{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:32:19Z","timestamp":1789097539793,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["NMP-2011-1.2-2-280761"],"award-info":[{"award-number":["NMP-2011-1.2-2-280761"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004435","name":"Universidad de Navarra","doi-asserted-by":"publisher","award":["ADA"],"award-info":[{"award-number":["ADA"]}],"id":[{"id":"10.13039\/501100004435","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s13346-020-00796-3","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T13:07:37Z","timestamp":1591621657000},"page":"1601-1611","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Zein-based nanoparticles for the oral delivery of insulin"],"prefix":"10.1007","volume":"10","author":[{"given":"Laura","family":"Inchaurraga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Mart\u00ednez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nekane","family":"Martin-Arbella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9687-3436","authenticated-orcid":false,"given":"Juan M.","family":"Irache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"796_CR1","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/01.mjt.0000178767.67857.63","volume":"12","author":"JW Yoon","year":"2005","unstructured":"Yoon JW, Jun HS. Autoimmune destruction of pancreatic beta cells. Am J Ther. 2005;12:580\u201391. https:\/\/doi.org\/10.1097\/01.mjt.0000178767.67857.63.","journal-title":"Am J Ther."},{"key":"796_CR2","doi-asserted-by":"publisher","unstructured":"Burrack AL, Martinov T, Fife BT. T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes, Front Endocrinol (Lausanne). 2017;8:343. https:\/\/doi.org\/10.3389\/fendo.2017.00343.","DOI":"10.3389\/fendo.2017.00343"},{"key":"796_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mcna.2014.08.015","volume":"99","author":"CC Thomas","year":"2015","unstructured":"Thomas CC, Philipson LH. Update on diabetes classification. Med Clin North Am. 2015;99:1\u201316. https:\/\/doi.org\/10.1016\/j.mcna.2014.08.015.","journal-title":"Med Clin North Am."},{"key":"796_CR4","unstructured":"International Diabetes Federation. Diabetes atlas\u20148th edition, Http:\/\/www.diabetesatlas.org\/resources\/2017-atlas, Accessed Feb 28, 2020."},{"key":"796_CR5","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2471\/BLT.13.128371","volume":"92","author":"S Akter","year":"2014","unstructured":"Akter S, Rahman MM, Abe SK, Sultana P. Prevalence of diabetes and prediabetes and their risk factors among Bangladeshi adults: a nationwide survey. Bull World Health Organ. 2014;92:204\u201313. https:\/\/doi.org\/10.2471\/BLT.13.128371.","journal-title":"Bull World Health Organ."},{"key":"796_CR6","doi-asserted-by":"publisher","first-page":"868","DOI":"10.4103\/2230-8210.141388","volume":"18","author":"J Bhutani","year":"2014","unstructured":"Bhutani J, Bhutani S. Worldwide burden of diabetes. Indian J Endocrinol Metab. 2014;18:868\u201370. https:\/\/doi.org\/10.4103\/2230-8210.141388.","journal-title":"Indian J Endocrinol Metab."},{"key":"796_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14:88\u201398. https:\/\/doi.org\/10.1038\/nrendo.2017.151.","journal-title":"Nat Rev Endocrinol."},{"key":"796_CR8","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.2337\/dci18-0023","volume":"41","author":"JL Chiang","year":"2018","unstructured":"Chiang JL, Maahs DM, Garvey KC, Hood KK, Laffel LM, Weinzimer SA, et al. Type 1 diabetes in children and adolescents: a position statement by the American Diabetes Association. Diabetes Care. 2018;41:2026\u201344. https:\/\/doi.org\/10.2337\/dci18-0023.","journal-title":"Diabetes Care."},{"key":"796_CR9","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s13300-018-0384-6","volume":"9","author":"B Silver","year":"2018","unstructured":"Silver B, Ramaiya K, Andrew SB, Fredrick O, Bajaj S, Kalra S, et al. EADSG Guidelines: insulin therapy in diabetes. Diabetes Ther. 2018;9:449\u201392. https:\/\/doi.org\/10.1007\/s13300-018-0384-6.","journal-title":"Diabetes Ther."},{"key":"796_CR10","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1177\/193229680900300322","volume":"3","author":"E Arbit","year":"2009","unstructured":"Arbit E, Kidron M. Oral insulin: the rationale for this approach and current developments. J Diabetes Sci Technol. 2009;3:562\u20137.","journal-title":"J Diabetes Sci Technol."},{"key":"796_CR11","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/BF00400466","volume":"37","author":"S Del Prato","year":"1994","unstructured":"Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia. 1994;37:1025\u201335. https:\/\/doi.org\/10.1007\/BF00400466.","journal-title":"Diabetologia."},{"key":"796_CR12","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/cbdd.12318","volume":"84","author":"S Hosseininasab","year":"2014","unstructured":"Hosseininasab S, Pashaei-Asl R, Khandaghi AA, Nasrabadi HT, Nejati-Koshki K, Akbarzadeh A, et al. Hanifehpour Y, S. Davaran S. Synthesis, characterization, and in vitro studies of PLGA-PEG nanoparticles for oral insulin delivery. Chem Biol Drug Des. 2014;84:307\u201315. https:\/\/doi.org\/10.1111\/cbdd.12318.","journal-title":"Chem Biol Drug Des."},{"key":"796_CR13","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1177\/193229680900300323","volume":"3","author":"L Heinemann","year":"2009","unstructured":"Heinemann L, Jacques Y. Oral insulin and buccal insulin: a critical reappraisal. J Diabetes Sci Technol. 2009;3:568\u201384.","journal-title":"J Diabetes Sci Technol."},{"key":"796_CR14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cocis.2010.12.005","volume":"16","author":"L Plapied","year":"2011","unstructured":"Plapied L, Duhem N, des Rieux A, Pr\u00e9at V. Fate of polymeric nanocarriers for oral drug delivery. Curr Opin Colloid Interface Sci. 2011;16:228\u201337. https:\/\/doi.org\/10.1016\/j.cocis.2010.12.005.","journal-title":"Curr Opin Colloid Interface Sci."},{"key":"796_CR15","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1111\/jphp.12607","volume":"68","author":"CY Wong","year":"2016","unstructured":"Wong CY, Martinez J, Dass CR. Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities. J Pharm Pharmacol. 2016;68:1093\u2013108. https:\/\/doi.org\/10.1111\/jphp.12607.","journal-title":"J Pharm Pharmacol."},{"key":"796_CR16","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1615\/JEnvironPatholToxicolOncol.2017020182","volume":"36","author":"DK Chellappan","year":"2017","unstructured":"Chellappan DK, Yenese Y, Wei CC, Chellian J, Gupta G. Oral insulin: current status, challenges, future perspectives. J Environ Pathol Toxicol Oncol. 2017;36:283\u201391. https:\/\/doi.org\/10.1615\/JEnvironPatholToxicolOncol.2017020182.","journal-title":"J Environ Pathol Toxicol Oncol."},{"key":"796_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ijbiomac.2018.12.182","volume":"126","author":"LC Tsai","year":"2019","unstructured":"Tsai LC, Chen CH, Lin CW, Ho YC, Mi FL. Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin. Int J Biol Macromol. 2019;126:141\u201350. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.12.182.","journal-title":"Int J Biol Macromol."},{"key":"796_CR18","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1021\/bm700916h","volume":"9","author":"B Deutel","year":"2008","unstructured":"Deutel B, Greindl M, Thaurer M, Bernkop-Schn\u00fcrch A. Novel insulin thiomer nanoparticles: in vivo evaluation of an oral drug delivery system. Biomacromolecules. 2008;9:278\u201385. https:\/\/doi.org\/10.1021\/bm700916h.","journal-title":"Biomacromolecules."},{"key":"796_CR19","doi-asserted-by":"publisher","first-page":"15430","DOI":"10.1021\/acsami.5b03555","volume":"7","author":"J Sheng","year":"2015","unstructured":"Sheng J, Han L, Qin J, Ru G, Li R, Wu L, et al. N-trimethyl chitosan chloride-coated PLGA nanoparticles overcoming multiple barriers to oral insulin absorption. ACS Appl. Mater. Interfaces. 2015;7:15430\u201341. https:\/\/doi.org\/10.1021\/acsami.5b03555.","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"796_CR20","first-page":"743","volume":"2","author":"B Sarmento","year":"2007","unstructured":"Sarmento B, Martins S, Ferreira D, Souto EB. Oral insulin delivery by means of solid lipid nanoparticles. Int J Nanomedicine. 2007;2:743\u20139.","journal-title":"Int J Nanomedicine."},{"key":"796_CR21","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1007\/s00592-019-01403-9","volume":"56","author":"E Muntoni","year":"2019","unstructured":"Muntoni E, Marini E, Ahmadi N, Milla P, Ghe C, Bargoni A, et al. Lipid nanoparticles as vehicles for oral delivery of insulin and insulin analogs: preliminary ex vivo and in vivo studies. Acta Diabetol. 2019;56:1283\u201392. https:\/\/doi.org\/10.1007\/s00592-019-01403-9.","journal-title":"Acta Diabetol."},{"key":"796_CR22","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/B978-0-12-391860-4.00015-X","volume":"508","author":"P Fonte","year":"2012","unstructured":"Fonte P, Andrade F, Ara\u00fajo F. Andrade C, das Neves J, Sarmento B, Chitosan-coated solid lipid nanoparticles for insulin delivery. Methods Enzymol. 2012;508:295\u2013314. https:\/\/doi.org\/10.1016\/B978-0-12-391860-4.00015-X.","journal-title":"Methods Enzymol."},{"key":"796_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jfda.2015.01.007","volume":"23","author":"MS Alai","year":"2015","unstructured":"Alai MS, Lin WJ, Pingale SS. Application of polymeric nanoparticles and micelles in insulin oral delivery. J Food Drug Anal. 2015;23:351\u20138. https:\/\/doi.org\/10.1016\/j.jfda.2015.01.007.","journal-title":"J Food Drug Anal."},{"key":"796_CR24","doi-asserted-by":"publisher","first-page":"100006","DOI":"10.1016\/J.IJPX.2019.100006","volume":"1","author":"L Inchaurraga","year":"2019","unstructured":"Inchaurraga L, Mart\u00ednez-L\u00f3pez AL, Abdulkarim M, Gumbleton M, Quincoces G, Pe\u00f1uelas I, et al. Modulation of the fate of zein nanoparticles by their coating with a Gantrez\u00ae AN-thiamine polymer conjugate. Int J Pharm X. 2019;1:100006. https:\/\/doi.org\/10.1016\/J.IJPX.2019.100006.","journal-title":"Int J Pharm X."},{"key":"796_CR25","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ejps.2018.11.025","volume":"128","author":"L Inchaurraga","year":"2019","unstructured":"Inchaurraga L, Mart\u00ednez-L\u00f3pez AL, Cattoz B, Griffiths PC, Wilcox M, Pearson JP, et al. The effect of thiamine-coating nanoparticles on their biodistribution and fate following oral administration. Eur J Pharm Sci. 2019;128:81\u201390. https:\/\/doi.org\/10.1016\/j.ejps.2018.11.025.","journal-title":"Eur J Pharm Sci."},{"key":"796_CR26","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.1021\/jf505694e","volume":"63","author":"R Penalva","year":"2015","unstructured":"Penalva R, Esparza I, Larraneta E, Gonz\u00e1lez-Navarro CJ, Gamazo C, Irache JM. Zein-based nanoparticles improve the oral bioavailability of resveratrol and its anti-inflammatory effects in a mouse model of endotoxic shock. J. Agric. Food Chem. 2015;63:5603\u201311. https:\/\/doi.org\/10.1021\/jf505694e.","journal-title":"J. Agric. Food Chem."},{"key":"796_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0047-2484(78)80101-8","volume":"77","author":"S Brenner","year":"1974","unstructured":"Brenner S. The genetics of Caenorabditis elegans. Genetics. 1974;77:71\u201394. https:\/\/doi.org\/10.1016\/S0047-2484(78)80101-8.","journal-title":"Genetics"},{"key":"796_CR28","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.2337\/db09-0567","volume":"58","author":"A Schlotterer","year":"2009","unstructured":"Schlotterer A, Kukudov G, Bozorgmehr F, Hutter H, Du X, Oikonomou D, et al. C. elegans as model for the study of high glucose-mediated life span reduction. Diabetes. 2009;58:2450\u20136. https:\/\/doi.org\/10.2337\/db09-0567.","journal-title":"Diabetes."},{"key":"796_CR29","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1039\/c7fo01625e","volume":"9","author":"D Navarro-Herrera","year":"2018","unstructured":"Navarro-Herrera D, Aranaz P, Eder-Azanza L, Zabala M, Hurtado C, Romo-Hualde A, et al. Dihomo-gamma-linolenic acid induces fat loss in C. Elegans in an omega-3-independent manner by promoting peroxisomal fatty acid \u03b2-oxidation. Food Funct. 2018;9:1621\u201337. https:\/\/doi.org\/10.1039\/c7fo01625e.","journal-title":"Food Funct."},{"key":"796_CR30","doi-asserted-by":"publisher","first-page":"50180","DOI":"10.3791\/50180","volume":"73","author":"EC Pino","year":"2013","unstructured":"Pino EC, Webster CM, Carr CE, Soukas AA. Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis Elegans. J Vis Exp. 2013;73:50180. https:\/\/doi.org\/10.3791\/50180.","journal-title":"J Vis Exp."},{"key":"796_CR31","doi-asserted-by":"publisher","first-page":"11071","DOI":"10.1021\/jf3031138","volume":"60","author":"P Martorell","year":"2012","unstructured":"Martorell P, Llopis S, Gonz\u00e1lez N, Mont\u00f3n F, Ortiz P, Genov\u00e9s S, et al. Caenorhabditis elegans as a model to study the effectiveness and metabolic targets of dietary supplements used for obesity treatment: The specific case of a conjugated linoleic acid mixture (Tonalin). J Agric Food Chem. 2012;60:11071\u20139. https:\/\/doi.org\/10.1021\/jf3031138.","journal-title":"J Agric Food Chem."},{"key":"796_CR32","doi-asserted-by":"publisher","unstructured":"Thangaraj P. Evaluation of anti-diabetic property on streptozotocin-induced diabetic rats BT - pharmacological assays of plant-based natural products. In: Parimelazhagan T, editor. Cham: Springer International Publishing; 2016. p. 145\u20139. https:\/\/doi.org\/10.1007\/978-3-319-26811-8_24","DOI":"10.1007\/978-3-319-26811-8_24"},{"key":"796_CR33","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.nantod.2014.04.008","volume":"9","author":"S Barua","year":"2014","unstructured":"Barua S, Mitragotri S. Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects. Nano Today. 2014;9:223\u201343. https:\/\/doi.org\/10.1016\/j.nantod.2014.04.008.","journal-title":"Nano Today."},{"key":"796_CR34","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/J.ADDR.2011.12.009","volume":"64","author":"LM Ensign","year":"2012","unstructured":"Ensign LM, Cone R, Hanes J. Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliv Rev. 2012;64:557\u201370. https:\/\/doi.org\/10.1016\/J.ADDR.2011.12.009.","journal-title":"Adv Drug Deliv Rev."},{"key":"796_CR35","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/J.ADDR.2008.11.002","volume":"61","author":"SK Lai","year":"2009","unstructured":"Lai SK, Wang YY, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 2009;61:158\u201371. https:\/\/doi.org\/10.1016\/J.ADDR.2008.11.002.","journal-title":"Adv Drug Deliv Rev."},{"key":"796_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-24148-x","volume":"8","author":"H Schneider","year":"2018","unstructured":"Schneider H, Pelaseyed T, Svensson F, Johansson MEV. Study of mucin turnover in the small intestine by in vivo labeling. Sci Rep. 2018;8:1\u201311. https:\/\/doi.org\/10.1038\/s41598-018-24148-x.","journal-title":"Sci Rep."},{"key":"796_CR37","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.2217\/nnm-2017-0075","volume":"12","author":"JM Irache","year":"2017","unstructured":"Irache JM, Gonzalez-Navarro CJ. Zein nanoparticles as vehicles for oral delivery purposes. Nanomedicine (Lond). 2017;12:1209\u201311. https:\/\/doi.org\/10.2217\/nnm-2017-0075.","journal-title":"Nanomedicine (Lond)."},{"key":"796_CR38","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.ejps.2010.08.009","volume":"41","author":"CB Woitiski","year":"2010","unstructured":"Woitiski CB, Neufeld RJ, Veiga F, Carvalho RA, Figueiredo IV. Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. Eur J Pharm Sci. 2010;41:556\u201363. https:\/\/doi.org\/10.1016\/j.ejps.2010.08.009.","journal-title":"Eur J Pharm Sci."},{"key":"796_CR39","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/J.JCONREL.2006.10.023","volume":"117","author":"C Damg\u00e9","year":"2007","unstructured":"Damg\u00e9 C, Maincent P, Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release. 2007;117:163\u201370. https:\/\/doi.org\/10.1016\/J.JCONREL.2006.10.023.","journal-title":"J Control Release."},{"key":"796_CR40","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/J.CMET.2007.08.011","volume":"6","author":"TJ Schulz","year":"2007","unstructured":"Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007;6:280\u201393. https:\/\/doi.org\/10.1016\/J.CMET.2007.08.011.","journal-title":"Cell Metab."},{"key":"796_CR41","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1039\/c5ib00243e","volume":"8","author":"G Zhu","year":"2016","unstructured":"Zhu G, Yin Y, Wang L, Wei W, Jiang L, Qin J. Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice. Integr Biol (UK). 2016;8:30\u20138. https:\/\/doi.org\/10.1039\/c5ib00243e.","journal-title":"Integr Biol (UK)."},{"key":"796_CR42","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1101\/gad.266304.115","volume":"29","author":"D Lee","year":"2015","unstructured":"Lee D, Jeong DE, Son HG, Yamaoka Y, Kim H, Seo K, et al. SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat. Genes Dev. 2015;29:2490\u2013503. https:\/\/doi.org\/10.1101\/gad.266304.115.","journal-title":"Genes Dev."},{"key":"796_CR43","doi-asserted-by":"publisher","first-page":"e0199888","DOI":"10.1371\/journal.pone.0199888","volume":"13","author":"J Alc\u00e1ntar-Fern\u00e1ndez","year":"2018","unstructured":"Alc\u00e1ntar-Fern\u00e1ndez J, Navarro RE, Salazar-Mart\u00ednez AM, P\u00e9rez-Andrade ME, Miranda-R\u00edos J. Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors. PLoS One. 2018;13:e0199888. https:\/\/doi.org\/10.1371\/journal.pone.0199888.","journal-title":"PLoS One."},{"key":"796_CR44","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00125-014-3415-5","volume":"58","author":"M Mendler","year":"2014","unstructured":"Mendler M, Schlotterer A, Ibrahim Y, Kukudov G, Fleming T, Bierhaus A, et al. daf-16\/FOXO and glod-4\/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans. Diabetologia. 2014;58:393\u2013401. https:\/\/doi.org\/10.1007\/s00125-014-3415-5.","journal-title":"Diabetologia"},{"key":"796_CR45","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1101\/gad.867301","volume":"15","author":"SB Pierce","year":"2001","unstructured":"Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15:672\u201386. https:\/\/doi.org\/10.1101\/gad.867301.","journal-title":"Genes Dev."},{"key":"796_CR46","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1242\/bio.012260","volume":"4","author":"JL Everman","year":"2015","unstructured":"Everman JL, Ziaie NR, Bechler J, Bermudez LE. Establishing Caenorhabditis elegans as a model for Mycobacterium avium subspecies hominissuis infection and intestinal colonization. Biol Open. 2015;4:1330\u20135. https:\/\/doi.org\/10.1242\/bio.012260.","journal-title":"Biol Open."},{"key":"796_CR47","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1021\/cb900254y","volume":"4","author":"ST Laughlin","year":"2009","unstructured":"Laughlin ST, Bertozzi CR. In vivo imaging of Caenorhabditis elegans glycans. ACS Chem Biol. 2009;4:1068\u201372. https:\/\/doi.org\/10.1021\/cb900254y.","journal-title":"ACS Chem Biol."},{"key":"796_CR48","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijpharm.2011.12.038","volume":"440","author":"G Sharma","year":"2013","unstructured":"Sharma G, van der Walle CF, Ravi Kumar MN. Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: development, pharmacokinetics, biodistribution and pharmacodynamics. Int J Pharm. 2013;440:99\u2013110. https:\/\/doi.org\/10.1016\/j.ijpharm.2011.12.038.","journal-title":"Int J Pharm."},{"key":"796_CR49","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1021\/bm900035u","volume":"10","author":"F Cui","year":"2009","unstructured":"Cui F, Qian F, Zhao Z, Yin L, Tang C, Yin C. Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles. Biomacromolecules. 2009;10:1253\u20138. https:\/\/doi.org\/10.1021\/bm900035u.","journal-title":"Biomacromolecules."},{"key":"796_CR50","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ejps.2010.12.007","volume":"42","author":"A Makhlof","year":"2011","unstructured":"Makhlof A, Tozuka Y, Takeuchi H. Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur. J. Pharm. Sci. 2011;42:445\u201351. https:\/\/doi.org\/10.1016\/j.ejps.2010.12.007.","journal-title":"Eur. J. Pharm. Sci."},{"key":"796_CR51","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/j.biomaterials.2011.10.075","volume":"33","author":"Y Jin","year":"2012","unstructured":"Jin Y, Song Y, Zhu X, Zhou D, Chen C, Zhang Z, et al. Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport. Biomaterials. 2012;33:1573\u201382. https:\/\/doi.org\/10.1016\/j.biomaterials.2011.10.075.","journal-title":"Biomaterials."}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-020-00796-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-020-00796-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-020-00796-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T23:46:11Z","timestamp":1623109571000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-020-00796-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["796"],"URL":"https:\/\/doi.org\/10.1007\/s13346-020-00796-3","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]},"assertion":[{"value":"8 June 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}