{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:11:33Z","timestamp":1779235893577,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s13346-017-0418-z","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T09:21:35Z","timestamp":1502788895000},"page":"695-708","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preclinical development of an automated injection device for intradermal delivery of a cell-based therapy"],"prefix":"10.1007","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-6853","authenticated-orcid":false,"given":"Giulia","family":"Leoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Lyness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Ginty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rindi","family":"Schutte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopalan","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayatri","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Mount","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"issue":"4","key":"418_CR1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1089\/dia.2010.0204","volume":"13","author":"J Gupta","year":"2011","unstructured":"Gupta J, Felner EI, Prausnitz MR. Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects. Diabetes Technol Ther. 2011;13(4):451\u20136. doi:\n10.1089\/dia.2010.0204\n\n.","journal-title":"Diabetes Technol Ther"},{"key":"418_CR2","unstructured":"Mantoux C. L\u2019intradermo-r\u00e9action \u00e0 la tuberculine et son interpr\u00e9tation clinique. Presse M\u00e9d. 1910;18:10-3."},{"issue":"52","key":"418_CR3","doi-asserted-by":"publisher","first-page":"8833","DOI":"10.1016\/j.vaccine.2007.10.020","volume":"25","author":"PE Laurent","year":"2007","unstructured":"Laurent PE, Bonnet S, Alchas P, Regolini P, Mikszta JA, Pettis R, et al. Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system. Vaccine. 2007;25(52):8833\u201342. doi:\n10.1016\/j.vaccine.2007.10.020\n\n.","journal-title":"Vaccine"},{"key":"418_CR4","doi-asserted-by":"crossref","unstructured":"Quinlan NJea. Investigations of gas and particle dynamics in first generation needle-free drug delivery devices. Shock Waves 2001;10(6):395-404.","DOI":"10.1007\/PL00004052"},{"issue":"4","key":"418_CR5","doi-asserted-by":"publisher","first-page":"e10266","DOI":"10.1371\/journal.pone.0010266","volume":"5","author":"GJ Fernando","year":"2010","unstructured":"Fernando GJ, Chen X, Prow TW, Crichton ML, Fairmaid EJ, Roberts MS, et al. Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model. PLoS One. 2010;5(4):e10266. doi:\n10.1371\/journal.pone.0010266\n\n.","journal-title":"PLoS One"},{"issue":"12","key":"418_CR6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jevs.2011.06.012","volume":"31","author":"JC Phillips","year":"2011","unstructured":"Phillips JC. Evaluation of needle-free injection devices for intramuscular vaccination in horses. Journal of Equine Veterinary Science. 2011;31(12):738\u201343.","journal-title":"Journal of Equine Veterinary Science"},{"issue":"3","key":"418_CR7","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jconrel.2005.05.023","volume":"106","author":"J Baxter","year":"2005","unstructured":"Baxter J, Mitragotri S. Jet-induced skin puncture and its impact on needle-free jet injections: experimental studies and a predictive model. J Control Release. 2005;106(3):361\u201373. doi:\n10.1016\/j.jconrel.2005.05.023\n\n.","journal-title":"J Control Release"},{"issue":"6","key":"418_CR8","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.jaad.2013.08.014","volume":"69","author":"SS Venugopal","year":"2013","unstructured":"Venugopal SS, Yan W, Frew JW, Cohn HI, Rhodes LM, Tran K, et al. A phase II randomized vehicle-controlled trial of intradermal allogeneic fibroblasts for recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol. 2013;69(6):898\u2013908 e7. doi:\n10.1016\/j.jaad.2013.08.014\n\n.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"418_CR9","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1111\/bjd.12599","volume":"169","author":"G Petrof","year":"2013","unstructured":"Petrof G, Martinez-Queipo M, Mellerio JE, Kemp P, McGrath JA. Fibroblast cell therapy enhances initial healing in recessive dystrophic epidermolysis bullosa wounds: results of a randomized, vehicle-controlled trial. Br J Dermatol. 2013;169(5):1025\u201333. doi:\n10.1111\/bjd.12599\n\n.","journal-title":"Br J Dermatol"},{"key":"418_CR10","unstructured":"Council Directive 93\/42\/EEC of 14 June 1993 concerning medical devices. Off J Eur Communities. 1993;L 169:0001-0043"},{"key":"418_CR11","unstructured":"Directive 2007\/47\/EC of the European Parliament and of the Council of 5 September 2007. Off J Eur Communities. 2007;L 247\/21:0001-0035"},{"issue":"Pt 4","key":"418_CR12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1469-7580.1997.19040601.x","volume":"190","author":"NJ Vardaxis","year":"1997","unstructured":"Vardaxis NJ, Brans TA, Boon ME, Kreis RW, Marres LM. Confocal laser scanning microscopy of porcine skin: implications for human wound healing studies. J Anat. 1997;190(Pt 4):601\u201311.","journal-title":"J Anat"},{"key":"418_CR13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000029928","volume":"13","author":"GAM Simon","year":"2000","unstructured":"Simon GAM, H.I. The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations\u2014an overview. Skin Pharmacol Appl Ski Physiol. 2000;13:229\u201334.","journal-title":"Skin Pharmacol Appl Ski Physiol"},{"key":"418_CR14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000401274","volume":"7","author":"W Meyer","year":"1978","unstructured":"Meyer W, Schwarz R, Neurand K. The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig. Curr Probl Dermatol. 1978;7:39\u201352.","journal-title":"Curr Probl Dermatol"},{"issue":"3","key":"418_CR15","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.jmbbm.2010.12.015","volume":"4","author":"G Kang","year":"2011","unstructured":"Kang G, Wu X. Ratchetting of porcine skin under uniaxial cyclic loading. J Mech Behav Biomed Mater. 2011;4(3):498\u2013506. doi:\n10.1016\/j.jmbbm.2010.12.015\n\n.","journal-title":"J Mech Behav Biomed Mater"},{"issue":"34","key":"418_CR16","doi-asserted-by":"publisher","first-page":"6423","DOI":"10.1016\/j.vaccine.2007.05.046","volume":"25","author":"A Laurent","year":"2007","unstructured":"Laurent A, Mistretta F, Bottigioli D, Dahel K, Goujon C, Nicolas JF, et al. Echographic measurement of skin thickness in adults by high frequency ultrasound to assess the appropriate microneedle length for intradermal delivery of vaccines. Vaccine. 2007;25(34):6423\u201330. doi:\n10.1016\/j.vaccine.2007.05.046\n\n.","journal-title":"Vaccine"},{"issue":"1","key":"418_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tiv.2008.10.008","volume":"23","author":"AMFH Barbero","year":"2009","unstructured":"Barbero AMFH. Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review. Toxicol in Vitro. 2009;23(1):1\u201313.","journal-title":"Toxicol in Vitro"},{"issue":"5\u20136","key":"418_CR18","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.3109\/03602538409033556","volume":"15","author":"EJ Calabrese","year":"1984","unstructured":"Calabrese EJ. Gastrointestinal and dermal absorption: interspecies differences. Drug Metab Rev. 1984;15(5\u20136):1013\u201332. doi:\n10.3109\/03602538409033556\n\n.","journal-title":"Drug Metab Rev"},{"key":"418_CR19","volume-title":"The pig as a model for cutaneous pharmacology and toxicology research","author":"NARJ Monteiro-Riviere","year":"1996","unstructured":"Monteiro-Riviere NARJ. In: Tumbleson M, Schook L, editors. The pig as a model for cutaneous pharmacology and toxicology research. US: Springer; 1996."},{"key":"418_CR20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/jid.1964.110","volume":"42","author":"W Montagna","year":"1964","unstructured":"Montagna W, Yun JS. The skin of the domestic pig. J Invest Dermatol. 1964;42:11\u201321.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"418_CR21","first-page":"29","volume":"11","author":"E Konishi","year":"1985","unstructured":"Konishi E, Yoshizawa Y. Estimation of depth of basal cell layer of skin for radiation protection. Radiat Prot Dosim. 1985;11(1):29\u201333.","journal-title":"Radiat Prot Dosim"},{"issue":"6","key":"418_CR22","first-page":"657","volume":"106","author":"CY Tan","year":"1982","unstructured":"Tan CY, Statham B, Marks R, Payne PA. Skin thickness measurement by pulsed ultrasound: its reproducibility, validation and variability. Br J Dermatol. 1982;106(6):657\u201367.","journal-title":"Br J Dermatol"},{"issue":"2","key":"418_CR23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0026-2862(80)90006-0","volume":"20","author":"CM Young","year":"1980","unstructured":"Young CM, Hopewell JW. The evaluation of an isotope clearance technique in the dermis of pig skin: a correlation of functional and morphological parameters. Microvasc Res. 1980;20(2):182\u201394.","journal-title":"Microvasc Res"},{"issue":"5","key":"418_CR24","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1046\/j.1365-2133.1998.02506.x","volume":"139","author":"M Gniadecka","year":"1998","unstructured":"Gniadecka M, Jemec GB. Quantitative evaluation of chronological ageing and photoageing in vivo: studies on skin echogenicity and thickness. Br J Dermatol. 1998;139(5):815\u201321.","journal-title":"Br J Dermatol"},{"issue":"1","key":"418_CR25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.0909-752x.2001.10297.x","volume":"8","author":"K Sauermann","year":"2002","unstructured":"Sauermann K, Clemann S, Jaspers S, Gambichler T, Altmeyer P, Hoffmann K, et al. Age related changes of human skin investigated with histometric measurements by confocal laser scanning microscopy in vivo. Skin Res Technol. 2002;8(1):52\u20136.","journal-title":"Skin Res Technol"},{"issue":"7\u20138","key":"418_CR26","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1089\/ten.TEA.2011.0391","volume":"18","author":"BA Aguado","year":"2012","unstructured":"Aguado BA, Mulyasasmita W, Su J, Lampe KJ, Heilshorn SC. Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Tissue Eng Part A. 2012;18(7\u20138):806\u201315. doi:\n10.1089\/ten.TEA.2011.0391\n\n.","journal-title":"Tissue Eng Part A."},{"issue":"5","key":"418_CR27","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/jphp.12362","volume":"67","author":"MH Amer","year":"2014","unstructured":"Amer MH, White LJ, Shakesheff KM. The effect of injection using narrow-bore needles on mammalian cells: administration and formulation considerations for cell therapies. J Pharm Pharmacol. 2014;67(5):640\u201350.","journal-title":"J Pharm Pharmacol"},{"issue":"1","key":"418_CR28","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/14653240701762356","volume":"10","author":"M Tol","year":"2008","unstructured":"Tol M, Akar AR, Durdu S, Ayyildiz E, Ilhan O. Comparison of different needle diameters and flow rates on bone marrow mononuclear stem cell viability: an ex vivo experimental study. Cytotherapy. 2008;10(1):98\u20139. doi:\n10.1080\/14653240701762356\n\n.","journal-title":"Cytotherapy"},{"issue":"6","key":"418_CR29","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/term.55","volume":"1","author":"F Cao","year":"2007","unstructured":"Cao F, Sadrzadeh Rafie AH, Abilez OJ, Wang H, Blundo JT, Pruitt B, et al. In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival. J Tissue Eng Regen Med. 2007;1(6):465\u20138. doi:\n10.1002\/term.55\n\n.","journal-title":"J Tissue Eng Regen Med"},{"issue":"6","key":"418_CR30","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1089\/ten.TEA.2009.0768","volume":"16","author":"SB Seif-Naraghi","year":"2010","unstructured":"Seif-Naraghi SB, Salvatore MA, Schup-Magoffin PJ, Hu DP, Christman KL. Design and characterization of an injectable pericardial matrix gel: a potentially autologous scaffold for cardiac tissue engineering. Tissue Eng Part A. 2010;16(6):2017\u201327. doi:\n10.1089\/ten.TEA.2009.0768\n\n.","journal-title":"Tissue Eng Part A"},{"issue":"9\u201310","key":"418_CR31","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1089\/ten.2004.10.1566","volume":"10","author":"CM Smith","year":"2004","unstructured":"Smith CM, Stone AL, Parkhill RL, Stewart RL, Simpkins MW, Kachurin AM, et al. Three-dimensional bioassembly tool for generating viable tissue-engineered constructs. Tissue Eng. 2004;10(9\u201310):1566\u201376. doi:\n10.1089\/ten.2004.10.1566\n\n.","journal-title":"Tissue Eng"},{"issue":"3","key":"418_CR32","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1089\/ten.TEC.2009.0178","volume":"16","author":"M Li","year":"2010","unstructured":"Li M, Tian X, Zhu N, Schreyer DJ, Chen X. Modeling process-induced cell damage in the biodispensing process. Tissue Eng Part C Methods. 2010;16(3):533\u201342. doi:\n10.1089\/ten.TEC.2009.0178\n\n.","journal-title":"Tissue Eng Part C Methods"},{"issue":"Suppl 1","key":"418_CR33","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.4103\/2152-7806.109190","volume":"4","author":"MB Potts","year":"2013","unstructured":"Potts MB, Silvestrini MT, Lim DA. Devices for cell transplantation into the central nervous system: design considerations and emerging technologies. Surg Neurol Int. 2013;4(Suppl 1):S22\u201330. doi:\n10.4103\/2152-7806.109190\n\n.","journal-title":"Surg Neurol Int"},{"issue":"9","key":"418_CR34","first-page":"813","volume":"27","author":"ES Gardner","year":"2001","unstructured":"Gardner ES, Sumner WT, Cook JL. Predictable tissue shrinkage during frozen section histopathologic processing for Mohs micrographic surgery. Dermatol Surg. 2001;27(9):813\u20138.","journal-title":"Dermatol Surg"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13346-017-0418-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-017-0418-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-017-0418-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T11:20:26Z","timestamp":1504005626000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13346-017-0418-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["418"],"URL":"https:\/\/doi.org\/10.1007\/s13346-017-0418-z","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]}}}