{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T18:10:53Z","timestamp":1793988653579,"version":"4.8.0"},"reference-count":389,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["TP210132"],"award-info":[{"award-number":["TP210132"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s13311-023-01435-8","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:01:56Z","timestamp":1695819716000},"page":"1565-1591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury"],"prefix":"10.1016","volume":"20","author":[{"given":"Sonia","family":"Villapol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary C.","family":"Janatpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwame O.","family":"Affram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-9939","authenticated-orcid":false,"given":"Aviva J.","family":"Symes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/neu.2013.3019","article-title":"Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup","volume":"31","author":"Diaz-Arrastia","year":"2014","journal-title":"J Neurotrauma"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.pmr.2016.01.003","article-title":"The molecular pathophysiology of concussive brain injury - an update","volume":"27","author":"Barkhoudarian","year":"2016","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jamaneurol.2014.3558","article-title":"Inflammation and neuroprotection in traumatic brain injury","volume":"72","author":"Corps","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.1007\/s13311-023-01435-8_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/B978-0-444-63954-7.00006-9","article-title":"Concussion: pathophysiology and clinical translation","volume":"158","author":"Giza","year":"2018","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13311-014-0319-5","article-title":"Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?","volume":"12","author":"Faden","year":"2015","journal-title":"Neurotherapeutics"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3233\/JAD-190028","article-title":"Traumatic brain injury and risk of long-term brain changes, accumulation of pathological markers, and developing dementia: a review","volume":"70","author":"LoBue","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1176\/appi.psy.50.3.198","article-title":"Neuropsychiatric problems after traumatic brain injury: unraveling the silent epidemic","volume":"50","author":"Vaishnavi","year":"2009","journal-title":"Psychosomatics"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1474-4422(17)30279-X","article-title":"The chronic and evolving neurological consequences of traumatic brain injury","volume":"16","author":"Wilson","year":"2017","journal-title":"Lancet Neurol"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib9","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2174\/138161212799436593","article-title":"Role of renin-angiotensin system in inflammation, immunity and aging","volume":"18","author":"Capettini","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1007\/s13311-023-01435-8_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejim.2022.04.006","article-title":"Renin-angiotensin-aldosterone system inhibition in patients affected by heart failure: efficacy, mechanistic effects and practical use of sacubitril\/valsartan. Position Paper of the Italian Society of Cardiology","volume":"102","author":"Perrone-Filardi","year":"2022","journal-title":"Eur J Intern Med"},{"key":"10.1007\/s13311-023-01435-8_bib11","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399411001815","article-title":"Angiotensin II and the vascular phenotype in hypertension","volume":"13","author":"Savoia","year":"2011","journal-title":"Expert Rev Mol Med"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib12","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1097\/01.hjh.0000220416.07235.37","article-title":"Angiotensin receptor blockers and cerebral protection in stroke","volume":"24","author":"Thone-Reineke","year":"2006","journal-title":"J Hypertens Suppl"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib13","first-page":"160","article-title":"Angiotensin receptor blockers are not just for hypertension anymore","volume":"36","author":"Saavedra","year":"2021","journal-title":"Physiology (Bethesda)"},{"issue":"7\u20138","key":"10.1007\/s13311-023-01435-8_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/neu.2021.0401","article-title":"Renin Angiotensin System as a potential treatment target for traumatic brain injury: a systematic review and meta-analysis","volume":"39","author":"Baron","year":"2022","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01435-8_bib15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fendo.2013.00158","article-title":"A role for the brain RAS in Alzheimer's and Parkinson's diseases","volume":"4","author":"Wright","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib16","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/CCM.0b013e31822f08b9","article-title":"Delayed inhibition of angiotensin II receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma*","volume":"40","author":"Timaru-Kast","year":"2012","journal-title":"Crit Care Med"},{"issue":"13","key":"10.1007\/s13311-023-01435-8_bib17","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1038\/npp.2012.152","article-title":"Candesartan, an angiotensin II AT(1)-receptor blocker and PPAR-gamma agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice","volume":"37","author":"Villapol","year":"2012","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib18","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/j.2040-4603.2014.tb00567.x","article-title":"Classical Renin-Angiotensin system in kidney physiology","volume":"4","author":"Sparks","year":"2014","journal-title":"Compr Physiol"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrneph.2015.52","article-title":"Hypertension: New non-RAS peptide modulates the vasoregulatory effects of angiotensin II","volume":"11","author":"Carney","year":"2015","journal-title":"Nat Rev Nephrol"},{"issue":"Suppl 4","key":"10.1007\/s13311-023-01435-8_bib20","first-page":"S281","article-title":"Neuro-endocrine regulation of blood pressure","volume":"15","author":"Chopra","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib21","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.3892\/mmr.2017.7168","article-title":"Role of the ACE2Ang(17)Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review)","volume":"16","author":"Lin","year":"2017","journal-title":"Mol Med Rep"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib22","article-title":"Angiotensin-(1\u20137): a novel peptide to treat hypertension and nephropathy in diabetes?","volume":"6","author":"Padda","year":"2015","journal-title":"J Diabetes Metab."},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib23","doi-asserted-by":"crossref","first-page":"R804","DOI":"10.1152\/ajpregu.00222.2010","article-title":"ACE2\/ANG-(1\u20137)\/Mas pathway in the brain: the axis of good","volume":"300","author":"Xu","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1007\/s13311-023-01435-8_bib24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fphar.2018.00440","article-title":"Targeting renin-angiotensin system against Alzheimer's disease","volume":"9","author":"Gebre","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1007\/s13311-023-01435-8_bib25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fphys.2017.00276","article-title":"The ACE2\/angiotensin-(1\u20137)\/mas receptor axis: pleiotropic roles in cancer","volume":"8","author":"Xu","year":"2017","journal-title":"Front Physiol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/physrev.00036.2005","article-title":"Physiology of local renin-angiotensin systems","volume":"86","author":"Paul","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1007\/s13311-023-01435-8_bib27","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.pharmtox.010909.105610","article-title":"Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy","volume":"50","author":"Bader","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"2A","key":"10.1007\/s13311-023-01435-8_bib28","doi-asserted-by":"crossref","first-page":"3A","DOI":"10.1016\/S0002-9149(01)02321-9","article-title":"The role of the renin-angiotensin system in the development of cardiovascular disease","volume":"89","author":"Unger","year":"2002","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00441-006-0190-8","article-title":"The CNS renin-angiotensin system","volume":"326","author":"Halbach","year":"2006","journal-title":"Cell Tissue Res"},{"key":"10.1007\/s13311-023-01435-8_bib30","doi-asserted-by":"crossref","first-page":"107684","DOI":"10.1016\/j.pharmthera.2020.107684","article-title":"The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI)","volume":"218","author":"Vadhan","year":"2021","journal-title":"Pharmacol Ther"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/frne.1997.0155","article-title":"Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review","volume":"18","author":"Lenkei","year":"1997","journal-title":"Front Neuroendocrinol"},{"issue":"12 Pt 2","key":"10.1007\/s13311-023-01435-8_bib32","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1097\/00004872-199816121-00026","article-title":"Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors","volume":"16","author":"Zhuo","year":"1998","journal-title":"J Hypertens"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-0115(95)00015-4","article-title":"Location and secretion of brain angiotensinogen","volume":"57","author":"Sernia","year":"1995","journal-title":"Regul Pept"},{"issue":"4884","key":"10.1007\/s13311-023-01435-8_bib34","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.3201232","article-title":"Astrocytes synthesize angiotensinogen in brain","volume":"242","author":"Stornetta","year":"1988","journal-title":"Science"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-3940(93)90524-O","article-title":"Cellular localization of angiotensin type 1 receptor and angiotensinogen mRNAs in the subfornical organ of the rat brain","volume":"150","author":"Lippoldt","year":"1993","journal-title":"Neurosci Lett"},{"issue":"1\u20133","key":"10.1007\/s13311-023-01435-8_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.regpep.2009.02.002","article-title":"Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia","volume":"154","author":"Imboden","year":"2009","journal-title":"Regul Pept"},{"issue":"1\u20133","key":"10.1007\/s13311-023-01435-8_bib37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.regpep.2010.03.004","article-title":"Intraneuronal angiotensinergic system in rat and human dorsal root ganglia","volume":"162","author":"Patil","year":"2010","journal-title":"Regul Pept"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2011.07.001","article-title":"Brain renin-angiotensin\u2013a new look at an old system","volume":"95","author":"Wright","year":"2011","journal-title":"Prog Neurobiol"},{"issue":"16","key":"10.1007\/s13311-023-01435-8_bib39","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/0024-3205(87)90737-5","article-title":"Cellular organization of the brain renin-angiotensin system","volume":"41","author":"Moffett","year":"1987","journal-title":"Life Sci"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib40","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/01.HYP.0000125143.73301.94","article-title":"Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model","volume":"43","author":"Lavoie","year":"2004","journal-title":"Hypertension"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0006-8993(78)90681-9","article-title":"Regional distribution of angiotensinogen in rat brain","volume":"158","author":"Lewicki","year":"1978","journal-title":"Brain Res"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib42","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1152\/ajplegacy.1971.221.6.1733","article-title":"Renin in dog brain","volume":"221","author":"Ganten","year":"1971","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.HYP.0000203308.52919.dc","article-title":"Evidence supporting a functional role for intracellular renin in the brain","volume":"47","author":"Lavoie","year":"2006","journal-title":"Hypertension"},{"issue":"4\u20135","key":"10.1007\/s13311-023-01435-8_bib44","first-page":"346","article-title":"Renin activity in the brain, the kidneys and the peripheral plasma or rats with different experimental models of hypertension","volume":"19","author":"Kiprov","year":"1977","journal-title":"Cor Vasa"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1210\/endo-99-1-93","article-title":"Renin activity in dog brain: enzymological similarity to cathepsin D","volume":"99","author":"Day","year":"1976","journal-title":"Endocrinology"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib46","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/01.RES.84.2.240","article-title":"Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing","volume":"84","author":"Lee-Kirsch","year":"1999","journal-title":"Circ Res"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib47","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/HYPERTENSIONAHA.117.09167","article-title":"No brain renin-angiotensin system: deja vu all over again?","volume":"69","author":"Sigmund","year":"2017","journal-title":"Hypertension"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib48","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1161\/HYPERTENSIONAHA.116.08922","article-title":"Brain renin-angiotensin system: does it exist?","volume":"69","author":"van Thiel","year":"2017","journal-title":"Hypertension"},{"issue":"13","key":"10.1007\/s13311-023-01435-8_bib49","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/sj.onc.1202052","article-title":"Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells","volume":"17","author":"Yanagisawa","year":"1998","journal-title":"Oncogene"},{"issue":"14","key":"10.1007\/s13311-023-01435-8_bib50","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1042\/CS20210579","article-title":"Fifty years of research on the brain renin-angiotensin system: what have we learned?","volume":"135","author":"Cruz-Lopez","year":"2021","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib51","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/HYPERTENSIONAHA.111.173534","article-title":"Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion","volume":"58","author":"Dong","year":"2011","journal-title":"Hypertension"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib52","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/physiolgenomics.00131.2003","article-title":"Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model","volume":"16","author":"Lavoie","year":"2004","journal-title":"Physiol Genomics"},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib53","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1073\/pnas.77.9.5458","article-title":"Wide distribution of immunoreactive renin in nerve cells of human brain","volume":"77","author":"Slater","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(87)91637-4","article-title":"Presence of renin in primary neuronal and glial cells from rat brain","volume":"437","author":"Hermann","year":"1987","journal-title":"Brain Res"},{"key":"10.1007\/s13311-023-01435-8_bib55","first-page":"187","article-title":"An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy","volume":"23","author":"Grobe","year":"2008","journal-title":"Physiology (Bethesda)"},{"issue":"25","key":"10.1007\/s13311-023-01435-8_bib56","doi-asserted-by":"crossref","first-page":"22217","DOI":"10.1074\/jbc.M302579200","article-title":"Human prorenin has \u201cgate and handle\u201d regions for its non-proteolytic activation","volume":"278","author":"Suzuki","year":"2003","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib57","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI0214276","article-title":"Pivotal role of the renin\/prorenin receptor in angiotensin II production and cellular responses to renin","volume":"109","author":"Nguyen","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1007\/s13311-023-01435-8_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/290635","article-title":"The prorenin and (pro)renin receptor: new players in the brain renin-angiotensin system?","volume":"2012","author":"Li","year":"2012","journal-title":"Int J Hypertens"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib59","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2826.2010.01980.x","article-title":"Expression of (pro)renin receptor in the human brain and pituitary, and co-localisation with arginine vasopressin and oxytocin in the hypothalamus","volume":"22","author":"Takahashi","year":"2010","journal-title":"J Neuroendocrinol"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib60","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1113\/expphysiol.2008.041988","article-title":"Characterization of a functional (pro)renin receptor in rat brain neurons","volume":"93","author":"Shan","year":"2008","journal-title":"Exp Physiol"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib61","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1172\/JCI21398","article-title":"Inhibition of diabetic nephropathy by a decoy peptide corresponding to the \u201chandle\u201d region for nonproteolytic activation of prorenin","volume":"114","author":"Ichihara","year":"2004","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib62","doi-asserted-by":"crossref","first-page":"e43829","DOI":"10.1371\/journal.pone.0043829","article-title":"Influence of age on brain edema formation, secondary brain damage and inflammatory response after brain trauma in mice","volume":"7","author":"Timaru-Kast","year":"2012","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib63","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/1440-1681.12376","article-title":"Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia","volume":"42","author":"Zhu","year":"2015","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib64","first-page":"120","article-title":"Regional ischemia after head injury","volume":"10","author":"Coles","year":"2004","journal-title":"Curr Opin Crit Care"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib65","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1097\/00006123-199806000-00042","article-title":"Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia","volume":"42","author":"Schroder","year":"1998","journal-title":"Neurosurgery"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib66","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1097\/00003246-199911000-00056","article-title":"Ameliorating cerebral hypoperfusion after traumatic brain injury","volume":"27","author":"DeWitt","year":"1999","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030876","article-title":"Within the brain: the renin angiotensin system","volume":"19","author":"Jackson","year":"2018","journal-title":"Int J Mol Sci."},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib68","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1073\/pnas.81.5.1599","article-title":"Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway","volume":"81","author":"Strittmatter","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib69","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0169-328X(91)90026-T","article-title":"Expression of angiotensin converting enzyme mRNA in rat brain","volume":"11","author":"Whiting","year":"1991","journal-title":"Brain Res Mol Brain Res"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib70","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1357-2725(02)00306-0","article-title":"The brain renin-angiotensin system: location and physiological roles","volume":"35","author":"McKinley","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.coph.2010.11.001","article-title":"Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE)","volume":"11","author":"Bernstein","year":"2011","journal-title":"Curr Opin Pharmacol"},{"key":"10.1007\/s13311-023-01435-8_bib72","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.15806","article-title":"Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders","author":"Santiago","year":"2023","journal-title":"J Neurochem."},{"issue":"6585","key":"10.1007\/s13311-023-01435-8_bib73","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1126\/science.abl5130","article-title":"Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid","volume":"375","author":"Trieu","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib74","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000124046","article-title":"Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study","volume":"40","author":"Lind","year":"1985","journal-title":"Neuroendocrinology"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib75","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0304-3940(76)90020-3","article-title":"Immunohistochemical evidence for the existence of angiotensin II-containing nerve terminals in the brain and spinal cord in the rat","volume":"2","author":"Fuxe","year":"1976","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib76","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0006-8993(84)90174-4","article-title":"Angiotensin II immunoreactivity in the neural afferents and efferents of the subfornical organ of the rat","volume":"321","author":"Lind","year":"1984","journal-title":"Brain Res"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib77","doi-asserted-by":"crossref","first-page":"R444","DOI":"10.1152\/ajpregu.00078.2015","article-title":"Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control","volume":"309","author":"de Kloet","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"13","key":"10.1007\/s13311-023-01435-8_bib78","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1523\/JNEUROSCI.3674-16.2017","article-title":"A unique, \u201cangiotensin-sensitive\u201d neuronal population coordinates neuroendocrine, cardiovascular, and behavioral responses to stress","volume":"37","author":"de Kloet","year":"2017","journal-title":"J Neurosci"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib79","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0149-7634(94)90034-5","article-title":"Brain angiotensin receptor subtypes in the control of physiological and behavioral responses","volume":"18","author":"Wright","year":"1994","journal-title":"Neurosci Biobehav Rev"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib80","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0196-9781(98)00044-8","article-title":"Angiotensin II inhibits long-term potentiation within the lateral nucleus of the amygdala through AT1 receptors","volume":"19","author":"von Bohlen und Halbach","year":"1998","journal-title":"Peptides"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib81","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1161\/01.STR.0000217404.64352.d7","article-title":"AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats","volume":"37","author":"Zhou","year":"2006","journal-title":"Stroke"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib82","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/HYPERTENSIONAHA.112.203679","article-title":"Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein","volume":"61","author":"Herrera","year":"2013","journal-title":"Hypertension"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib83","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s003359900419","article-title":"Mouse angiotensin receptor genes Agtr1a and Agtr1b map to chromosomes 13 and 3","volume":"8","author":"MacTaggart","year":"1997","journal-title":"Mamm Genome"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib84","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/cvr\/cvq004","article-title":"Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts","volume":"86","author":"van Esch","year":"2010","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib85","doi-asserted-by":"crossref","first-page":"H461","DOI":"10.1152\/ajpheart.00582.2019","article-title":"Differential expression of angiotensin II type 1 receptor subtypes within the cerebral microvasculature","volume":"318","author":"Yamasaki","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib86","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/CS20060342","article-title":"Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology","volume":"112","author":"Higuchi","year":"2007","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib87","doi-asserted-by":"crossref","first-page":"H137","DOI":"10.1152\/ajpheart.00618.2015","article-title":"Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?","volume":"310","author":"Chappell","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib88","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol Rev"},{"issue":"6323","key":"10.1007\/s13311-023-01435-8_bib89","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/351233a0","article-title":"Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor","volume":"351","author":"Murphy","year":"1991","journal-title":"Nature"},{"issue":"6323","key":"10.1007\/s13311-023-01435-8_bib90","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/351230a0","article-title":"Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor","volume":"351","author":"Sasaki","year":"1991","journal-title":"Nature"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib91","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1043-2760(97)00101-X","article-title":"Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways","volume":"8","author":"Schmitz","year":"1997","journal-title":"Trends Endocrinol Metab"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib92","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/01.RES.0000105920.33926.60","article-title":"Cellular mechanism of vasoconstriction induced by angiotensin II: it remains to be determined","volume":"93","author":"Kanaide","year":"2003","journal-title":"Circ Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib93","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.coph.2010.12.001","article-title":"The central nervous system and inflammation in hypertension","volume":"11","author":"Marvar","year":"2011","journal-title":"Curr Opin Pharmacol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib94","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10253890701350735","article-title":"Brain and peripheral angiotensin II play a major role in stress","volume":"10","author":"Saavedra","year":"2007","journal-title":"Stress"},{"issue":"1\u20133","key":"10.1007\/s13311-023-01435-8_bib95","first-page":"231","article-title":"Role of the local renin-angiotensin system in the autoregulation of the cerebral circulation","volume":"28","author":"Paulson","year":"1991","journal-title":"Blood Vessels"},{"issue":"1_suppl","key":"10.1007\/s13311-023-01435-8_bib96","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1177\/14703203010020011801","article-title":"Review: The role of angiotensin II AT1-receptors in the regulation of the cerebral blood flow and brain ischaemia","volume":"2","author":"Saavedra","year":"2001","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib97","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00109-008-0331-5","article-title":"Brain renin angiotensin in disease","volume":"86","author":"Phillips","year":"2008","journal-title":"J Mol Med"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib98","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1161\/01.STR.31.10.2478","article-title":"Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats","volume":"31","author":"Nishimura","year":"2000","journal-title":"Stroke"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib99","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10571-011-9754-6","article-title":"Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders","volume":"32","author":"Saavedra","year":"2012","journal-title":"Cell Mol Neurobiol"},{"issue":"7\u20138","key":"10.1007\/s13311-023-01435-8_bib100","first-page":"1099","article-title":"Mechanisms of the anti-ischemic effect of angiotensin II AT(1) receptor antagonists in the brain","volume":"26","author":"Saavedra","year":"2006","journal-title":"Cell Mol Neurobiol"},{"key":"10.1007\/s13311-023-01435-8_bib101","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fendo.2017.00231","article-title":"Temporal changes in cortical and hippocampal expression of genes important for brain glucose metabolism following controlled cortical impact injury in mice","volume":"8","author":"Zhou","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib102","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1006\/jmcc.2002.2111","article-title":"NF-kappaB activation is essential for angiotensin II-dependent proliferation and migration of vascular smooth muscle cells","volume":"34","author":"Zahradka","year":"2002","journal-title":"J Mol Cell Cardiol"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib103","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.STR.0000081225.46324.AA","article-title":"Angiotensin II produces superoxide-mediated impairment of endothelial function in cerebral arterioles","volume":"34","author":"Didion","year":"2003","journal-title":"Stroke"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib104","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.HYP.33.3.856","article-title":"Effects of an angiotensin-converting enzyme inhibitor and a beta-blocker on cerebral arterioles in rats","volume":"33","author":"Chillon","year":"1999","journal-title":"Hypertension"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib105","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1172\/JCI125173","article-title":"Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature","volume":"129","author":"Fan","year":"2019","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib106","article-title":"Angiotensin receptors: structure, function, signaling and clinical applications","volume":"1","author":"Singh","year":"2016","journal-title":"J Cell Signal."},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib107","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1042\/CS20220024","article-title":"Angiotensin receptors - affinitiy and beyond","volume":"136","author":"Sumners","year":"2022","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib108","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41440-019-0374-8","article-title":"Brain angiotensin type-1 and type-2 receptors: cellular locations under normal and hypertensive conditions","volume":"43","author":"Sumners","year":"2020","journal-title":"Hypertens Res"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib109","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/FJC.0000000000000208","article-title":"AT2 receptor activities and pathophysiological implications","volume":"65","author":"Matavelli","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib110","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1124\/pharmrev.120.000281","article-title":"The angiotensin AT(2) receptor: from a binding site to a novel therapeutic target","volume":"74","author":"Steckelings","year":"2022","journal-title":"Pharmacol Rev"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib111","doi-asserted-by":"crossref","first-page":"e69234","DOI":"10.1371\/journal.pone.0069234","article-title":"Commercially available angiotensin II At(2) receptor antibodies are nonspecific","volume":"8","author":"Hafko","year":"2013","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib112","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11906-017-0746-x","article-title":"Protective angiotensin type 2 receptors in the brain and hypertension","volume":"19","author":"de Kloet","year":"2017","journal-title":"Curr Hypertens Rep"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib113","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00429-014-0943-1","article-title":"Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system","volume":"221","author":"de Kloet","year":"2016","journal-title":"Brain Struct Funct"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib114","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/(SICI)1096-9861(19960923)373:3<322::AID-CNE2>3.0.CO;2-4","article-title":"Distribution of angiotensin II type-2 receptor (AT2) mRNA expression in the adult rat brain","volume":"373","author":"Lenkei","year":"1996","journal-title":"J Comp Neurol"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib115","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/1440-1681.12137","article-title":"Protective arms of the renin-angiotensin-system in neurological disease","volume":"40","author":"Sumners","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1007\/s13311-023-01435-8_bib116","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3389\/fphar.2017.00564","article-title":"Anti-fibrotic potential of AT(2) receptor agonists","volume":"8","author":"Wang","year":"2017","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib117","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.bbadis.2016.03.013","article-title":"Angiotensin II type-2 receptor stimulation induces neuronal VEGF synthesis after cerebral ischemia","volume":"1862","author":"Mateos","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib118","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/cne.903160407","article-title":"Mapping of angiotensin II receptor subtype heterogeneity in rat brain","volume":"316","author":"Song","year":"1992","journal-title":"J Comp Neurol"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib119","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0006-8993(99)01098-7","article-title":"Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor","volume":"821","author":"Okuyama","year":"1999","journal-title":"Brain Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib120","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11906-013-0416-6","article-title":"AT(2) receptor and tissue injury: therapeutic implications","volume":"16","author":"Namsolleck","year":"2014","journal-title":"Curr Hypertens Rep"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib121","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1042\/CS20171549","article-title":"Neuroprotection via AT(2) receptor agonists in ischemic stroke","volume":"132","author":"Bennion","year":"2018","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib122","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1161\/STROKEAHA.108.531509","article-title":"Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke","volume":"40","author":"McCarthy","year":"2009","journal-title":"Stroke"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib123","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1124\/pr.114.010454","article-title":"International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli [corrected]","volume":"67","author":"Karnik","year":"2015","journal-title":"Pharmacol Rev"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib124","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00109-016-1406-3","article-title":"Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice","volume":"94","author":"Schwengel","year":"2016","journal-title":"J Mol Med (Berl)"},{"issue":"14","key":"10.1007\/s13311-023-01435-8_bib125","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/01.CIR.0000094734.67990.99","article-title":"Increased angiotensin-(1\u20137)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2","volume":"108","author":"Zisman","year":"2003","journal-title":"Circulation"},{"issue":"17","key":"10.1007\/s13311-023-01435-8_bib126","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"10.1007\/s13311-023-01435-8_bib127","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/BJ20040634","article-title":"Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism","volume":"383","author":"Rice","year":"2004","journal-title":"Biochem J"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib128","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1111\/j.1523-1755.2005.00675.x","article-title":"Effects of renin-angiotensin system blockade on renal angiotensin-(1\u20137) forming enzymes and receptors","volume":"68","author":"Ferrario","year":"2005","journal-title":"Kidney Int"},{"issue":"14","key":"10.1007\/s13311-023-01435-8_bib129","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib130","doi-asserted-by":"crossref","first-page":"11903","DOI":"10.1038\/s41598-017-12074-3","article-title":"Ang-(1\u20137) is an endogenous beta-arrestin-biased agonist of the AT(1) receptor with protective action in cardiac hypertrophy","volume":"7","author":"Teixeira","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib131","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/HYPERTENSIONAHA.116.07572","article-title":"G-protein-coupled receptor MrgD is a receptor for angiotensin-(1\u20137) involving adenylyl cyclase, cAMP, and phosphokinase A","volume":"68","author":"Tetzner","year":"2016","journal-title":"Hypertension"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib132","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/HYPERTENSIONAHA.116.08814","article-title":"Evidence for heterodimerization and functional interaction of the angiotensin type 2 receptor and the receptor MAS","volume":"69","author":"Leonhardt","year":"2017","journal-title":"Hypertension"},{"key":"10.1007\/s13311-023-01435-8_bib133","doi-asserted-by":"crossref","first-page":"33678","DOI":"10.1038\/srep33678","article-title":"Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney","volume":"6","author":"Domenig","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib134","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","article-title":"Angiotensin-(1\u20137) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways","volume":"49","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"key":"10.1007\/s13311-023-01435-8_bib135","doi-asserted-by":"crossref","DOI":"10.1038\/jcbfm.2014.93","article-title":"Neuroprotection after traumatic brain injury in heat-acclimated mice involves induced neurogenesis and activation of angiotensin receptor type 2 signaling","author":"Umschweif","year":"2014","journal-title":"J Cereb Blood Flow Metab."},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib136","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.4049\/jimmunol.1000314","article-title":"Anti-inflammatory effects of the activation of the angiotensin-(1\u20137) receptor, MAS, in experimental models of arthritis","volume":"185","author":"da Silveira","year":"2010","journal-title":"J Immunol"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib137","article-title":"Therapeutic approaches to the alternative angiotensin-(1\u20137) axis of the renin-angiotensin system","volume":"2","author":"Chappell","year":"2017","journal-title":"Ann Pharmacol Pharm."},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib138","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/sj.ki.5001509","article-title":"Angiotensin-(1\u20137) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells","volume":"69","author":"Su","year":"2006","journal-title":"Kidney Int"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib139","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00005344-200007000-00015","article-title":"Evidence that prostaglandins mediate the antihypertensive actions of angiotensin-(1\u20137) during chronic blockade of the renin-angiotensin system","volume":"36","author":"Iyer","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib140","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1042\/CS20140329","article-title":"Angiotensin-(1\u20137) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice","volume":"128","author":"Shi","year":"2015","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib141","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.beem.2018.02.003","article-title":"Novel mechanisms of G-protein-coupled receptors functions: AT(1) angiotensin receptor acts as a signaling hub and focal point of receptor cross-talk","volume":"32","author":"Toth","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib142","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1007\/s12035-017-0805-y","article-title":"Paracrine and intracrine angiotensin 1\u20137\/Mas receptor axis in the substantia nigra of rodents, monkeys, and humans","volume":"55","author":"Costa-Besada","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib143","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1\u20139","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib144","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib145","doi-asserted-by":"crossref","first-page":"C1073","DOI":"10.1152\/ajpcell.00364.2012","article-title":"Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1\/2 signaling","volume":"304","author":"Xiao","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib146","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1161\/STROKEAHA.112.667063","article-title":"Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging","volume":"43","author":"Pena Silva","year":"2012","journal-title":"Stroke"},{"issue":"18","key":"10.1007\/s13311-023-01435-8_bib147","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1111\/bph.12770","article-title":"Angiotensin-(1\u20137) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas\/eNOS-dependent pathway","volume":"171","author":"Jiang","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib148","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00441-012-1354-3","article-title":"Immunohistochemical localization of the angiotensin-(1\u20137) receptor Mas in the murine forebrain","volume":"348","author":"Freund","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1007\/s13311-023-01435-8_bib149","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuropharm.2013.03.025","article-title":"Anti-inflammatory effects of angiotensin-(1\u20137) in ischemic stroke","volume":"71","author":"Regenhardt","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1007\/s13311-023-01435-8_bib150","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.freeradbiomed.2013.08.183","article-title":"Angiotensin-(1\u20137) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling","volume":"65","author":"Moore","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib151","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1043-2760(02)00037-1","article-title":"AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement","volume":"14","author":"Albiston","year":"2003","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib152","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1460-9568.2008.06347.x","article-title":"The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus\u2013potential role in modulation of glucose uptake in neurones?","volume":"28","author":"Fernando","year":"2008","journal-title":"Eur J Neurosci"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib153","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1471-4159.2007.04659.x","article-title":"Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons","volume":"102","author":"Fernando","year":"2007","journal-title":"J Neurochem"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib154","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1046\/j.1471-4159.2003.01852.x","article-title":"Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)","volume":"86","author":"Lew","year":"2003","journal-title":"J Neurochem"},{"key":"10.1007\/s13311-023-01435-8_bib155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2017.08.055","article-title":"The renin angiotensin system and the brain: New developments","volume":"46","author":"Farag","year":"2017","journal-title":"J Clin Neurosci"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib156","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1476-5381.2011.01402.x","article-title":"Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers","volume":"164","author":"Albiston","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib157","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0165-0173(97)00019-2","article-title":"Important role for angiotensin III and IV in the brain renin-angiotensin system","volume":"25","author":"Wright","year":"1997","journal-title":"Brain Res Brain Res Rev"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib158","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0167-0115(96)02116-7","article-title":"Angiotensin II- and IV-induced changes in cerebral blood flow. Roles of AT1, AT2, and AT4 receptor subtypes","volume":"68","author":"Kramar","year":"1997","journal-title":"Regul Pept"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib159","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1124\/jpet.114.218735","article-title":"The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor\/c-met system","volume":"351","author":"Benoist","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib160","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1755-5949.2008.00057.x","article-title":"Ang II and Ang IV: unraveling the mechanism of action on synaptic plasticity, memory, and epilepsy","volume":"14","author":"De Bundel","year":"2008","journal-title":"CNS Neurosci Ther"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib161","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/1470320308099084","article-title":"The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease","volume":"9","author":"Wright","year":"2008","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"1\u20132","key":"10.1007\/s13311-023-01435-8_bib162","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0006-8993(01)02100-X","article-title":"The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro","volume":"897","author":"Kram\u00e1r","year":"2001","journal-title":"Brain Res"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib163","first-page":"329","article-title":"Cerebroprotective effect of angiotensin IV in experimental ischemic stroke in the rat mediated by AT(4) receptors","volume":"57","author":"Faure","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"10.1007\/s13311-023-01435-8_bib164","doi-asserted-by":"crossref","first-page":"104644","DOI":"10.1016\/j.nbd.2019.104644","article-title":"Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease","volume":"134","author":"Royea","year":"2020","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib165","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11906-012-0319-y","article-title":"The \u201chis and hers\u201d of the renin-angiotensin system","volume":"15","author":"Hilliard","year":"2013","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib166","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41398-019-0374-0","article-title":"Estradiol modulation of the renin-angiotensin system and the regulation of fear extinction","volume":"9","author":"Parrish","year":"2019","journal-title":"Transl Psychiatry"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib167","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.genm.2012.06.005","article-title":"Sex differences in hypertension: contribution of the renin-angiotensin system","volume":"9","author":"Maric-Bilkan","year":"2012","journal-title":"Gend Med"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib168","doi-asserted-by":"crossref","first-page":"H191","DOI":"10.1152\/ajpheart.01012.2013","article-title":"Estrogen regulation of the brain renin-angiotensin system in protection against angiotensin II-induced sensitization of hypertension","volume":"307","author":"Xue","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib169","doi-asserted-by":"crossref","first-page":"R759","DOI":"10.1152\/ajpregu.00595.2004","article-title":"17beta-estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats","volume":"288","author":"Dean","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib170","doi-asserted-by":"crossref","first-page":"R498","DOI":"10.1152\/ajpregu.00182.2014","article-title":"Estrogen status and the renin angiotensin aldosterone system","volume":"307","author":"O'Donnell","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib171","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1159\/000126157","article-title":"Estrogens regulate angiotensin-converting enzyme and angiotensin receptors in female rat anterior pituitary","volume":"55","author":"Seltzer","year":"1992","journal-title":"Neuroendocrinology"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib172","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1472-8206.2010.00854.x","article-title":"Gender and the renin-angiotensin-aldosterone system","volume":"24","author":"Komukai","year":"2010","journal-title":"Fundam Clin Pharmacol"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib173","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10286-020-00720-2","article-title":"Sex differences in cardiovascular actions of the renin-angiotensin system","volume":"30","author":"Medina","year":"2020","journal-title":"Clin Auton Res"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib174","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1152\/ajpregu.00387.2006","article-title":"Temporal-spatial expression of ANG-(1\u20137) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats","volume":"293","author":"Joyner","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib175","doi-asserted-by":"crossref","DOI":"10.1177\/1470320317722270","article-title":"Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2","volume":"18","author":"da Silva","year":"2017","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib176","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1016\/j.mayocp.2021.08.009","article-title":"The renin-angiotensin-aldosterone system in postmenopausal women: the promise of hormone therapy","volume":"96","author":"Gersh","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib177","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/glia.23171","article-title":"Sexual dimorphism in the inflammatory response to traumatic brain injury","volume":"65","author":"Villapol","year":"2017","journal-title":"Glia"},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib178","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1751-7176.2011.00518.x","article-title":"Angiotensin receptor blockers: pharmacology, efficacy, and safety","volume":"13","author":"Taylor","year":"2011","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib179","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/HYPERTENSIONAHA.120.16667","article-title":"Comparative first-line effectiveness and safety of ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers: a multinational cohort study","volume":"78","author":"Chen","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib180","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1124\/pr.112.007278","article-title":"A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists","volume":"65","author":"Michel","year":"2013","journal-title":"Pharmacol Rev"},{"issue":"17","key":"10.1007\/s13311-023-01435-8_bib181","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.2174\/1381612811319170005","article-title":"Class- and molecule-specific differential effects of angiotensin II type 1 receptor blockers","volume":"19","author":"Imaizumi","year":"2013","journal-title":"Curr Pharm Des"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib182","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s40265-016-0592-1","article-title":"fimasartan: a new angiotensin receptor blocker","volume":"76","author":"Lee","year":"2016","journal-title":"Drugs"},{"issue":"Suppl 1","key":"10.1007\/s13311-023-01435-8_bib183","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1038\/sj.jhh.1000991","article-title":"Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension","volume":"14","author":"Israili","year":"2000","journal-title":"J Hum Hypertens"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib184","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/me.2007-0312","article-title":"Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state","volume":"22","author":"Miura","year":"2008","journal-title":"Mol Endocrinol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib185","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/HYPERTENSIONAHA.121.17595","article-title":"Blood-brain barrier crossing renin-angiotensin system drugs: considerations for dementia and cognitive decline","volume":"78","author":"Glodzik","year":"2021","journal-title":"Hypertension"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib186","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1097\/HJH.0b013e328165d159","article-title":"Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker","volume":"25","author":"Shao","year":"2007","journal-title":"J Hypertens"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib187","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/ajh.2008.202","article-title":"Molecule-specific effects of angiotensin II-receptor blockers independent of the renin-angiotensin system","volume":"21","author":"Kurtz","year":"2008","journal-title":"Am J Hypertens"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib188","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.nucmedbio.2012.06.012","article-title":"Brain penetration of telmisartan, a unique centrally acting angiotensin II type 1 receptor blocker, studied by PET in conscious rhesus macaques","volume":"39","author":"Noda","year":"2012","journal-title":"Nucl Med Biol"},{"key":"10.1007\/s13311-023-01435-8_bib189","doi-asserted-by":"crossref","first-page":"600163","DOI":"10.3389\/fphar.2021.600163","article-title":"Angiotensin AT2 receptor is anti-inflammatory and reno-protective in lipopolysaccharide mice model: role of IL-10","volume":"12","author":"Fatima","year":"2021","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib190","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3317\/jraas.2001.024","article-title":"Pre-treatment with candesartan protects from cerebral ischaemia","volume":"2","author":"Ito","year":"2001","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib191","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0006-8993(00)02377-5","article-title":"Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors","volume":"871","author":"Nishimura","year":"2000","journal-title":"Brain Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib192","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/hr.2009.200","article-title":"Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system","volume":"33","author":"Pelisch","year":"2010","journal-title":"Hypertens Res"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib193","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/HYPERTENSIONAHA.121.17049","article-title":"Blood-brain barrier crossing renin-angiotensin drugs and cognition in the elderly: a meta-analysis","volume":"78","author":"Ho","year":"2021","journal-title":"Hypertension"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib194","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13195-021-00778-8","article-title":"The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE \u03b54 carrier status","volume":"13","author":"Ouk","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"10.1007\/s13311-023-01435-8_bib195","doi-asserted-by":"crossref","first-page":"1137197","DOI":"10.3389\/fnagi.2023.1137197","article-title":"Neuroprotective effect of angiotensin II receptor blockers on the risk of incident Alzheimer's disease: a nationwide population-based cohort study","volume":"15","author":"Lee","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib196","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1524-6175.2005.05141.x","article-title":"Angiotensin receptor blockers: new considerations in their mechanism of action","volume":"8","author":"Sica","year":"2006","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib197","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1097\/CCM.0b013e31828a6688","article-title":"Angiotensin-(1\u20137) protects from experimental acute lung injury","volume":"41","author":"Klein","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1007\/s13311-023-01435-8_bib198","doi-asserted-by":"crossref","first-page":"109809","DOI":"10.1016\/j.cellsig.2020.109809","article-title":"The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: Insight from preclinical stroke studies and therapeutic potential","volume":"76","author":"McFall","year":"2020","journal-title":"Cell Signal"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib199","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.HYP.0000123072.34629.57","article-title":"Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity","volume":"43","author":"Benson","year":"2004","journal-title":"Hypertension"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib200","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.vph.2006.05.002","article-title":"Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists","volume":"45","author":"Erbe","year":"2006","journal-title":"Vascul Pharmacol"},{"issue":"Pt 11","key":"10.1007\/s13311-023-01435-8_bib201","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/brain\/awv172","article-title":"Neurorestoration after traumatic brain injury through angiotensin II receptor blockage","volume":"138","author":"Villapol","year":"2015","journal-title":"Brain"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib202","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.coph.2006.11.008","article-title":"Metabolic actions of angiotensin receptor antagonists: PPAR-gamma agonist actions or a class effect?","volume":"7","author":"Ernsberger","year":"2007","journal-title":"Curr Opin Pharmacol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib203","first-page":"73","article-title":"Role of PPARgamma, a nuclear hormone receptor in neuroprotection","volume":"48","author":"Gillespie","year":"2011","journal-title":"Indian J Biochem Biophys"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib204","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ajh\/hpu197","article-title":"Neuroprotective effects of angiotensin receptor blockers","volume":"28","author":"Villapol","year":"2015","journal-title":"Am J Hypertens"},{"key":"10.1007\/s13311-023-01435-8_bib205","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbi.2015.07.015","article-title":"Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKbeta-dependent AMPK activation","volume":"50","author":"Xu","year":"2015","journal-title":"Brain Behav Immun"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib206","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/HYPERTENSIONAHA.109.143958","article-title":"Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways","volume":"55","author":"He","year":"2010","journal-title":"Hypertension"},{"key":"10.1007\/s13311-023-01435-8_bib207","doi-asserted-by":"crossref","first-page":"636259","DOI":"10.3389\/fnins.2021.636259","article-title":"Transcriptomic analysis of mouse brain after traumatic brain injury reveals that the angiotensin receptor blocker candesartan acts through novel pathways","volume":"15","author":"Attilio","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1007\/s13311-023-01435-8_bib208","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3389\/fnins.2019.01043","article-title":"The effect of candesartan alone and its combination with estrogen on post-traumatic brain injury outcomes in female rats","volume":"13","author":"Hajmohammadi","year":"2019","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib209","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2010.06.044","article-title":"Angiotensin-converting enzyme (ACE) inhibitors exacerbate histological damage and motor deficits after experimental traumatic brain injury","volume":"481","author":"Harford-Wright","year":"2010","journal-title":"Neurosci Lett"},{"issue":"22","key":"10.1007\/s13311-023-01435-8_bib210","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1089\/neu.2019.6376","article-title":"Subcutaneous administration of angiotensin-(1\u20137) improves recovery after traumatic brain injury in mice","volume":"36","author":"Janatpour","year":"2019","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01435-8_bib211","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fnagi.2019.00063","article-title":"Angiotensin ii receptor 1 blockage limits brain damage and improves functional outcome after brain injury in aged animals despite age-dependent reduction in AT1 expression","volume":"11","author":"Timaru-Kast","year":"2019","journal-title":"Front Aging Neurosci"},{"issue":"13","key":"10.1007\/s13311-023-01435-8_bib212","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"N Engl J Med."},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib213","first-page":"615","article-title":"Does inhibition of angiotensin function cause neuroprotection in diffuse traumatic brain injury?","volume":"21","author":"Khaksari","year":"2018","journal-title":"Iran J Basic Med Sci"},{"key":"10.1007\/s13311-023-01435-8_bib214","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3389\/fneur.2020.00992","article-title":"Losartan treatment could improve the outcome of TBI mice","volume":"11","author":"Xiong","year":"2020","journal-title":"Front Neurol"},{"key":"10.1007\/s13311-023-01435-8_bib215","first-page":"1","article-title":"Angiotensin II type 1 receptor deficiency protects against the impairment of blood-brain barrier in a mouse model of traumatic brain injury","author":"Yang","year":"2022","journal-title":"Int J Neurosci."},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib216","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrneurol.2017.13","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib217","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.nurt.2010.07.002","article-title":"Role of microglia in neurotrauma","volume":"7","author":"Loane","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1007\/s13311-023-01435-8_bib218","doi-asserted-by":"crossref","first-page":"108902","DOI":"10.1016\/j.intimp.2022.108902","article-title":"Intervention of neuroinflammation in the traumatic brain injury trajectory: in vivo and clinical approaches","volume":"108","author":"Prabhakar","year":"2022","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib219","first-page":"88","article-title":"Adverse effects of angiotensin II type 1 receptor blockers","volume":"42","author":"Preobrazhenskii","year":"2002","journal-title":"Kardiologiia"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib220","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1161\/HYPERTENSIONAHA.122.19378","article-title":"Angiotensin receptor blockers are associated with a lower risk of progression from mild cognitive impairment to dementia","volume":"79","author":"Deng","year":"2022","journal-title":"Hypertension"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib221","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12974-020-02005-x","article-title":"Cellular infiltration in traumatic brain injury","volume":"17","author":"Alam","year":"2020","journal-title":"J Neuroinflammation"},{"key":"10.1007\/s13311-023-01435-8_bib222","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.expneurol.2014.01.001","article-title":"Pattern recognition receptors and central nervous system repair","volume":"258","author":"Kigerl","year":"2014","journal-title":"Exp Neurol"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib223","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1248\/yakushi.13-00255-2","article-title":"Anti-high mobility group box-1 antibody therapy for traumatic brain injury","volume":"134","author":"Okuma","year":"2014","journal-title":"Yakugaku Zasshi"},{"issue":"14","key":"10.1007\/s13311-023-01435-8_bib224","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1096\/fj.07-8770com","article-title":"Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats","volume":"21","author":"Liu","year":"2007","journal-title":"FASEB J"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib225","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/02699052.2016.1217045","article-title":"The danger zone: systematic review of the role of HMGB1 danger signalling in traumatic brain injury","volume":"31","author":"Parker","year":"2017","journal-title":"Brain Inj"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib226","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ana.23602","article-title":"Anti-high mobility group box-1 antibody therapy for traumatic brain injury","volume":"72","author":"Okuma","year":"2012","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib227","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4236\/jbbs.2017.72006","article-title":"High Mobility Group Box 1 and Traumatic Brain Injury","volume":"7","author":"Richard","year":"2017","journal-title":"J Behav Brain Sci"},{"issue":"7\u20138","key":"10.1007\/s13311-023-01435-8_bib228","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2119\/2008-00034.Klune","article-title":"HMGB1: endogenous danger signaling","volume":"14","author":"Klune","year":"2008","journal-title":"Mol Med"},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib229","doi-asserted-by":"crossref","first-page":"18899","DOI":"10.3390\/ijms140918899","article-title":"Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1\/RAGE axis in prevention and acute treatment of stroke","volume":"14","author":"Kikuchi","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib230","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1097\/01.hjh.0000220418.09021.ee","article-title":"Angiotensin II: multitasking in the brain","volume":"24","author":"Saavedra","year":"2006","journal-title":"J Hypertens Suppl"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib231","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1096\/fj.01-0601com","article-title":"Ischemic injury in experimental stroke depends on angiotensin II","volume":"16","author":"Walther","year":"2002","journal-title":"FASEB J"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib232","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders","volume":"123","author":"Saavedra","year":"2012","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib233","first-page":"152","article-title":"Inflammation in hypertension","volume":"15","author":"Savoia","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib234","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.037","article-title":"Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke","volume":"24","author":"Kono","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib235","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/138161206780574579","article-title":"PPAR-gamma agonists as regulators of microglial activation and brain inflammation","volume":"12","author":"Bernardo","year":"2006","journal-title":"Curr Pharm Des"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib236","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1097\/HJH.0b013e3283314bc7","article-title":"Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes","volume":"27","author":"Larrayoz","year":"2009","journal-title":"J Hypertens"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib237","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/HJH.0b013e32834dde5f","article-title":"Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-gamma activation in human monocytes","volume":"30","author":"Pang","year":"2012","journal-title":"J Hypertens"},{"key":"10.1007\/s13311-023-01435-8_bib238","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2008.09.074","article-title":"PPARgamma agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms","volume":"1244","author":"Yi","year":"2008","journal-title":"Brain Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib239","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.gendis.2019.05.002","article-title":"Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARgamma\/NF-kappaB\/IL-6 signaling pathway","volume":"7","author":"Deng","year":"2020","journal-title":"Genes Dis"},{"issue":"1 Pt 2","key":"10.1007\/s13311-023-01435-8_bib240","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1161\/01.HYP.29.1.366","article-title":"Angiotensin II signaling in vascular smooth muscle. New concepts","volume":"29","author":"Griendling","year":"1997","journal-title":"Hypertension"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib241","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0306-3623(97)00021-9","article-title":"Angiotensin II receptors in endothelial cells","volume":"29","author":"Pueyo","year":"1997","journal-title":"Gen Pharmacol"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib242","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1172\/JCI11003","article-title":"Brain tissue responses to ischemia","volume":"106","author":"Lee","year":"2000","journal-title":"J Clin Invest"},{"issue":"17","key":"10.1007\/s13311-023-01435-8_bib243","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1089\/neu.2012.2348","article-title":"Traumatic brain injury-associated coagulopathy","volume":"29","author":"Zhang","year":"2012","journal-title":"J Neurotrauma"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib244","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1161\/HYPERTENSIONAHA.110.158220","article-title":"Angiotensin II-mediated microvascular thrombosis","volume":"56","author":"Senchenkova","year":"2010","journal-title":"Hypertension"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib245","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/sj.jhh.1001735","article-title":"Losartan, an angiotensin II (AT1) receptor antagonist, preserves cerebral blood flow in hypertensive patients with a history of stroke","volume":"18","author":"Moriwaki","year":"2004","journal-title":"J Hum Hypertens"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib246","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/00207450903389362","article-title":"The angiotensin II type 1 receptor antagonist olmesartan preserves cerebral blood flow and cerebrovascular reserve capacity, and accelerates rehabilitative outcomes in hypertensive patients with a history of stroke","volume":"120","author":"Matsumoto","year":"2010","journal-title":"Int J Neurosci"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib247","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/jamaneurol.2016.0091","article-title":"Pathophysiologic mechanisms of cerebral ischemia and diffusion hypoxia in traumatic brain injury","volume":"73","author":"Veenith","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1007\/s13311-023-01435-8_bib248","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fneur.2014.00114","article-title":"Imaging of cerebral blood flow in patients with severe traumatic brain injury in the neurointensive care","volume":"5","author":"Rostami","year":"2014","journal-title":"Front Neurol"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib249","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1177\/0271678X17701460","article-title":"Response of the cerebral vasculature following traumatic brain injury","volume":"37","author":"Salehi","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib250","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/j.2040-4603.2015.tb00640.x","article-title":"Role of microvascular disruption in brain damage from traumatic brain injury","volume":"5","author":"Logsdon","year":"2015","journal-title":"Compr Physiol"},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib251","doi-asserted-by":"crossref","first-page":"e24551","DOI":"10.1371\/journal.pone.0024551","article-title":"Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke","volume":"6","author":"Guan","year":"2011","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib252","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/jpet.112.197483","article-title":"AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator","volume":"344","author":"Alhusban","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib253","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1161\/STROKEAHA.108.537225","article-title":"Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke","volume":"40","author":"Kozak","year":"2009","journal-title":"Stroke"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib254","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1124\/jpet.113.212613","article-title":"Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B","volume":"349","author":"Soliman","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib255","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2010.05.020","article-title":"Angiotensin II induces C-reactive protein expression through ERK1\/2 and JNK signaling in human aortic endothelial cells","volume":"212","author":"Han","year":"2010","journal-title":"Atherosclerosis"},{"issue":"6\u20137","key":"10.1007\/s13311-023-01435-8_bib256","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s10571-009-9368-4","article-title":"Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery","volume":"29","author":"Benicky","year":"2009","journal-title":"Cell Mol Neurobiol"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib257","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/emmm.201000080","article-title":"Angiotensin II revisited: new roles in inflammation, immunology and aging","volume":"2","author":"Benigni","year":"2010","journal-title":"EMBO Mol Med"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib258","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1089\/ars.2012.4641","article-title":"Angiotensin II, NADPH oxidase, and redox signaling in the vasculature","volume":"19","author":"Nguyen Dinh Cat","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib259","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1182\/blood-2003-08-2974","article-title":"Direct evidence of leukocyte adhesion in arterioles by angiotensin II","volume":"104","author":"Alvarez","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib260","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0253-7613.62395","article-title":"Angiogenesis: future of pharmacological modulation","volume":"42","author":"Bisht","year":"2010","journal-title":"Indian J Pharmacol"},{"key":"10.1007\/s13311-023-01435-8_bib261","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1196\/annals.1296.043","article-title":"Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain","volume":"1018","author":"Ando","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib262","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/01.WCB.0000047369.05600.03","article-title":"Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition","volume":"23","author":"Yamakawa","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1007\/s13311-023-01435-8_bib263","doi-asserted-by":"crossref","first-page":"102086","DOI":"10.1016\/j.nicl.2019.102086","article-title":"Assessment of cerebrovascular dysfunction after traumatic brain injury with fMRI and fNIRS","volume":"25","author":"Amyot","year":"2020","journal-title":"Neuroimage Clin"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib264","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/17474930231153313","article-title":"Effects of candesartan on cerebral microvascular function in mild cognitive impairment: results of two clinical trials","volume":"18","author":"Henley","year":"2023","journal-title":"Int J Stroke"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib265","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/jcbfm.2008.158","article-title":"Angiotensin II modulates BBB permeability via activation of the AT(1) receptor in brain endothelial cells","volume":"29","author":"Fleegal-DeMotta","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib266","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbr.2010.11.032","article-title":"ACE I\/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment","volume":"218","author":"Zhang","year":"2011","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib267","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/15734021113099990003","article-title":"RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects","volume":"9","author":"Pelisch","year":"2013","journal-title":"Curr Hypertens Rev"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib268","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/ajh.2010.241","article-title":"Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats","volume":"24","author":"Pelisch","year":"2011","journal-title":"Am J Hypertens"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib269","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuroscience.2004.06.046","article-title":"Edema and brain trauma","volume":"129","author":"Unterberg","year":"2004","journal-title":"Neuroscience"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib270","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nec.2016.05.008","article-title":"Cerebral edema in traumatic brain injury: pathophysiology and prospective therapeutic targets","volume":"27","author":"Winkler","year":"2016","journal-title":"Neurosurg Clin N Am"},{"issue":"Pt B","key":"10.1007\/s13311-023-01435-8_bib271","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuropharm.2018.08.004","article-title":"Pathophysiology and treatment of cerebral edema in traumatic brain injury","volume":"145","author":"Jha","year":"2019","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib272","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/WCO.0b013e328337f451","article-title":"Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments","volume":"23","author":"Donkin","year":"2010","journal-title":"Curr Opin Neurol"},{"issue":"14","key":"10.1007\/s13311-023-01435-8_bib273","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1089\/neu.2013.3169","article-title":"Activation of NF-kappaB mediates astrocyte swelling and brain edema in traumatic brain injury","volume":"31","author":"Jayakumar","year":"2014","journal-title":"J Neurotrauma"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib274","first-page":"536","article-title":"Blockade of central angiotensin II AT1 receptor protects the brain from ischemia\/reperfusion injury in normotensive rats","volume":"39","author":"Panahpour","year":"2014","journal-title":"Iran J Med Sci"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib275","first-page":"Br394-7","article-title":"The \u201cno-reflow\u201d phenomenon in cerebral circulation","volume":"9","author":"Asiedu-Gyekye","year":"2003","journal-title":"Med Sci Monit"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib276","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1113\/JP271584","article-title":"Compromised blood-brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension","volume":"594","author":"Biancardi","year":"2016","journal-title":"J Physiol"},{"issue":"19","key":"10.1007\/s13311-023-01435-8_bib277","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1089\/neu.2014.3675","article-title":"Mildly reduced brain swelling and improved neurological outcome in aquaporin-4 knockout mice following controlled cortical impact brain injury","volume":"32","author":"Yao","year":"2015","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01435-8_bib278","first-page":"20","article-title":"Renin-angiotensin system plays an important role in the regulation of water transport in the peritoneum","volume":"17","author":"Imai","year":"2001","journal-title":"Adv Perit Dial"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib279","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00441-012-1336-5","article-title":"Role of the lesion scar in the response to damage and repair of the central nervous system","volume":"349","author":"Kawano","year":"2012","journal-title":"Cell Tissue Res"},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib280","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/j.1528-1167.2005.34004.x","article-title":"Predicting posttraumatic epilepsy with MRI: prospective longitudinal morphologic study in adults","volume":"46","author":"Messori","year":"2005","journal-title":"Epilepsia"},{"issue":"6039","key":"10.1007\/s13311-023-01435-8_bib281","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1126\/science.1203165","article-title":"A pericyte origin of spinal cord scar tissue","volume":"333","author":"Goritz","year":"2011","journal-title":"Science"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib282","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat Rev Neurosci"},{"issue":"34","key":"10.1007\/s13311-023-01435-8_bib283","doi-asserted-by":"crossref","first-page":"13882","DOI":"10.1523\/JNEUROSCI.2524-13.2013","article-title":"Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury","volume":"33","author":"Soderblom","year":"2013","journal-title":"J Neurosci"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib284","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1365-2362.2009.02183.x","article-title":"Effects of AT1- and beta-adrenergic receptor antagonists on TGF-beta1-induced fibrosis in transgenic mice","volume":"39","author":"Seeland","year":"2009","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib285","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/art.37873","article-title":"Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade","volume":"65","author":"Marut","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib286","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ana.24147","article-title":"Losartan prevents acquired epilepsy via TGF-beta signaling suppression","volume":"75","author":"Bar-Klein","year":"2014","journal-title":"Ann Neurol"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib287","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/aps.2012.115","article-title":"Telmisartan attenuates hepatic fibrosis in bile duct-ligated rats","volume":"33","author":"Yi","year":"2012","journal-title":"Acta Pharmacol Sin"},{"issue":"26","key":"10.1007\/s13311-023-01435-8_bib288","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1056\/NEJMoa0706585","article-title":"Angiotensin II blockade and aortic-root dilation in Marfan's syndrome","volume":"358","author":"Brooke","year":"2008","journal-title":"N Engl J Med"},{"issue":"5770","key":"10.1007\/s13311-023-01435-8_bib289","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"10.1007\/s13311-023-01435-8_bib290","doi-asserted-by":"crossref","first-page":"71323","DOI":"10.1155\/2007\/71323","article-title":"The role of PPARs in lung fibrosis","volume":"2007","author":"Lakatos","year":"2007","journal-title":"PPAR Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib291","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10571-015-0327-y","article-title":"Evidence to consider angiotensin ii receptor blockers for the treatment of early Alzheimer's disease","volume":"36","author":"Saavedra","year":"2016","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib292","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfj007","article-title":"Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons","volume":"89","author":"Nakatsu","year":"2006","journal-title":"Toxicol Sci"},{"key":"10.1007\/s13311-023-01435-8_bib293","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuropharm.2013.11.022","article-title":"Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT(1) receptor blockade and PPARgamma activation","volume":"79","author":"Wang","year":"2014","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib294","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1007\/s12035-017-0812-z","article-title":"Angiotensin II causes neuronal damage in stretch-injured neurons: protective effects of losartan, an angiotensin T(1) receptor blocker","volume":"55","author":"Abdul-Muneer","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib295","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.bbrc.2013.08.091","article-title":"Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking","volume":"439","author":"Sohn","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib296","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00004647-200405000-00008","article-title":"Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat","volume":"24","author":"Lou","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib297","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1007\/s11064-013-1185-y","article-title":"Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke","volume":"38","author":"Ishrat","year":"2013","journal-title":"Neurochem Res"},{"key":"10.1007\/s13311-023-01435-8_bib298","doi-asserted-by":"crossref","first-page":"101612","DOI":"10.1016\/j.arr.2022.101612","article-title":"Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future","volume":"77","author":"Gouveia","year":"2022","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib299","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/ACO.0000000000001183","article-title":"Cerebral metabolic derangements following traumatic brain injury","volume":"35","author":"Demers-Marcil","year":"2022","journal-title":"Curr Opin Anaesthesiol"},{"issue":"5\u20136","key":"10.1007\/s13311-023-01435-8_bib300","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1089\/neu.2022.0161","article-title":"Cerebral metabolic dysfunction at the acute phase of traumatic brain injury correlates with long-term tissue loss","volume":"40","author":"Bernini","year":"2023","journal-title":"J Neurotrauma"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib301","doi-asserted-by":"crossref","first-page":"103108","DOI":"10.1016\/j.isci.2021.103108","article-title":"Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods","volume":"24","author":"Sowers","year":"2021","journal-title":"iScience"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib302","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/prca.201600003","article-title":"Lipid peroxidation and tyrosine nitration in traumatic brain injury: Insights into secondary injury from redox proteomics","volume":"10","author":"Butterfield","year":"2016","journal-title":"Proteomics Clin Appl"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib303","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070693","article-title":"Autophagy in neurotrauma: good, bad, or dysregulated","volume":"8","author":"Wu","year":"2019","journal-title":"Cells."},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib304","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/MAJ.0000000000000506","article-title":"Traumatic brain injury and mitochondrial dysfunction","volume":"350","author":"Hiebert","year":"2015","journal-title":"Am J Med Sci"},{"key":"10.1007\/s13311-023-01435-8_bib305","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnene.2013.00011","article-title":"N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation","volume":"5","author":"Moffett","year":"2013","journal-title":"Front Neuroenergetics"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib306","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1161\/01.ATV.0000140059.04717.f3","article-title":"Angiotensin II-induced insulin resistance and protein tyrosine phosphatases","volume":"24","author":"Marrero","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib307","doi-asserted-by":"crossref","first-page":"E538","DOI":"10.1152\/ajpendo.00537.2012","article-title":"Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment","volume":"304","author":"Wang","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib308","doi-asserted-by":"crossref","first-page":"769","DOI":"10.31083\/j.rcm2203083","article-title":"Role of the ACE2\/Ang-(1\u20137)\/Mas axis in glucose metabolism","volume":"22","author":"Zhao","year":"2021","journal-title":"Rev Cardiovasc Med"},{"issue":"35","key":"10.1007\/s13311-023-01435-8_bib309","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.3346\/jkms.2020.35.e289","article-title":"Activation of AMPK by telmisartan decreases basal and PDGF-stimulated VSMC proliferation via inhibiting the mTOR\/p70S6K signaling axis","volume":"35","author":"Hwang","year":"2020","journal-title":"J Korean Med Sci"},{"issue":"15","key":"10.1007\/s13311-023-01435-8_bib310","doi-asserted-by":"crossref","first-page":"e1801054","DOI":"10.1002\/mnfr.201801054","article-title":"Brain trauma disrupts hepatic lipid metabolism: blame it on fructose?","volume":"63","author":"Rege","year":"2019","journal-title":"Mol Nutr Food Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib311","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/bja\/aet305","article-title":"Liver function test abnormalities after traumatic brain injury: is hepato-biliary ultrasound a sensitive diagnostic tool?","volume":"112","author":"Sanfilippo","year":"2014","journal-title":"Br J Anaesth"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib312","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.clnu.2013.06.003","article-title":"Changes in weight after traumatic brain injury in adult patients: a longitudinal study","volume":"33","author":"Crenn","year":"2014","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib313","first-page":"145","article-title":"Stress insulin resistance is a marker for mortality in traumatic brain injury","volume":"66","author":"Mowery","year":"2009","journal-title":"J Trauma"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib314","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/02699059009026189","article-title":"Hypertension in traumatic brain injury","volume":"4","author":"Labi","year":"1990","journal-title":"Brain Inj"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib315","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s11906-005-0040-1","article-title":"Hypertension and head injury","volume":"7","author":"Shiozaki","year":"2005","journal-title":"Curr Hypertens Rep"},{"issue":"3\u20134","key":"10.1007\/s13311-023-01435-8_bib316","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3121\/cmr.2018.1437","article-title":"Cardiac dysfunction in adult patients with traumatic brain injury: a prospective cohort study","volume":"16","author":"Venkata","year":"2018","journal-title":"Clin Med Res"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib317","doi-asserted-by":"crossref","first-page":"74","DOI":"10.23861\/EJBM20112768","article-title":"Brain-spleen inflammatory coupling: a literature review","volume":"27","author":"Rasouli","year":"2011","journal-title":"Einstein J Biol Med"},{"key":"10.1007\/s13311-023-01435-8_bib318","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916647055","article-title":"Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge","volume":"12","author":"Rowe","year":"2016","journal-title":"Mol Pain."},{"issue":"19","key":"10.1007\/s13311-023-01435-8_bib319","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1089\/neu.2019.6963","article-title":"Systemic inflammation persists the first year after mild traumatic brain injury: results from the prospective trondheim mild traumatic brain injury study","volume":"37","author":"Chaban","year":"2020","journal-title":"J Neurotrauma"},{"key":"10.1007\/s13311-023-01435-8_bib320","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fneur.2015.00235","article-title":"Traumatic brain injury and peripheral immune suppression: primer and prospectus","volume":"6","author":"Hazeldine","year":"2015","journal-title":"Front Neurol"},{"key":"10.1007\/s13311-023-01435-8_bib321","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/B978-0-444-63954-7.00017-3","article-title":"Postconcussion syndrome","volume":"158","author":"Dwyer","year":"2018","journal-title":"Handb Clin Neurol"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib322","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/jama.300.6.711","article-title":"Prevalence of chronic pain after traumatic brain injury: a systematic review","volume":"300","author":"Nampiaparampil","year":"2008","journal-title":"JAMA"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib323","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.289.1.65","article-title":"Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial","volume":"289","author":"Tronvik","year":"2003","journal-title":"JAMA"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib324","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/0333102413515348","article-title":"A comparative study of candesartan versus propranolol for migraine prophylaxis: a randomised, triple-blind, placebo-controlled, double cross-over study","volume":"34","author":"Stovner","year":"2014","journal-title":"Cephalalgia"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib325","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1038\/s41598-021-83508-2","article-title":"Real world effectiveness and tolerability of candesartan in the treatment of migraine: a retrospective cohort study","volume":"11","author":"Sanchez-Rodriguez","year":"2021","journal-title":"Sci Rep"},{"issue":"17","key":"10.1007\/s13311-023-01435-8_bib326","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1212\/WNL.0b013e3182535d20","article-title":"Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society","volume":"78","author":"Silberstein","year":"2012","journal-title":"Neurology"},{"issue":"9","key":"10.1007\/s13311-023-01435-8_bib327","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1468-2982.2008.01825.x","article-title":"Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial","volume":"29","author":"Diener","year":"2009","journal-title":"Cephalalgia"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib328","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10072-017-2854-4","article-title":"Treatment with telmisartan, a long-acting angiotensin II receptor blocker, prevents migraine attacks in Japanese non-responders to lomerizine","volume":"38","author":"Ikeda","year":"2017","journal-title":"Neurol Sci"},{"key":"10.1007\/s13311-023-01435-8_bib329","doi-asserted-by":"crossref","first-page":"173063","DOI":"10.1016\/j.pbb.2020.173063","article-title":"Targeting the renin angiotensin system for the treatment of anxiety and depression","volume":"199","author":"Chrissobolis","year":"2020","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib330","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1523\/JNEUROSCI.1647-20.2020","article-title":"Limbic neuropeptidergic modulators of emotion and their therapeutic potential for anxiety and post-traumatic stress disorder","volume":"41","author":"Marvar","year":"2021","journal-title":"J Neurosci"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib331","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/10253890701476621","article-title":"Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic-pituitary-adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: preliminary results","volume":"11","author":"Pavlatou","year":"2008","journal-title":"Stress"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib332","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/080370502760050395","article-title":"Cognitive function and health-related quality of life in elderly patients with hypertension\u2013baseline data from the study on cognition and prognosis in the elderly (SCOPE)","volume":"11","author":"Degl'Innocenti","year":"2002","journal-title":"Blood Press"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib333","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.jhh.1001657","article-title":"Health-related quality of life during treatment of elderly patients with hypertension: results from the Study on COgnition and Prognosis in the Elderly (SCOPE)","volume":"18","author":"Degl'Innocenti","year":"2004","journal-title":"J Hum Hypertens"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib334","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4088\/JCP.11m07316","article-title":"The renin-angiotensin pathway in posttraumatic stress disorder: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are associated with fewer traumatic stress symptoms","volume":"73","author":"Khoury","year":"2012","journal-title":"J Clin Psychiatry"},{"issue":"7","key":"10.1007\/s13311-023-01435-8_bib335","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.biopsych.2021.05.012","article-title":"Randomized, placebo-controlled trial of the angiotensin receptor antagonist losartan for posttraumatic stress disorder","volume":"90","author":"Stein","year":"2021","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib336","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1177\/19417381211031842","article-title":"Stimulant therapy utilization for neurocognitive deficits in mild traumatic brain injury","volume":"14","author":"Coris","year":"2022","journal-title":"Sports Health"},{"issue":"8","key":"10.1007\/s13311-023-01435-8_bib337","doi-asserted-by":"crossref","first-page":"e2012252","DOI":"10.1001\/jamanetworkopen.2020.12252","article-title":"Effects of candesartan vs lisinopril on neurocognitive function in older adults with executive mild cognitive impairment: a randomized clinical trial","volume":"3","author":"Hajjar","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib338","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/braincomms\/fcac270","article-title":"Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer's disease","volume":"4","author":"Hajjar","year":"2022","journal-title":"Brain Commun"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib339","first-page":"1175","article-title":"Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE)","volume":"44","author":"Papademetriou","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"19 Pt 2","key":"10.1007\/s13311-023-01435-8_bib340","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1212\/01.wnl.0000311447.85948.78","article-title":"Candesartan and cognitive decline in older patients with hypertension: a substudy of the SCOPE trial","volume":"70","author":"Saxby","year":"2008","journal-title":"Neurology"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib341","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1097\/01.hjh.0000220415.99610.22","article-title":"The Study on COgnition and Prognosis in the Elderly (SCOPE)\u2013recent analyses","volume":"24","author":"Trenkwalder","year":"2006","journal-title":"J Hypertens Suppl"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib342","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3233\/JAD-171119","article-title":"The coming of age of the angiotensin hypothesis in Alzheimer's disease: progress toward disease prevention and treatment?","volume":"62","author":"Kehoe","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1007\/s13311-023-01435-8_bib343","doi-asserted-by":"crossref","first-page":"104230","DOI":"10.1016\/j.phrs.2019.04.014","article-title":"Improvements of symptoms of Alzheimer's disease by inhibition of the angiotensin system","volume":"154","author":"Quitterer","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1007\/s13311-023-01435-8_bib344","doi-asserted-by":"crossref","first-page":"105375","DOI":"10.1016\/j.neuint.2022.105375","article-title":"Contralesional angiotensin type 2 receptor activation contributes to recovery in experimental stroke","volume":"158","author":"Fouda","year":"2022","journal-title":"Neurochem Int"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib345","doi-asserted-by":"crossref","first-page":"14280","DOI":"10.1038\/s41598-022-18338-x","article-title":"AT2 activation does not influence brain damage in the early phase after experimental traumatic brain injury in male mice","volume":"12","author":"Timaru-Kast","year":"2022","journal-title":"Sci Rep"},{"key":"10.1007\/s13311-023-01435-8_bib346","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2017.02.016","article-title":"Role of interleukin-10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia\/reperfusion injury","volume":"799","author":"Fouda","year":"2017","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib347","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/HJH.0000000000000364","article-title":"Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke","volume":"33","author":"Alhusban","year":"2015","journal-title":"J Hypertens"},{"issue":"5","key":"10.1007\/s13311-023-01435-8_bib348","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/CS20180100","article-title":"Protective effects of the angiotensin II AT(2) receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach","volume":"132","author":"Bennion","year":"2018","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib349","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/jnr.20649","article-title":"Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury","volume":"82","author":"Zhao","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1007\/s13311-023-01435-8_bib350","doi-asserted-by":"crossref","DOI":"10.1007\/s13311-014-0286-x","article-title":"Angiotensin receptor type 2 activation induces neuroprotection and neurogenesis after traumatic brain injury","author":"Umschweif","year":"2014","journal-title":"Neurotherapeutics"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib351","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12017-021-08687-7","article-title":"Compound 21, a direct AT2R agonist, induces IL-10 and inhibits inflammation in mice following traumatic brain injury","volume":"24","author":"Ismael","year":"2022","journal-title":"Neuromolecular Med"},{"key":"10.1007\/s13311-023-01435-8_bib352","first-page":"CD008170","article-title":"First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive drug classes for hypertension","volume":"11","author":"Chen","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib353","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.112.006809","article-title":"A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme","volume":"65","author":"Bernstein","year":"2013","journal-title":"Pharmacol Rev"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib354","first-page":"202","article-title":"Attenuation of focal cerebral ischemic injury following post-ischemic inhibition of angiotensin converting enzyme (ACE) activity in normotensive rat","volume":"16","author":"Panahpour","year":"2012","journal-title":"Iran Biomed J"},{"issue":"Suppl 3","key":"10.1007\/s13311-023-01435-8_bib355","doi-asserted-by":"crossref","first-page":"S321","DOI":"10.3233\/JAD-132189","article-title":"Brain-penetrating angiotensin-converting enzyme inhibitors and cognitive change in patients with dementia due to Alzheimer's disease","volume":"42","author":"de Oliveira","year":"2014","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib356","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-130716","article-title":"Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer's disease in the absence of apolipoprotein E4 allele","volume":"37","author":"Qiu","year":"2013","journal-title":"J Alzheimers Dis"},{"issue":"Suppl 2","key":"10.1007\/s13311-023-01435-8_bib357","doi-asserted-by":"crossref","first-page":"S251","DOI":"10.3233\/JAD-2012-111376","article-title":"The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis?","volume":"30","author":"Kehoe","year":"2012","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib358","article-title":"Risk of developing Alzheimer's disease and related dementias in allhat trial participants receiving diuretic, ace-inhibitor, or calcium-channel blocker with 18 years of follow-Up","volume":"12","author":"Du","year":"2022","journal-title":"J Alzheimers Dis Parkinsonism."},{"key":"10.1007\/s13311-023-01435-8_bib359","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105515","article-title":"Association between renin-angiotensin-aldosterone system inhibitors and risk of dementia: a meta-analysis","volume":"166","author":"Scotti","year":"2021","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib360","first-page":"197","article-title":"Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels","volume":"51","author":"Tiret","year":"1992","journal-title":"Am J Hum Genet"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib361","doi-asserted-by":"crossref","first-page":"e0260498","DOI":"10.1371\/journal.pone.0260498","article-title":"Angiotensin-converting enzyme polymorphisms AND Alzheimer's disease susceptibility: an updated meta-analysis","volume":"16","author":"Xin","year":"2021","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib362","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/mp.55.1.29","article-title":"Association of the D allele of the angiotensin I converting enzyme polymorphism with malignant vascular injury","volume":"55","author":"Mayer","year":"2002","journal-title":"Mol Pathol"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib363","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/ggi.12929","article-title":"Angiotensin-converting enzyme insertion\/deletion polymorphism and the longitudinal progression of Alzheimer's disease","volume":"17","author":"Chou","year":"2017","journal-title":"Geriatr Gerontol Int"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib364","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1176\/jnp.18.1.39","article-title":"Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury","volume":"18","author":"Ariza","year":"2006","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1007\/s13311-023-01435-8_bib365","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biopha.2017.05.062","article-title":"ACE-2\/Ang1-7\/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats","volume":"92","author":"Abuohashish","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib366","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00210-016-1278-7","article-title":"Captopril improves postresuscitation hemodynamics protective against pulmonary embolism by activating the ACE2\/Ang-(1\u20137)\/Mas axis","volume":"389","author":"Xiao","year":"2016","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib367","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11906-014-0512-2","article-title":"Neuroprotective mechanisms of the ACE2-angiotensin-(1\u20137)-Mas axis in stroke","volume":"17","author":"Bennion","year":"2015","journal-title":"Curr Hypertens Rep"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib368","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/CS20130324","article-title":"Cerebroprotective action of angiotensin peptides in stroke","volume":"126","author":"Regenhardt","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"10.1007\/s13311-023-01435-8_bib369","doi-asserted-by":"crossref","first-page":"903980","DOI":"10.3389\/fnbeh.2022.903980","article-title":"Angiotensin-(1\u20137) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury","volume":"16","author":"Bruhns","year":"2022","journal-title":"Front Behav Neurosci"},{"issue":"6","key":"10.1007\/s13311-023-01435-8_bib370","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.4103\/1673-5374.270304","article-title":"The extended renin-angiotensin system: a promising target for traumatic brain injury therapeutics","volume":"15","author":"Janatpour","year":"2020","journal-title":"Neural Regen Res"},{"key":"10.1007\/s13311-023-01435-8_bib371","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1096\/fasebj.24.1_supplement.1032.3","article-title":"Diminazene aceturate Is an ACE2 activator and a novel antihypertensive drug","volume":"24","author":"Gjymishka","year":"2010","journal-title":"FASEB J"},{"issue":"10","key":"10.1007\/s13311-023-01435-8_bib372","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1113\/expphysiol.2011.058578","article-title":"Cerebroprotection by angiotensin-(1\u20137) in endothelin-1-induced ischaemic stroke","volume":"96","author":"Mecca","year":"2011","journal-title":"Exp Physiol"},{"key":"10.1007\/s13311-023-01435-8_bib373","doi-asserted-by":"crossref","first-page":"4592768","DOI":"10.1155\/2016\/4592768","article-title":"Phase II trial of angiotensin-(1\u20137) for the treatment of patients with metastatic sarcoma","volume":"2016","author":"Savage","year":"2016","journal-title":"Sarcoma"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib374","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/1389203724666221130140416","article-title":"Potential of angiotensin-(1\u20137) in COVID-19 treatment","volume":"24","author":"Luna","year":"2023","journal-title":"Curr Protein Pept Sci"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib375","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/HYPERTENSIONAHA.115.05185","article-title":"Activation of the neuroprotective angiotensin-converting enzyme 2 in rat ischemic stroke","volume":"66","author":"Bennion","year":"2015","journal-title":"Hypertension"},{"key":"10.1007\/s13311-023-01435-8_bib376","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuropharm.2014.01.004","article-title":"Neuronal over-expression of ACE2 protects brain from ischemia-induced damage","volume":"79","author":"Chen","year":"2014","journal-title":"Neuropharmacology"},{"issue":"12","key":"10.1007\/s13311-023-01435-8_bib377","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.imbio.2015.07.013","article-title":"Mas receptor deficiency exacerbates lipopolysaccharide-induced cerebral and systemic inflammation in mice","volume":"220","author":"Oliveira-Lima","year":"2015","journal-title":"Immunobiology"},{"issue":"11","key":"10.1007\/s13311-023-01435-8_bib378","doi-asserted-by":"crossref","first-page":"e0142087","DOI":"10.1371\/journal.pone.0142087","article-title":"Effect of a selective mas receptor agonist in cerebral ischemia in vitro and in vivo","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib379","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yexcr.2015.06.010","article-title":"Angiotensin-(1\u20137) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2\/ROS and PI3K\/NO pathways","volume":"336","author":"Xiao","year":"2015","journal-title":"Exp Cell Res"},{"key":"10.1007\/s13311-023-01435-8_bib380","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2014.12.007","article-title":"Ang-(1\u20137) exerts protective role in blood-brain barrier damage by the balance of TIMP-1\/MMP-9","volume":"748","author":"Wu","year":"2015","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1007\/s13311-023-01435-8_bib381","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jad.2012.07.024","article-title":"Angiotensin-(1\u20137) central administration induces anxiolytic-like effects in elevated plus maze and decreased oxidative stress in the amygdala","volume":"145","author":"Bild","year":"2013","journal-title":"J Affect Disord"},{"issue":"19","key":"10.1007\/s13311-023-01435-8_bib382","doi-asserted-by":"crossref","first-page":"11867","DOI":"10.1074\/jbc.273.19.11867","article-title":"Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene","volume":"273","author":"Walther","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1007\/s13311-023-01435-8_bib383","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuropharm.2015.12.026","article-title":"Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors","volume":"105","author":"Wang","year":"2016","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1007\/s13311-023-01435-8_bib384","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13041-023-01040-y","article-title":"Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice","volume":"16","author":"Nakagawasai","year":"2023","journal-title":"Mol Brain"},{"key":"10.1007\/s13311-023-01435-8_bib385","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2014.05.019","article-title":"Angiotensin-(1\u20137) improves cognitive function in rats with chronic cerebral hypoperfusion","volume":"1573","author":"Xie","year":"2014","journal-title":"Brain Res"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib386","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mcn.2005.03.012","article-title":"Angiotensin-(1\u20137) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas","volume":"29","author":"Hellner","year":"2005","journal-title":"Mol Cell Neurosci"},{"issue":"3","key":"10.1007\/s13311-023-01435-8_bib387","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00401-019-02098-6","article-title":"ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease","volume":"139","author":"Evans","year":"2020","journal-title":"Acta Neuropathol"},{"issue":"14","key":"10.1007\/s13311-023-01435-8_bib388","doi-asserted-by":"crossref","first-page":"14819","DOI":"10.18632\/aging.103544","article-title":"ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice","volume":"12","author":"Duan","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10.1007\/s13311-023-01435-8_bib389","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s12035-015-9260-9","article-title":"Angiotensin-(1\u20137) is reduced and inversely correlates with tau hyperphosphorylation in animal models of Alzheimer's disease","volume":"53","author":"Jiang","year":"2016","journal-title":"Mol Neurobiol"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-023-01435-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-023-01435-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923019980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923019980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-023-01435-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:13:43Z","timestamp":1761808423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923019980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":389,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1878747923019980"],"URL":"https:\/\/doi.org\/10.1007\/s13311-023-01435-8","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-023-01435-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}