{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:13:35Z","timestamp":1775276015391,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82151309"],"award-info":[{"award-number":["82151309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825012"],"award-info":[{"award-number":["81825012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730048"],"award-info":[{"award-number":["81730048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2022T150788"],"award-info":[{"award-number":["2022T150788"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s13311-023-01442-9","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:02:32Z","timestamp":1697454152000},"page":"1755-1766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor"],"prefix":"10.1016","volume":"20","author":[{"given":"Jiaji","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoxuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dekang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianbing","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayou","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Sepulcre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longsheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-5171","authenticated-orcid":false,"given":"Xin","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib1","first-page":"150","volume":"205","author":"Ghanouni","year":"2015","journal-title":"Transcranial MRI-guided focused ultrasound: a review of the technologic and neurologic applications"},{"issue":"8","key":"10.1007\/s13311-023-01442-9_bib2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1056\/NEJMoa1600159","article-title":"A randomized trial of focused ultrasound thalamotomy for essential tremor","volume":"375","author":"Elias","year":"2016","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1007\/s13311-023-01442-9_bib3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/mds.20037","article-title":"Lesion therapy for Parkinson's disease and other movement disorders: update and controversies","volume":"19","author":"Okun","year":"2004","journal-title":"Movement disorders : official journal of the Movement Disorder Society"},{"issue":"44","key":"10.1007\/s13311-023-01442-9_bib4","doi-asserted-by":"crossref","first-page":"12574","DOI":"10.1073\/pnas.1608282113","article-title":"Situating the default-mode network along a principal gradient of macroscale cortical organization","volume":"113","author":"Margulies","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1007\/s13311-023-01442-9_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrn2667","article-title":"Is the rostro-caudal axis of the frontal lobe hierarchical?","volume":"10","author":"Badre","year":"2009","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0166-4328(82)90081-X","article-title":"Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys","volume":"6","author":"Mishkin","year":"1982","journal-title":"Behav Brain Res"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tics.2017.11.002","article-title":"Large-scale gradients in human cortical organization","volume":"22","author":"Huntenburg","year":"2018","journal-title":"Trends Cogn Sci"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib8","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41467-019-08944-1","article-title":"Atypical functional connectome hierarchy in autism","volume":"10","author":"Hong","year":"2019","journal-title":"Nat Commun."},{"key":"10.1007\/s13311-023-01442-9_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101947","article-title":"The impact of ischemic stroke on connectivity gradients","volume":"24","author":"Bayrak","year":"2019","journal-title":"NeuroImage Clinical"},{"key":"10.1007\/s13311-023-01442-9_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117831","article-title":"Systematically disrupted functional gradient of the cortical connectome in generalized epilepsy: initial discovery and independent sample replication","volume":"230","author":"Meng","year":"2021","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-023-01442-9_bib11","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.neuroimage.2016.08.028","article-title":"Defining thalamic nuclei and topographic connectivity gradients in vivo","volume":"158","author":"Lambert","year":"2017","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-023-01442-9_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36652","article-title":"Functional gradients of the cerebellum","volume":"7","author":"Guell","year":"2018","journal-title":"eLife."},{"issue":"3","key":"10.1007\/s13311-023-01442-9_bib13","first-page":"237","article-title":"Thalamocortical dysrhythmia I.: functional and imaging aspects","volume":"1","author":"Llin\u00e1s","year":"2001","journal-title":"Thalamus & Related Systems"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"10.1007\/s13311-023-01442-9_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118550","article-title":"Convergent structural network and gene signatures for MRgFUS thalamotomy in patients with Parkinson's disease","volume":"243","author":"Lin","year":"2021","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-023-01442-9_bib16","first-page":"386","article-title":"GRETNA: a graph theoretical network analysis toolbox for imaging connectomics","volume":"9","author":"Wang","year":"2015","journal-title":"Front Hum Neurosci"},{"issue":"9","key":"10.1007\/s13311-023-01442-9_bib17","first-page":"3095","volume":"28","author":"Schaefer","year":"2018","journal-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI"},{"issue":"5","key":"10.1007\/s13311-023-01442-9_bib18","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1152\/jn.00339.2011","article-title":"The organization of the human cerebellum estimated by intrinsic functional connectivity","volume":"106","author":"Buckner","year":"2011","journal-title":"J Neurophysiol"},{"issue":"8","key":"10.1007\/s13311-023-01442-9_bib19","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1152\/jn.00270.2012","article-title":"The organization of the human striatum estimated by intrinsic functional connectivity","volume":"108","author":"Choi","year":"2012","journal-title":"J Neurophysiol"},{"key":"10.1007\/s13311-023-01442-9_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuroimage.2014.12.002","article-title":"Lead-DBS: a toolbox for deep brain stimulation electrode localizations and visualizations","volume":"107","author":"Horn","year":"2015","journal-title":"Neuroimage"},{"issue":"3","key":"10.1007\/s13311-023-01442-9_bib21","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s42003-020-0794-7","article-title":"BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets","volume":"3","author":"Vos de Wael","year":"2020","journal-title":"Commun Biol."},{"key":"10.1007\/s13311-023-01442-9_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117322","article-title":"Toward a connectivity gradient-based framework for reproducible biomarker discovery","volume":"223","author":"Hong","year":"2020","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-023-01442-9_bib24","series-title":"Predicting activation across individuals with resting-state functional connectivity based multi-atlas label fusion","first-page":"313","author":"Langs","year":"2015"},{"issue":"31","key":"10.1007\/s13311-023-01442-9_bib25","doi-asserted-by":"crossref","first-page":"10649","DOI":"10.1523\/JNEUROSCI.0759-12.2012","article-title":"Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain","volume":"32","author":"Sepulcre","year":"2012","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"issue":"5","key":"10.1007\/s13311-023-01442-9_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/1073858414531657","article-title":"Functional streams and cortical integration in the human brain","volume":"20","author":"Sepulcre","year":"2014","journal-title":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry"},{"key":"10.1007\/s13311-023-01442-9_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72129","article-title":"Standardizing workflows in imaging transcriptomics with the abagen toolbox","volume":"10","author":"Markello","year":"2021","journal-title":"Elife."},{"issue":"W1","key":"10.1007\/s13311-023-01442-9_bib28","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"10.1007\/s13311-023-01442-9_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013701","article-title":"Comparing brain networks of different size and connectivity density using graph theory","volume":"5","author":"van Wijk","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1007\/s13311-023-01442-9_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroimage.2016.11.052","article-title":"Towards a consensus regarding global signal regression for resting state functional connectivity MRI","volume":"154","author":"Murphy","year":"2017","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-023-01442-9_bib31","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuroimage.2017.02.005","article-title":"Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: issues and recommendations","volume":"152","author":"van den Heuvel","year":"2017","journal-title":"Neuroimage"},{"key":"10.1007\/s13311-023-01442-9_bib32","first-page":"202","volume":"13","author":"Zeng","year":"2019","journal-title":"The ventral Intermediate nucleus differently modulates subtype-related networks in Parkinson's disease"},{"issue":"2\u20133","key":"10.1007\/s13311-023-01442-9_bib33","first-page":"103","volume":"44","author":"Schweighofer","year":"2004","journal-title":"Cerebellar aminergic neuromodulation: towards a functional understanding"},{"issue":"8","key":"10.1007\/s13311-023-01442-9_bib34","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/hbm.25393","article-title":"The default mode network and cognition in Parkinson's disease: a multimodal resting-state network approach","volume":"42","author":"Ruppert","year":"2021","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/mds.27557","article-title":"Disruption of the default mode network and its intrinsic functional connectivity underlies minor hallucinations in Parkinson's disease","volume":"34","author":"Bejr-Kasem","year":"2019","journal-title":"Movement disorders : official journal of the Movement Disorder Society"},{"key":"10.1007\/s13311-023-01442-9_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1007\/s13311-023-01442-9_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112048","article-title":"The functional interaction of the brain default network with motor networks is modified by aging","volume":"372","author":"Rodriguez-Sabate","year":"2019","journal-title":"Behav Brain Res"},{"issue":"9","key":"10.1007\/s13311-023-01442-9_bib38","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00234-021-02653-7","article-title":"Disrupted brain gray matter networks in drug-na\u00efve participants with essential tremor","volume":"63","author":"Yang","year":"2021","journal-title":"Neuroradiology"},{"issue":"49","key":"10.1007\/s13311-023-01442-9_bib39","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001936","article-title":"Altered functional connectivity in essential tremor: a resting-state fMRI study","volume":"94","author":"Benito-Le\u00f3n","year":"2015","journal-title":"Medicine"},{"issue":"14","key":"10.1007\/s13311-023-01442-9_bib40","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/mds.26375","article-title":"Multiple resting-state networks are associated with tremors and cognitive features in essential tremor","volume":"30","author":"Fang","year":"2015","journal-title":"Movement disorders : official journal of the Movement Disorder Society"},{"key":"10.1007\/s13311-023-01442-9_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.814745","article-title":"Disrupted brain functional network topology in essential tremor patients with poor sleep quality","volume":"16","author":"Peng","year":"2022","journal-title":"Front Neurosci"},{"issue":"4","key":"10.1007\/s13311-023-01442-9_bib42","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00062-021-01002-8","article-title":"Disrupted brain network topology in drug-na\u00efve essential tremor patients with and without depression : a resting state functional magnetic resonance imaging study","volume":"31","author":"Li","year":"2021","journal-title":"Clin Neuroradiol"},{"key":"10.1007\/s13311-023-01442-9_bib43","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.nicl.2018.05.010","article-title":"Diffusion MRI tractography for improved transcranial MRI-guided focused ultrasound thalamotomy targeting for essential tremor","volume":"19","author":"Tian","year":"2018","journal-title":"NeuroImage Clin."},{"issue":"3","key":"10.1007\/s13311-023-01442-9_bib44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3171\/2021.3.JNS204329","article-title":"Correlation of visual area with tremor improvement after MRgFUS thalamotomy in Parkinson's disease","volume":"136","author":"Xiong","year":"2022","journal-title":"J Neurosurg"},{"key":"10.1007\/s13311-023-01442-9_bib45","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fneur.2016.00184","article-title":"Immediate and longitudinal alterations of functional networks after thalamotomy in essential tremor","volume":"7","author":"Jang","year":"2016","journal-title":"Front Neurol"},{"key":"10.1007\/s13311-023-01442-9_bib46","article-title":"Resting state functional connectivity signatures of MRgFUS Vim thalamotomy in Parkinson's disease: a preliminary study","volume":"12","author":"Stanziano","year":"2021","journal-title":"Front Neurol"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41531-022-00319-6","article-title":"Neuropathology of Parkinson's disease after focused ultrasound thalamotomy","volume":"8","author":"Koga","year":"2022","journal-title":"NPJ Parkinson's disease"},{"key":"10.1007\/s13311-023-01442-9_bib48","doi-asserted-by":"crossref","first-page":"589","DOI":"10.5334\/tohm.441","article-title":"Essential tremor and Parkinson's disease: exploring the relationship","volume":"8","author":"Tarakad","year":"2018","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"1","key":"10.1007\/s13311-023-01442-9_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2008.01.023","article-title":"Mitochondrial DNA in patients with essential tremor","volume":"434","author":"Yoo","year":"2008","journal-title":"Neurosci Lett"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-023-01442-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13311-023-01442-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923020135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923020135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13311-023-01442-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:16:42Z","timestamp":1761808602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923020135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1878747923020135"],"URL":"https:\/\/doi.org\/10.1007\/s13311-023-01442-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2784660\/v1","asserted-by":"object"}]},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s13311-023-01442-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}