{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:16:49Z","timestamp":1779243409439,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004172","name":"Mersin University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004172","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian Pediatr"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Fc gamma receptor IIa (<jats:italic>FCGR2A<\/jats:italic>) gene polymorphism is associated with increased susceptibility to autoimmune and infectious diseases. The aim of the present study was to evaluate the association of <jats:italic>FCGR2A<\/jats:italic> rs1801274 polymorphism with the development and severity of multisystem inflammatory syndrome in children (MIS-C).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This case-control study was conducted in a single center with MIS-C patients and healthy children. Clinical and cardiac imaging data of the participants was collected. The association between the clinical severity of the disease and <jats:italic>FCGR2A<\/jats:italic> rs1801274 polymorphism were investigated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>There was no significant association between <jats:italic>FCGR2A<\/jats:italic> rs1801274 polymorphism and cardiovascular complications in MIS-C patients. However, those with homozygous <jats:italic>FCGR2A<\/jats:italic> rs1801274 gene polymorphism developed severe cardiac dysfunction and required immunomodulatory agents other than intravenous immunoglobulin. The mean age of the patients with severe MIS-C was significantly higher than those with mild MIS-C, and systolic dysfunction was significant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Further multicenter studies in different ethnic groups are needed to evaluate the association between differences in the <jats:italic>FCGR2A<\/jats:italic> rs1801274 gene and severity of MIS-C and\/or other inflammatory diseases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial Registry<\/jats:title>\n            <jats:p>Mersin University Clinical Trial Registry, Decision number 2022\/280 dated April 20, 2022.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s13312-025-00047-z","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T10:27:18Z","timestamp":1744367238000},"page":"372-377","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["FCGR2A Gene Polymorphism Association in Children with Multisystem Inflammatory Syndrome"],"prefix":"10.1007","volume":"62","author":[{"given":"Esra","family":"Ye\u015filtepe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-1709","authenticated-orcid":false,"given":"Derya","family":"Duman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6721-4105","authenticated-orcid":false,"given":"Necdet","family":"Kuyucu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-8212","authenticated-orcid":false,"given":"Sevcan Tu\u011f","family":"Bozdo\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"\u00c7\u0131t\u0131r\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-9959","authenticated-orcid":false,"given":"Edanur","family":"Ye\u015fil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-1403","authenticated-orcid":false,"given":"Derya","family":"Karpuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"47_CR1","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.1002\/ppul.25687","volume":"56","author":"C Zhou","year":"2021","unstructured":"Zhou C, Zhao Y, Wang X, Huang Y, Tang X, Tang L. 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