{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:49:10Z","timestamp":1790732950906,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s13311-022-01300-0","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T14:04:00Z","timestamp":1664460240000},"page":"1966-1975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["ATH434 Rescues Pre-motor Hyposmia in a Mouse Model of Parkinsonism"],"prefix":"10.1016","volume":"19","author":[{"given":"Leah C.","family":"Beauchamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang M.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Vella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Adlard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley I.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Finkelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Barnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"s1","key":"10.1007\/s13311-022-01300-0_bib1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J Parkinsons Dis"},{"issue":"S3","key":"10.1007\/s13311-022-01300-0_bib2","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","article-title":"Oxidative stress in Parkinson's disease","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann Neurol"},{"issue":"6","key":"10.1007\/s13311-022-01300-0_bib3","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1039\/C3SC53461H","article-title":"An iron\u2013dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta","volume":"5","author":"Hare","year":"2014","journal-title":"Chem Sci"},{"issue":"26","key":"10.1007\/s13311-022-01300-0_bib4","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.1073\/pnas.0403495101","article-title":"The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging","volume":"101","author":"Zecca","year":"2004","journal-title":"Proc Natl Acad Sci"},{"key":"10.1007\/s13311-022-01300-0_bib5","article-title":"The Sources of reactive oxygen species and its possible role in the pathogenesis of Parkinson's disease.","volume":"2018","author":"Weng","year":"2018","journal-title":"Parkinsons Dis."},{"issue":"2","key":"10.1007\/s13311-022-01300-0_bib6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1471-4159.1989.tb09133.x","article-title":"Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease","volume":"52","author":"Dexter","year":"1989","journal-title":"J Neurochem"},{"issue":"6","key":"10.1007\/s13311-022-01300-0_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13031","article-title":"Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease","volume":"18","author":"Trist","year":"2019","journal-title":"Aging Cell"},{"key":"10.1007\/s13311-022-01300-0_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/624925","article-title":"Oxidative stress in genetic mouse models of Parkinson's disease","volume":"2012","author":"Var\u00e7in","year":"2012","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1007\/s13311-022-01300-0_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"Non-motor symptoms of Parkinson's disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"The Lancet Neurology"},{"issue":"5","key":"10.1007\/s13311-022-01300-0_bib10","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/ene.12950","article-title":"The impact of non-motor symptoms on the quality of life of Parkinson's disease patients: a longitudinal study","volume":"23","author":"Prakash","year":"2016","journal-title":"Eur J Neurol"},{"issue":"7","key":"10.1007\/s13311-022-01300-0_bib11","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.parkreldis.2008.12.005","article-title":"Prevalence of smell loss in Parkinson's disease\u2013a multicenter study","volume":"15","author":"Haehner","year":"2009","journal-title":"Parkinsonism Relat Disord"},{"issue":"S2","key":"10.1007\/s13311-022-01300-0_bib12","doi-asserted-by":"crossref","first-page":"S656","DOI":"10.1002\/mds.22672","article-title":"When does Parkinson's disease begin?","volume":"24","author":"Gaig","year":"2009","journal-title":"Mov Disord"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40478-018-0560-y","article-title":"Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease","volume":"6","author":"Beauchamp","year":"2018","journal-title":"Acta Neuropathol Commun"},{"issue":"2","key":"10.1007\/s13311-022-01300-0_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm.2613","article-title":"Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export","volume":"18","author":"Lei","year":"2012","journal-title":"Nat Med"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1750-1326-9-29","article-title":"Motor and cognitive deficits in aged tau knockout mice in two background strains","volume":"9","author":"Lei","year":"2014","journal-title":"Mol Neurodegener"},{"issue":"Pt 4","key":"10.1007\/s13311-022-01300-0_bib16","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/114.4.1953","article-title":"Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia","volume":"114","author":"Dexter","year":"1991","journal-title":"Brain"},{"issue":"2","key":"10.1007\/s13311-022-01300-0_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1471-4159.1989.tb09150.x","article-title":"Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains","volume":"52","author":"Riederer","year":"1989","journal-title":"J Neurochem"},{"issue":"8569","key":"10.1007\/s13311-022-01300-0_bib18","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0140-6736(87)91361-4","article-title":"Increased nigral iron content in postmortem parkinsonian brain","volume":"2","author":"Dexter","year":"1987","journal-title":"Lancet"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib19","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1038\/s41598-017-10659-6","article-title":"Metal concentrations and distributions in the human olfactory bulb in Parkinson's disease","volume":"7","author":"Gardner","year":"2017","journal-title":"Sci Rep"},{"issue":"12","key":"10.1007\/s13311-022-01300-0_bib20","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1212\/01.wnl.0000276988.50742.5e","article-title":"San Francisco\/Oakland Bay Bridge Welder Study: olfactory function","volume":"69","author":"Antunes","year":"2007","journal-title":"Neurology"},{"issue":"11","key":"10.1007\/s13311-022-01300-0_bib21","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1055\/s-1999-8762","article-title":"[Anosmia caused by inhaled hazardous substances. Significance for expert assessment general practice].","volume":"78","author":"Klimek","year":"1999","journal-title":"Laryngo- rhino- otologie."},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-017-0456-2","article-title":"The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease","volume":"5","author":"Finkelstein","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"10.1007\/s13311-022-01300-0_bib23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.nbd.2015.03.015","article-title":"Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse","volume":"81","author":"Lei","year":"2015","journal-title":"Neurobiol Dis"},{"issue":"Pt 6","key":"10.1007\/s13311-022-01300-0_bib24","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1242\/jcs.114.6.1179","article-title":"Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice","volume":"114","author":"Dawson","year":"2001","journal-title":"J Cell Sci"},{"issue":"4","key":"10.1007\/s13311-022-01300-0_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060691","article-title":"Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease","volume":"8","author":"Petit","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1007\/s13311-022-01300-0_bib26","article-title":"Measuring motor coordination in mice","volume":"75","author":"Deacon","year":"2013","journal-title":"Journal of visualized experiments : JoVE"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0270(96)02211-X","article-title":"Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion","volume":"73","author":"Matsuura","year":"1997","journal-title":"J Neurosci Methods"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40478-017-0456-2","article-title":"The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease","volume":"5","author":"Finkelstein","year":"2017","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005072-196801000-00001","article-title":"Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue","volume":"27","author":"Earle","year":"1968","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"10.1007\/s13311-022-01300-0_bib30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF01244786","article-title":"Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain","volume":"74","author":"Sofic","year":"1988","journal-title":"J Neural Transm"},{"issue":"6","key":"10.1007\/s13311-022-01300-0_bib31","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1111\/j.1471-4159.1989.tb07264.x","article-title":"Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease","volume":"52","author":"Dexter","year":"1989","journal-title":"J Neurochem"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00401-013-1136-3","article-title":"Olfactory impairment and pathology in neurodegenerative disorders with brain iron accumulation.","volume":"126","author":"Dziewulska","year":"2013","journal-title":"Acta neuropathologica."},{"issue":"47","key":"10.1007\/s13311-022-01300-0_bib33","doi-asserted-by":"crossref","first-page":"44284","DOI":"10.1074\/jbc.M105343200","article-title":"Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure.","volume":"276","author":"Uversky","year":"2001","journal-title":"J Biol Chem."},{"issue":"12","key":"10.1007\/s13311-022-01300-0_bib34","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00415-009-0063-7","article-title":"Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson's disease","volume":"255","author":"Bharucha","year":"2008","journal-title":"J Neurol"},{"issue":"5","key":"10.1007\/s13311-022-01300-0_bib35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-0773.1999.tb02015.x","article-title":"Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease","volume":"85","author":"Torsdottir","year":"1999","journal-title":"Pharmacol Toxicol"},{"issue":"9","key":"10.1007\/s13311-022-01300-0_bib36","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s11064-008-9610-3","article-title":"Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.","volume":"33","author":"Boll","year":"2008","journal-title":"Neurochem Res."},{"issue":"3","key":"10.1007\/s13311-022-01300-0_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3940(99)00221-9","article-title":"Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease","volume":"265","author":"Boll","year":"1999","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1007\/s13311-022-01300-0_bib38","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/ana.23817","article-title":"Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease","volume":"73","author":"Ayton","year":"2013","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1007\/s13311-022-01300-0_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0022-510X(99)00192-6","article-title":"Hydroxyl radical and superoxide dismutase in blood of patients with Parkinson's disease: relationship to clinical data","volume":"170","author":"Ihara","year":"1999","journal-title":"J Neurol Sci"},{"issue":"4","key":"10.1007\/s13311-022-01300-0_bib40","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/etc.5620200427","article-title":"Effects of copper on olfaction of Colorado pikeminnow","volume":"20","author":"Beyers","year":"2001","journal-title":"Environ Toxicol Chem"},{"issue":"4","key":"10.1007\/s13311-022-01300-0_bib41","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF01623554","article-title":"Acute metal toxicology of olfaction in coho salmon: behavior, receptors, and odor-metal complexation","volume":"36","author":"Rehnberg","year":"1986","journal-title":"Bull Environ Contam Toxicol"},{"issue":"7","key":"10.1007\/s13311-022-01300-0_bib42","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1139\/f76-197","article-title":"Effects of mercury and copper on the olfactory response in rainbow trout, Salmo gairdneri","volume":"33","author":"Hara","year":"1976","journal-title":"J Fish Res Board Can"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s12035-013-8514-7","article-title":"Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection","volume":"49","author":"da Silva","year":"2014","journal-title":"Mol Neurobiol"},{"issue":"12","key":"10.1007\/s13311-022-01300-0_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144848","article-title":"Iron chelators and antioxidants regenerate neuritic tree and nigrostriatal fibers of MPP+\/MPTP-lesioned dopaminergic neurons","volume":"10","author":"Aguirre","year":"2015","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1007\/s13311-022-01300-0_bib45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40478-017-0456-2","article-title":"The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease","volume":"5","author":"Finkelstein","year":"2017","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"10.1007\/s13311-022-01300-0_bib46","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/1531-8257(199907)14:4<612::AID-MDS1010>3.0.CO;2-6","article-title":"Apomorphine protects against MPTP-induced neurotoxicity in mice","volume":"14","author":"Grunblatt","year":"1999","journal-title":"Movement disorders : official journal of the Movement Disorder Society"},{"key":"10.1007\/s13311-022-01300-0_bib47","first-page":"57","article-title":"Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6-hydroxydopamine induced neurotoxicity","volume":"55","author":"Grunblatt","year":"1999","journal-title":"J Neural Transm Suppl"},{"issue":"6","key":"10.1007\/s13311-022-01300-0_bib48","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0896-6273(03)00126-0","article-title":"Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease","volume":"37","author":"Kaur","year":"2003","journal-title":"Neuron"},{"issue":"2","key":"10.1007\/s13311-022-01300-0_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.mad.2004.08.023","article-title":"Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases","volume":"126","author":"Youdim","year":"2005","journal-title":"Mech Ageing Dev"},{"issue":"2","key":"10.1007\/s13311-022-01300-0_bib50","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbrc.2005.05.150","article-title":"Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration","volume":"333","author":"Zhang","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"14","key":"10.1007\/s13311-022-01300-0_bib51","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1096\/fj.07-8386com","article-title":"Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators","volume":"21","author":"Zhu","year":"2007","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"7","key":"10.1007\/s13311-022-01300-0_bib52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/biom9070269","article-title":"Metal chelation therapy and Parkinson's disease: a critical review on the thermodynamics of complex formation between relevant metal ions and promising or established drugs","volume":"9","author":"Tosato","year":"2019","journal-title":"Biomolecules"},{"issue":"4","key":"10.1007\/s13311-022-01300-0_bib53","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0163-7827(03)00014-6","article-title":"4-Hydroxy-2-nonenal: a product and mediator of oxidative stress","volume":"42","author":"Uchida","year":"2003","journal-title":"Prog Lipid Res"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-022-01300-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-022-01300-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923001484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923001484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-022-01300-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:35:15Z","timestamp":1761806115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923001484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1878747923001484"],"URL":"https:\/\/doi.org\/10.1007\/s13311-022-01300-0","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATH434 Rescues Pre-motor Hyposmia in a Mouse Model of Parkinsonism","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-022-01300-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The Author(s). Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}