{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:39:55Z","timestamp":1761946795077,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25870654"],"award-info":[{"award-number":["25870654"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007591","name":"Akiyama Life Science Foundation","doi-asserted-by":"crossref","award":["10"],"award-info":[{"award-number":["10"]}],"id":[{"id":"10.13039\/100007591","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s13346-016-0310-2","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T06:57:18Z","timestamp":1466665038000},"page":"565-571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sustained distribution of aerosolized PEGylated liposomes in epithelial lining fluids on alveolar surfaces"],"prefix":"10.1007","volume":"6","author":[{"given":"Keita","family":"Kaneko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Togami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirou","family":"Itagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Chono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"310_CR1","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1128\/AAC.36.6.1171","volume":"36","author":"DR Baldwin","year":"1992","unstructured":"Baldwin DR, Honeybourne D, Wise R. Pulmonary disposition of antimicrobial agents: methodological considerations. Antimicrob Agents Chemother. 1992;36:1171\u20135.","journal-title":"Antimicrob Agents Chemother"},{"key":"310_CR2","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1183\/09031936.96.09071523","volume":"9","author":"R Wilson","year":"1996","unstructured":"Wilson R, Dowling RB, Jackson AD. The biology of bacterial colonization and invasion of the respiratory mucosa. Eur Respir J. 1996;9:1523\u201330.","journal-title":"Eur Respir J"},{"key":"310_CR3","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1080\/10611860600834375","volume":"14","author":"S Chono","year":"2006","unstructured":"Chono S, Tanino T, Seki T, Morimoto K. Influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes. J Drug Target. 2006;14:557\u201366.","journal-title":"J Drug Target"},{"key":"310_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jconrel.2007.12.011","volume":"127","author":"S Chono","year":"2008","unstructured":"Chono S, Tanino T, Seki T, Morimoto K. Efficient drug targeting to rat alveolar macrophages by pulmonary administration of ciprofloxacin incorporated into mannosylated liposomes for treatment of respiratory intracellular parasitic infections. J Control Release. 2008;127:50\u20138.","journal-title":"J Control Release"},{"key":"310_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jconrel.2009.03.019","volume":"137","author":"S Chono","year":"2009","unstructured":"Chono S, Fukuchi R, Seki T, Morimoto K. Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery. J Control Release. 2009;137:104\u20139.","journal-title":"J Control Release"},{"key":"310_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3109\/03639045.2010.513389","volume":"37","author":"S Chono","year":"2011","unstructured":"Chono S, Suzuki H, Togami K, Morimoto K. Efficient drug delivery to lung epithelial lining fluid by aerosolization of ciprofloxacin incorporated into PEGylated liposomes for treatment of respiratory infections. Drug Dev Ind Pharm. 2011;37:367\u201372.","journal-title":"Drug Dev Ind Pharm"},{"key":"310_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.xphs.2015.12.010","volume":"105","author":"K Togami","year":"2016","unstructured":"Togami K, Chono S, Tada H. Alteration in intrapulmonary pharmacokinetics of aerosolized model compounds due to disruption of the alveolar epithelial barriers following bleomycin-induced pulmonary fibrosis in rats. J Pharm Sci. 2016;105:1327\u201334.","journal-title":"J Pharm Sci"},{"key":"310_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jddst.2016.04.001","volume":"33","author":"Y Kanehira","year":"2016","unstructured":"Kanehira Y, Togami K, Tada H, Chono S. Tumor distribution and anti-tumor effect of doxorubicin following intrapulmonary administration to mice with metastatic lung tumor. J Drug Delivery Sci Technol. 2016;33:143\u20138.","journal-title":"J Drug Delivery Sci Technol"},{"key":"310_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0005-2736(91)90246-5","volume":"1066","author":"TM Allen","year":"1991","unstructured":"Allen TM, Hansen C, Martin F, Redemann C, Yau-Young A. Liposomes containing synthetic lipid derivatives of poly (ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta. 1991;1066:29\u201336.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0005-2736(94)90003-5","volume":"1195","author":"VP Torchilin","year":"1994","unstructured":"Torchilin VP, Omelyanenko VG, Papisov MI, Bogdanov Jr AA, Trubetskoy VS, Herron JN, Gentry CA. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim Biophys Acta. 1994;1195:11\u201320.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR11","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1183\/09031936.94.07020372","volume":"7","author":"J Johansson","year":"1994","unstructured":"Johansson J, Curstedt T, Robertson B. The proteins of the surfactant system. Eur Respir J. 1994;7:372\u201391.","journal-title":"Eur Respir J"},{"key":"310_CR12","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1002\/eji.1830270413","volume":"27","author":"CA Benne","year":"1997","unstructured":"Benne CA, Benaissa-Trouw B, van Strijp JA, Kraaijeveld CA, van Iwaarden JF. Surfactant protein A, but not surfactant protein D, is an opsonin for influenza A virus phagocytosis: binding and neutralization. Eur J Immunol. 1997;27:886\u201390.","journal-title":"Eur J Immunol"},{"key":"310_CR13","doi-asserted-by":"publisher","first-page":"10794","DOI":"10.1073\/pnas.96.19.10794","volume":"96","author":"U Holmskov","year":"1999","unstructured":"Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, et al. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Proc Natl Acad Sci U S A. 1999;96:10794\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"310_CR14","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.4049\/jimmunol.166.4.2727","volume":"166","author":"TL Schagat","year":"2001","unstructured":"Schagat TL, Wofford JA, Wright JR. Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils. J Immunol. 2001;166:2727\u201333.","journal-title":"J Immunol"},{"key":"310_CR15","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0022-2836(65)80093-6","volume":"13","author":"AD Bangham","year":"1965","unstructured":"Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol. 1965;13:238\u201352.","journal-title":"J Mol Biol"},{"key":"310_CR16","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/BF02535225","volume":"17","author":"GL Pool","year":"1982","unstructured":"Pool GL, French ME, Edwards RA, Huang L, Lumb RH. Use of radiolabeled hexadecyl cholesterol ester as a liposome marker. Lipids. 1982;17:445\u201352.","journal-title":"Lipids"},{"key":"310_CR17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0167-4889(87)90047-4","volume":"931","author":"JT Derksen","year":"1987","unstructured":"Derksen JT, Morselt HW, Scherphof GL. Processing of different liposomal markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages. Biochim Biophys Acta. 1987;931:33\u201340.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR18","doi-asserted-by":"publisher","first-page":"S151","DOI":"10.1016\/0006-2952(91)90405-T","volume":"42","author":"JM Antonini","year":"1991","unstructured":"Antonini JM, Reasor MJ. Accumulation of amiodarone and desethylamiodarone by rat alveolar macrophages in cell culture. Biochem Pharmacol. 1991;42:S151\u20136.","journal-title":"Biochem Pharmacol"},{"key":"310_CR19","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1152\/jappl.1986.60.2.532","volume":"60","author":"SI Rennard","year":"1986","unstructured":"Rennard SI, Basse G, Lecossier D, O\u2019Donnell KM, Pinkston P, Martin PG, et al. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J Appl Physiol. 1986;60:532\u20138.","journal-title":"J Appl Physiol"},{"key":"310_CR20","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1093\/jac\/26.4.503","volume":"26","author":"Y Kohno","year":"1990","unstructured":"Kohno Y, Yoshida H, Suwa T, Suga T. Uptake of clarithromycin by rat lung cells. J Antimicrob Chemother. 1990;26:503\u201313.","journal-title":"J Antimicrob Chemother"},{"key":"310_CR21","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Branford","year":"1976","unstructured":"Branford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248\u201354.","journal-title":"Anal Biochem"},{"key":"310_CR22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0169-409X(96)00456-5","volume":"24","author":"B Ceh","year":"1997","unstructured":"Ceh B, Winterhalter M, Frederik PM, Vallner JJ, Lasic DD. Stealth\u00ae liposomes: from theory to product. Adv Drug Deliv Rev. 1997;24:165\u201377.","journal-title":"Adv Drug Deliv Rev"},{"key":"310_CR23","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.bbamem.2006.12.013","volume":"1768","author":"N Dos Santos","year":"2007","unstructured":"Dos Santos N, Allen C, Doppen AM, Anantha M, Cox KAK, Gallagher RC, et al. Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding. Biochim Biophys Acta. 2007;1768:1367\u201377.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.chemphyslip.2005.02.003","volume":"135","author":"O Garbuzenko","year":"2005","unstructured":"Garbuzenko O, Barenholz Y, Priev A. Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer. Chem Phys Lipids. 2005;135:117\u201329.","journal-title":"Chem Phys Lipids"},{"key":"310_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0005-2736(92)90112-Y","volume":"1108","author":"D Needham","year":"1992","unstructured":"Needham D, Mclatosh TJ, Lasic DD. Repulsive interactions and mechanical stability of polymer-grafted lipid membranes. Biochim Biophys Acta. 1992;1108:40\u20138.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0005-2736(91)90337-8","volume":"1062","author":"J Senior","year":"1991","unstructured":"Senior J, Delgado C, Fisher D, Tilcock C, Gregoriadis G. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim Biophys Acta. 1991;1062:77\u201382.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0014-5793(96)00452-8","volume":"386","author":"PS Uster","year":"1996","unstructured":"Uster PS, Allen TM, Daniel BE, Mendez CJ, Newman MS, Zhu GZ. Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time. FEBS Lett. 1996;386:243\u20136.","journal-title":"FEBS Lett"},{"key":"310_CR28","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1248\/cpb.34.1249","volume":"34","author":"H Kiwada","year":"1986","unstructured":"Kiwada H, Obara S, Nishiwaki H, Kato Y. Studies on the uptake mechanism of liposomes by perfused rat liver. I. An investigation of effluent profiles with perfusate containing no blood component. Chem Pharm Bull. 1986;34:1249\u201356.","journal-title":"Chem Pharm Bull"},{"key":"310_CR29","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/0005-2736(92)90087-3","volume":"1103","author":"K Funato","year":"1992","unstructured":"Funato K, Yoda R, Kiwada H. Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma. Biochim Biophys Acta. 1992;1103:198\u2013204.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR30","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.4049\/jimmunol.146.12.4234","volume":"146","author":"A Chonn","year":"1991","unstructured":"Chonn A, Cullis PR, Devine DV. The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. J Immunol. 1991;146:4234\u201341.","journal-title":"J Immunol"},{"key":"310_CR31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0925-4439(98)00060-X","volume":"1408","author":"J Goerke","year":"1998","unstructured":"Goerke J. Pulmonary surfactant: functions and molecular composition. Biochim Biophys Acta. 1998;1408:79\u201389.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR32","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/S0925-4439(98)00061-1","volume":"1408","author":"R Veldhuizen","year":"1998","unstructured":"Veldhuizen R, Nag K, Orgeig S, Possmayer F. The role of lipids in pulmonary surfactant. Biochim Biophys Acta. 1998;1408:90\u2013108.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR33","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0005-2736(00)00256-X","volume":"1467","author":"EJ Veldhuizen","year":"2000","unstructured":"Veldhuizen EJ, Haagsman HP. Role of pulmonary surfactant components in surface film formation and dynamics. Biochim Biophys Acta. 2000;1467:255\u201370.","journal-title":"Biochim Biophys Acta"},{"key":"310_CR34","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1128\/IAI.00795-06","volume":"74","author":"A Balagopal","year":"2006","unstructured":"Balagopal A, MacFarlane AS, Mohapatra N, Soni S, Gunn JS, Schlesinger LS. Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages. Infect Immun. 2006;74:5114\u201325.","journal-title":"Infect Immun"},{"key":"310_CR35","doi-asserted-by":"publisher","first-page":"16375","DOI":"10.1074\/jbc.271.27.16375","volume":"271","author":"ZC Chroneos","year":"1996","unstructured":"Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996;271:16375\u201383.","journal-title":"J Biol Chem"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-016-0310-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13346-016-0310-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-016-0310-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-016-0310-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:08:29Z","timestamp":1692403709000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13346-016-0310-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["310"],"URL":"https:\/\/doi.org\/10.1007\/s13346-016-0310-2","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"type":"print","value":"2190-393X"},{"type":"electronic","value":"2190-3948"}],"subject":[],"published":{"date-parts":[[2016,6,22]]},"assertion":[{"value":"22 June 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}