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Fang Zhang and Xiaohong Gong wrote the manuscript and prepared the figures. Fang Zhang, Rui Wu, Yanfang Liu, and Shu Dai conducted the sample collection and data analysis. Yunxia Li conceived the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}},{"value":"This study was supported by National Natural Science Foundation of China (grant nos. 82004052, 81891012 and U19A2010), Postdoctoral Science Foundation (grant no. 2021M692327), Sichuan Province Science and Technology Support Program (nos. 2021JDRC0041 and 22ZYZYTS0071), Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (no. ZYYCXTD-D-202209).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors (Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xiaohong Gong, Yunxia Li) declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All animal experiments were conducted strictly in accordance with ethical guidelines approved by the Animal Ethical Committee of Chengdu University of Traditional Chinese Medicine and handled according to the Management and Experimental Guidelines for Laboratory Animals of Chengdu University of Traditional Chinese Medicine (permit number: SYXK 2020-124, approval date: 04-12-2020). All institutional and national guidelines for the care of the laboratory animals were followed.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"All data and materials are available from the corresponding author.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Materials"}},{"value":"Not applicable.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}}]}}