{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:22:56Z","timestamp":1771230176529,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["GOIPG\/2015\/2804"],"award-info":[{"award-number":["GOIPG\/2015\/2804"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["202558\/2015-0"],"award-info":[{"award-number":["202558\/2015-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004770","name":"Universit\u00e0 degli Studi di Parma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004770","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s13311-021-01109-3","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T20:40:20Z","timestamp":1630701620000},"page":"2608-2622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hybrid Nanoparticles as a Novel Tool for Regulating Psychosine-Induced Neuroinflammation and Demyelination In Vitro and Ex vivo"],"prefix":"10.1016","volume":"18","author":[{"given":"Adryana","family":"Clementino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Velasco-Estevez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Buttini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-1456","authenticated-orcid":false,"given":"Fabio","family":"Sonvico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumlesh K.","family":"Dev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1007\/s13311-021-01109-3_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/08830738030180090201","article-title":"Globoid Cell Leukodystrophy (Krabbe's Disease): Update","volume":"18","author":"Suzuki","year":"2003","journal-title":"J Child Neurol."},{"issue":"7","key":"10.1007\/s13311-021-01109-3_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1096\/fj.01-0798com","article-title":"Galactosylsphingosine (psychosine) -induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C\/EBP: implications for Krabbe disease","volume":"16","author":"Giri","year":"2002","journal-title":"Faseb J."},{"issue":"6","key":"10.1007\/s13311-021-01109-3_bib3","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1046\/j.1471-4159.2003.01941.x","article-title":"Molecular mechanism of psychosine-induced cell death in human oligodendrocyte cell line","volume":"86","author":"Haq","year":"2003","journal-title":"J Neurochem."},{"issue":"21","key":"10.1007\/s13311-021-01109-3_bib4","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1242\/jcs.169342","article-title":"Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling","volume":"128","author":"O'Sullivan","year":"2015","journal-title":"J Cell Sci."},{"issue":"5","key":"10.1007\/s13311-021-01109-3_bib5","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1111\/j.1471-4159.2008.05279.x","article-title":"The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe Disease","volume":"105","author":"Giri","year":"2008","journal-title":"J Neurochem."},{"issue":"11","key":"10.1007\/s13311-021-01109-3_bib6","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/jnr.23822","article-title":"Treatment for Krabbe's disease: Finding the combination","volume":"94","author":"Mikulka","year":"2016","journal-title":"J Neurosci Res."},{"issue":"1","key":"10.1007\/s13311-021-01109-3_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood-brain barrier: bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"Neurother."},{"issue":"7","key":"10.1007\/s13311-021-01109-3_bib8","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.addr.2011.11.010","article-title":"Modern methods for delivery of drugs across the blood\u2013brain barrier","volume":"64","author":"Chen","year":"2012","journal-title":"Adv Drug Deliver Rev."},{"issue":"5","key":"10.1007\/s13311-021-01109-3_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3390\/pharmaceutics11050248","article-title":"Drug Delivery Technology to the CNS in the Treatment of Brain Tumors: The Sherbrooke Experience","volume":"11","author":"Fortin","year":"2019","journal-title":"Pharmaceutics."},{"issue":"10","key":"10.1007\/s13311-021-01109-3_bib10","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3390\/ph5101092","article-title":"Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors","volume":"5","author":"Taki","year":"2012","journal-title":"Pharmaceuticals."},{"key":"10.1007\/s13311-021-01109-3_bib11","doi-asserted-by":"crossref","unstructured":"Lorenzoni R, Davies S, Cordenonsi LM, Vi\u00e7osa JA da S, Mezzomo NJ, Oliveira AL de, et al. Lipid-core nanocapsules containing simvastatin improve the cognitive impairment induced by obesity and hypercholesterolemia in adult rats. Eur J Pharm Sci. 2020;151:105397.","DOI":"10.1016\/j.ejps.2020.105397"},{"key":"10.1007\/s13311-021-01109-3_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejps.2018.10.006","article-title":"Development of injectable liposomes and drug-in-cyclodextrin-in-liposome formulations encapsulating estetrol to prevent cerebral ischemia of premature babies","volume":"127","author":"Palazzo","year":"2019","journal-title":"Eur J Pharm Sci."},{"issue":"1","key":"10.1007\/s13311-021-01109-3_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejpb.2014.02.007","article-title":"Haloperidol-loaded intranasally administered lectin functionalized poly(ethylene glycol)\u2013block-poly(d, l)-lactic-co-glycolic acid (PEG\u2013PLGA) nanoparticles for the treatment of schizophrenia","volume":"87","author":"Piazza","year":"2014","journal-title":"Eur J Pharm Biopharm."},{"key":"10.1007\/s13311-021-01109-3_bib14","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.2147\/IJN.S119033","article-title":"The nasal delivery of nanoencapsulated statins \u2013 an approach for brain delivery","volume":"11","author":"Clementino","year":"2016","journal-title":"Int J Nanomed."},{"key":"10.1007\/s13311-021-01109-3_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jpba.2018.03.046","article-title":"Development and validation of a RP-HPLC method for the simultaneous detection and quantification of simvastatin's isoforms and coenzyme Q10 in lecithin\/chitosan nanoparticles","volume":"155","author":"Clementino","year":"2018","journal-title":"J Pharmaceut Biomed Anal."},{"issue":"6","key":"10.1007\/s13311-021-01109-3_bib16","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/jnc.14313","article-title":"Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia","volume":"144","author":"O'Sullivan","year":"2018","journal-title":"J Neurochem."},{"issue":"2","key":"10.1007\/s13311-021-01109-3_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/glia.22757","article-title":"EBI2 regulates intracellular signaling and migration in human astrocyte","volume":"63","author":"Rutkowska","year":"2014","journal-title":"Glia."},{"issue":"5","key":"10.1007\/s13311-021-01109-3_bib18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/glia.22637","article-title":"The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes","volume":"62","author":"Elain","year":"2014","journal-title":"Glia."},{"key":"10.1007\/s13311-021-01109-3_bib19","doi-asserted-by":"crossref","unstructured":"Misslin C, Velasco-Estevez M, Albert M, O'Sullivan SA, Dev KK. Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination. Plos One. 2017;12(11):e0187217.","DOI":"10.1371\/journal.pone.0187217"},{"issue":"10","key":"10.1007\/s13311-021-01109-3_bib20","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s11745-997-0133-x","article-title":"Physicochemical characterization of psychosine by 1H nuclear magnetic resonance and electron microscopy","volume":"32","author":"Orfi","year":"1997","journal-title":"Lipids."},{"issue":"7","key":"10.1007\/s13311-021-01109-3_bib21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/glia.23148","article-title":"Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors","volume":"65","author":"O'Sullivan","year":"2017","journal-title":"Glia."},{"issue":"2","key":"10.1007\/s13311-021-01109-3_bib22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/glia.23722","article-title":"Inhibition of Piezo1 attenuates demyelination in the central nervous system","volume":"68","author":"Velasco-Estevez","year":"2020","journal-title":"Glia."},{"key":"10.1007\/s13311-021-01109-3_bib23","doi-asserted-by":"crossref","unstructured":"Louis ED, Ma K, Babij R, Cort\u00e9s E, Liem RK, Vonsattel J-PG, et al. Neurofilament protein levels: Quantitative analysis in essential tremor cerebellar cortex. Neurosci Lett. 2012;518(1):49\u201354.","DOI":"10.1016\/j.neulet.2012.04.054"},{"issue":"1","key":"10.1007\/s13311-021-01109-3_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/pharmaceutics10010034","article-title":"Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting","volume":"10","author":"Sonvico","year":"2018","journal-title":"Pharmaceutics."},{"issue":"7","key":"10.1007\/s13311-021-01109-3_bib25","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.xphs.2020.04.007","article-title":"Coated Lipidic Nanoparticles as a New Strategy for Enhancing Nose-to-Brain Delivery of a Hydrophilic Drug Molecule","volume":"109","author":"Salem","year":"2020","journal-title":"J Pharm Sci."},{"issue":"1\u20132","key":"10.1007\/s13311-021-01109-3_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijpharm.2015.06.021","article-title":"Ex vivo permeation of tamoxifen and its 4-OH metabolite through rat intestine from lecithin\/chitosan nanoparticles","volume":"491","author":"Barbieri","year":"2015","journal-title":"Int J Pharm."},{"issue":"1","key":"10.1007\/s13311-021-01109-3_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/ijms18010032","article-title":"In Vivo Assessment of Clobetasol Propionate-Loaded Lecithin-Chitosan Nanoparticles for Skin Delivery","volume":"18","author":"\u015eenyi\u011fit","year":"2016","journal-title":"Int J Mol Sci."},{"issue":"3","key":"10.1007\/s13311-021-01109-3_bib28","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3390\/brainsci3031109","article-title":"Astrocyte Regulation of CNS Inflammation and Remyelination","volume":"3","author":"Claycomb","year":"2013","journal-title":"Brain Sci."},{"issue":"2","key":"10.1007\/s13311-021-01109-3_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00401-010-0704-z","article-title":"Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination","volume":"120","author":"Sharma","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1007\/s13311-021-01109-3_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12974-016-0494-x","article-title":"The dual S1PR1\/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures","volume":"13","author":"O'Sullivan","year":"2016","journal-title":"J Neuroinflamm."},{"key":"10.1007\/s13311-021-01109-3_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","article-title":"DLS and zeta potential - What they are and what they are not?","volume":"235","author":"Bhattacharjee","year":"2016","journal-title":"J Control Release."},{"issue":"2","key":"10.1007\/s13311-021-01109-3_bib32","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1016\/j.ymgme.2019.11.374","article-title":"Effects of cyclodextrin analogs on psychosine cytotoxicity","volume":"129","author":"Salazar","year":"2020","journal-title":"Mol Genet Metab."},{"key":"10.1007\/s13311-021-01109-3_bib33","doi-asserted-by":"crossref","unstructured":"D\u00edaz Y de las MZ, Caby S, Bongarzone ER, Fanani ML. Psychosine remodels model lipid membranes at neutral pH. Biochim Biophys Acta. 2018;1860(12):2515\u20132526.","DOI":"10.1016\/j.bbamem.2018.09.015"},{"issue":"12","key":"10.1007\/s13311-021-01109-3_bib34","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1194\/jlr.M039610","article-title":"Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture","volume":"54","author":"Hawkins-Salsbury","year":"2013","journal-title":"J Lipid Res."},{"issue":"1","key":"10.1007\/s13311-021-01109-3_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1742-2094-2-25","article-title":"A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices","volume":"2","author":"Huuskonen","year":"2005","journal-title":"J Neuroinflamm."},{"issue":"3","key":"10.1007\/s13311-021-01109-3_bib36","doi-asserted-by":"crossref","first-page":"e2671","DOI":"10.1038\/cddis.2017.97","article-title":"Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures","volume":"8","author":"Croft","year":"2017","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1007\/s13311-021-01109-3_bib37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jconrel.2013.02.009","article-title":"Lecithin\/chitosan controlled release nanopreparations of tamoxifen citrate: Loading, enzyme-trigger release and cell uptake","volume":"167","author":"Barbieri","year":"2013","journal-title":"J Control Release."}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-021-01109-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-021-01109-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923007274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923007274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-021-01109-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:40:58Z","timestamp":1761806458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923007274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1878747923007274"],"URL":"https:\/\/doi.org\/10.1007\/s13311-021-01109-3","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hybrid Nanoparticles as a Novel Tool for Regulating Psychosine-Induced Neuroinflammation and Demyelination In Vitro and Ex vivo","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-021-01109-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The authors. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}