{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:47:18Z","timestamp":1768740438167,"version":"3.49.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Drug Metab Pharmacokinet"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s13318-023-00870-4","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T19:03:02Z","timestamp":1704308582000},"page":"181-190","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Improved Pharmacokinetic and Pharmacodynamic Profile of Deuterium-Reinforced Tricyclic Antidepressants Doxepin, Dosulepin, and Clomipramine\u00a0in Animal Models"],"prefix":"10.1007","volume":"49","author":[{"given":"Shreyash","family":"Moharir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Likhit","family":"Akotkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urmila","family":"Aswar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dileep","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bapu","family":"Gawade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9920-5660","authenticated-orcid":false,"given":"Rajesh","family":"Rane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"870_CR1","unstructured":"Almasi A, Meza CE. Doxepin. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. 2022 Jan 3."},{"issue":"1","key":"870_CR2","first-page":"11","volume":"43","author":"T Nakagawa","year":"1993","unstructured":"Nakagawa T, Ukai K, Kubo S. Antidepressive effects of the stereoisomer cis-dosulepin hydrochloride. Arzneimittelforschung. 1993;43(1):11\u20135.","journal-title":"Arzneimittelforschung"},{"key":"870_CR3","unstructured":"Wilson M, Tripp J. Clomipramine. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. 2022 Dec 11."},{"key":"870_CR4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.2165\/00003088-199120060-00002","volume":"20","author":"AE Balant-Gorgia","year":"1991","unstructured":"Balant-Gorgia AE, Gex-Fabry M, Balant LP. Clinical pharmacokinetics of clomipramine. Clin Pharmacokinet. 1991;20:447\u201362.","journal-title":"Clin Pharmacokinet"},{"issue":"8","key":"870_CR5","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1016\/0006-2952(69)90290-1","volume":"18","author":"DC Hobbs","year":"1969","unstructured":"Hobbs DC. Distribution and metabolism of doxepin. Biochem Pharmacol. 1969;18(8):1941\u201354.","journal-title":"Biochem Pharmacol"},{"issue":"7","key":"870_CR6","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.3390\/molecules26071917","volume":"26","author":"BM Eh-Haj","year":"2021","unstructured":"Eh-Haj BM. Metabolic N-dealkylation and N-oxidation as elucidators of the role of alkylamino moieties in drugs acting at various receptors. Molecules. 2021;26(7):1917.","journal-title":"Molecules"},{"issue":"15","key":"870_CR7","doi-asserted-by":"publisher","first-page":"5659","DOI":"10.1021\/jacs.1c01923","volume":"143","author":"M Feng","year":"2021","unstructured":"Feng M, De Oliveira J, Sallustrau A, Destro G, Thu\u00e9ry P, Roy S, et\u00a0al. Direct carbon isotope exchange of pharmaceuticals via reversible decyanation. J Am Chem Soc. 2021;143(15):5659\u201365.","journal-title":"J Am Chem Soc"},{"issue":"6","key":"870_CR8","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/jat.3277","volume":"36","author":"MJ G\u00f3mez-Lech\u00f3n","year":"2016","unstructured":"G\u00f3mez-Lech\u00f3n MJ, Tolosa L, Donato MT. Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs. J Appl Toxicol. 2016;36(6):752\u201368.","journal-title":"J Appl Toxicol"},{"issue":"6","key":"870_CR9","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1002\/med.21592","volume":"39","author":"A Hunyadi","year":"2019","unstructured":"Hunyadi A. The mechanism (s) of action of antioxidants: From scavenging reactive oxygen\/nitrogen species to redox signaling and the generation of bioactive secondary metabolites. Med Res Rev. 2019;39(6):2505\u201333.","journal-title":"Med Res Rev"},{"issue":"46","key":"870_CR10","doi-asserted-by":"publisher","first-page":"11751","DOI":"10.1002\/chem.202101179","volume":"27","author":"J Steverlynck","year":"2021","unstructured":"Steverlynck J, Sitdikov R, Rueping M. The Deuterated \u201cMagic Methyl\u201d Group: A Guide to Site-Selective Trideuteromethyl Incorporation and Labeling by Using CD3 Reagents. Chem A Eur J. 2021;27(46):11751\u201372.","journal-title":"Chem A Eur J."},{"issue":"9","key":"870_CR11","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1021\/jm4007998","volume":"57","author":"TG Gant","year":"2014","unstructured":"Gant TG. Using deuterium in drug discovery: leaving the label in the drug. J Med Chem. 2014;57(9):3595\u2013611.","journal-title":"J Med Chem"},{"issue":"5","key":"870_CR12","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.apsb.2018.04.003","volume":"8","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Tang W. Drug metabolism in drug discovery and development. Acta Pharmaceutica Sinica B. 2018;8(5):721\u201332.","journal-title":"Acta Pharmaceutica Sinica B."},{"issue":"10","key":"870_CR13","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1517\/13543776.2014.943184","volume":"24","author":"GS Timmins","year":"2014","unstructured":"Timmins GS. Deuterated drugs: where are we now? Expert Opin Ther Pat. 2014;24(10):1067\u201375.","journal-title":"Expert Opin Ther Pat"},{"issue":"2","key":"870_CR14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1177\/1060028018797110","volume":"53","author":"EM Russak","year":"2019","unstructured":"Russak EM, Bednarczyk EM. Impact of deuterium substitution on the pharmacokinetics of pharmaceuticals. Ann Pharmacother. 2019;53(2):211\u20136.","journal-title":"Ann Pharmacother"},{"key":"870_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s40520-015-0359-7","volume":"28","author":"A Collamati","year":"2016","unstructured":"Collamati A, Martone AM, Poscia A, Brandi V, Celi M, Marzetti E, et\u00a0al. Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence. Aging Clin Exp Res. 2016;28:25\u201335.","journal-title":"Aging Clin Exp Res"},{"issue":"3","key":"870_CR16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1080\/15563650701226192","volume":"45","author":"AD Woolf","year":"2007","unstructured":"Woolf AD, Erdman AR, Nelson LS, Caravati EM, Cobaugh DJ, Booze LL, et\u00a0al. Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol. 2007;45(3):203\u201333.","journal-title":"Clin Toxicol"},{"issue":"11","key":"870_CR17","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1111\/jgs.13702","volume":"63","author":"DM Fick","year":"2015","unstructured":"By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2015;63(11):2227\u201346. https:\/\/doi.org\/10.1111\/jgs.13702.","journal-title":"J Am Geriatrics Soc."},{"key":"870_CR18","volume-title":"Tricyclic antidepressants","author":"J Moraczewski","year":"2022","unstructured":"Moraczewski J, Awosika AO, Aedma KK. Tricyclic Antidepressants. 2023 Aug 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023."},{"issue":"1\u20132","key":"870_CR19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jad.2012.06.007","volume":"144","author":"A Von Wolff","year":"2013","unstructured":"Von Wolff A, H\u00f6lzel L, Westphal A, H\u00e4rter M, Kriston L. Selective serotonin reuptake inhibitors and tricyclic antidepressants in the acute treatment of chronic depression and dysthymia: a systematic review and meta-analysis. J Affect Disord. 2013;144(1\u20132):7\u201315.","journal-title":"J Affect Disord"},{"issue":"3","key":"870_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0304-3959(79)90089-7","volume":"7","author":"NG Ward","year":"1979","unstructured":"Ward NG, Bloom VL, Friedel RO. The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression. Pain. 1979;7(3):331\u201341.","journal-title":"Pain"},{"issue":"6","key":"870_CR21","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/clpt.2014.59","volume":"95","author":"B Vrijens","year":"2014","unstructured":"Vrijens B, Urquhart J. Methods for measuring, enhancing, and accounting for medication adherence in clinical trials. Clin Pharmacol Ther. 2014;95(6):617\u201326.","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"870_CR22","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/j.1368-5031.2006.00865.x","volume":"60","author":"H Westenberg","year":"2006","unstructured":"Westenberg H, Sandner C. Tolerability and safety of fluvoxamine and other antidepressants. Int J Clin Pract. 2006;60(4):482\u201391.","journal-title":"Int J Clin Pract"},{"issue":"12","key":"870_CR23","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1080\/004982597239831","volume":"27","author":"J-H Yan","year":"1997","unstructured":"Yan J-H, Hubbard J, McKay G, Midha K. Stereoselective in vivo and in vitro studies on the metabolism of doxepin and N-desmethyldoxepin. Xenobiotica. 1997;27(12):1245\u201358.","journal-title":"Xenobiotica"},{"issue":"6","key":"870_CR24","first-page":"140","volume":"11","author":"GJ-B Oussou","year":"2021","unstructured":"Oussou GJ-B, Kouakou KL, Ettien AS, Yapo AP, Ehil\u00e9 EE. Antidepressant-like effects of aqueous leaf extract of Macaranga barteri Mull. and Arg (Euphorbiaceae) in rats. J Appl Pharm Sci. 2021;11(6):140\u20135.","journal-title":"J Appl Pharm Sci."},{"issue":"1","key":"870_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s002130050638","volume":"138","author":"J Redrobe","year":"1998","unstructured":"Redrobe J, Bourin M, Colombel M, Baker G. Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity. Psychopharmacology. 1998;138(1):1\u20138.","journal-title":"Psychopharmacology"},{"key":"870_CR26","doi-asserted-by":"crossref","unstructured":"Akotkar L, Aswar U, Patil R, Kumar D, Aswar M, Pandey J. Modulation of CUMS Induced Behaviour Deficits in Rats by Alpha Lipoic Acid: Possible Involvement of Dopaminergic and Serotonergic Neurotransmission. 2022.","DOI":"10.21203\/rs.3.rs-1398766\/v1"},{"issue":"1","key":"870_CR27","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3126\/njhs.v2i1.47173","volume":"2","author":"CK Yadav","year":"2022","unstructured":"Yadav CK, Poudel K, Shrivastava A, Mehta R, Yadav T. Anti-depressant Activity of the Seeds of Zanthoxylum armatum on Swiss Albino Mice. Nepal J Health Sci. 2022;2(1):98\u2013103.","journal-title":"Nepal J Health Sci."},{"issue":"1","key":"870_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/FTD.0b013e31823bf0fd","volume":"34","author":"MdMR Fern\u00e1ndez","year":"2012","unstructured":"Fern\u00e1ndez MdMR, Wille SM, Samyn N. Quantitative method validation for the analysis of 27 antidepressants and metabolites in plasma with ultraperformance liquid chromatography\u2013tandem mass spectrometry. Therap Drug Monitor. 2012;34(1):11\u201324.","journal-title":"Therap Drug Monitor."},{"issue":"4","key":"870_CR29","first-page":"431","volume":"44","author":"C-N Lin","year":"2014","unstructured":"Lin C-N, Juenke JM, Johnson-Davis KL. Method validation of a tricyclic antidepressant drug panel in urine by UPLC-MS\/MS. Ann Clin Lab Sci. 2014;44(4):431\u20136.","journal-title":"Ann Clin Lab Sci"},{"issue":"11\u201312","key":"870_CR30","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.cca.2010.02.067","volume":"411","author":"AR Breaud","year":"2010","unstructured":"Breaud AR, Harlan R, Di Bussolo JM, McMillin GA, Clarke W. A rapid and fully-automated method for the quantitation of tricyclic antidepressants in serum using turbulent-flow liquid chromatography\u2013tandem mass spectrometry. Clin Chim Acta. 2010;411(11\u201312):825\u201332.","journal-title":"Clin Chim Acta"},{"issue":"1","key":"870_CR31","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2174\/1389557519666190617150518","volume":"20","author":"N Manousi","year":"2020","unstructured":"Manousi N, Samanidou VF. Recent advances in the HPLC analysis of tricyclic antidepressants in bio-samples. Mini Rev Med Chem. 2020;20(1):24\u201338.","journal-title":"Mini Rev Med Chem"},{"issue":"12","key":"870_CR32","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.clinbiochem.2009.05.006","volume":"42","author":"AR Breaud","year":"2009","unstructured":"Breaud AR, Harlan R, Kozak M, Clarke W. A rapid and reliable method for the quantitation of tricyclic antidepressants in serum using HPLC-MS\/MS. Clin Biochem. 2009;42(12):1300\u20137.","journal-title":"Clin Biochem"},{"issue":"1","key":"870_CR33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1471-4159.1988.tb13239.x","volume":"50","author":"KS Kanba","year":"1988","unstructured":"Kanba KS, Kanba S, Nelson A, Okazaki H, Richelson E. [3H] neurotensin (8\u201313) binds in human brain to the same sites as does [3H] neurotensin but with higher affinity. J Neurochem. 1988;50(1):131\u20137.","journal-title":"J Neurochem"},{"issue":"2","key":"870_CR34","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1056-8719(02)00166-1","volume":"46","author":"HC Cheng","year":"2001","unstructured":"Cheng HC. The power issue: determination of KB or Ki from IC50: a closer look at the Cheng-Prusoff equation, the Schild plot and related power equations. J Pharmacol Toxicol Methods. 2001;46(2):61\u201371.","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"28","key":"870_CR35","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1016\/j.tetlet.2017.05.092","volume":"58","author":"H Li","year":"2017","unstructured":"Li H, Zhang B, Dong Y, Liu T, Zhang Y, Nie H, et\u00a0al. A selective and cost-effective method for the reductive deuteration of activated alkenes. Tetrahedron Lett. 2017;58(28):2757\u201360.","journal-title":"Tetrahedron Lett"},{"issue":"10","key":"870_CR36","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1002\/ajoc.202100381","volume":"10","author":"X Yang","year":"2021","unstructured":"Yang X, Ben H, Ragauskas AJ. Recent Advances in the Synthesis of Deuterium-Labeled Compounds. Asian J Organic Chem. 2021;10(10):2473\u201385.","journal-title":"Asian J Organic Chem."},{"key":"870_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2019.121955","volume":"1138","author":"Y Yi","year":"2020","unstructured":"Yi Y, Ren G, Zheng M, Zhao D, Li N, Chen X, et\u00a0al. Simultaneous determination of deuterated vortioxetine and its major metabolite in human plasma by UPLC-MS\/MS and application to a pharmacokinetic study in healthy volunteers. J Chromatogr B. 2020;1138: 121955.","journal-title":"J Chromatogr B"},{"issue":"1","key":"870_CR38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2217\/nmt-2018-0040","volume":"9","author":"A Richard","year":"2019","unstructured":"Richard A, Frank S. Deutetrabenazine in the treatment of Huntington\u2019s disease. Neurodegenerative Dis Manag. 2019;9(1):31\u20137.","journal-title":"Neurodegenerative Dis Manag."},{"issue":"6","key":"870_CR39","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1080\/14656566.2017.1307340","volume":"18","author":"AP Porsteinsson","year":"2017","unstructured":"Porsteinsson AP, Antonsdottir IM. An update on the advancements in the treatment of agitation in Alzheimer\u2019s disease. Expert Opin Pharmacother. 2017;18(6):611\u201320.","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"870_CR40","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/14728214.2021.1898588","volume":"26","author":"A Majeed","year":"2021","unstructured":"Majeed A, Xiong J, Teopiz KM, Ng J, Ho R, Rosenblat JD, et\u00a0al. Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials. Expert Opin Emerg Drugs. 2021;26(1):63\u201374.","journal-title":"Expert Opin Emerg Drugs"},{"issue":"5","key":"870_CR41","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.4103\/1673-5374.324842","volume":"17","author":"R Khoury","year":"2022","unstructured":"Khoury R. Deuterated dextromethorphan\/quinidine for agitation in Alzheimer\u2019s disease. Neural Regen Res. 2022;17(5):1013.","journal-title":"Neural Regen Res"},{"key":"870_CR42","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1021\/acsmedchemlett.2c00354","volume":"13","author":"RB Kargbo","year":"2022","unstructured":"Kargbo RB. Application of deuterated N, N-dimethyltryptamine in the potential treatment of psychiatric and neurological disorders. ACS Med Chem Lett. 2022;13:1402\u20134.","journal-title":"ACS Med Chem Lett"},{"issue":"14","key":"870_CR43","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1016\/j.bmcl.2018.06.025","volume":"28","author":"F Wang","year":"2018","unstructured":"Wang F, Jiang H, Deng Y, Yu J, Zhan M, Zhao L, et\u00a0al. Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties. Bioorg Med Chem Lett. 2018;28(14):2399\u2013402.","journal-title":"Bioorg Med Chem Lett"},{"issue":"12","key":"870_CR44","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1016\/j.bmcl.2017.04.071","volume":"27","author":"X Pang","year":"2017","unstructured":"Pang X, Wang Y, Chen Y. Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2017;27(12):2803\u20136.","journal-title":"Bioorg Med Chem Lett"},{"issue":"11","key":"870_CR45","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1016\/j.bmcl.2015.03.088","volume":"25","author":"S Guo","year":"2015","unstructured":"Guo S, Pang X, Peng L, Zhan M, Fan L, Gong Y, et\u00a0al. Design, synthesis and biological evaluation of deuterated Tivozanib for improving pharmacokinetic properties. Bioorg Med Chem Lett. 2015;25(11):2425\u20138.","journal-title":"Bioorg Med Chem Lett"},{"key":"870_CR46","first-page":"403","volume":"46","author":"SL Harbeson","year":"2011","unstructured":"Harbeson SL, Tung RD. Deuterium in drug discovery and development. Annu Rep Med Chem. 2011;46:403\u201317.","journal-title":"Annu Rep Med Chem"},{"issue":"19","key":"870_CR47","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1021\/ol502404e","volume":"16","author":"M Szostak","year":"2014","unstructured":"Szostak M, Spain M, Procter DJ. Selective synthesis of \u03b1, \u03b1-dideuterio alcohols by the reduction of carboxylic acids using SmI2 and D2O as deuterium source under SET conditions. Org Lett. 2014;16(19):5052\u20135.","journal-title":"Org Lett"},{"key":"870_CR48","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/0165-6147(84)90534-0","volume":"5","author":"AB Foster","year":"1984","unstructured":"Foster AB. Deuterium isotope effects in studies of drug metabolism. Trends Pharmacol Sci. 1984;5:524\u20137.","journal-title":"Trends Pharmacol Sci"},{"key":"870_CR49","volume":"1","author":"S Kaur","year":"2017","unstructured":"Kaur S, Gupta M. Deuteration as a tool for optimization of metabolic stability and toxicity of drugs. Glob J Pharmaceu Sci. 2017;1: 555566.","journal-title":"Glob J Pharmaceu Sci."},{"issue":"7","key":"870_CR50","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1002\/anie.201704146","volume":"57","author":"J Atzrodt","year":"2018","unstructured":"Atzrodt J, Derdau V, Kerr WJ, Reid M. Deuterium-and tritium-labelled compounds: applications in the life sciences. Angew Chem Int Ed. 2018;57(7):1758\u201384.","journal-title":"Angew Chem Int Ed"},{"key":"870_CR51","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.2147\/DDDT.S111352","volume":"10","author":"J Jiang","year":"2016","unstructured":"Jiang J, Pang X, Li L, Dai X, Diao X, Chen X, et\u00a0al. Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide. Drug Design Dev Therapy. 2016;10:2181\u201391.","journal-title":"Drug Design Dev Therapy."},{"issue":"4","key":"870_CR52","doi-asserted-by":"publisher","first-page":"331","DOI":"10.2174\/157015909790031201","volume":"7","author":"DM Marks","year":"2009","unstructured":"Marks DM, Shah MJ, Patkar AA, Masand PS, Park G-Y, Pae C-U. Serotonin-norepinephrine reuptake inhibitors for pain control: premise and promise. Curr Neuropharmacol. 2009;7(4):331\u20136.","journal-title":"Curr Neuropharmacol"}],"container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13318-023-00870-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13318-023-00870-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13318-023-00870-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T18:22:29Z","timestamp":1709230949000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13318-023-00870-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["870"],"URL":"https:\/\/doi.org\/10.1007\/s13318-023-00870-4","relation":{},"ISSN":["0378-7966","2107-0180"],"issn-type":[{"value":"0378-7966","type":"print"},{"value":"2107-0180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]},"assertion":[{"value":"15 November 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The funding for the experimental work was provided by Cleanchem Lifesciences LPP, Navi, Mumbai.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"All authors have no any conflict of competing interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The animal experiments were carried out in accordance with the protocol (1120\/IAEC\/2022-2023; dated 12\/08\/2022) approved by the Institutional Animal Ethics Committee (IAEC), AIIMS, New Delhi and as per the guidelines laid down by the Committee for Control and Supervision of Experimental Animals (CCSEA), New Delhi.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The supporting data for this article will be made available by the corresponding author on the request from reader.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"R.R. wrote the manuscript with support from S.M., L.A. and U.A. D.K. contributed for the analysis and interpretation of data for this manuscript. B.G. and K.P. helped R.R. to supervise the project.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}