{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T01:02:25Z","timestamp":1779325345877,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s13346-018-0531-7","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T10:32:22Z","timestamp":1527071542000},"page":"994-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A hyaluronic acid- and chondroitin sulfate-based medical device improves gastritis pain, discomfort, and endoscopic features"],"prefix":"10.1007","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-0562","authenticated-orcid":false,"given":"Tommaso","family":"Iannitti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C\u00e9sar","family":"Morales-Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Merighi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Boarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Laurino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vadal\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beniamino","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"issue":"Suppl 4","key":"531_CR1","doi-asserted-by":"publisher","first-page":"S373","DOI":"10.1016\/S1590-8658(11)60593-8","volume":"43","author":"M Rugge","year":"2011","unstructured":"Rugge M, Pennelli G, Pilozzi E, Fassan M, Ingravallo G, Russo VM, et al. Gastritis: the histology report. Dig Liver Dis. 2011;43(Suppl 4):S373\u201384.","journal-title":"Dig Liver Dis"},{"key":"531_CR2","doi-asserted-by":"crossref","unstructured":"Marcial G, Rodr\u00edguez C, Medici M, de Valdez GF. New approaches in gastritis treatment, gastritis and gastric cancer. In: Tonino P, editor. New insights in gastroprotection, diagnosis and treatments. Croatia - EUROPEAN UNION: InTech Publisher; 2011. pp. 153\u201376.","DOI":"10.5772\/23221"},{"issue":"1","key":"531_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0016-5107(83)72493-4","volume":"29","author":"R Cheli","year":"1983","unstructured":"Cheli R, Giacosa A. Chronic atrophic gastritis and gastric mucosal atrophy\u2014one and the same. Gastrointest Endosc. 1983;29(1):23\u20135.","journal-title":"Gastrointest Endosc"},{"key":"531_CR4","doi-asserted-by":"publisher","first-page":"758397","DOI":"10.1155\/2010\/758397","volume":"2010","author":"B Dewan","year":"2010","unstructured":"Dewan B, Balasubramanian A. Troxipide in the management of gastritis: a randomized comparative trial in general practice. Gastroenterol Res Pract. 2010;2010:758397.","journal-title":"Gastroenterol Res Pract"},{"issue":"3","key":"531_CR5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0016-5107(73)73979-1","volume":"19","author":"C Sugawa","year":"1973","unstructured":"Sugawa C, Lucas CE, Rosenberg BF, Riddle JM, Walt AJ. Differential topography of acute erosive gastritis due to trauma or sepsis, ethanol and aspirin. Gastrointest Endosc. 1973;19(3):127\u201330.","journal-title":"Gastrointest Endosc"},{"issue":"1\u20132","key":"531_CR6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000198052","volume":"16","author":"T Sekino","year":"1977","unstructured":"Sekino T, Murata K, Saito Y, Tsubura K. A study of acidic glycosaminoglycans in human gastric tissue. Digestion. 1977;16(1\u20132):28\u201339.","journal-title":"Digestion"},{"issue":"4","key":"531_CR7","first-page":"487","volume":"18","author":"S Geocze","year":"1985","unstructured":"Geocze S, Nader HB, Mincis M, Novo NF, Paiva ER. Sulfated glycosaminoglycan composition of human gastric mucosa: effect of aging, chronic superficial gastritis and adenocarcinoma. Braz J Med Biol Res. 1985;18(4):487\u201392.","journal-title":"Braz J Med Biol Res"},{"key":"531_CR8","first-page":"229","volume-title":"Proteoglycans and sulfated glycosaminoglycans, Essentials of glycobiology","author":"JD Esko","year":"2009","unstructured":"Esko JD, Kimata K, Lindahl U. Proteoglycans and sulfated glycosaminoglycans, Essentials of glycobiology. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 2009. p. 229\u201348."},{"issue":"5","key":"531_CR9","first-page":"463","volume":"27","author":"BP Babkin","year":"1932","unstructured":"Babkin BP, Komarov SA. The influence of gastric mucus on peptic digestion. Can Med Assoc J. 1932;27(5):463\u20139.","journal-title":"Can Med Assoc J"},{"issue":"Suppl 3","key":"531_CR10","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1016\/j.joca.2008.06.006","volume":"16","author":"D Uebelhart","year":"2008","unstructured":"Uebelhart D. Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthr Cartil. 2008;16(Suppl 3):S19\u201321.","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"531_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10787-011-0098-0","volume":"19","author":"N Volpi","year":"2011","unstructured":"Volpi N. Anti-inflammatory activity of chondroitin sulphate: new functions from an old natural macromolecule. Inflammopharmacology. 2011;19(6):299\u2013306.","journal-title":"Inflammopharmacology"},{"issue":"3","key":"531_CR12","doi-asserted-by":"publisher","first-page":"536","DOI":"10.2165\/00003495-199447030-00009","volume":"47","author":"KL Goa","year":"1994","unstructured":"Goa KL, Benfield P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs. 1994;47(3):536\u201366.","journal-title":"Drugs"},{"issue":"5","key":"531_CR13","first-page":"343","volume":"17","author":"H Li","year":"2000","unstructured":"Li H, Guo L, Li J, Liu N, Liu J. Alternative splicing of RHAMM gene in Chinese gastric cancers and its in vitro regulation. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2000;17(5):343\u20137.","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"issue":"5","key":"531_CR14","first-page":"329","volume":"21","author":"H Li","year":"1999","unstructured":"Li H, Li J, Guo L. Characteristics of expression of CD44v and receptor for HA-mediated motility (RHAMM) in multi-step gastrocarcinogenesis. Zhonghua Zhong Liu Za Zhi. 1999;21(5):329\u201331.","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"issue":"7","key":"531_CR15","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nrc1391","volume":"4","author":"BP Toole","year":"2004","unstructured":"Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer. 2004;4(7):528\u201339.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"531_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1096\/fj.05-4682rev","volume":"20","author":"KR Taylor","year":"2006","unstructured":"Taylor KR, Gallo RL. Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation. FASEB J. 2006;20(1):9\u201322.","journal-title":"FASEB J"},{"issue":"10","key":"531_CR17","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1007\/s10856-011-4408-2","volume":"22","author":"A Ardizzoni","year":"2011","unstructured":"Ardizzoni A, Neglia RG, Baschieri MC, Cermelli C, Caratozzolo M, Righi E, et al. Influence of hyaluronic acid on bacterial and fungal species, including clinically relevant opportunistic pathogens. J Mater Sci Mater Med. 2011;22(10):2329\u201338.","journal-title":"J Mater Sci Mater Med"},{"key":"531_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/1743-422X-8-141","volume":"8","author":"C Cermelli","year":"2011","unstructured":"Cermelli C, Cuoghi A, Scuri M, Bettua C, Neglia RG, Ardizzoni A, et al. In vitro evaluation of antiviral and virucidal activity of a high molecular weight hyaluronic acid. Virol J. 2011;8:141.","journal-title":"Virol J"},{"issue":"2","key":"531_CR19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10735-012-9457-4","volume":"44","author":"T Iannitti","year":"2013","unstructured":"Iannitti T, Elhensheri M, Bingol AO, Palmieri B. Preliminary histopathological study of intra-articular injection of a novel highly cross-linked hyaluronic acid in a rabbit model of knee osteoarthritis. J Mol Histol. 2013;44(2):191\u2013201.","journal-title":"J Mol Histol"},{"issue":"4","key":"531_CR20","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1177\/039463201202500426","volume":"25","author":"T Iannitti","year":"2012","unstructured":"Iannitti T, Rottigni V, Palmieri B. A pilot study to compare two different hyaluronic acid compounds for treatment of knee osteoarthritis. Int J Immunopathol Pharmacol. 2012;25(4):1093\u20138.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"531_CR21","first-page":"7","volume":"7","author":"B Palmieri","year":"2013","unstructured":"Palmieri B, Rottigni V, Iannitti T. Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain. Drug Des Devel Ther. 2013;7:7\u201312.","journal-title":"Drug Des Devel Ther"},{"key":"531_CR22","doi-asserted-by":"crossref","unstructured":"Iannitti T, Rottigni V, Torricelli F, Palmieri B. Combination therapy of hyaluronic acid mesotherapic injections and sclerotherapy for treatment of lower leg telangiectasia without major venous insufficiency: a preliminary clinical study. Clin Appl Thromb Hemost. 2014;20(3):326\u201330.","DOI":"10.1177\/1076029612461844"},{"issue":"3","key":"531_CR23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/ijir.2013.13","volume":"25","author":"A Littara","year":"2013","unstructured":"Littara A, Palmieri B, Rottigni V, Iannitti T. A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation. Int J Impot Res. 2013;25(3):117\u201320.","journal-title":"Int J Impot Res"},{"key":"531_CR24","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.ijpharm.2013.06.066","volume":"456","author":"T Iannitti","year":"2013","unstructured":"Iannitti T, Bingol AO, Rottigni V, Palmieri B. Biocompatibility and rheological properties of a new highly viscoelastic hyaluronic acid in a rat model for biomaterial implants and first-in-man clinical investigation in esthetic and restorative medicine. Int J Pharm. 2013;456:583\u201392.","journal-title":"Int J Pharm"},{"issue":"3 Suppl 1","key":"531_CR25","first-page":"1","volume":"66","author":"T Iannitti","year":"2011","unstructured":"Iannitti T, Capone S, Palmieri B. Short review on face rejuvenation procedures: focus on preoperative antiseptic and anesthetic delivery by JetPeel-3 (a high pressure oxygen delivery device). Minerva Chir. 2011;66(3 Suppl 1):1\u20138.","journal-title":"Minerva Chir"},{"key":"531_CR26","first-page":"1441","volume":"7","author":"W Marusza","year":"2012","unstructured":"Marusza W, Mlynarczyk G, Olszanski R, Netsvyetayeva I, Obrowski M, Iannitti T, et al. Probable biofilm formation in the cheek as a complication of soft tissue filler resulting from improper endodontic treatment of tooth 16. Int J Nanomedicine. 2012;7:1441\u20137.","journal-title":"Int J Nanomedicine"},{"issue":"10","key":"531_CR27","first-page":"1051","volume":"33","author":"A Cerbo Di","year":"2012","unstructured":"Di Cerbo A, Palmieri B. The economic impact of second opinion in pathology. Saudi Med J. 2012;33(10):1051\u20132.","journal-title":"Saudi Med J"},{"issue":"2","key":"531_CR28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.pec.2011.02.019","volume":"85","author":"B Palmieri","year":"2011","unstructured":"Palmieri B, Iannitti T. The Web Babel syndrome. Patient Educ Couns. 2011;85(2):331\u20133.","journal-title":"Patient Educ Couns"},{"issue":"6","key":"531_CR29","first-page":"575","volume":"162","author":"B Palmieri","year":"2011","unstructured":"Palmieri B, Iannitti T, Capone S, Fistetto G, Arisi E. Second opinion clinic: is the Web Babel syndrome treatable? Clin Ter. 2011;162(6):575\u201383.","journal-title":"Clin Ter"},{"issue":"1","key":"531_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cjp2.63","volume":"3","author":"B Palmieri","year":"2017","unstructured":"Palmieri B, Laurino C, Vadal\u00e0 M. The \u201csecond opinion medical network\u201d. Int J Pathol Clin Res. 2017;3(1):1\u20137.","journal-title":"Int J Pathol Clin Res"},{"issue":"3","key":"531_CR31","first-page":"3","volume":"18","author":"A Wunsch","year":"2013","unstructured":"Wunsch A, B P. The role of second opinion in oncology: an update. Eur J Oncol. 2013;18(3):3\u201310.","journal-title":"Eur J Oncol"},{"issue":"10","key":"531_CR32","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","volume":"20","author":"MF Dixon","year":"1996","unstructured":"Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney system. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol. 1996;20(10):1161\u201381.","journal-title":"Am J Surg Pathol"},{"key":"531_CR33","unstructured":"Batchelor HK. Novel bioadhesive formulations in drug delivery. Drug Delivery Companies Report Autumn\/Winter; 2004. p. 16\u201319."},{"key":"531_CR34","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2147\/CEG.S31404","volume":"5","author":"MP Simone Di","year":"2012","unstructured":"Di Simone MP, Baldi F, Vasina V, Scorrano F, Bacci ML, Ferrieri A, et al. Barrier effect of Esoxx((R)) on esophageal mucosal damage: experimental study on ex-vivo swine model. Clin Exp Gastroenterol. 2012;5:103\u20137.","journal-title":"Clin Exp Gastroenterol"},{"key":"531_CR35","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3181\/00379727-30-6638","volume":"30","author":"LA Crandall","year":"1933","unstructured":"Crandall LA, Roberts GM. Observations on administration of chondroitin in peptic ulcers. Proc Soc Exp Biol Med. 1933;30:704\u20138.","journal-title":"Proc Soc Exp Biol Med"},{"issue":"9","key":"531_CR36","first-page":"350","volume":"108","author":"MA Fialkova","year":"1989","unstructured":"Fialkova MA, Smirnova T, Ivanova GI, Aboiants RK, Golubeva VF. The effect of chondroitin sulfate preparations on wound healing and the strength of the surgical scar. Biull Eksp Biol Med. 1989;108(9):350\u20131.","journal-title":"Biull Eksp Biol Med"},{"issue":"11","key":"531_CR37","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/S0161-6420(82)34653-9","volume":"89","author":"SE Harrison","year":"1982","unstructured":"Harrison SE, Soll DB, Shayegan M, Clinch T. A new and effective protective agent for intraocular lens insertion. Ophthalmology. 1982;89(11):1254\u201360.","journal-title":"Ophthalmology"},{"issue":"5","key":"531_CR38","first-page":"286","volume":"54","author":"L Barthe","year":"2004","unstructured":"Barthe L, Woodley J, Lavit M, Przybylski C, Philibert C, Houin G. In vitro intestinal degradation and absorption of chondroitin sulfate, a glycosaminoglycan drug. Arzneimittelforschung. 2004;54(5):286\u201392.","journal-title":"Arzneimittelforschung"},{"issue":"5\u20136","key":"531_CR39","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1159\/000198219","volume":"18","author":"T Sekino","year":"1978","unstructured":"Sekino T, Murata K. Age-dependent constitutional change in acidic glycosaminoglycans in human esophagus. Digestion. 1978;18(5\u20136):319\u201328.","journal-title":"Digestion"},{"issue":"3","key":"531_CR40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1620\/tjem.127.273","volume":"127","author":"T Sekino","year":"1979","unstructured":"Sekino T, Murata K, Saito Y. Acidic glycosaminoglycans in human esophagus tissue. Tohoku J Exp Med. 1979;127(3):273\u201380.","journal-title":"Tohoku J Exp Med"},{"issue":"10","key":"531_CR41","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1053\/joca.2002.0824","volume":"10","author":"N Volpi","year":"2002","unstructured":"Volpi N. Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers. Osteoarthr Cartil. 2002;10(10):768\u201377.","journal-title":"Osteoarthr Cartil"},{"issue":"Pt B","key":"531_CR42","first-page":"731","volume":"539","author":"G Steinhoff","year":"2003","unstructured":"Steinhoff G, Ittah B, Rowan S. The efficacy of intravesicular sterile sodium chondroitin sulfate 0.2% in potassium tested positive patients with interstitial cystitis. Adv Exp Med Biol. 2003;539(Pt B):731\u20139.","journal-title":"Adv Exp Med Biol"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13346-018-0531-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-018-0531-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-018-0531-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T01:37:49Z","timestamp":1558575469000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13346-018-0531-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,23]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["531"],"URL":"https:\/\/doi.org\/10.1007\/s13346-018-0531-7","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,23]]},"assertion":[{"value":"23 May 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This retrospective, anecdotal, double-blind randomised placebo-controlled study was conducted in accordance with the Declaration of Helsinki and institutional review board rules.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Written informed consent was obtained from the patients for publication of the data included in this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}