{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T19:06:44Z","timestamp":1778094404991,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s13346-020-00889-z","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T15:23:43Z","timestamp":1610637823000},"page":"2209-2223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A new dual function orodissolvable\/dispersible meclizine HCL tablet to challenge patient inconvenience: in vitro evaluation and in vivo assessment in human volunteers"],"prefix":"10.1007","volume":"11","author":[{"given":"Alaa Y.","family":"Darwesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa S.","family":"El-Dahhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahasen M.","family":"Meshali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"issue":"1","key":"889_CR1","first-page":"1","volume":"3","author":"T Ghosh","year":"2011","unstructured":"Ghosh T, Ghosh A, Prasad D. A review on new generation orodispersible tablets and its future prospective. Int J Pharmacy and Pharm Sci. 2011;3(1):1\u20137.","journal-title":"Int J Pharmacy and Pharm Sci"},{"key":"889_CR2","doi-asserted-by":"crossref","unstructured":"Hirani JJ, Rathod DA, Vadalia KR. Orally disintegrating tablets: a review. Trop J Pharm Res. 2009;8:(2). 161\u201372.","DOI":"10.4314\/tjpr.v8i2.44525"},{"issue":"1","key":"889_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4103\/0250-474X.180244","volume":"78","author":"P Hannan","year":"2016","unstructured":"Hannan P, Khan J, Khan A, Safiullah S. Oral dispersible system: a new approach in drug delivery system. Indian J Pharm Sci. 2016;78(1):2\u20137.","journal-title":"Indian J Pharm Sci"},{"issue":"17","key":"889_CR4","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1021\/jf202135j","volume":"59","author":"X Xie","year":"2011","unstructured":"Xie X, Tao Q, Zou Y, Zhang F, Guo M, Wang Y, et al. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. J Agric Food Chem. 2011;59(17):9280\u20139.","journal-title":"J Agric Food Chem"},{"issue":"2","key":"889_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0169-409X(01)00231-9","volume":"52","author":"M Thanou","year":"2001","unstructured":"Thanou M, Verhoef J, Junginger H. Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev. 2001;52(2):117\u201326.","journal-title":"Adv Drug Deliv Rev"},{"key":"889_CR6","doi-asserted-by":"crossref","unstructured":"Mourya VK, Inamdar NN, Choudhari YM. Chitooligosaccharides: synthesis, characterization and applications. Polym Sci Ser A. 2011; 53(7): 583\u2013612.","DOI":"10.1134\/S0965545X11070066"},{"issue":"1","key":"889_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ijpharm.2004.02.030","volume":"278","author":"S Limmatvapirat","year":"2004","unstructured":"Limmatvapirat S, Limmatvapirat C, Luangtana-Anan M, Nunthanid J, Oguchi T, Tozuka Y. Modification of physicochemical and mechanical properties of shellac by partial hydrolysis. Int J Pharm. 2004;278(1):41\u20139.","journal-title":"Int J Pharm"},{"issue":"4","key":"889_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.carbpol.2005.08.012","volume":"62","author":"S-K Kim","year":"2005","unstructured":"Kim S-K, Rajapakse N. Enzymatic production and biological activities of chitosan oligosaccharides (COS): a review. Carbohydr Polym. 2005;62(4):357\u201368.","journal-title":"Carbohydr Polym"},{"key":"889_CR9","first-page":"179","volume":"3","author":"PN Patel","year":"2011","unstructured":"Patel PN, Ambizas EM. Meclizine: safety and efficacy in the treatment and prevention of motion sickness. Clin Med Insights Ther. 2011;3:179\u201383.","journal-title":"Clin Med Insights Ther"},{"key":"889_CR10","doi-asserted-by":"crossref","unstructured":"Vemula SK, Vangala M. Formulation development and characterization of meclizine hydrochloride sublimated fast dissolving tablets. Int Sch Res Notices. 2014; Article ID 281376: 1\u20138.","DOI":"10.1155\/2014\/281376"},{"issue":"9","key":"889_CR11","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1177\/0091270011414575","volume":"52","author":"Z Wang","year":"2012","unstructured":"Wang Z, Lee B, Pearce D, Qian S, Wang Y, Zhang Q, et al. Meclizine metabolism and pharmacokinetics: formulation on its absorption. J Clin Pharmacol. 2012;52(9):1343\u20139.","journal-title":"J Clin Pharmacol"},{"key":"889_CR12","first-page":"150","volume":"1","author":"M Gupta","year":"2011","unstructured":"Gupta M, Kedawat M. Enhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with \u00c3Y-cyclodextrine. J Appl Pharm Sci. 2011;1:150\u20133.","journal-title":"J Appl Pharm Sci"},{"key":"889_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jddst.2018.08.012","volume":"47","author":"RA Husseiny","year":"2018","unstructured":"Husseiny RA, Lila ASA, Abdallah MH, Hamed EE, El-ghamry HA. Design, in vitro\/in vivo evaluation of meclizine HCl-loaded floating microspheres targeting pregnancy-related nausea and vomiting. J Drug Deliv Sci Technol. 2018;47:395\u2013403.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"3","key":"889_CR14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3109\/10837450.2012.685657","volume":"18","author":"P Kraisit","year":"2013","unstructured":"Kraisit P, Limmatvapirat S, Nunthanid J, Sriamornsak P, Luangtana-anan M. Nanoparticle formation by using shellac and chitosan for a protein delivery system. Pharm Dev Technol. 2013;18(3):686\u201393.","journal-title":"Pharm Dev Technol"},{"key":"889_CR15","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.ejps.2018.09.001","volume":"124","author":"RM Aman","year":"2018","unstructured":"Aman RM, Hashim IIA, Meshali MM. Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical \u201cApocynin.\u201d Eur J Pharm Sci. 2018;124:304\u201318.","journal-title":"Eur J Pharm Sci"},{"key":"889_CR16","unstructured":"Farag Y. Characterization of different shellac types and development of shellac coated dosage forms. PhD dissertation. Hamburg. Universit\u00e4t Hamburg; 2010."},{"key":"889_CR17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.colsurfb.2013.03.027","volume":"109","author":"D Jain","year":"2013","unstructured":"Jain D, Athawale R, Bajaj A, Shrikhande S, Goel PN, Gude RP. Studies on stabilization mechanism and stealth effect of poloxamer 188 onto PLGA nanoparticles. Colloids Surf B Biointerfaces. 2013;109:59\u201367.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"8","key":"889_CR18","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/coatings8080275","volume":"8","author":"S Brajnicov","year":"2018","unstructured":"Brajnicov S, Bercea A, Marascu V, Matei A, Mitu B. Shellac thin films obtained by matrix-assisted pulsed laser evaporation (MAPLE). Coatings. 2018;8(8):275.","journal-title":"Coatings"},{"issue":"3","key":"889_CR19","doi-asserted-by":"publisher","first-page":"E195","DOI":"10.1208\/pt0803076","volume":"8","author":"CM Lopes","year":"2007","unstructured":"Lopes CM, Lobo JMS, Pinto JF, Costa PC. Compressed matrix core tablet as a quick\/slow dual-component delivery system containing ibuprofen. AAPS PharmSciTech. 2007;8(3):E195\u2013202.","journal-title":"AAPS PharmSciTech"},{"key":"889_CR20","unstructured":"The United States pharmacopeia. National formulary. 40th revision. Rockville (MD) 20852: United States Pharmacopeial Convention; 2017."},{"issue":"1","key":"889_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10837450.2010.495396","volume":"17","author":"AA Aboelwafa","year":"2012","unstructured":"Aboelwafa AA, Fahmy RH. A pilot human pharmacokinetic study and influence of formulation factors on orodispersible tablet incorporating meloxicam solid dispersion using factorial design. Pharm Dev Technol. 2012;17(1):1\u201314.","journal-title":"Pharm Dev Technol"},{"issue":"4","key":"889_CR22","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jsps.2015.01.015","volume":"23","author":"W Brniak","year":"2015","unstructured":"Brniak W, Jachowicz R, Pelka P. The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets (ODTs). Saudi Pharm J. 2015;23(4):437\u201343.","journal-title":"Saudi Pharm J"},{"issue":"3","key":"889_CR23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ejpb.2005.03.002","volume":"60","author":"M Vertzoni","year":"2005","unstructured":"Vertzoni M, Dressman J, Butler J, Hempenstall J, Reppas C. Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds. Eur J Pharm Biopharm. 2005;60(3):413\u20137.","journal-title":"Eur J Pharm Biopharm"},{"issue":"4","key":"889_CR24","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1007\/s11270-011-0976-5","volume":"223","author":"J Mart\u00edn-Pascual","year":"2012","unstructured":"Mart\u00edn-Pascual J, L\u00f3pez-L\u00f3pez C, Cerd\u00e1 A, Gonz\u00e1lez-L\u00f3pez J, Hontoria E, Poyatos JM. Comparative kinetic study of carrier type in a moving bed system applied to organic matter removal in urban wastewater treatment. Water Air Soil Pollut. 2012;223(4):1699\u2013712.","journal-title":"Water Air Soil Pollut"},{"key":"889_CR25","doi-asserted-by":"crossref","unstructured":"Higuchi T. Mechanism of sustained\u2010action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963;52(12):1145\u20139.","DOI":"10.1002\/jps.2600521210"},{"issue":"2","key":"889_CR26","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ejpb.2009.11.010","volume":"74","author":"MI Tadros","year":"2010","unstructured":"Tadros MI. Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: development, optimization and in vitro\u2013in vivo evaluation in healthy human volunteers. Eur J Pharm Biopharm. 2010;74(2):332\u20139.","journal-title":"Eur J Pharm Biopharm"},{"issue":"6","key":"889_CR27","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/jbm.820170615","volume":"17","author":"NA Peppas","year":"1983","unstructured":"Peppas NA. A model of dissolution-controlled solute release from porous drug delivery polymeric systems. J Biomed Mater Res. 1983;17(6):1079\u201387.","journal-title":"J Biomed Mater Res"},{"issue":"8","key":"889_CR28","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1039\/c3ay41698d","volume":"6","author":"N Sher","year":"2014","unstructured":"Sher N, Siddiqui FA, Hasan N, Shafi N, Zubair A, Mirza AZ. Simultaneous determination of antihistamine anti-allergic drugs, cetirizine, domperidone, chlorphenamine maleate, loratadine, meclizine and buclizine in pharmaceutical formulations, human serum and pharmacokinetics application. Anal Methods. 2014;6(8):2704\u201314.","journal-title":"Anal Methods"},{"key":"889_CR29","doi-asserted-by":"crossref","unstructured":"Mohammed NMS, Flowers T, Duncan H. Development and validation of an HPLC method for the analysis of chlorpropham and 3-chloroaniline in potato extracts. Chromatogr Res Int. 2014; Article ID 108694, 1\u20135.","DOI":"10.1155\/2014\/108694"},{"key":"889_CR30","unstructured":"ICH Expert Working Group. ICH Harmonised tripartite guideline, validation of analytical procedures: Text and Methodology Q2 (R1). 2005."},{"issue":"6","key":"889_CR31","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/jps.2600520629","volume":"52","author":"JG Wagner","year":"1963","unstructured":"Wagner JG, Nelson E. Percent absorbed time plots derived from blood level and\/or urinary excretion data. J Pharm Sci. 1963;52(6):610\u20131.","journal-title":"J Pharm Sci"},{"issue":"2","key":"889_CR32","first-page":"133","volume":"2","author":"M Vangala","year":"2014","unstructured":"Vangala M, Veerareddy PR, Devadasu VR, Vemula SK. Meclizine hydro chloride fast dissolving tablets by sublimation method: formulation and evaluation. Am J Adv Drug Deliv. 2014;2(2):133\u201344.","journal-title":"Am J Adv Drug Deliv"},{"issue":"1","key":"889_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12944-017-0466-x","volume":"16","author":"F Qazi","year":"2017","unstructured":"Qazi F, Shoaib MH, Yousuf RI, Nasiri MI, Ahmed K, Ahmad M. Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent\u2014meclizine HCl. Lipids Health Dis. 2017;16(1):1\u201316.","journal-title":"Lipids Health Dis"},{"issue":"3","key":"889_CR34","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ejpb.2007.04.008","volume":"67","author":"S Limmatvapirat","year":"2007","unstructured":"Limmatvapirat S, Limmatvapirat C, Puttipipatkhachorn S, Nuntanid J, Luangtana-anan M. Enhanced enteric properties and stability of shellac films through composite salts formation. Eur J Pharm Biopharm. 2007;67(3):690\u20138.","journal-title":"Eur J Pharm Biopharm"},{"issue":"2","key":"889_CR35","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.flm.2018.07.003","volume":"2","author":"M Anand","year":"2018","unstructured":"Anand M, Sathyapriya P, Maruthupandy M, Beevi AH. Synthesis of chitosan nanoparticles by TPP and their potential mosquito larvicidal application. Frontiers in Laboratory Medicine. 2018;2(2):72\u20138.","journal-title":"Frontiers in Laboratory Medicine"},{"issue":"4","key":"889_CR36","first-page":"507","volume":"60","author":"M Hashem","year":"2017","unstructured":"Hashem M, Kamel A, El-Ghaffar MA, Ahmed M, Akl MAA. Amino acid combined chitosan nanoparticles for controlled release of doxorubicin hydrochloride. Egypt J Chem. 2017;60(4):507\u201318.","journal-title":"Egypt J Chem"},{"issue":"3","key":"889_CR37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.59566\/IJBS.2008.4221","volume":"4","author":"P Li","year":"2008","unstructured":"Li P, Dai Y-N, Zhang J-P, Wang AQ, Wei Q. Chitosan-alginate nanoparticles as a novel drug delivery system for nifedipine. Int J Biomed Sci. 2008;4(3):221\u20138.","journal-title":"Int J Biomed Sci"},{"issue":"4","key":"889_CR38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.4103\/0975-1483.104365","volume":"4","author":"S George","year":"2012","unstructured":"George S, Vasudevan D. Studies on the preparation, characterization, and solubility of 2-HP-\u03b2-cyclodextrin-meclizine HCI inclusion complexes. J Young Pharm. 2012;4(4):220\u20137.","journal-title":"J Young Pharm"},{"issue":"1","key":"889_CR39","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ejpb.2008.03.002","volume":"70","author":"S Limmatvapirat","year":"2008","unstructured":"Limmatvapirat S, Panchapornpon D, Limmatvapirat C, Nunthanid J, Luangtana-Anan M, Puttipipatkhachorn S. Formation of shellac succinate having improved enteric film properties through dry media reaction. Eur J Pharm Biopharm. 2008;70(1):335\u201344.","journal-title":"Eur J Pharm Biopharm"},{"key":"889_CR40","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.tca.2006.03.003","volume":"444","author":"LS Guinesi","year":"2006","unstructured":"Guinesi LS, Cavalheiro ETG. The use of DSC curves to determine the acetylation degree of chitin\/chitosan samples. Thermochim Acta. 2006;444:128\u201333.","journal-title":"Thermochim Acta"},{"issue":"3","key":"889_CR41","first-page":"1004","volume":"69","author":"S Limmatvapirat","year":"2008","unstructured":"Limmatvapirat S, Limmatvapirat C, Puttipipatkhachorn S, Nunthanid J, Luangtana-anan M, Sriamornsak P. Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process Eur J Pharm Biopharm. 2008;69(3):1004\u201313.","journal-title":"Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process Eur J Pharm Biopharm"},{"key":"889_CR42","doi-asserted-by":"publisher","first-page":"E605","DOI":"10.1208\/pt060475","volume":"6","author":"WT Leach","year":"2005","unstructured":"Leach WT, Simpson DT, Val TN, Yu Z, Lim KT, Park EJ, et al. Encapsulation of protein nanoparticles into uniform-sized microspheres formed in a spinning oil film. AAPS PharmSciTech. 2005;6:E605\u201317.","journal-title":"AAPS PharmSciTech"},{"issue":"1\u20132","key":"889_CR43","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0378-5173(02)00058-3","volume":"238","author":"J Vandervoort","year":"2002","unstructured":"Vandervoort J, Ludwig A. Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study. Int J Pharm. 2002;238(1\u20132):77\u201392.","journal-title":"Int J Pharm"},{"issue":"3","key":"889_CR44","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ejps.2012.12.007","volume":"48","author":"S Md","year":"2013","unstructured":"Md S, Khan RA, Mustafa G, Chuttani K, Baboota S, Sahni JK, Ali J. Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: pharmacodynamic, pharmacokinetic and scintigraphy study in mice model. Eur J Pharm Sci. 2013;48(3):393\u2013405.","journal-title":"Eur J Pharm Sci"},{"issue":"4","key":"889_CR45","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s13346-016-0295-x","volume":"6","author":"S Dyawanapelly","year":"2016","unstructured":"Dyawanapelly S, Koli U, Dharamdasani V, Jain R, Dandekar P. Improved mucoadhesion and cell uptake of chitosan and chitosan oligosaccharide surface-modified polymer nanoparticles for mucosal delivery of proteins. Drug Deliv Transl Res. 2016;6(4):365\u201379.","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"889_CR46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4103\/0975-1483.100021","volume":"4","author":"R Pabari","year":"2012","unstructured":"Pabari R, Ramtoola Z. Effect of a disintegration mechanism on wetting, water absorption, and disintegration time of orodispersible tablets. J Young Pharm. 2012;4(3):157\u201363.","journal-title":"J Young Pharm"},{"issue":"4","key":"889_CR47","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","volume":"116","author":"N Kamaly","year":"2016","unstructured":"Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release. Chem Rev. 2016;116(4):2602\u201363.","journal-title":"Chem Rev"},{"key":"889_CR48","doi-asserted-by":"crossref","unstructured":"Maghrabia AE, Boughdady MF, Meshali MM. New Perspective Enteric-Coated Tablet Dosage Form for Oral Administration of Ceftriaxone: In Vitro and In Vivo Assessments. AAPS PharmSciTech. 2019;20(7): 306.","DOI":"10.1208\/s12249-019-1512-y"},{"key":"889_CR49","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.3389\/fphar.2019.01328","volume":"10","author":"S Hua","year":"2019","unstructured":"Hua S. Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration. Front Pharmacol. 2019;10:1328.","journal-title":"Front Pharmacol"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-020-00889-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-020-00889-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-020-00889-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T10:52:41Z","timestamp":1724323961000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-020-00889-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["889"],"URL":"https:\/\/doi.org\/10.1007\/s13346-020-00889-z","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"assertion":[{"value":"16 December 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. The study was approved by the Ethics Committee in Faculty of Pharmacy in Mansoura University (Ethics board approval number: 2020-65). Informed consent was obtained from all patients for being included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All authors agree for the manuscript publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}