{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:00:44Z","timestamp":1740160844038,"version":"3.37.3"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Mitacs Elevate Strategic Fellowship Program"},{"DOI":"10.13039\/501100000145","name":"AIHS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000145","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s13346-017-0407-2","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T13:41:53Z","timestamp":1500385313000},"page":"482-496","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bone-targeting parathyroid hormone conjugates outperform unmodified PTH in the anabolic treatment of osteoporosis in rats"],"prefix":"10.1007","volume":"7","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Aghazadeh-Habashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Panahifar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna H.","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Doschak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"407_CR1","volume-title":"Osteoporosis","author":"AM Parfitt","year":"2013","unstructured":"A. M. Parfitt, Osteoporosis. 2013."},{"issue":"12","key":"407_CR2","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","volume":"115","author":"LG Raisz","year":"2005","unstructured":"Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Investig. 2005;115(12):3318\u201325.","journal-title":"J Clin Investig"},{"issue":"4","key":"407_CR3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.060107","volume":"21","author":"JI Aguirre","year":"2006","unstructured":"Aguirre JI, et al. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res. 2006;21(4):605\u201315.","journal-title":"J Bone Miner Res"},{"issue":"5 Pt 2","key":"407_CR4","first-page":"F665","volume":"277","author":"M Mannstadt","year":"1999","unstructured":"Mannstadt M, J\u00fcppner H, Gardella TJ. Receptors for PTH and PTHrP: their biological importance and functional properties. Am J Phys. 1999;277(5 Pt 2):F665\u201375.","journal-title":"Am J Phys"},{"key":"407_CR5","first-page":"566","volume":"10","author":"S Offermanns","year":"1996","unstructured":"Offermanns S, Iida-Klein A, Segre GV, Simon MI. Gaq family members couple parathyroid hormone (PTH)\/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells. Mol Endocrinol. 1996;10:566\u201374.","journal-title":"Mol Endocrinol"},{"issue":"26","key":"407_CR6","doi-asserted-by":"crossref","first-page":"15455","DOI":"10.1074\/jbc.270.26.15455","volume":"270","author":"TB Usdin","year":"1995","unstructured":"Usdin TB, Gruber C, Bonner TI. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. J Biol Chem. 1995;270(26):15455\u20138.","journal-title":"J Biol Chem"},{"issue":"1","key":"407_CR7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2003-0024","volume":"26","author":"TM Murray","year":"2005","unstructured":"Murray TM, Rao LG, Divieti P, Bringhurst FR. Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands. Endocr Rev. 2005;26(1):78\u2013113.","journal-title":"Endocr Rev"},{"issue":"3","key":"407_CR8","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1172\/JCI116273","volume":"91","author":"AB Hodsman","year":"1993","unstructured":"Hodsman AB, Fraher LJ, Ostbye T, Adachi JD, Steer BM. An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. J Clin Investig. 1993;91(3):1138\u201348.","journal-title":"J Clin Investig"},{"issue":"6","key":"407_CR9","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bone.2007.03.017","volume":"40","author":"RL Jilka","year":"2007","unstructured":"Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone. 2007;40(6):1434\u201346.","journal-title":"Bone"},{"issue":"8","key":"407_CR10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5312\/wjo.v2.i8.67","volume":"2","author":"NS Datta","year":"2011","unstructured":"Datta NS. Osteoporotic fracture and parathyroid hormone. World J Orthop. 2011;2(8):67\u201374.","journal-title":"World J Orthop"},{"issue":"Suppl 1","key":"407_CR11","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/BF01621907","volume":"3","author":"M Neer","year":"1993","unstructured":"Neer M, et al. Treatment of postmenopausal osteoporosis with daily parathyroid hormone plus calcitriol. Osteoporos Int. 1993;3(Suppl 1):204\u20135.","journal-title":"Osteoporos Int"},{"issue":"9077","key":"407_CR12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(97)02342-8","volume":"350","author":"R Lindsay","year":"1997","unstructured":"Lindsay R, et al. Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet. 1997;350(9077):550\u20135.","journal-title":"Lancet"},{"issue":"6","key":"407_CR13","first-page":"2129","volume":"85","author":"RS Rittmaster","year":"2000","unstructured":"Rittmaster RS, et al. Enhancement of bone mass in osteoporotic women with parathyroid hormone followed by alendronate. J Clin Endocrinol Metab. 2000;85(6):2129\u201334.","journal-title":"J Clin Endocrinol Metab"},{"issue":"19","key":"407_CR14","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","volume":"344","author":"RM Neer","year":"2001","unstructured":"Neer RM, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344(19):1434\u201341.","journal-title":"N Engl J Med"},{"issue":"7","key":"407_CR15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3949\/ccjm.70.7.585","volume":"70","author":"C Deal","year":"2003","unstructured":"Deal C, Gideon J. Recombinant human PTH 1-34 (Forteo): an anabolic drug for osteoporosis. Cleve Clin J Med. 2003;70(7):585\u2013601.","journal-title":"Cleve Clin J Med"},{"issue":"3","key":"407_CR16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1359\/jbmr.2003.18.3.539","volume":"18","author":"JR Zanchetta","year":"2003","unstructured":"Zanchetta JR, et al. Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res. 2003;18(3):539\u201343.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"407_CR17","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/clinchem\/48.10.1731","volume":"48","author":"C Bieglmayer","year":"2002","unstructured":"Bieglmayer C, Prager G, Niederle B. Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy. Clin Chem. 2002;48(10):1731\u20138.","journal-title":"Clin Chem"},{"issue":"3","key":"407_CR18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/cs0680311","volume":"68","author":"MS Seshadri","year":"1985","unstructured":"Seshadri MS, et al. Some problems associated with adenylate cyclase bioassays for parathyroid hormone. Clin Sci. 1985;68(3):311\u20139.","journal-title":"Clin Sci"},{"issue":"11","key":"407_CR19","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/jps.20720","volume":"95","author":"KO Jones","year":"2006","unstructured":"Jones KO, Owusu-Ababio G, Vick AM, Khan MA. Pharmacokinetics and hepatic extraction of recombinant human parathyroid hormone, hPTH (1-34), in rat, dog, and monkey. J Pharm Sci. 2006;95(11):2499\u2013506.","journal-title":"J Pharm Sci"},{"issue":"18","key":"407_CR20","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.2165\/0003495-200868180-00012","volume":"68","author":"SKA Blick","year":"2008","unstructured":"Blick SKA, Dhillon S, Keam SJ. Teriparatide: a review of its use in osteoporosis. Drugs. 2008;68(18):2709\u201337.","journal-title":"Drugs"},{"issue":"3","key":"407_CR21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/01926230252929882","volume":"30","author":"JL Vahle","year":"2002","unstructured":"Vahle JL, et al. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol Pathol. 2002;30(3):312\u201321.","journal-title":"Toxicol Pathol"},{"issue":"2","key":"407_CR22","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1021\/mp8002368","volume":"6","author":"MR Doschak","year":"2009","unstructured":"Doschak MR, Kucharski CM, Wright JEI, Zernicke RF, Uludag H. Improved bone delivery of osteoprotegerin by bisphosphonate conjugation in a rat model of osteoarthritis. Mol Pharm. 2009;6(2):634\u201340.","journal-title":"Mol Pharm"},{"issue":"1","key":"407_CR23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jconrel.2011.09.096","volume":"158","author":"KH Bhandari","year":"2012","unstructured":"Bhandari KH, Newa M, Chapman J, Doschak MR. Synthesis, characterization and evaluation of bone targeting salmon calcitonin analogs in normal and osteoporotic rats. J Control Release. 2012;158(1):44\u201352.","journal-title":"J Control Release"},{"issue":"5","key":"407_CR24","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s11095-013-1237-7","volume":"31","author":"Y Yang","year":"2014","unstructured":"Yang Y, Bhandari KH, Panahifar A, Doschak MR. Synthesis, characterization and biodistribution studies of 125I-radioiodinated di-PEGylated bone targeting salmon calcitonin analogue in healthy rats. Pharm Res. 2014;31(5):1146\u201357.","journal-title":"Pharm Res"},{"issue":"12","key":"407_CR25","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/j.biomaterials.2013.01.059","volume":"34","author":"JN Yewle","year":"2013","unstructured":"Yewle JN, Puleo DA, Bachas LG. Bifunctional bisphosphonates for delivering PTH (1-34) to bone mineral with enhanced bioactivity. Biomaterials. 2013;34(12):3141\u20139.","journal-title":"Biomaterials"},{"issue":"3","key":"407_CR26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.drudis.2013.07.015","volume":"19","author":"T Ponnapakkam","year":"2014","unstructured":"Ponnapakkam T, Katikaneni R, Sakon J, Stratford R, Gensure RC. Treating osteoporosis by targeting parathyroid hormone to bone. Drug Discov Today. 2014;19(3):204\u20138.","journal-title":"Drug Discov Today"},{"key":"407_CR27","first-page":"711","volume":"4","author":"AA Reszka","year":"2004","unstructured":"Reszka AA, Rodan GA. Nitrogen-containing bisphosphonate mechanism of action. Mini Rev Med Chem. 2004;4:711\u20139.","journal-title":"Mini Rev Med Chem"},{"key":"407_CR28","volume-title":"PEG-binding PTH or PEG-binding PTH derivative","author":"M Sekimori","year":"2003","unstructured":"M. Sekimori, Y. Nakamura, T. Shimizu, \u201cPEG-binding PTH or PEG-binding PTH derivative,\u201d 2003."},{"issue":"11","key":"407_CR29","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s00198-009-0882-5","volume":"20","author":"JEM Brouwers","year":"2009","unstructured":"Brouwers JEM, Van Rietbergen B, Huiskes R, Ito K. Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT. Osteoporos Int. 2009;20(11):1823\u201335.","journal-title":"Osteoporos Int"},{"issue":"7","key":"407_CR30","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.joca.2012.03.021","volume":"20","author":"A Panahifar","year":"2012","unstructured":"Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthr Cartil. 2012;20(7):694\u2013702.","journal-title":"Osteoarthr Cartil"},{"issue":"16","key":"407_CR31","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1016\/S0021-9258(18)47626-0","volume":"262","author":"DT Yamaguchi","year":"1987","unstructured":"Yamaguchi DT, Hahn TJ, Iida-Klein A, Kleeman CR, Muallem S. Parathyroid hormone-activated calcium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-dependent and cAMP-independent calcium channels. J Biol Chem. 1987;262(16):7711\u20138.","journal-title":"J Biol Chem"},{"issue":"1","key":"407_CR32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.18433\/J3C59H","volume":"16","author":"Y Wu","year":"2013","unstructured":"Wu Y, Adeeb SM, John Duke M, Munoz-Paniagua D, Doschak MR. Compositional and material properties of rat bone after bisphosphonate and\/or strontium ranelate drug treatment. J Pharm Pharm Sci. 2013;16(1):52\u201364.","journal-title":"J Pharm Pharm Sci"},{"issue":"11","key":"407_CR33","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/jor.22937","volume":"33","author":"A Panahifar","year":"2015","unstructured":"Panahifar A, Cooper DML, Doschak MR. 3-D localization of non-radioactive strontium in osteoarthritic bone: role in the dynamic labeling of bone pathological changes. J Orthop Res. 2015;33(11):1655\u201362.","journal-title":"J Orthop Res"},{"issue":"6","key":"407_CR34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/10520299209110046","volume":"67","author":"ZA Ralis","year":"1992","unstructured":"Ralis ZA, Watkins G. Modified tetrachrome method for osteoid and defectively mineralized bone in paraffin sections. Biotech Histochem. 1992;67(6):339\u201345.","journal-title":"Biotech Histochem"},{"issue":"8","key":"407_CR35","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1359\/jbmr.060511","volume":"21","author":"O Lepp\u00e4nen","year":"2006","unstructured":"Lepp\u00e4nen O, Siev\u00e4nen H, Jokihaara J, Pajam\u00e4ki I, J\u00e4rvinen TLN. Three-point bending of rat femur in the mediolateral direction: introduction and validation of a novel biomechanical testing protocol. J Bone Miner Res. 2006;21(8):1231\u20137.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"407_CR36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF02509543","volume":"58","author":"Y Jiang","year":"1996","unstructured":"Jiang Y, et al. Effects of low-dose long-term sodium fluoride preventive treatment on rat bone mass and biomechanical properties. Calcif Tissue Int. 1996;58(1):30\u20139.","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"407_CR37","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bone.2007.06.019","volume":"41","author":"Y Washimi","year":"2007","unstructured":"Washimi Y, et al. Effect of combined humanPTH(1-34) and calcitonin treatment in ovariectomized rats. Bone. 2007;41(5):786\u201393.","journal-title":"Bone"},{"issue":"4","key":"407_CR38","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1359\/jbmr.2000.15.4.740","volume":"15","author":"V Shen","year":"2000","unstructured":"Shen V, Birchman R, Wu DD, Lindsay R. Skeletal effects of parathyroid hormone infusion in ovariectomized rats with or without estrogen repletion. J Bone Miner Res. 2000;15(4):740\u20136.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"407_CR39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S8756-3282(98)00025-8","volume":"22","author":"TL J\u00e4rvinen","year":"1998","unstructured":"J\u00e4rvinen TL, Siev\u00e4nen H, Kannus P, J\u00e4rvinen M. Dual-energy X-ray absorptiometry in predicting mechanical characteristics of rat femur. Bone. 1998;22(5):551\u20138.","journal-title":"Bone"},{"issue":"12","key":"407_CR40","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1359\/jbmr.040906","volume":"19","author":"P Ammann","year":"2004","unstructured":"Ammann P, Shen V, Robin B, Mauras Y, Bonjour J-P, Rizzoli R. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J Bone Miner Res. 2004;19(12):2012\u201320.","journal-title":"J Bone Miner Res"},{"key":"407_CR41","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1039\/b906865a","volume":"2","author":"MW Jones","year":"2009","unstructured":"Jones MW, Mantovani G, Ryan SM, Wang X, Brayden DJ, Haddleton DM. Phosphine-mediated one-pot thiol\u2013ene \u2018click\u2019 approach to polymer\u2013protein conjugates. Chem Commun. 2009;2, no. 35:5272.","journal-title":"Chem Commun"},{"issue":"2","key":"407_CR42","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ab.2004.04.036","volume":"331","author":"DH Na","year":"2004","unstructured":"Na DH, Lee KC. Capillary electrophoretic characterization of PEGylated human parathyroid hormone with matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry. Anal Biochem. 2004;331(2):322\u20138.","journal-title":"Anal Biochem"},{"issue":"1","key":"407_CR43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2008.12.014","volume":"135","author":"SM Ryan","year":"2009","unstructured":"Ryan SM, Wang X, Mantovani G, Sayers CT, Haddleton DM, Brayden DJ. Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate. J Control Release. 2009;135(1):51\u20139.","journal-title":"J Control Release"},{"issue":"3","key":"407_CR44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/jcb.240550308","volume":"55","author":"NC Partridge","year":"1994","unstructured":"Partridge NC, Bloch SR, Pearman AT. Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression. J Cell Biochem. 1994;55(3):321\u20137.","journal-title":"J Cell Biochem"},{"issue":"35","key":"407_CR45","doi-asserted-by":"crossref","first-page":"27238","DOI":"10.1016\/S0021-9258(19)61502-4","volume":"275","author":"L Jin","year":"2000","unstructured":"Jin L, et al. Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution. J Biol Chem. 2000;275(35):27238\u201344.","journal-title":"J Biol Chem"},{"issue":"8","key":"407_CR46","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2174\/1381612013397825","volume":"7","author":"SR Hoare","year":"2001","unstructured":"Hoare SR, Usdin TB. Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors. Curr Pharm Des. 2001;7(8):689\u2013713.","journal-title":"Curr Pharm Des"},{"issue":"6","key":"407_CR47","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1210\/endo-93-6-1349","volume":"93","author":"GW Tregear","year":"1973","unstructured":"Tregear GW, et al. Bovine parathyroid hormone: minimum chain length of synthetic peptide required for biological activity. Endocrinology. 1973;93(6):1349\u201353.","journal-title":"Endocrinology"},{"issue":"5","key":"407_CR48","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S8756-3282(97)00020-3","volume":"20","author":"CH S\u00f8gaard","year":"1997","unstructured":"S\u00f8gaard CH, Mosekilde L, Thomsen JS, Richards A, McOsker JE. A comparison of the effects of two anabolic agents (fluoride and PTH) on ash density and bone strength assessed in an osteopenic rat model. Bone. 1997;20(5):439\u201349.","journal-title":"Bone"},{"issue":"1","key":"407_CR49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2005.03.013","volume":"37","author":"A Valenta","year":"2005","unstructured":"Valenta A, et al. Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats. Bone. 2005;37(1):87\u201395.","journal-title":"Bone"},{"issue":"9","key":"407_CR50","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1359\/JBMR.050405","volume":"20","author":"D Farlay","year":"2005","unstructured":"Farlay D, Boivin G, Panczer G, Lalande A, Meunier PJ. Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone. J Bone Miner Res. 2005;20(9):1569\u201378.","journal-title":"J Bone Miner Res"},{"issue":"9","key":"407_CR51","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/jbmr.5650110915","volume":"11","author":"G Boivin","year":"1996","unstructured":"Boivin G, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996;11(9):1302\u201311.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"407_CR52","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1359\/jbmr.091038","volume":"25","author":"C Li","year":"2010","unstructured":"Li C, et al. Strontium is incorporated into mineral crystals only in newly formed bone during strontium ranelate treatment. J Bone Miner Res. 2010;25(5):968\u201375.","journal-title":"J Bone Miner Res"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13346-017-0407-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-017-0407-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-017-0407-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T15:55:14Z","timestamp":1719330914000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13346-017-0407-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,18]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["407"],"URL":"https:\/\/doi.org\/10.1007\/s13346-017-0407-2","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"type":"print","value":"2190-393X"},{"type":"electronic","value":"2190-3948"}],"subject":[],"published":{"date-parts":[[2017,7,18]]}}}