{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:06:55Z","timestamp":1768450015414,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s13311-021-01106-6","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T14:09:59Z","timestamp":1631023799000},"page":"2598-2607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Disease Reactivation after Fingolimod Discontinuation in Pregnant Multiple Sclerosis Patients"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-0949","authenticated-orcid":false,"given":"Assunta","family":"Bianco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-2297","authenticated-orcid":false,"given":"Matteo","family":"Lucchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5852-7743","authenticated-orcid":false,"given":"Rocco","family":"Totaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7527-575X","authenticated-orcid":false,"given":"Roberta","family":"Fantozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7693-2256","authenticated-orcid":false,"given":"Giovanna","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Di Lemme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-1709","authenticated-orcid":false,"given":"Giorgia","family":"Presicce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-4166","authenticated-orcid":false,"given":"Valeria","family":"Di Tommaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-0733","authenticated-orcid":false,"given":"Roberta","family":"Pastorino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-8170","authenticated-orcid":false,"given":"Chiara","family":"De Fino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-3299","authenticated-orcid":false,"given":"Valeria","family":"De Arcangelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-8545","authenticated-orcid":false,"given":"Diego","family":"Centonze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-114X","authenticated-orcid":false,"given":"Massimiliano","family":"Mirabella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-021-01106-6_bib1","unstructured":"MSIF. Atlas of MS 2013 (2013). Mapping multiple sclerosis around the world. https:\/\/www.msif.org\/wp-content\/uploads\/2019\/01\/Atlas-of-MS.pdf. Accessed 20 Feb 2021."},{"key":"10.1007\/s13311-021-01106-6_bib2","doi-asserted-by":"crossref","unstructured":"Povolo CA, Blair M, Mehta S, Rosehart H, Morrow SA. Predictors of vocational status among persons with multiple sclerosis. Multiple sclerosis and related disorders. 2019;36:101411.","DOI":"10.1016\/j.msard.2019.101411"},{"issue":"9648","key":"10.1007\/s13311-021-01106-6_bib3","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet (London, England)."},{"issue":"1","key":"10.1007\/s13311-021-01106-6_bib4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/CPJ.0b013e31823cc2c2","article-title":"Multiple sclerosis therapeutic strategies: Use second-line agents as first-line agents when time is of the essence","volume":"1","author":"Freedman","year":"2011","journal-title":"Neurology Clinical practice."},{"issue":"Pt 6","key":"10.1007\/s13311-021-01106-6_bib5","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/brain\/awh152","article-title":"Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse","volume":"127","author":"Vukusic","year":"2004","journal-title":"Brain: a journal of neurology."},{"issue":"Suppl 1","key":"10.1007\/s13311-021-01106-6_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000367640","article-title":"Pregnancy in multiple sclerosis","volume":"72","author":"Hellwig","year":"2014","journal-title":"European neurology."},{"issue":"5","key":"10.1007\/s13311-021-01106-6_bib7","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1055\/s-2007-991127","article-title":"Pregnancy and multiple sclerosis","volume":"27","author":"Houtchens","year":"2007","journal-title":"Seminars in neurology."},{"key":"10.1007\/s13311-021-01106-6_bib8","doi-asserted-by":"crossref","unstructured":"Zeydan B, Atkinson EJ, Weis DM, Smith CY, Gazzuola Rocca L, Rocca WA, et al. Reproductive history and progressive multiple sclerosis risk in women. Brain Commu. 2020;2(2):fcaa185.","DOI":"10.1093\/braincomms\/fcaa185"},{"key":"10.1007\/s13311-021-01106-6_bib9","doi-asserted-by":"crossref","unstructured":"Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group. The New England journal of medicine. 1998;339(5):285\u201391.","DOI":"10.1056\/NEJM199807303390501"},{"key":"10.1007\/s13311-021-01106-6_bib10","doi-asserted-by":"crossref","unstructured":"Battaglia M, Kobelt G, Ponzio M, Berg J, Capsa D, Dal\u00e9n J. New insights into the burden and costs of multiple sclerosis in Europe: Results for Italy. Multiple sclerosis (Houndmills, Basingstoke, England). 2017;23(2_suppl):104\u201316.","DOI":"10.1177\/1352458517708176"},{"issue":"4","key":"10.1007\/s13311-021-01106-6_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/2055217319891744","article-title":"Pregnancy and multiple sclerosis: Risk of unplanned pregnancy and drug exposure in utero","volume":"5","author":"Smith","year":"2019","journal-title":"Multiple sclerosis journal - experimental, translational and clinical."},{"issue":"6","key":"10.1007\/s13311-021-01106-6_bib12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/1352458516634872","article-title":"Interferon-beta exposure during first trimester is safe in women with multiple sclerosis-A prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry","volume":"22","author":"Thiel","year":"2016","journal-title":"Multiple sclerosis (Houndmills, Basingstoke, England)."},{"key":"10.1007\/s13311-021-01106-6_bib13","doi-asserted-by":"crossref","unstructured":"Tisovic K, Amezcua L. Women's Health: Contemporary Management of MS in Pregnancy and Post-Partum. Biomedicines. 2019;7(2).","DOI":"10.3390\/biomedicines7020032"},{"issue":"6","key":"10.1007\/s13311-021-01106-6_bib14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/1352458515623366","article-title":"Glatiramer acetate during early pregnancy: A prospective cohort study","volume":"22","author":"Herbstritt","year":"2016","journal-title":"Multiple sclerosis (Houndmills, Basingstoke, England)."},{"issue":"1","key":"10.1007\/s13311-021-01106-6_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7224\/1537-2073.2016-079","article-title":"Pregnancy Outcomes from the Branded Glatiramer Acetate Pregnancy Database","volume":"20","author":"Sandberg-Wollheim","year":"2018","journal-title":"International journal of MS care."},{"issue":"10","key":"10.1007\/s13311-021-01106-6_bib16","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1212\/WNL.0000000000005065","article-title":"Relapse occurrence in women with multiple sclerosis during pregnancy in the new treatment era","volume":"90","author":"Alroughani","year":"2018","journal-title":"Neurology."},{"issue":"5","key":"10.1007\/s13311-021-01106-6_bib17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nrneurol.2015.53","article-title":"Multiple sclerosis and pregnancy in the \u2018treatment era\u2018","volume":"11","author":"Vukusic","year":"2015","journal-title":"Nature reviews Neurology."},{"issue":"7","key":"10.1007\/s13311-021-01106-6_bib18","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/jamaneurol.2016.0826","article-title":"Rebound Syndrome in Patients With Multiple Sclerosis After Cessation of Fingolimod Treatment","volume":"73","author":"Hatcher","year":"2016","journal-title":"JAMA neurology."},{"key":"10.1007\/s13311-021-01106-6_bib19","doi-asserted-by":"crossref","unstructured":"Novi G, Ghezzi A, Pizzorno M, Lapucci C, Bandini F, Annovazzi P, et al. Dramatic rebounds of MS during pregnancy following fingolimod withdrawal. Neurology(R) neuroimmunology & neuroinflammation. 2017;4(5):e377.","DOI":"10.1212\/NXI.0000000000000377"},{"key":"10.1007\/s13311-021-01106-6_bib20","doi-asserted-by":"crossref","unstructured":"Sep\u00falveda M, Montejo C, Llufriu S, Sola-Valls N, Reyes D, Martinez-Lapiscina EH, et al. Rebound of multiple sclerosis activity after fingolimod withdrawal due to planning pregnancy: Analysis of predisposing factors. Multiple sclerosis and related disorders. 2020;38:101483.","DOI":"10.1016\/j.msard.2019.101483"},{"issue":"7","key":"10.1007\/s13311-021-01106-6_bib21","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1177\/1352458517731913","article-title":"Recurrence of disease activity during pregnancy after cessation of fingolimod in multiple sclerosis","volume":"24","author":"Meinl","year":"2018","journal-title":"Multiple sclerosis (Houndmills, Basingstoke, England)."},{"issue":"8","key":"10.1007\/s13311-021-01106-6_bib22","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1111\/ene.12195","article-title":"Rebound of disease activity during pregnancy after withdrawal of fingolimod","volume":"20","author":"Sempere","year":"2013","journal-title":"European journal of neurology."},{"key":"10.1007\/s13311-021-01106-6_bib23","doi-asserted-by":"crossref","unstructured":"Caniba\u00f1o B, Ali M, Mesraoua B, Melikyan G, Al Hail H, Ibrahim F, et al. Severe rebound disease activity after fingolimod withdrawal in a pregnant woman with multiple sclerosis managed with rituximab: A case study. Case reports in women's health. 2020;25:e00162.","DOI":"10.1016\/j.crwh.2019.e00162"},{"issue":"10","key":"10.1007\/s13311-021-01106-6_bib24","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/cns.12992","article-title":"Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod","volume":"24","author":"Evangelopoulos","year":"2018","journal-title":"CNS neuroscience & therapeutics."},{"issue":"10","key":"10.1007\/s13311-021-01106-6_bib25","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/ene.13694","article-title":"Clinical activity after fingolimod cessation: disease reactivation or rebound?","volume":"25","author":"Frau","year":"2018","journal-title":"European journal of neurology."},{"key":"10.1007\/s13311-021-01106-6_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.msard.2016.11.003","article-title":"Severe rebound after withdrawal of fingolimod treatment in patients with multiple sclerosis","volume":"11","author":"Gunduz","year":"2017","journal-title":"Multiple sclerosis and related disorders."},{"key":"10.1007\/s13311-021-01106-6_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fneur.2020.00105","article-title":"Pregnancy and the Postpartum Period in Women With Relapsing-Remitting Multiple Sclerosis Treated With Old and New Disease-Modifying Treatments: A Real-World Multicenter Experience","volume":"11","author":"Zangh\u00ec","year":"2020","journal-title":"Frontiers in neurology."},{"issue":"2","key":"10.1007\/s13311-021-01106-6_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s40120-019-00160-9","article-title":"Fingolimod Rebound: A Review of the Clinical Experience and Management Considerations","volume":"8","author":"Barry","year":"2019","journal-title":"Neurology and therapy."},{"issue":"2","key":"10.1007\/s13311-021-01106-6_bib29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"The Lancet Neurology."},{"issue":"1","key":"10.1007\/s13311-021-01106-6_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis","volume":"50","author":"McDonald","year":"2001","journal-title":"Annals of neurology."},{"issue":"11","key":"10.1007\/s13311-021-01106-6_bib31","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology."},{"key":"10.1007\/s13311-021-01106-6_bib32","doi-asserted-by":"crossref","unstructured":"Cuello JP, Mart\u00ednez Gin\u00e9s ML, Tejeda-Velarde A, Medina Heras S, Garc\u00eda Dom\u00ednguez JM, Fern\u00e1ndez Velasco JI, et al. Cytokine profile during pregnancy predicts relapses during pregnancy and postpartum in multiple sclerosis. Journal of the neurological sciences. 2020;414:116811.","DOI":"10.1016\/j.jns.2020.116811"},{"issue":"1","key":"10.1007\/s13311-021-01106-6_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.clim.2008.10.013","article-title":"T-bet, pSTAT1 and pSTAT3 expression in peripheral blood mononuclear cells during pregnancy correlates with post-partum activation of multiple sclerosis","volume":"131","author":"Iorio","year":"2009","journal-title":"Clinical immunology (Orlando, Fla)."},{"issue":"4","key":"10.1007\/s13311-021-01106-6_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMct1101691","article-title":"Fingolimod for multiple sclerosis","volume":"366","author":"Pelletier","year":"2012","journal-title":"The New England journal of medicine."},{"issue":"1","key":"10.1007\/s13311-021-01106-6_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pharmthera.2007.04.006","article-title":"Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology","volume":"115","author":"Brinkmann","year":"2007","journal-title":"Pharmacology & therapeutics."},{"issue":"8","key":"10.1007\/s13311-021-01106-6_bib36","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1212\/WNL.0000000000000137","article-title":"Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis","volume":"82","author":"Karlsson","year":"2014","journal-title":"Neurology."},{"key":"10.1007\/s13311-021-01106-6_bib37","unstructured":"European Medicines Agency. Updated restrictions for Gilenya: Multiple sclerosis medicine not to be used in pregnancy, July 2019, https:\/\/www.ema.europa.eu\/en\/documents\/press-release\/updated-restrictions-gilenyamultiple-sclerosis-medicine-not-be-used-pregnancy_en.pdf (accessed 6 April 2021)."},{"issue":"3","key":"10.1007\/s13311-021-01106-6_bib38","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/1352458520929628","article-title":"Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS study","volume":"27","author":"Pauliat","year":"2021","journal-title":"Multiple sclerosis (Houndmills, Basingstoke, England)."},{"key":"10.1007\/s13311-021-01106-6_bib39","doi-asserted-by":"crossref","unstructured":"Villaverde-Gonz\u00e1lez R, Candeliere-Merlicco A, Alonso-Fr\u00edas MA, Aparicio Castro E, Carrillo Alcaraz A, Mallada Frech\u00edn J, et al. Discontinuation of disease-modifying treatments in multiple sclerosis to plan a pregnancy: A retrospective registry study. Multiple sclerosis and related disorders. 2020;46:102518.","DOI":"10.1016\/j.msard.2020.102518"},{"issue":"14","key":"10.1007\/s13311-021-01106-6_bib40","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1212\/WNL.0b013e3182143564","article-title":"Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS","volume":"76","author":"Kowarik","year":"2011","journal-title":"Neurology."},{"key":"10.1007\/s13311-021-01106-6_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbi.2015.06.019","article-title":"Dysregulation of sphingosine 1 phosphate receptor-1 (S1P1) signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS rebound","volume":"50","author":"Cavone","year":"2015","journal-title":"Brain, behavior, and immunity."},{"issue":"3","key":"10.1007\/s13311-021-01106-6_bib42","doi-asserted-by":"crossref","DOI":"10.1177\/2055217317730096","article-title":"A comparison of multiple sclerosis disease activity after discontinuation of fingolimod and placebo","volume":"3","author":"Vermersch","year":"2017","journal-title":"Multiple sclerosis journal - experimental, translational and clinical."},{"issue":"1","key":"10.1007\/s13311-021-01106-6_bib43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/NRL.0000000000000154","article-title":"Factors Predictive of Severe Multiple Sclerosis Disease Reactivation After Fingolimod Cessation","volume":"23","author":"Uygunoglu","year":"2018","journal-title":"The neurologist."},{"key":"10.1007\/s13311-021-01106-6_bib44","unstructured":"Hemat S, Houtchens M, Vidal-Jordana A, Guger M, Landi D, D\u00b4Haeseleer M, et al. Disease activity during pregnancy after fingolimod withdrawal due to planning a pregnancy in women with multiple sclerosis. Poster presented at 70th American Academy of Neurology Annual Meeting; April 21\u201327, 2018; Los Angeles, CA ECTRIMS Online Library. 2018."}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-021-01106-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-021-01106-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923007262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923007262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-021-01106-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:47:10Z","timestamp":1761806830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923007262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1878747923007262"],"URL":"https:\/\/doi.org\/10.1007\/s13311-021-01106-6","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disease Reactivation after Fingolimod Discontinuation in Pregnant Multiple Sclerosis Patients","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-021-01106-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The authors. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}