{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:04:31Z","timestamp":1756811071926,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Queensland Pathology","award":["5959_Cossart_Staatz"],"award-info":[{"award-number":["5959_Cossart_Staatz"]}]},{"DOI":"10.13039\/100010398","name":"Metro South Health","doi-asserted-by":"crossref","award":["846301"],"award-info":[{"award-number":["846301"]}],"id":[{"id":"10.13039\/100010398","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Strategies Grant from The School of Pharmacy, University of Queensland;","award":["Staatz_2018"],"award-info":[{"award-number":["Staatz_2018"]}]},{"DOI":"10.13039\/501100001794","name":"The University of Queensland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Drug Metab Pharmacokinet"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s13318-024-00914-3","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T18:02:49Z","timestamp":1724954569000},"page":"751-761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does Age Influence Immunosuppressant Drug Pharmacokinetics in Kidney Transplant Recipients?"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-6657","authenticated-orcid":false,"given":"Amelia R.","family":"Cossart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Isbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott B.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"McWhinney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Staatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"issue":"3","key":"914_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/01.tp.0000275423.69689.dc","volume":"84","author":"GM Danovitch","year":"2007","unstructured":"Danovitch GM, Gill J, Bunnapradist S. Immunosuppression of the elderly kidney transplant recipient. Transplantation. 2007;84(3):285\u201391.","journal-title":"Transplantation"},{"issue":"4","key":"914_CR2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.trre.2015.04.007","volume":"29","author":"YY Shi","year":"2015","unstructured":"Shi YY, Hesselink DA, van Gelder T. Pharmacokinetics and pharmacodynamics of immunosuppressive drugs in elderly kidney transplant recipients. Transplant Rev (Orlando). 2015;29(4):224\u201330.","journal-title":"Transplant Rev (Orlando)"},{"issue":"3","key":"914_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000356020","volume":"60","author":"K Welzl","year":"2014","unstructured":"Welzl K, Kern G, Mayer G, Weinberger B, Saemann MD, Sturm G, et al. Effect of different immunosuppressive drugs on immune cells from young and old healthy persons. Gerontology. 2014;60(3):229\u201338.","journal-title":"Gerontology"},{"issue":"10","key":"914_CR4","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1097\/TP.0000000000002762","volume":"103","author":"DK Metz","year":"2019","unstructured":"Metz DK, Holford N, Kausman JY, Walker A, Cranswick N, Staatz CE, et al. Optimizing mycophenolic acid exposure in kidney transplant recipients: time for target concentration intervention. Transplantation. 2019;103(10):2012\u201330.","journal-title":"Transplantation"},{"issue":"11","key":"914_CR5","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1111\/j.1432-2277.2012.01553.x","volume":"25","author":"KA Barraclough","year":"2012","unstructured":"Barraclough KA, Staatz CE, Johnson DW, Lee KJ, McWhinney BC, Ungerer JP, et al. Kidney transplant outcomes are related to tacrolimus, mycophenolic acid and prednisolone exposure in the first week. Transpl Int. 2012;25(11):1182\u201393.","journal-title":"Transpl Int"},{"key":"914_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/FTD.0000000000000871","volume":"43","author":"S Bergan","year":"2021","unstructured":"Bergan S, Brunet M, Hesselink DA, Johnson-Davis KL, Kunicki PK, Lemaitre F, et al. Personalized therapy for mycophenolate: consensus report by the international association of therapeutic drug monitoring and clinical toxicology. Ther Drug Monit. 2021;43:150\u2013200.","journal-title":"Ther Drug Monit"},{"issue":"2","key":"914_CR7","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/cpdd.763","volume":"9","author":"PH Hinderling","year":"2020","unstructured":"Hinderling PH, Papoian T. Why collecting pharmacokinetic information after intravenous drug administration is important. Clin Pharmacol Drug Dev. 2020;9(2):146\u201350.","journal-title":"Clin Pharmacol Drug Dev."},{"issue":"12","key":"914_CR8","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1111\/j.1600-6143.2012.04232.x","volume":"12","author":"PA Jacobson","year":"2012","unstructured":"Jacobson PA, Schladt D, Oetting WS, Leduc R, Guan W, Matas AJ, et al. Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs. Am J Transplant. 2012;12(12):3326\u201336.","journal-title":"Am J Transplant"},{"issue":"9","key":"914_CR9","doi-asserted-by":"publisher","first-page":"715","DOI":"10.2165\/11316480-000000000-00000","volume":"26","author":"DRJ Kuypers","year":"2009","unstructured":"Kuypers DRJ. Immunotherapy in elderly transplant recipients: a guide to clinically significant drug interactions. Drugs Aging. 2009;26(9):715\u201337.","journal-title":"Drugs Aging"},{"issue":"10","key":"914_CR10","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1111\/j.1600-6143.2012.04245.x","volume":"12","author":"M Abecassis","year":"2012","unstructured":"Abecassis M, Bridges ND, Clancy CJ, Dew MA, Eldadah B, Englesbe MJ, et al. Solid-organ transplantation in older adults: current status and future research. Am J Transplant. 2012;12(10):2608\u201322.","journal-title":"Am J Transplant"},{"issue":"28","key":"914_CR11","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1016\/j.jchromb.2010.08.044","volume":"878","author":"BC McWhinney","year":"2010","unstructured":"McWhinney BC, Briscoe SE, Ungerer JP, Pretorius CJ. Measurement of cortisol, cortisone, prednisolone, dexamethasone and 11-deoxycortisol with ultra high performance liquid chromatography-tandem mass spectrometry: application for plasma, plasma ultrafiltrate, urine and saliva in a routine laboratory. J Chromatogr B Anal Technol Biomed Life Sci. 2010;878(28):2863\u20139.","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"914_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/FTD.0000000000000486","volume":"40","author":"EK Brooks","year":"2018","unstructured":"Brooks EK, Tett SE, Isbel NM, McWhinney B, Staatz CE. Evaluation of multiple linear regression-based limited sampling strategies for enteric-coated mycophenolate sodium in adult kidney transplant recipients. Ther Drug Monit. 2018;40:195\u2013201.","journal-title":"Ther Drug Monit"},{"issue":"10","key":"914_CR13","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00228-009-0721-9","volume":"65","author":"M Miura","year":"2009","unstructured":"Miura M, Satoh S, Kagaya H, Saito M, Inoue T, Tsuchiya N, et al. No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantation. Eur J Clin Pharmacol. 2009;65(10):1047\u201353.","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"914_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.trre.2010.06.001","volume":"25","author":"SE Tett","year":"2011","unstructured":"Tett SE, Saint-Marcoux F, Staatz CE, Brunet M, Vinks AA, Miura M, et al. Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure. Transplant Rev (Orlando). 2011;25(2):47\u201357.","journal-title":"Transplant Rev (Orlando)"},{"issue":"4","key":"914_CR15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s13318-015-0262-9","volume":"41","author":"J Sobiak","year":"2016","unstructured":"Sobiak J, Resztak M, Glyda M, Szczepaniak P, Chrzanowska M. Pharmacokinetics of mycophenolate sodium co-administered with tacrolimus in the first year after renal transplantation. Eur J Drug Metab Pharmacokinet. 2016;41(4):331\u20138.","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"914_CR16","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.2165\/00003495-200565080-00001","volume":"65","author":"M Behrend","year":"2005","unstructured":"Behrend M, Braun F. Enteric-coated mycophenolate sodium: tolerability profile compared with mycophenolate mofetil. Drugs. 2005;65:1037\u201350.","journal-title":"Drugs"},{"issue":"8","key":"914_CR17","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1177\/0091270003256151","volume":"43","author":"DR Kuypers","year":"2003","unstructured":"Kuypers DR, Claes K, Evenepoel P, Maes B, Coosemans W, Pirenne J, et al. Long-term changes in mycophenolic acid exposure in combination with tacrolimus and corticosteroids are dose dependent and not reflected by trough plasma concentration: a prospective study in 100 de novo renal allograft recipients. J Clin Pharmacol. 2003;43(8):866\u201380.","journal-title":"J Clin Pharmacol"},{"key":"914_CR18","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.2165\/00003088-200544100-00006","volume":"44","author":"RM van Hest","year":"2005","unstructured":"van Hest RM, van Gelder T, Vulto AG, Mathot RAA. Population pharmacokinetics of mycophenolic acid in renal transplant recipients. Clin Pharmacokinet. 2005;44:1083\u201396.","journal-title":"Clin Pharmacokinet"},{"key":"914_CR19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1365-2125.2004.02235.x","volume":"59","author":"BA Atcheson","year":"2004","unstructured":"Atcheson BA, Taylor PJ, Mudge DW, Johnson DW, Hawley CM, Campbell SB, et al. Mycophenolic acid pharmacokinetics and related outcomes early after renal transplant. Br J Clin Pharmacol. 2004;59:271\u201380.","journal-title":"Br J Clin Pharmacol"},{"issue":"7","key":"914_CR20","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00228-005-0927-4","volume":"61","author":"CE Staatz","year":"2005","unstructured":"Staatz CE, Duffull SB, Kiberd B, Fraser AD, Tett SE. Population pharmacokinetics of mycophenolic acid during the first week after renal transplantation. Eur J Clin Pharmacol. 2005;61(7):507\u201316.","journal-title":"Eur J Clin Pharmacol"},{"key":"914_CR21","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/nep.13718","volume":"25","author":"TJW Rennie","year":"2020","unstructured":"Rennie TJW, Petrie M, Metcalfe W, Walbaum D, Joss N, Barton E, et al. The impact of age on patient tolerance of mycophenolate following kidney transplantation. Nephrology (Carlton). 2020;25:566\u201374.","journal-title":"Nephrology (Carlton)"},{"issue":"11","key":"914_CR22","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s40262-012-0007-8","volume":"51","author":"TK Bergmann","year":"2012","unstructured":"Bergmann TK, Barraclough KA, Lee KJ, Staatz CE. Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation. Clin Pharmacokinet. 2012;51(11):711\u201341.","journal-title":"Clin Pharmacokinet"},{"issue":"12","key":"914_CR23","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s00228-011-1071-y","volume":"67","author":"KA Barraclough","year":"2011","unstructured":"Barraclough KA, Isbel NM, McWhinney BC, Ungerer JP, Medley G, Johnson DW, et al. Evaluation of limited sampling strategies for total and free prednisolone in adult kidney transplant recipients. Eur J Clin Pharmacol. 2011;67(12):1243\u201352.","journal-title":"Eur J Clin Pharmacol"},{"issue":"6","key":"914_CR24","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/ki.1983.110","volume":"23","author":"H Bergrem","year":"1983","unstructured":"Bergrem H. Pharmacokinetics and protein binding of prednisolone in patients with nephrotic syndrome and patients undergoing hemodialysis. Kidney Int. 1983;23(6):876\u201381.","journal-title":"Kidney Int"},{"key":"914_CR25","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1097\/FTD.0b013e318187bb2f","volume":"30","author":"HA Bergrem","year":"2008","unstructured":"Bergrem HA, Bergrem H, Hartmann A, Hjelmesaeth J, Jenssen T. Role of prednisolone pharmacokinetics in postchallenge glycemia after renal transplantation. Ther Drug Monit. 2008;30:583\u201390.","journal-title":"Ther Drug Monit"},{"issue":"6","key":"914_CR26","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1097\/TP.0000000000001369","volume":"101","author":"E David-Neto","year":"2017","unstructured":"David-Neto E, Romano P, Kamada Triboni AH, Ramos F, Agena F, Almeida Rezende Ebner P, et al. Longitudinal pharmacokinetics of tacrolimus in elderly compared with younger recipients in the first 6 months after renal transplantation. Transplantation. 2017;101(6):1365\u201372.","journal-title":"Transplantation"},{"issue":"2","key":"914_CR27","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/jppr.1788","volume":"52","author":"AR Cossart","year":"2022","unstructured":"Cossart AR, Cottrell WN, McStea M, Isbel NM, Campbell SB, Staatz CE. Immunosuppressant prescribing patterns in elderly kidney transplant recipients using registry data from Australia and New Zealand. J Pharm Pract Res. 2022;52(2):108\u201316.","journal-title":"J Pharm Pract Res"},{"key":"914_CR28","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1016\/j.transproceed.2021.06.024","volume":"53","author":"BP Doucet","year":"2021","unstructured":"Doucet BP, Cho Y, Campbell SB, Johnson DW, Hawley CM, Teixeira-Pinto ARM, et al. Kidney transplant outcomes in elderly recipients: an Australia and New Zealand dialysis and transplant (ANZDATA) registry study. Transplant Proc. 2021;53:1915\u201326.","journal-title":"Transplant Proc"}],"container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13318-024-00914-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13318-024-00914-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13318-024-00914-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T13:10:48Z","timestamp":1731071448000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13318-024-00914-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["914"],"URL":"https:\/\/doi.org\/10.1007\/s13318-024-00914-3","relation":{},"ISSN":["0378-7966","2107-0180"],"issn-type":[{"type":"print","value":"0378-7966"},{"type":"electronic","value":"2107-0180"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"12 August 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors contributed to the study conception and design. Recruitment was performed by NI and AC. Data collection and data analysis was performed by AC, with assay analysis performed by BM. The first draft of the manuscript was written by AC, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}},{"value":"This research was funded by three (3) grants\u2014a Research Strategies Grant from The School of Pharmacy, University of Queensland; a Metro South Health Research Support Scheme Innovation (Seed) Small Grant; and a Study Education and Research Committee (SERC) grant from Pathology Queensland.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"De-identified raw data is not available for distribution as stated in the Ethics approval. A summary of findings, as presented to participants, is available on request.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"Authors declare that they have no conflict of interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by Metro South Health (MSH) (HREC\/18\/QPAH\/172) and The University of Queensland (UQ) (2018002551\/HREC\/18\/QPAH\/172).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study, prior to study this participation.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent was obtained from all individual participants included in the study, to publish a study of the study findings.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"Not applicable.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}