{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:22:47Z","timestamp":1775060567741,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100005674","name":"Cystinosis Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s13346-020-00890-6","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T20:18:59Z","timestamp":1612469939000},"page":"2224-2238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A sustained release cysteamine microsphere\/thermoresponsive gel eyedrop for corneal cystinosis improves drug stability"],"prefix":"10.1007","volume":"11","author":[{"given":"Jorge","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Washington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayde L.","family":"Resnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken K.","family":"Nischal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8949-8305","authenticated-orcid":false,"given":"Morgan V.","family":"Fedorchak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"890_CR1","volume-title":"Cornea: fundamentals, diagnosis and management","author":"JH Krachmer","year":"2011","unstructured":"Krachmer JH, Mannis MJ, Holland EJ. Cornea: fundamentals, diagnosis and management, vol. 1. Philadelphia, PA: Elsevier\/Mosby; 2011."},{"key":"890_CR2","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.drudis.2019.03.005","volume":"24","author":"J Jimenez","year":"2019","unstructured":"Jimenez J, Sakthivel M, Nischal KK, Fedorchak MV. Drug delivery systems and novel formulations to improve treatment of rare corneal disease. Drug Discovery Today. 2019;24:1564\u201374. https:\/\/doi.org\/10.1016\/j.drudis.2019.03.005.","journal-title":"Drug Discovery Today"},{"issue":"2","key":"890_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMra020552","volume":"347","author":"WA Gahl","year":"2002","unstructured":"Gahl WA, Thoene JG, Schneider JA. Cystinosis. The New England Journal of Medicine. 2002;347(2):111\u201321. https:\/\/doi.org\/10.1056\/NEJMra020552.","journal-title":"The New England Journal of Medicine"},{"key":"890_CR4","unstructured":"Nesterov G, Gahl WA. \u201cCystinosis.\u201d In GeneReviews\u00ae, edited by Margaret P. Adam, Holly H. Ardinger, Roberta A. Pagon, Stephanie E. Wallace, Lora JH Bean, Karen Stephens, and Anne Amemiya. Seattle (WA): University of Washington, Seattle, 1993. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1400\/."},{"issue":"5","key":"890_CR5","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1001\/archopht.1986.01050170096030","volume":"104","author":"MI Kaiser-Kupfer","year":"1986","unstructured":"Kaiser-Kupfer MI, Caruso RC, Minkler DS, Gahl WA. Long-term ocular manifestations in nephropathic cystinosis. Archives of Ophthalmology (Chicago, Ill: 1960). 1986;104(5):706\u201311.","journal-title":"Archives of Ophthalmology (Chicago, Ill.: 1960)"},{"issue":"1\u20132","key":"890_CR6","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1006\/mgme.2000.3062","volume":"71","author":"WA Gahl","year":"2000","unstructured":"Gahl WA, Kuehl EM, Iwata F, Lindblad A, Kaiser-Kupfer MI. Corneal crystals in nephropathic cystinosis: natural history and treatment with cysteamine eyedrops. Mol Genet Metab. 2000;71(1\u20132):100\u201320. https:\/\/doi.org\/10.1006\/mgme.2000.3062.","journal-title":"Mol Genet Metab"},{"issue":"4","key":"890_CR7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.7326\/0003-4819-147-4-200708210-00006","volume":"147","author":"WA Gahl","year":"2007","unstructured":"Gahl WA, Balog JZ, Kleta R. Nephropathic cystinosis in adults: natural history and effects of oral cysteamine therapy. Ann Intern Med. 2007;147(4):242\u201350.","journal-title":"Ann Intern Med"},{"issue":"8","key":"890_CR8","doi-asserted-by":"publisher","first-page":"4791","DOI":"10.1016\/S0021-9258(18)89141-4","volume":"260","author":"RL Pisoni","year":"1985","unstructured":"Pisoni RL, Thoene JG, Christensen HN. Detection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. Role in therapeutic cystine removal? J Biol Chem. 1985;260(8):4791\u20138.","journal-title":"J Biol Chem"},{"issue":"4","key":"890_CR9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1586\/17469899.2013.814885","volume":"8","author":"N Huynh","year":"2013","unstructured":"Huynh N, Gahl WA, Bishop RJ. Cysteamine ophthalmic solution 0.44% for the treatment of corneal cystine crystals in cystinosis. Expert Review of Ophthalmology. 2013;8(4):341. https:\/\/doi.org\/10.1586\/17469899.2013.814885.","journal-title":"Expert Review of Ophthalmology"},{"issue":"2","key":"890_CR10","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s40123-018-0146-6","volume":"7","author":"S Biswas","year":"2018","unstructured":"Biswas S, Gaviria M, Malheiro L, Marques JP, Giordano V, Liang H. Latest clinical approaches in the ocular management of cystinosis: a review of current practice and opinion from the ophthalmology cystinosis forum. Ophthalmology and Therapy. 2018;7(2):307\u201322. https:\/\/doi.org\/10.1007\/s40123-018-0146-6.","journal-title":"Ophthalmology and Therapy"},{"issue":"1","key":"890_CR11","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ijpharm.2010.03.065","volume":"392","author":"B Buchan","year":"2010","unstructured":"Buchan B, Kay G, Heneghan A, Matthews KH, Cairns D. Gel formulations for treatment of the ophthalmic complications in cystinosis. Int J Pharm. 2010;392(1):192\u20137. https:\/\/doi.org\/10.1016\/j.ijpharm.2010.03.065.","journal-title":"Int J Pharm"},{"issue":"3","key":"890_CR12","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ymgme.2013.12.298","volume":"111","author":"A Labb\u00e9","year":"2014","unstructured":"Labb\u00e9 A, Baudouin C, Desch\u00eanes G, Loirat C, Charbit M, Guest G, Niaudet P. A new gel formulation of topical cysteamine for the treatment of corneal cystine crystals in cystinosis: the cystadrops OCT-1 study. Mol Genet Metab. 2014;111(3):314\u201320. https:\/\/doi.org\/10.1016\/j.ymgme.2013.12.298.","journal-title":"Mol Genet Metab"},{"issue":"1\u20132","key":"890_CR13","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.ijpharm.2017.06.060","volume":"528","author":"A Luaces-Rodr\u00edguez","year":"2017","unstructured":"Luaces-Rodr\u00edguez A, D\u00edaz-Tom\u00e9 V, Gonz\u00e1lez-Barcia M, Silva-Rodr\u00edguez J, Herranz M, Gil-Mart\u00ednez M, Rodr\u00edguez-Ares MT, et al. Cysteamine polysaccharide hydrogels: study of extended ocular delivery and biopermanence time by PET imaging. Int J Pharm. 2017;528(1\u20132):714\u201322. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.06.060.","journal-title":"Int J Pharm"},{"issue":"3, Part A","key":"890_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.ejpb2013.04.017","volume":"85","author":"KH Hsu","year":"2013","unstructured":"Hsu KH, Fentzke RC, Chauhan A. Feasibility of corneal drug delivery of cysteamine using vitamin E modified silicone hydrogel contact lenses. Eur J Pharm Biopharm. 2013;85(3, Part A):531\u201340. https:\/\/doi.org\/10.1016\/j.ejpb2013.04.017.","journal-title":"Eur J Pharm Biopharm"},{"issue":"10","key":"890_CR15","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1021\/acs.molpharmaceut.6b00488","volume":"13","author":"DC Marcano","year":"2016","unstructured":"Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G. Synergistic cysteamine delivery nanowafer as an efficacious treatment modality for corneal cystinosis. Mol Pharm. 2016;13(10):3468\u201377. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.6b00488.","journal-title":"Mol Pharm"},{"issue":"10","key":"890_CR16","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1517\/17425247.2014.935338","volume":"11","author":"JJ Kang-Mieler","year":"2014","unstructured":"Kang-Mieler JJ, Osswald CR, Mieler WF. Advances in ocular drug delivery: emphasis on the posterior segment. Expert Opinion on Drug Delivery. 2014;11(10):1647\u201360. https:\/\/doi.org\/10.1517\/17425247.2014.935338.","journal-title":"Expert Opinion on Drug Delivery"},{"issue":"2","key":"890_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1089\/jop.2015.0047","volume":"32","author":"VK Yellepeddi","year":"2015","unstructured":"Yellepeddi VK, Palakurthi S. Recent advances in topical ocular drug delivery. J Ocul Pharmacol Ther. 2015;32(2):67\u201382. https:\/\/doi.org\/10.1089\/jop.2015.0047.","journal-title":"J Ocul Pharmacol Ther"},{"key":"890_CR18","doi-asserted-by":"publisher","first-page":"8639","DOI":"10.1038\/s41598-017-09379-8","volume":"7","author":"MV Fedorchak","year":"2017","unstructured":"Fedorchak MV, Conner P, Schuman JS, Cugini A, Little SR. Long term glaucoma drug delivery using a topically retained gel\/microsphere eye drop. Scientific Reports. 2017;7:8639. https:\/\/doi.org\/10.1038\/s41598-017-09379-8.","journal-title":"Scientific Reports."},{"issue":"6","key":"890_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/tvst.5.6.12","volume":"5","author":"A Mammen","year":"2016","unstructured":"Mammen A, Romanowski EG, Fedorchak MV, Dhaliwal DK, Shanks RM, Kowalski RP. Endophthalmitis prophylaxis using a single drop of thermoresponsive controlled-release microspheres loaded with moxifloxacin in a rabbit model. Translational Vision Science & Technology. 2016;5(6):12\u201312. https:\/\/doi.org\/10.1167\/tvst.5.6.12.","journal-title":"Translational Vision Science & Technology"},{"issue":"4","key":"890_CR20","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/bmc.959","volume":"22","author":"K Ku\u015bmierek","year":"2008","unstructured":"Ku\u015bmierek K, Bald E. Measurement of reduced and total mercaptamine in urine using liquid chromatography with ultraviolet detection. Biomed Chromatogr. 2008;22(4):441\u20135. https:\/\/doi.org\/10.1002\/bmc.959.","journal-title":"Biomed Chromatogr"},{"issue":"9","key":"890_CR21","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1081\/JLC-100103450","volume":"24","author":"E Bald","year":"2001","unstructured":"Bald E, Glowacki R. 2-Chloro-1-methylquinolinium tetrafluoroborate as an effective and thiol specific UV-tagging reagent for liquid chromatography. J Liq Chromatogr Relat Technol. 2001;24(9):1323\u201339. https:\/\/doi.org\/10.1081\/JLC-100103450.","journal-title":"J Liq Chromatogr Relat Technol"},{"key":"890_CR22","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jpba.2017.08.046","volume":"146","author":"Q Zhang","year":"2017","unstructured":"Zhang Q, Guo N, Sun Y, Li X, Yang H. Absolute quantification of poly(dl-lactide-co-glycolide) in microspheres using quantitative 1H NMR spectroscopy. J Pharm Biomed Anal. 2017;146:273\u20138. https:\/\/doi.org\/10.1016\/j.jpba.2017.08.046.","journal-title":"J Pharm Biomed Anal"},{"key":"890_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejpb.2016.07.009","volume":"107","author":"S Pescina","year":"2016","unstructured":"Pescina S, Carra F, Padula C, Santi P, Nicoli S. Effect of PH and penetration enhancers on cysteamine stability and trans-corneal transport. Eur J Pharm Biopharm. 2016;107:171\u20139. https:\/\/doi.org\/10.1016\/j.ejpb.2016.07.009.","journal-title":"Eur J Pharm Biopharm"},{"issue":"3","key":"890_CR24","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.vascn.2013.08.002","volume":"68","author":"G Eichenbaum","year":"2013","unstructured":"Eichenbaum G, Zhou J, De Smedt A, De Jonghe S, Looszova A, Arien T, Van Goethem F, Vervoort I, Shukla U, Lammens L. Methods to evaluate and improve the injection site tolerability of intravenous formulations prior to first-in-human testing. J Pharmacol Toxicol Methods. 2013;68(3):394\u2013406.","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"1","key":"890_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2012.04.063","volume":"432","author":"H Abdelkader","year":"2012","unstructured":"Abdelkader H, Ismail S, Hussein A, Wu Z, Al-Kassas R, Alany RG. Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen\u2019s egg chorioallantoic membrane and excised bovine cornea models. Int J Pharm. 2012;432(1):1\u201310. https:\/\/doi.org\/10.1016\/j.ijpharm.2012.04.063.","journal-title":"Int J Pharm"},{"key":"890_CR26","unstructured":"OECD. Test No. 437: Bovine Corneal Opacity and Permeability Test method for identifying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage. Paris: Organisation for Economic Co-operation and Development (2013). http:\/\/www.oecd-ilibrary.org\/content\/book\/9789264203846-en. Accessed 6\u00a0October 2016."},{"issue":"1","key":"890_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s10561-017-9665-y","volume":"19","author":"D Spinozzi","year":"2018","unstructured":"Spinozzi D, Miron A, Bruinsma M, Lie JT, Dapena I, Oellerich S, Melles GRJ. Improving the success rate of human corneal endothelial cell cultures from single donor corneas with stabilization medium. Cell Tissue Banking. 2018;19(1):9\u201317. https:\/\/doi.org\/10.1007\/s10561-017-9665-y.","journal-title":"Cell Tissue Banking"},{"issue":"2","key":"890_CR28","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000326632","volume":"38","author":"WJ Armitage","year":"2011","unstructured":"Armitage WJ. Preservation of human cornea. Transfusion Medicine and Hemotherapy. 2011;38(2):143\u20137. https:\/\/doi.org\/10.1159\/000326632.","journal-title":"Transfusion Medicine and Hemotherapy"},{"key":"890_CR29","first-page":"183","volume":"89","author":"JM Dixon","year":"1991","unstructured":"Dixon JM, Blackwood L. Thermal variations of the human eye. Trans Am Ophthalmol Soc. 1991;89:183\u201393.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"890_CR30","unstructured":"Cystaran (cysteamine ophthalmic solution) 0.44% sterile, prescribing information: http:\/\/www.cystaran.com\/Cystaran_PI.pdf. Accessed 17 July 2017."},{"issue":"4","key":"890_CR31","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1167\/iovs.16-21080","volume":"58","author":"H Liang","year":"2017","unstructured":"Liang H, Labb\u00e9 A, Le Mouha\u00ebr J, Plisson C, Baudouin C. A new viscous cysteamine eye drops treatment for ophthalmic cystinosis: an open-label randomized comparative phase III pivotal study. Invest Ophthalmol Vis Sci. 2017;58(4):2275\u201383. https:\/\/doi.org\/10.1167\/iovs.16-21080.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"890_CR32","first-page":"515","volume-title":"Alternative Methods in Toxicology","author":"PJ Weterings","year":"1987","unstructured":"Weterings PJ, Vanerp YH. Validation of the Becam assay: an eye irritancy screening test. In: Goldberg AM, editor. Alternative Methods in Toxicology. New York: Mary Ann Liebert Inc.; 1987. p. 515\u201321."},{"issue":"1\u20132","key":"890_CR33","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ijpharm.2016.10.044","volume":"515","author":"B McKenzie","year":"2016","unstructured":"McKenzie B, Kay G, Matthews KH, Knott R, Cairns D. Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. Int J Pharm. 2016;515(1\u20132):575\u201382. https:\/\/doi.org\/10.1016\/j.ijpharm.2016.10.044.","journal-title":"Int J Pharm"},{"issue":"1\u20132","key":"890_CR34","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.ijpharm.2016.01.020","volume":"499","author":"F Ramazani","year":"2016","unstructured":"Ramazani F, Chen W, van Nostrum CF, Storm G, Kiessling F, Lammers T, Hennink WE, Kok RJ. Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: state-of-the-art and challenges. Int J Pharm. 2016;499(1\u20132):358\u201367. https:\/\/doi.org\/10.1016\/j.ijpharm.2016.01.020.","journal-title":"Int J Pharm"},{"issue":"49","key":"890_CR35","doi-asserted-by":"publisher","first-page":"16594","DOI":"10.1021\/jp105652c","volume":"114","author":"H Du","year":"2010","unstructured":"Du H, Wickramasinghe R, Qian X. Effects of salt on the lower critical solution temperature of poly (n-isopropylacrylamide). J Phys Chem B. 2010;114(49):16594\u2013604. https:\/\/doi.org\/10.1021\/jp105652c.","journal-title":"J Phys Chem B"},{"issue":"25","key":"890_CR36","doi-asserted-by":"publisher","first-page":"8916","DOI":"10.1021\/jp0690603","volume":"111","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Furyk S, Sagle LB, Cho Y, Bergbreiter DE, Cremer PS. Effects of Hofmeister anions on the LCST of PNIPAM as a function of molecular weight. The Journal of Physical Chemistry C. 2007;111(25):8916\u201324. https:\/\/doi.org\/10.1021\/jp0690603.","journal-title":"The Journal of Physical Chemistry C"},{"issue":"4","key":"890_CR37","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1002\/jps.24361","volume":"104","author":"J Meeus","year":"2015","unstructured":"Meeus J, Lenaerts M, Scurr DJ, Amssoms K, Davies MC, Roberts CJ, Van Den Mooter G. The influence of spray-drying parameters on phase behavior, drug distribution, and in vitro release of injectable microspheres for sustained release. J Pharm Sci. 2015;104(4):1451\u201360. https:\/\/doi.org\/10.1002\/jps.24361.","journal-title":"J Pharm Sci"},{"key":"890_CR38","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fphar.2016.00185","volume":"7","author":"FY Han","year":"2016","unstructured":"Han FY, Thurecht KJ, Whittaker AK, Smith MT. Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading. Frontiers in Pharmacology. 2016;7:185. https:\/\/doi.org\/10.3389\/fphar.2016.00185.","journal-title":"Frontiers in Pharmacology"},{"issue":"04","key":"890_CR39","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1055\/s-2008-1035436","volume":"206","author":"M Gr\u00e4f","year":"1995","unstructured":"Gr\u00e4f M, Kalinowski H-O. 1H-NMR-spektroskopische Untersuchung von Cysteamin-Augentropfen. Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde. 1995;206(04):262\u20135. https:\/\/doi.org\/10.1055\/s-2008-1035436.","journal-title":"Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"},{"issue":"21","key":"890_CR40","doi-asserted-by":"publisher","first-page":"762232","DOI":"10.1128\/MCB.22.21.7622-7632.2002","volume":"22","author":"S Cherqui","year":"2002","unstructured":"Cherqui S, Sevin C, Hamard G, Kalatzis V, Sich M, Pequignot MO, Gogat K, et al. Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis. Mol Cell Biol. 2002;22(21):762232. https:\/\/doi.org\/10.1128\/MCB.22.21.7622-7632.2002.","journal-title":"Mol Cell Biol"},{"issue":"1","key":"890_CR41","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1136\/bjo.87.1.28","volume":"87","author":"ET Tsilou","year":"2003","unstructured":"Tsilou ET, Thompson D, Lindblad AS, Reed GF, Rubin B, Gahl W, Thoene J, et al. A multicentre randomised double masked clinical trial of a new formulation of topical cysteamine for the treatment of corneal cystine crystals in cystinosis. The British Journal of Ophthalmology. 2003;87(1):28\u201331.","journal-title":"The British Journal of Ophthalmology"},{"issue":"3","key":"890_CR42","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1208\/s12249-010-9522-9","volume":"11","author":"SF Ng","year":"2010","unstructured":"Ng SF, Rouse JJ, Sanderson FD, Meidan V, Eccleston GM. Validation of a static Franz diffusion cell system for in vitro permeation studies. AAPS PharmSciTech. 2010;11(3):1432\u201341. https:\/\/doi.org\/10.1208\/s12249-010-9522-9.","journal-title":"AAPS PharmSciTech"},{"issue":"12","key":"890_CR43","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1038\/eye.2012.211","volume":"26","author":"MQ Rahman","year":"2012","unstructured":"Rahman MQ, Chuah K-S, Macdonald ECA, Trusler JPM, Ramaesh K. The effect of PH, dilution, and temperature on the viscosity of ocular lubricants\u2014shift in rheological parameters and potential clinical significance. Eye. 2012;26(12):1579\u201384. https:\/\/doi.org\/10.1038\/eye.2012.211.","journal-title":"Eye"},{"issue":"11","key":"890_CR44","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1185\/030079907x233197","volume":"23","author":"J Tauber","year":"2007","unstructured":"Tauber J. Efficacy, tolerability and comfort of a 0.3% hypromellose gel ophthalmic lubricant in the treatment of patients with moderate to severe dry eye syndrome. Curr Med Res Opin. 2007;23(11):2629\u201336. https:\/\/doi.org\/10.1185\/030079907x233197.","journal-title":"Curr Med Res Opin"},{"issue":"2","key":"890_CR45","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/fcp.12009","volume":"28","author":"R Dohil","year":"2014","unstructured":"Dohil R, Cabrera BL, Gangoiti JA, Barshop BA, Rioux P. Pharmacokinetics of cysteamine bitartrate following intraduodenal delivery. Fundam Clin Pharmacol. 2014;28(2):136\u201343. https:\/\/doi.org\/10.1111\/fcp.12009.","journal-title":"Fundam Clin Pharmacol"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-020-00890-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-020-00890-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-020-00890-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T14:54:29Z","timestamp":1630940069000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-020-00890-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["890"],"URL":"https:\/\/doi.org\/10.1007\/s13346-020-00890-6","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,4]]},"assertion":[{"value":"21 December 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}