{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:38:23Z","timestamp":1792100303417,"version":"4.4.0"},"reference-count":129,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s13311-023-01411-2","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T12:03:27Z","timestamp":1690286607000},"page":"1457-1471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Management Strategies Based on Multi-Modality Neuromonitoring in Severe Traumatic Brain Injury"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-4830","authenticated-orcid":false,"given":"Christos","family":"Lazaridis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Foreman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s13311-023-01411-2_bib1","doi-asserted-by":"crossref","unstructured":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(1):56\u201387.","DOI":"10.1016\/S1474-4422(18)30444-7"},{"key":"10.1007\/s13311-023-01411-2_bib2","first-page":"1","article-title":"Estimating the global incidence of traumatic brain injury","volume":"1","author":"Dewan","year":"2018","journal-title":"J Neurosurg"},{"key":"10.1007\/s13311-023-01411-2_bib3","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1089\/neu.2015.4233","article-title":"A state-of-the-science overview of randomized controlled trials evaluating acute management of moderate-to-severe traumatic brain injury","volume":"33","author":"Bragge","year":"2016","journal-title":"J Neurotrauma"},{"issue":"7250","key":"10.1007\/s13311-023-01411-2_bib4","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1136\/bmj.320.7250.1631","article-title":"Disability in young people and adults one year after head injury: prospective cohort study","volume":"320","author":"Thornhill","year":"2000","journal-title":"BMJ"},{"issue":"2","key":"10.1007\/s13311-023-01411-2_bib5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00005373-199302000-00006","article-title":"The role of secondary brain injury in determining outcome from severe head injury","volume":"34","author":"Chesnut","year":"1993","journal-title":"J Trauma"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00006123-199601000-00007","article-title":"Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury","volume":"38","author":"van Santbrink","year":"1996","journal-title":"Neurosurgery"},{"issue":"10","key":"10.1007\/s13311-023-01411-2_bib7","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1097\/00003246-199910000-00002","article-title":"Prevention of secondary ischemic insults after severe head injury","volume":"27","author":"Robertson","year":"1999","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib8","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s00701-017-3338-2","article-title":"A systematic review of cerebral microdialysis and outcomes in TBI: relationships to patient functional outcome, neurophysiologic measures, and tissue outcome","volume":"159","author":"Zeiler","year":"2017","journal-title":"Acta Neurochir (Wien)"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00130478-200007000-00003","article-title":"Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: lessons learned from the bedside","volume":"1","author":"Kochanek","year":"2000","journal-title":"Pediatr Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jcrc.2016.09.027","article-title":"Cerebral oxidative metabolism failure in traumatic brain injury: \u201cbrain shock\u201d","volume":"37","author":"Lazaridis","year":"2017","journal-title":"J Crit Care"},{"key":"10.1007\/s13311-023-01411-2_bib11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.wneu.2019.01.047","article-title":"Sustainability of applied intracranial multimodality neuromonitoring after severe brain injury","volume":"124","author":"Foreman","year":"2019","journal-title":"World Neurosurg"},{"issue":"7","key":"10.1007\/s13311-023-01411-2_bib12","article-title":"Brain shock-toward pathophysiologic phenotyping in traumatic brain injury","volume":"4","author":"Lazaridis","year":"2022","journal-title":"Crit Care Explor"},{"issue":"4","key":"10.1007\/s13311-023-01411-2_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nec.2016.05.010","article-title":"The role of multimodal invasive monitoring in acute traumatic brain injury","volume":"27","author":"Lazaridis","year":"2016","journal-title":"Neurosurg Clin N Am"},{"key":"10.1007\/s13311-023-01411-2_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","article-title":"Guidelines for the management of severe traumatic brain injury, fourth edition","volume":"80","author":"Carney","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1007\/s13311-023-01411-2_bib15","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1007\/s00134-019-05805-9","article-title":"A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)","volume":"45","author":"Hawryluk","year":"2019","journal-title":"Intensive Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13054-017-1816-9","article-title":"CENTER-TBI Investigators: variation in monitoring and treatment policies for in- tracranial hypertension in traumatic brain injury: a survey in 66 neu- rotrauma centers participating in the CENTER-TBI study","volume":"21","author":"Cnossen","year":"2017","journal-title":"Crit Care"},{"key":"10.1007\/s13311-023-01411-2_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jcrc.2017.01.005","article-title":"Hemodynamic and neuro-monitoring for neurocritically ill patients: an international survey of intensivists","volume":"39","author":"Sivakumar","year":"2017","journal-title":"J Crit Care"},{"key":"10.1007\/s13311-023-01411-2_bib18","first-page":"1","article-title":"Managing severe traumatic brain injury across resource settings: Latin American perspectives","volume":"12","author":"Alvarado-Dyer","year":"2023","journal-title":"Neurocrit Care"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12028-022-01605-0","article-title":"Latin America Brain Injury Consortium (LABIC) members. Current practices for intracranial pressure and cerebral oxygenation monitoring in severe traumatic brain injury: a Latin American survey","volume":"38","author":"Godoy","year":"2023","journal-title":"Neurocrit Care"},{"issue":"2","key":"10.1007\/s13311-023-01411-2_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s12028-011-9630-8","article-title":"Critical thresholds for cerebrovascular reactivity after traumatic brain injury","volume":"16","author":"Sorrentino","year":"2012","journal-title":"Neurocrit Care"},{"issue":"Suppl","key":"10.1007\/s13311-023-01411-2_bib21","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.3171\/sup.1991.75.1s.0s59","article-title":"Impact of ICP instability and hypotension on outcome in patients with severe head trauma","volume":"75","author":"Marmarou","year":"1991","journal-title":"J Neurosurg"},{"key":"10.1007\/s13311-023-01411-2_bib22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00134-007-0948-9","article-title":"Refractory intracranial hypertension and \u201csecond tier\u201d therapies in traumatic brain injury","volume":"34","author":"Stocchetti","year":"2008","journal-title":"Intensive Care Med"},{"issue":"22","key":"10.1007\/s13311-023-01411-2_bib23","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMra1208708","article-title":"Traumatic intracranial hypertension","volume":"370","author":"Stocchetti","year":"2014","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1007\/s13311-023-01411-2_bib24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00134-002-1235-4","article-title":"Specialist neurocritical care and outcome from head injury","volume":"28","author":"Patel","year":"2002","journal-title":"Intensive Care Med"},{"issue":"8","key":"10.1007\/s13311-023-01411-2_bib25","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1097\/00003246-200208000-00033","article-title":"Brain trauma foundation. Management of severe head injury: institutional variations in care and effect on outcome.","volume":"30","author":"Bulger","year":"2002","journal-title":"Crit Care Med."},{"issue":"9","key":"10.1007\/s13311-023-01411-2_bib26","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1097\/00003246-200209000-00029","article-title":"Outcome after traumatic brain injury improved by an organized secondary insult program and standardized neurointensive care","volume":"30","author":"Elf","year":"2002","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib27","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/01.TA.0000115650.07193.66","article-title":"Management of brain-injured patients by an evidence-based medicine protocol improves outcomes and decreases hospital charges.","volume":"56","author":"Fakhry","year":"2004","journal-title":"J Trauma."},{"key":"10.1007\/s13311-023-01411-2_bib28","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1089\/neu.2012.2802","article-title":"Intracranial pressure monitoring in severe traumatic brain injury: results from the American College of Surgeons Trauma Quality Improvement Program","volume":"30","author":"Alali","year":"2013","journal-title":"J Neurotrauma"},{"issue":"6","key":"10.1007\/s13311-023-01411-2_bib29","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3171\/2018.7.JNS18270","article-title":"The effect of ICP monitoring in severe traumatic brain injury: a propensity score-weighted and adjusted regression approach","volume":"131","author":"R\u00f8nning","year":"2018","journal-title":"J Neurosurg"},{"issue":"10","key":"10.1007\/s13311-023-01411-2_bib30","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1097\/01.CCM.0000181300.99078.B5","article-title":"Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury","volume":"33","author":"Cremer","year":"2005","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1007\/s13311-023-01411-2_bib31","first-page":"335","article-title":"Intracranial pressure monitoring in brain-injured patients is associated with worsening of survival","volume":"64","author":"Shafi","year":"2008","journal-title":"J Trauma"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/JETS.JETS_59_18","article-title":"The association of intracranial pressure monitoring and mortality: a propensity score-matched cohort of isolated severe blunt traumatic brain injury","volume":"12","author":"Ahl","year":"2019","journal-title":"J Emerg Trauma Shock."},{"key":"10.1007\/s13311-023-01411-2_bib33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.25259\/SNI_123_2020","article-title":"Adherence to brain trauma foundation guidelines for intracranial pressure monitoring in severe traumatic brain injury and the effect on outcome: a population-based study","volume":"11","author":"Khormi","year":"2020","journal-title":"Surg Neurol Int."},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00383-020-04618-y","article-title":"Intracranial pressure monitoring associated with increased mortality in pediatric brain injuries","volume":"36","author":"Delaplain","year":"2020","journal-title":"Pediatr Surg Int"},{"issue":"26","key":"10.1007\/s13311-023-01411-2_bib35","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1056\/NEJMoa1207363","article-title":"Global neurotrauma research group. A trial of intracranial-pressure monitoring in traumatic brain injury.","volume":"367","author":"Chesnut","year":"2012","journal-title":"N Engl J Med."},{"issue":"9","key":"10.1007\/s13311-023-01411-2_bib36","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/jamaneurol.2020.1310","article-title":"Analysis of normal high-frequency intracranial pressure values and treatment threshold in neurocritical care patients: insights into normal values and a potential treatment threshold","volume":"77","author":"Hawryluk","year":"2020","journal-title":"JAMA Neurol"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s12028-020-00940-4","article-title":"Intracranial pressure threshold heuristics in traumatic brain injury: one, none, many!","volume":"32","author":"Lazaridis","year":"2020","journal-title":"neurocrit care."},{"issue":"8","key":"10.1007\/s13311-023-01411-2_bib38","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1097\/CCM.0000000000004395","article-title":"Situational intracranial pressure management: an argument against a fixed treatment threshold","volume":"48","author":"Chesnut","year":"2020","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1007\/s13311-023-01411-2_bib39","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/CCM.0000000000004383","article-title":"Intracranial pressure in traumatic brain injury: from thresholds to heuristics","volume":"48","author":"Lazaridis","year":"2020","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-444-63600-3.00005-2","article-title":"Principles of intracranial pressure monitoring and treatment","volume":"140","author":"Czosnyka","year":"2017","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00006123-199707000-00005","article-title":"Continuous assessment of the cerebral vasomotor reactivity in head injury","volume":"41","author":"Czosnyka","year":"1997","journal-title":"Neurosurgery"},{"issue":"9","key":"10.1007\/s13311-023-01411-2_bib42","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1161\/STROKEAHA.108.514877","article-title":"Continuous measurement of autoregulation by spontaneous fluctuations in cerebral perfusion pressure: comparison of 3 methods","volume":"39","author":"Brady","year":"2008","journal-title":"Stroke"},{"key":"10.1007\/s13311-023-01411-2_bib43","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/00003246-200204000-00002","article-title":"Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury","volume":"30","author":"Steiner","year":"2002","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1007\/s13311-023-01411-2_bib44","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1097\/CCM.0b013e3182514eb6","article-title":"Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury","volume":"40","author":"Aries","year":"2012","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1007\/s13311-023-01411-2_bib45","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3171\/2014.1.JNS131292","article-title":"Patient-specific thresholds of intracranial pressure in severe traumatic brain injury","volume":"120","author":"Lazaridis","year":"2014","journal-title":"J Neurosurg."},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/ANA.0000000000000616","article-title":"High resolution ICU sub-study participants and investigators. Patient-specific ICP epidemiologic thresholds in adult traumatic brain injury: a CENTER-TBI validation study","volume":"33","author":"Zeiler","year":"2021","journal-title":"J Neurosurg Anesthesiol."},{"key":"10.1007\/s13311-023-01411-2_bib47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-3-319-22533-3_23","article-title":"Patient-specific thresholds and doses of intracranial hypertension in severe traumatic brain injury","volume":"122","author":"Lazaridis","year":"2016","journal-title":"Acta Neurochir Suppl"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib48","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s12028-020-01185-x","article-title":"Cerebrovascular autoregulation monitoring in the management of adult severe traumatic brain injury: a Delphi consensus of clinicians","volume":"34","author":"Depreitere","year":"2021","journal-title":"Neurocrit Care"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib49","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s12028-020-01186-w","article-title":"Cerebral autoregulation: the concept the legend the promise","volume":"34","author":"Lazaridis","year":"2021","journal-title":"Neurocrit Care"},{"issue":"20","key":"10.1007\/s13311-023-01411-2_bib50","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1089\/neu.2021.0197","article-title":"Targeting autoregulation-guided cerebral perfusion pressure after traumatic brain injury (COGiTATE): a feasibility randomized controlled clinical trial","volume":"38","author":"Tas","year":"2021","journal-title":"J Neurotrauma"},{"issue":"Pt B","key":"10.1007\/s13311-023-01411-2_bib51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuropharm.2018.06.005","article-title":"Secondary brain injury: predicting and preventing insults","volume":"145","author":"Lazaridis","year":"2019","journal-title":"Neuropharmacology"},{"issue":"9","key":"10.1007\/s13311-023-01411-2_bib52","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1097\/CCM.0000000000001838","article-title":"Predicting intracranial pressure and brain tissue oxygen crises in patients with severe traumatic brain injury","volume":"44","author":"Myers","year":"2016","journal-title":"Crit Care Med"},{"issue":"5\u20136","key":"10.1007\/s13311-023-01411-2_bib53","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1089\/neu.2022.0201","article-title":"Development of traumatic brain injury associated intracranial hypertension prediction algorithms: a narrative review","volume":"40","author":"McNamara","year":"2023","journal-title":"J Neurotrauma"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s00134-020-06247-4","article-title":"Prediction model for intracranial hypertension demonstrates robust performance during external validation on the CENTER-TBI dataset","volume":"47","author":"Carra","year":"2021","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib55","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/neur.2022.0055","article-title":"Prediction of intracranial hypertension and brain tissue hypoxia utilizing high-resolution data from the BOOST-II clinical trial","volume":"3","author":"Lazaridis","year":"2022","journal-title":"Neurotrauma Rep"},{"issue":"5\u20136","key":"10.1007\/s13311-023-01411-2_bib56","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1089\/neu.2022.0251","article-title":"Development and external validation of a machine learning model for the early prediction of doses of harmful intracranial pressure in patients with severe traumatic brain injury","volume":"40","author":"Carra","year":"2023","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01411-2_bib57","first-page":"41","article-title":"Monitor and control of blood and tissue oxygen tensions","volume":"2","author":"Clark","year":"1956","journal-title":"Trans Am Soc Artif Int Org"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib58","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12028-018-0551-7","article-title":"Safety and reliability of bedside, single burr hole technique for intracranial multimodality monitoring in severe traumatic brain injury","volume":"29","author":"Foreman","year":"2018","journal-title":"Neurocrit Care"},{"issue":"9","key":"10.1007\/s13311-023-01411-2_bib59","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4187\/respcare.04962","article-title":"Brain tissue oxygen monitoring and the intersection of brain and lung: a comprehensive review","volume":"61","author":"Ngwenya","year":"2016","journal-title":"Respir Care"},{"issue":"2","key":"10.1007\/s13311-023-01411-2_bib60","first-page":"115","article-title":"Advanced monitoring in the intensive care unit: brain tissue oxygen tension","volume":"8","author":"Haitsma","year":"2002","journal-title":"Curr Opin Crit Care"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib61","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/bja\/ael137","article-title":"The role of tissue oxygen monitoring in patients with acute brain injury","volume":"97","author":"Nortje","year":"2006","journal-title":"Br J Anaesth"},{"issue":"2","key":"10.1007\/s13311-023-01411-2_bib62","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3171\/jns.2002.96.2.0263","article-title":"Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method","volume":"96","author":"Gupta","year":"2002","journal-title":"J Neurosurg"},{"issue":"6","key":"10.1007\/s13311-023-01411-2_bib63","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1097\/01.CCM.0000127777.16609.08","article-title":"Diffusion limited oxygen delivery following head injury","volume":"32","author":"Menon","year":"2004","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1007\/s13311-023-01411-2_bib64","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3171\/jns.2007.106.4.526","article-title":"Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury","volume":"106","author":"Diringer","year":"2007","journal-title":"J Neurosurg"},{"issue":"6","key":"10.1007\/s13311-023-01411-2_bib65","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1097\/CCM.0b013e3181743d77","article-title":"Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury","volume":"36","author":"Rosenthal","year":"2008","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib66","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1001\/jamaneurol.2019.3854","article-title":"Spatial and temporal pattern of ischemia and abnormal vascular function following traumatic brain injury","volume":"77","author":"Launey","year":"2020","journal-title":"JAMA Neurol"},{"issue":"9","key":"10.1007\/s13311-023-01411-2_bib67","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1097\/00003246-199809000-00029","article-title":"Relationship of brain tissue PO2 to outcome after severe head injury","volume":"26","author":"Valadka","year":"1998","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1007\/s13311-023-01411-2_bib68","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12028-011-9621-9","article-title":"Brain tissue oxygen-based therapy and outcome after severe traumatic brain injury: a systematic literature review","volume":"17","author":"Nangunoori","year":"2012","journal-title":"Neurocrit Care"},{"issue":"4","key":"10.1007\/s13311-023-01411-2_bib69","first-page":"868","article-title":"Brain oxygen tension in severe head injury","volume":"46","author":"van den Brink","year":"2000","journal-title":"Neurosurgery"},{"issue":"11","key":"10.1007\/s13311-023-01411-2_bib70","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/CCM.0000000000002619","article-title":"Brain oxygen optimization in severe traumatic brain injury phase-II: a phase II randomized trial","volume":"45","author":"Okonkwo","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib71","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00134-015-3930-y","article-title":"Consensus statement from the 2014 International Microdialysis Forum","volume":"41","author":"Hutchinson","year":"2015","journal-title":"Intensive Care Med"},{"issue":"Suppl 2","key":"10.1007\/s13311-023-01411-2_bib72","first-page":"1","volume":"21","author":"Le","year":"2014","journal-title":"Neurocrit Care"},{"key":"10.1007\/s13311-023-01411-2_bib73","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/neu.2021.0502","article-title":"Microdialysis-based classifications of abnormal metabolic states after traumatic brain injury: a systematic review of the literature","volume":"40","author":"Venturini","year":"2023","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01411-2_bib74","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/sj.jcbfm.9600073","article-title":"Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study","volume":"25","author":"Vespa","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1007\/s13311-023-01411-2_bib75","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ana.24606","article-title":"Metabolic crisis occurs with seizures and periodic discharges after brain trauma","volume":"79","author":"Vespa","year":"2016","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-023-01411-2_bib76","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1089\/neu.2015.4226","article-title":"Excitotoxicity and metabolic crisis are associated with spreading depolarizations in severe traumatic brain injury patients","volume":"33","author":"Hinzman","year":"2016","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01411-2_bib77","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1097\/CCM.0b013e318186a4a0","article-title":"Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury","volume":"36","author":"Marcoux","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib78","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1089\/neu.2022.0161","article-title":"Cerebral metabolic dysfunction at the acute phase of traumatic brain injury correlates with long-term tissue loss","volume":"40","author":"Bernini","year":"2023","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01411-2_bib79","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1080\/02699052.2017.1370553","article-title":"Detection of metabolic pattern following decompressive craniectomy in severe traumatic brain injury: a microdialysis study","volume":"31","author":"Gupta","year":"2017","journal-title":"Brain Inj"},{"key":"10.1007\/s13311-023-01411-2_bib80","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fneur.2014.00091","article-title":"Glucose and the injured brain-monitored in the neurointensive care unit","volume":"5","author":"Rostami","year":"2014","journal-title":"Front Neurol"},{"key":"10.1007\/s13311-023-01411-2_bib81","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1097\/CCM.0b013e31818f4026","article-title":"Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study","volume":"36","author":"Oddo","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib82","first-page":"111","article-title":"Brain multimodality monitoring: an update","volume":"18","author":"Oddo","year":"2012","journal-title":"Curr Opin Crit Care"},{"key":"10.1007\/s13311-023-01411-2_bib83","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12028-013-9919-x","article-title":"Reduced brain\/serum glucose ratios predict cerebral metabolic distress and mortality after severe brain injury","volume":"19","author":"Kurtz","year":"2013","journal-title":"Neurocrit Care"},{"key":"10.1007\/s13311-023-01411-2_bib84","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12028-014-0007-7","article-title":"Brain tissue oxygenation, lactate-pyruvate ratio, and cerebrovascular pressure reactivity monitoring in severe traumatic brain injury: systematic review and viewpoint","volume":"21","author":"Lazaridis","year":"2014","journal-title":"Neurocrit Care"},{"key":"10.1007\/s13311-023-01411-2_bib85","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1097\/CCM.0b013e31824e0fcc","article-title":"Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial","volume":"40","author":"Vespa","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib86","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/neu.2015.4057","article-title":"Improvement of neuroenergetics by hypertonic lactate therapy in patients with traumatic brain injury is dependent on baseline cerebral lactate\/pyruvate ratio","volume":"33","author":"Quintard","year":"2016","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01411-2_bib87","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00134-013-3203-6","article-title":"Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain","volume":"40","author":"Bouzat","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib88","doi-asserted-by":"crossref","first-page":"11140","DOI":"10.1038\/s41598-018-29255-3","article-title":"The effect of succinate on brain NADH\/NAD(+) redox state and high energy phosphate metabolism in acute traumatic brain injury","volume":"8","author":"Stovell","year":"2018","journal-title":"Sci Rep"},{"key":"10.1007\/s13311-023-01411-2_bib89","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/0271678X211042112","article-title":"Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction","volume":"42","author":"Khellaf","year":"2022","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1007\/s13311-023-01411-2_bib90","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s00134-013-2938-4","article-title":"Recommendations on the use of EEG monitoring in critically ill patients: consensus statement from the neurointensive care section of the ESICM","volume":"39","author":"Claassen","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib91","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/WNP.0000000000000166","article-title":"Consensus statement on continuous EEG in critically ill adults and children, part I: indications","volume":"32","author":"Herman","year":"2015","journal-title":"J Clin Neurophysiol"},{"key":"10.1007\/s13311-023-01411-2_bib92","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12028-012-9695-z","article-title":"Guidelines for the evaluation and management of status epilepticus","volume":"17","author":"Brophy","year":"2012","journal-title":"Neurocrit Care"},{"key":"10.1007\/s13311-023-01411-2_bib93","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/CCM.0000000000003639","article-title":"Continuous electroencephalography after moderate to severe traumatic brain injury","volume":"47","author":"Lee","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01411-2_bib94","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1161\/01.STR.0000043073.69602.09","article-title":"Spreading and synchronous depressions of cortical activity in acutely injured human brain","volume":"33","author":"Strong","year":"2002","journal-title":"Stroke"},{"key":"10.1007\/s13311-023-01411-2_bib95","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1177\/0271678X16654496","article-title":"Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group","volume":"37","author":"Dreier","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1007\/s13311-023-01411-2_bib96","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ana.21721","article-title":"Intracortical electroencephalography in acute brain injury","volume":"66","author":"Waziri","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-023-01411-2_bib97","article-title":"Comparative efficacy of prophylactic anticonvulsant drugs following traumatic brain injury: a systematic review and network meta-analysis of randomized controlled trials","volume":"17","author":"Wang","year":"2022","journal-title":"PLoS ONE"},{"key":"10.1007\/s13311-023-01411-2_bib98","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12028-021-01267-4","article-title":"Seizures and cognitive outcome after traumatic brain injury: a post hoc analysis","volume":"36","author":"Foreman","year":"2022","journal-title":"Neurocrit Care"},{"key":"10.1007\/s13311-023-01411-2_bib99","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12028-022-01441-2","article-title":"The relationship between seizures and spreading depolarizations in patients with severe traumatic brain injury","volume":"37","author":"Foreman","year":"2022","journal-title":"Neurocrit Care"},{"key":"10.1007\/s13311-023-01411-2_bib100","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1177\/0271678X16654495","article-title":"The continuum of spreading depolarizations in acute cortical lesion development: examining Leao's legacy","volume":"37","author":"Hartings","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1007\/s13311-023-01411-2_bib101","first-page":"94","article-title":"Spreading depolarization monitoring in neurocritical care of acute brain injury","volume":"23","author":"Hartings","year":"2017","journal-title":"Curr Opin Crit Care"},{"key":"10.1007\/s13311-023-01411-2_bib102","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/ana.24256","article-title":"Spreading depression in continuous electroencephalography of brain trauma","volume":"76","author":"Hartings","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1007\/s13311-023-01411-2_bib103","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S1474-4422(11)70243-5","article-title":"Spreading depolarizations and outcome after traumatic brain injury: a prospective observational study","volume":"10","author":"Hartings","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1007\/s13311-023-01411-2_bib104","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jamaneurol.2019.4476","article-title":"Prognostic value of spreading depolarizations in patients with severe traumatic brain injury","volume":"77","author":"Hartings","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1007\/s13311-023-01411-2_bib105","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s12028-019-00777-6","article-title":"What should a clinician do when spreading depolarizations are observed in a patient?","volume":"32","author":"Helbok","year":"2020","journal-title":"Neurocrit Care"},{"key":"10.1007\/s13311-023-01411-2_bib106","first-page":"1","article-title":"Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial","author":"Carlson","year":"2018","journal-title":"J Neurosurg."},{"key":"10.1007\/s13311-023-01411-2_bib107","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/epi.12247","article-title":"Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study","volume":"54","author":"Gaspard","year":"2013","journal-title":"Epilepsia"},{"key":"10.1007\/s13311-023-01411-2_bib108","doi-asserted-by":"crossref","first-page":"e2286","DOI":"10.1212\/WNL.0000000000010611","article-title":"Ketamine to treat super-refractory status epilepticus","volume":"95","author":"Alkhachroum","year":"2020","journal-title":"Neurology"},{"issue":"13","key":"10.1007\/s13311-023-01411-2_bib109","doi-asserted-by":"crossref","first-page":"1071161","DOI":"10.3389\/fphys.2022.1071161","article-title":"Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury: a narrative review","volume":"1","author":"Tas","year":"2022","journal-title":"Front Physiol"},{"issue":"4","key":"10.1007\/s13311-023-01411-2_bib110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1017\/cjn.2017.25","article-title":"Implementation of neurocritical care is associated with improved outcomes in traumatic brain injury","volume":"44","author":"Sekhon","year":"2017","journal-title":"Can J Neurol Sci"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib111","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-060188","article-title":"Brain oxygen optimization in severe traumatic brain injury (BOOST-3): a multicentre, randomised, blinded-endpoint, comparative effectiveness study of brain tissue oxygen and intracranial pressure monitoring versus intracranial pressure alone","volume":"12","author":"Bernard","year":"2022","journal-title":"BMJ Open"},{"key":"10.1007\/s13311-023-01411-2_bib112","unstructured":"BONANZA-ANZICS [Internet].\u00a02021.\u00a0https:\/\/www.anzics.com.au\/current-active-endorsed-research\/bonanza\/. Accessed 1 April 2023."},{"issue":"8","key":"10.1007\/s13311-023-01411-2_bib113","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-040550","article-title":"Comparison of strategies for monitoring and treating patients at the early phase of severe traumatic brain injury: the multicenter randomized controlled OXY-TC trial study protocol","volume":"10","author":"Payen","year":"2020","journal-title":"BMJ Open"},{"issue":"4","key":"10.1007\/s13311-023-01411-2_bib114","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/neu.2017.5225","article-title":"Hyperbaric oxygen therapy in the treatment of acute severe traumatic brain injury: a systematic review","volume":"35","author":"Daly","year":"2018","journal-title":"J Neurotrauma"},{"issue":"5","key":"10.1007\/s13311-023-01411-2_bib115","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3171\/2009.7.JNS09363","article-title":"A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury","volume":"112","author":"Rockswold","year":"2010","journal-title":"J Neurosurg"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib116","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3171\/jns.2001.94.3.0403","article-title":"Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients","volume":"94","author":"Rockswold","year":"2001","journal-title":"J Neurosurg"},{"issue":"3","key":"10.1007\/s13311-023-01411-2_bib117","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3171\/jns.2004.101.3.0499","article-title":"Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats","volume":"101","author":"Daugherty","year":"2004","journal-title":"J Neurosurg"},{"issue":"5","key":"10.1007\/s13311-023-01411-2_bib118","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/pst.1755","article-title":"Hyperbaric oxygen brain injury treatment (HOBIT) trial: a multifactor design with response adaptive randomization and longitudinal modeling","volume":"15","author":"Gajewski","year":"2016","journal-title":"Pharm Stat"},{"key":"10.1007\/s13311-023-01411-2_bib119","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1089\/neu.2009.0961","article-title":"Spreading depolarizations and late secondary insults after traumatic brain injury","volume":"26","author":"Hartings","year":"2009","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01411-2_bib120","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1177\/0271678X17703940","article-title":"Brain temperature but not core temperature increases during spreading depolarizations in patients with spontaneous intracerebral hemorrhage","volume":"38","author":"Schiefecker","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1007\/s13311-023-01411-2_bib121","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.neuron.2015.02.007","article-title":"Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations","volume":"85","author":"von Bornstadt","year":"2015","journal-title":"Neuron"},{"key":"10.1007\/s13311-023-01411-2_bib122","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12975-022-01014-7","article-title":"Is the human touch always therapeutic? Patient stimulation and spreading depolarization after acute neurological injuries","volume":"14","author":"Carlson","year":"2023","journal-title":"Transl Stroke Res"},{"key":"10.1007\/s13311-023-01411-2_bib123","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1093\/brain\/aws152","article-title":"Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury","volume":"135","author":"Hertle","year":"2012","journal-title":"Brain"},{"key":"10.1007\/s13311-023-01411-2_bib124","doi-asserted-by":"crossref","DOI":"10.1227\/neu.0000000000002509","article-title":"improving neurotrauma by depolarization inhibition with combination therapy: a phase 2 randomized feasibility trial","author":"Hartings","year":"2023","journal-title":"Neurosurgery"},{"key":"10.1007\/s13311-023-01411-2_bib125","doi-asserted-by":"crossref","first-page":"636","DOI":"10.7326\/M17-2145","article-title":"Swan, Ganz, and their catheter: its evolution over the past half century","volume":"169","author":"Thakkar","year":"2018","journal-title":"Ann Intern Med"},{"key":"10.1007\/s13311-023-01411-2_bib126","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0140-6736(05)67061-4","article-title":"Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial","volume":"366","author":"Harvey","year":"2012","journal-title":"Lancet"},{"key":"10.1007\/s13311-023-01411-2_bib127","first-page":"2928","article-title":"A multicenter study of physicians' knowledge of the pulmonary artery catheter","volume":"264","author":"Iberti","year":"1990","journal-title":"Pulmonary Artery Catheter Study Group JAMA"},{"issue":"2","key":"10.1007\/s13311-023-01411-2_bib128","article-title":"Pulmonary artery catheters for adult patients in intensive care","volume":"2013","author":"Rajaram","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1007\/s13311-023-01411-2_bib129","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s12028-019-00689-5","article-title":"Lundberg and his Waves","volume":"31","author":"Wijdicks","year":"2019","journal-title":"Neurocrit Care"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-023-01411-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-023-01411-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923019906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923019906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-023-01411-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:16:12Z","timestamp":1761808572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923019906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":129,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1878747923019906"],"URL":"https:\/\/doi.org\/10.1007\/s13311-023-01411-2","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management Strategies Based on Multi-Modality Neuromonitoring in Severe Traumatic Brain Injury","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-023-01411-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}