sham: A randomized sham controlled crossover study","volume":"8","author":"Sahlem","year":"2015","journal-title":"Brain Stimul"},{"key":"10.1007\/s13311-020-00959-7_bib211","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.brs.2019.02.012","article-title":"Slow oscillatory transcranial direct current stimulation (so-tDCS) during slow wave sleep has no effects on declarative memory in healthy young subjects","volume":"12","author":"Bueno-Lopez","year":"2019","journal-title":"Brain Stimul"},{"key":"10.1007\/s13311-020-00959-7_bib212","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.brs.2013.05.006","article-title":"No effects of slow oscillatory transcranial direct current stimulation (tDCS) on sleep-dependent memory consolidation in healthy elderly subjects","volume":"6","author":"Eggert","year":"2013","journal-title":"Brain Stimul"},{"issue":"2","key":"10.1007\/s13311-020-00959-7_bib213","doi-asserted-by":"crossref","first-page":"e16905","DOI":"10.1371\/journal.pone.0016905","article-title":"Transcranial electrical currents to probe EEG brain rhythms and memory consolidation during sleep in humans","volume":"6","author":"Marshall","year":"2011","journal-title":"PLoS One"},{"key":"10.1007\/s13311-020-00959-7_bib214","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/ejn.13877","article-title":"Efficacy of slow oscillatory-transcranial direct current stimulation on EEG and memory \u2013 contribution of an inter-individual factor","volume":"47","author":"Koo","year":"2018","journal-title":"Eur J Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib215","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.schres.2012.12.014","article-title":"Effects of transcranial direct current stimulation during sleep on memory performance in patients with schizophrenia","volume":"144","author":"G\u00f6der","year":"2013","journal-title":"Schizophrenia Research Schizophr Res"},{"key":"10.1007\/s13311-020-00959-7_bib216","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1523\/JNEUROSCI.0260-17.2017","article-title":"Promoting sleep oscillations and their functional coupling by transcranial stimulation enhances memory consolidation in mild cognitive impairment","volume":"37","author":"Ladenbauer","year":"2017","journal-title":"J Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib217","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.sleep.2015.10.016","article-title":"Effects of phase-locked acoustic stimulation during a nap on EEG spectra and declarative memory consolidation","volume":"20","author":"Ong","year":"2016","journal-title":"Sleep Med"},{"key":"10.1007\/s13311-020-00959-7_bib218","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.neuron.2013.03.006","article-title":"Auditory closed-loop stimulation of the sleep slow oscillation enhances memory","volume":"78","author":"Ngo","year":"2013","journal-title":"Neuron."},{"key":"10.1007\/s13311-020-00959-7_bib219","doi-asserted-by":"crossref","first-page":"zsx003","DOI":"10.1093\/sleep\/zsx003","article-title":"Enhanced Memory Consolidation Via Automatic Sound Stimulation During Non-REM Sleep","volume":"40","author":"Leminen","year":"2017","journal-title":"Sleep."},{"key":"10.1007\/s13311-020-00959-7_bib220","first-page":"zsz197","article-title":"Acoustic slow wave sleep enhancement via a novel, automated device improves executive function in middle-aged men","volume":"43","author":"Diep","year":"2020","journal-title":"SLEEPJ."},{"key":"10.1007\/s13311-020-00959-7_bib221","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fnhum.2017.00109","article-title":"Acoustic enhancement of sleep slow oscillations and concomitant memory improvement in older adults","volume":"11","author":"Papalambros","year":"2017","journal-title":"Front Hum Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib222","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnhum.2018.00088","article-title":"Performance of an ambulatory dry-EEG device for auditory closed-loop stimulation of sleep slow oscillations in the home environment","volume":"12","author":"Debellemaniere","year":"2018","journal-title":"Front Hum Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib223","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0306-19.2019","article-title":"Closed-loop acoustic stimulation enhances sleep oscillations but not memory performance","volume":"6","author":"Henin","year":"2019","journal-title":"eNeuro."},{"key":"10.1007\/s13311-020-00959-7_bib224","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jneumeth.2018.09.006","article-title":"Insights on auditory closed-loop stimulation targeting sleep spindles in slow oscillation up-states","volume":"316","author":"Ngo","year":"2019","journal-title":"J Neurosci Methods"},{"key":"10.1007\/s13311-020-00959-7_bib225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101567","article-title":"Sound asleep: Processing and retention of slow oscillation phase-targeted stimuli","volume":"9","author":"Cox","year":"2014","journal-title":"PLoS One"},{"key":"10.1007\/s13311-020-00959-7_bib226","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1111\/ejn.13334","article-title":"Timing matters: open-loop stimulation does not improve overnight consolidation of word pairs in humans","volume":"44","author":"Weigenand","year":"2016","journal-title":"Eur J Neurosci"},{"key":"10.1007\/s13311-020-00959-7_bib227","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/acn3.796","article-title":"Acoustic enhancement of sleep slow oscillations in mild cognitive impairment","volume":"6","author":"Papalambros","year":"2019","journal-title":"Ann Clin Transl Neurol"}],"updated-by":[{"DOI":"10.1007\/s13311-020-00980-w","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000}}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00959-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-020-00959-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792301190X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792301190X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-020-00959-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T06:37:55Z","timestamp":1704695875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187874792301190X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":227,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S187874792301190X"],"URL":"https:\/\/doi.org\/10.1007\/s13311-020-00959-7","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Treatment of Sleep Dysfunction in Neurodegenerative Disorders","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-020-00959-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1007\/s13311-020-00980-w","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The authors. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}