{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:22:00Z","timestamp":1783732920837,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s13346-021-00943-4","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T16:02:35Z","timestamp":1615651355000},"page":"1586-1597","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Polymeric micelles with anti-virulence activity against Candida albicans in a single- and dual-species biofilm"],"prefix":"10.1007","volume":"11","author":[{"given":"Yassamin N.","family":"Albayaty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina D.","family":"Ram\u00edrez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-7535","authenticated-orcid":false,"given":"Clive A.","family":"Prestidge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,13]]},"reference":[{"key":"943_CR1","doi-asserted-by":"crossref","unstructured":"Prasad R, Shah AH, Dhamgaye S.\u00a0Mechanisms of drug resistance in fungi and their significance in biofilms, in Antibiofilm Agents. Springer 2014. p. 45\u201365.","DOI":"10.1007\/978-3-642-53833-9_4"},{"key":"943_CR2","doi-asserted-by":"crossref","unstructured":"Tsui C, Kong EF, Jabra-Rizk MA.\u00a0Pathogenesis of Candida albicans biofilm. FEMS Pathogens and Disease. 2016. 74(4): p. ftw018.","DOI":"10.1093\/femspd\/ftw018"},{"key":"943_CR3","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.2147\/IJN.S93105","volume":"11","author":"AR Voltan","year":"2016","unstructured":"Voltan AR, et al. Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy? Int J Nanomed. 2016;11:3715.","journal-title":"Int J Nanomed"},{"issue":"10","key":"943_CR4","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nrmicro2636","volume":"9","author":"PE Sudbery","year":"2011","unstructured":"Sudbery PE. Growth of Candida albicans hyphae. Nat Rev Microbiol. 2011;9(10):737\u201348.","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"943_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrmicro.2017.107","volume":"16","author":"MB Lohse","year":"2018","unstructured":"Lohse MB, et al. Development and regulation of single-and multi-species Candida albicans biofilms. Nat Rev Microbiol. 2018;16(1):19.","journal-title":"Nat Rev Microbiol"},{"key":"943_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ijbiomac.2017.08.094","volume":"110","author":"Y Tan","year":"2018","unstructured":"Tan Y, et al. Efficacy of carboxymethyl chitosan against Candida tropicalis and Staphylococcus epidermidis monomicrobial and polymicrobial biofilms. Int J Biol Macromol. 2018;110:150\u20136.","journal-title":"Int J Biol Macromol"},{"issue":"11","key":"943_CR7","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1590\/0074-02760160294","volume":"111","author":"MM Weerasekera","year":"2016","unstructured":"Weerasekera MM, et al. Culture media profoundly affect Candida albicans and Candida tropicalis growth, adhesion and biofilm development. Mem\u00f3rias Do Instituto Oswaldo Cruz. 2016;111(11):697\u2013702.","journal-title":"Mem\u00f3rias Do Instituto Oswaldo Cruz"},{"key":"943_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.micres.2016.06.003","volume":"192","author":"C Jiang","year":"2016","unstructured":"Jiang C, et al. Significance of hyphae formation in virulence of Candida tropicalis and transcriptomic analysis of hyphal cells. Microbiol Res. 2016;192:65\u201372.","journal-title":"Microbiol Res"},{"issue":"2","key":"943_CR9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ijantimicag.2013.10.023","volume":"43","author":"G Ramage","year":"2014","unstructured":"Ramage G, Robertson SN, Williams C. Strength in numbers: antifungal strategies against fungal biofilms. Int J Antimicrob Agents. 2014;43(2):114\u201320.","journal-title":"Int J Antimicrob Agents"},{"key":"943_CR10","volume-title":"Biofilms and vulvovaginal candidiasis","author":"C Rodr\u00edguez-Cerdeira","year":"2018","unstructured":"Rodr\u00edguez-Cerdeira C, et al. Biofilms and vulvovaginal candidiasis. Colloids and Surfaces B: Biointerfaces; 2018."},{"key":"943_CR11","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/j.biopha.2017.11.127","volume":"96","author":"B Sawant","year":"2017","unstructured":"Sawant B, Khan T. Recent advances in delivery of antifungal agents for therapeutic management of candidiasis. Biomed Pharmacother. 2017;96:1478\u201390.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"943_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1439-0507.2011.02076.x","volume":"55","author":"S Tobudic","year":"2012","unstructured":"Tobudic S, et al. Antifungal susceptibility of Candida albicans in biofilms. Mycoses. 2012;55(3):199\u2013204.","journal-title":"Mycoses"},{"key":"943_CR13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fmed.2018.00028","volume":"5","author":"M Cavalheiro","year":"2018","unstructured":"Cavalheiro M, Teixeira MC. Candida biofilms: threats, challenges, and promising strategies. Front Med. 2018;5:28.","journal-title":"Front Med"},{"key":"943_CR14","doi-asserted-by":"crossref","unstructured":"Fanning S, Mitchell AP.\u00a0Fungal biofilms. PLoS Pathog.\u00a02012. 8(4).","DOI":"10.1371\/journal.ppat.1002585"},{"key":"943_CR15","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3389\/fmicb.2019.01188","volume":"10","author":"RU Pathirana","year":"2019","unstructured":"Pathirana RU, et al. Filamentous non-albicans Candida species adhere to Candida albicans and benefit from dual biofilm growth. Frontiers in microbiology. 2019;10:1188.","journal-title":"Frontiers in microbiology"},{"key":"943_CR16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.pdpdt.2016.11.013","volume":"17","author":"JC Carmello","year":"2017","unstructured":"Carmello JC, et al. Photoinactivation of single and mixed biofilms of Candida albicans and non-albicans Candida species using Photodithazine\u00ae. Photodiagn Photodyn Ther. 2017;17:194\u20139.","journal-title":"Photodiagn Photodyn Ther"},{"issue":"11","key":"943_CR17","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1128\/AAC.46.11.3634-3636.2002","volume":"46","author":"G Ramage","year":"2002","unstructured":"Ramage G, et al. In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies. Antimicrob Agents Chemother. 2002;46(11):3634\u20136.","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"943_CR18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4161\/viru.22913","volume":"4","author":"FL Mayer","year":"2013","unstructured":"Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence. 2013;4(2):119\u201328.","journal-title":"Virulence"},{"issue":"3\u20134","key":"943_CR19","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.drudis.2008.11.013","volume":"14","author":"K Gauwerky","year":"2009","unstructured":"Gauwerky K, Borelli C, Korting HC. Targeting virulence: a new paradigm for antifungals. Drug Discovery Today. 2009;14(3\u20134):214\u201322.","journal-title":"Drug Discovery Today"},{"issue":"4","key":"943_CR20","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/21505594.2015.1039885","volume":"6","author":"J Cui","year":"2015","unstructured":"Cui J, et al. Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans. Virulence. 2015;6(4):362\u201371.","journal-title":"Virulence"},{"issue":"3","key":"943_CR21","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1586\/14787210.2014.885838","volume":"12","author":"JE Nett","year":"2014","unstructured":"Nett JE. Future directions for anti-biofilm therapeutics targeting Candida. Expert review of anti-infective therapy. 2014;12(3):375\u201382.","journal-title":"Expert review of anti-infective therapy"},{"issue":"7","key":"943_CR22","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.1021\/acs.nanolett.8b01000","volume":"18","author":"J Li","year":"2018","unstructured":"Li J, et al. Block copolymer nanoparticles remove biofilms of drug-resistant Gram-positive bacteria by nanoscale bacterial debridement. Nano Lett. 2018;18(7):4180\u20137.","journal-title":"Nano Lett"},{"issue":"8","key":"943_CR23","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1039\/C9TB02586C","volume":"8","author":"YN Albayaty","year":"2020","unstructured":"Albayaty YN, et al. pH-Responsive copolymer micelles to enhance itraconazole efficacy against Candida albicans biofilms. J Mater Chem B. 2020;8(8):1672\u201381.","journal-title":"J Mater Chem B"},{"key":"943_CR24","doi-asserted-by":"crossref","unstructured":"Ahmed N, et al.\u00a0Polymeric drug delivery systems for encapsulating hydrophobic drugs. Drug Delivery Strategies for Poorly Water-Soluble Drugs. 2013. p. 151.","DOI":"10.1002\/9781118444726.ch5"},{"issue":"88","key":"943_CR25","doi-asserted-by":"publisher","first-page":"71709","DOI":"10.1039\/C5RA13885J","volume":"5","author":"C Takahashi","year":"2015","unstructured":"Takahashi C, et al. Antibacterial activities of polymeric poly (dl-lactide-co-glycolide) nanoparticles and Soluplus\u00ae micelles against Staphylococcus epidermidis biofilm and their characterization. RSC Adv. 2015;5(88):71709\u201317.","journal-title":"RSC Adv"},{"issue":"9","key":"943_CR26","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1038\/nprot.2008.141","volume":"3","author":"CG Pierce","year":"2008","unstructured":"Pierce CG, et al. A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing. Nat Protoc. 2008;3(9):1494.","journal-title":"Nat Protoc"},{"issue":"1","key":"943_CR27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ijantimicag.2017.09.012","volume":"51","author":"M Lu","year":"2018","unstructured":"Lu M, et al. Gentamicin synergises with azoles against drug-resistant Candida albicans. Int J Antimicrob Agents. 2018;51(1):107\u201314.","journal-title":"Int J Antimicrob Agents"},{"issue":"9","key":"943_CR28","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1128\/AAC.00541-08","volume":"52","author":"C Seneviratne","year":"2008","unstructured":"Seneviratne C, et al. Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms. Antimicrob Agents Chemother. 2008;52(9):3259\u201366.","journal-title":"Antimicrob Agents Chemother"},{"key":"943_CR29","doi-asserted-by":"publisher","first-page":"23575","DOI":"10.1038\/srep23575","volume":"6","author":"F Haque","year":"2016","unstructured":"Haque F, et al. Inhibitory effect of sophorolipid on Candida albicans biofilm formation and hyphal growth. Sci Rep. 2016;6:23575.","journal-title":"Sci Rep"},{"key":"943_CR30","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3389\/fcimb.2017.00447","volume":"7","author":"RK Manoharan","year":"2017","unstructured":"Manoharan RK, et al. Alizarin and chrysazin inhibit biofilm and hyphal formation by Candida albicans. Front Cell Infect Microbiol. 2017;7:447.","journal-title":"Front Cell Infect Microbiol"},{"key":"943_CR31","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.vetmic.2016.07.022","volume":"192","author":"RSN Brilhante","year":"2016","unstructured":"Brilhante RSN, et al. Candida tropicalis from veterinary and human sources shows similar in vitro hemolytic activity, antifungal biofilm susceptibility and pathogenesis against Caenorhabditis elegans. Vet Microbiol. 2016;192:213\u20139.","journal-title":"Vet Microbiol"},{"issue":"5191","key":"943_CR32","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1126\/science.7992058","volume":"266","author":"H Liu","year":"1994","unstructured":"Liu H, Kohler J, Fink GR. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science. 1994;266(5191):1723\u20136.","journal-title":"Science"},{"issue":"26","key":"943_CR33","doi-asserted-by":"publisher","first-page":"21631","DOI":"10.1021\/acsami.7b03672","volume":"9","author":"K Richter","year":"2017","unstructured":"Richter K, et al. Taking the silver bullet colloidal silver particles for the topical treatment of biofilm-related infections. ACS Appl Mater Interfaces. 2017;9(26):21631\u20138.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"12","key":"943_CR34","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1038\/nprot.2008.193","volume":"3","author":"E Tampakakis","year":"2008","unstructured":"Tampakakis E, Okoli I, Mylonakis EAC. elegans-based, whole animal, in vivo screen for the identification of antifungal compounds. Nat Protoc. 2008;3(12):1925.","journal-title":"Nat Protoc"},{"key":"943_CR35","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3389\/fmicb.2015.00750","volume":"6","author":"S Thangamani","year":"2015","unstructured":"Thangamani S, Younis W, Seleem MN. Repurposing celecoxib as a topical antimicrobial agent. Frontiers in microbiology. 2015;6:750.","journal-title":"Frontiers in microbiology"},{"issue":"3","key":"943_CR36","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/14787210.2017.1268530","volume":"15","author":"H Bandara","year":"2017","unstructured":"Bandara H, Matsubara VH, Samaranayake LP. Future therapies targeted towards eliminating Candida biofilms and associated infections. Expert review of anti-infective therapy. 2017;15(3):299\u2013318.","journal-title":"Expert review of anti-infective therapy"},{"key":"943_CR37","doi-asserted-by":"crossref","unstructured":"Albayaty YN, et al.\u00a0Enzyme responsive copolymer micelles enhance the anti-biofilm efficacy of the antiseptic chlorhexidine. Int J Pharm. 2019.","DOI":"10.1016\/j.ijpharm.2019.05.069"},{"issue":"4","key":"943_CR38","doi-asserted-by":"publisher","first-page":"4779","DOI":"10.1021\/acsnano.6b01370","volume":"10","author":"Y Liu","year":"2016","unstructured":"Liu Y, et al. Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms. ACS Nano. 2016;10(4):4779\u201389.","journal-title":"ACS Nano"},{"issue":"3","key":"943_CR39","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1574-6968.1990.tb04231.x","volume":"69","author":"Y Miyake","year":"1990","unstructured":"Miyake Y, et al. Antifungal drugs effect adherence of Candida albicans to acrylic surfaces by changing the zeta-potential of fungal cells. FEMS Microbiol Lett. 1990;69(3):211\u20134.","journal-title":"FEMS Microbiol Lett"},{"issue":"9","key":"943_CR40","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1086\/651558","volume":"201","author":"LR Martinez","year":"2010","unstructured":"Martinez LR, et al. Demonstration of antibiofilm and antifungal efficacy of chitosan against candidal biofilms, using an in vivo central venous catheter model. J Infect Dis. 2010;201(9):1436\u201340.","journal-title":"J Infect Dis"},{"issue":"5","key":"943_CR41","doi-asserted-by":"publisher","first-page":"828","DOI":"10.4315\/0362-028X-65.5.828","volume":"65","author":"T Savard","year":"2002","unstructured":"Savard T, et al. Antimicrobial action of hydrolyzed chitosan against spoilage yeasts and lactic acid bacteria of fermented vegetables. J Food Prot. 2002;65(5):828\u201333.","journal-title":"J Food Prot"},{"key":"943_CR42","doi-asserted-by":"crossref","unstructured":"Shahalom S, et al.\u00a0Poly (DEAEMa-co-PEGMa): a new pH-responsive comb copolymer stabilizer for emulsions and dispersions. 2006;22(20):8311\u20138317.","DOI":"10.1021\/la061229g"},{"issue":"3","key":"943_CR43","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/2049-632X.12161","volume":"70","author":"CG Pierce","year":"2014","unstructured":"Pierce CG, Saville SP, Lopez-Ribot JL. High-content phenotypic screenings to identify inhibitors of Candida albicans biofilm formation and filamentation. Pathogens and Disease. 2014;70(3):423\u201331.","journal-title":"Pathogens and Disease"},{"issue":"4","key":"943_CR44","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3109\/1040841X.2014.974500","volume":"42","author":"ME Rodrigues","year":"2016","unstructured":"Rodrigues ME, et al. Novel strategies to fight Candida species infection. Crit Rev Microbiol. 2016;42(4):594\u2013606.","journal-title":"Crit Rev Microbiol"},{"key":"943_CR45","doi-asserted-by":"publisher","first-page":"e4999","DOI":"10.7717\/peerj.4999","volume":"6","author":"M Tome","year":"2018","unstructured":"Tome M, et al. Synergistic and antagonistic effects of immunomodulatory drugs on the action of antifungals against Candida glabrata and Saccharomyces cerevisiae. PeerJ. 2018;6:e4999.","journal-title":"PeerJ"},{"issue":"4","key":"943_CR46","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/pathogens6040062","volume":"6","author":"CF Rodrigues","year":"2017","unstructured":"Rodrigues CF, Henriques M. Liposomal and deoxycholate amphotericin B formulations: effectiveness against biofilm infections of Candida spp. Pathogens. 2017;6(4):62.","journal-title":"Pathogens"},{"issue":"7","key":"943_CR47","first-page":"2405","volume":"97","author":"J Torrado","year":"2008","unstructured":"Torrado J, et al. Amphotericin B formulations and drug targeting. 2008;97(7):2405\u201325.","journal-title":"Amphotericin B formulations and drug targeting"},{"key":"943_CR48","doi-asserted-by":"crossref","unstructured":"Buehler DC, Marsden MD, Shen S. 8, Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug. 2014.","DOI":"10.1021\/nn5002694"},{"key":"943_CR49","doi-asserted-by":"crossref","unstructured":"Vandermeulen G, et al.\u00a0Encapsulation of amphotericin B in poly (ethylene glycol)-block-poly (\u025b-caprolactone-co-trimethylenecarbonate) polymeric micelles. 2006;309(1\u20132):234\u2013240.","DOI":"10.1016\/j.ijpharm.2005.11.031"},{"issue":"2","key":"943_CR50","first-page":"248","volume":"66","author":"A Mu\u0163","year":"2018","unstructured":"Mu\u0163 A, et al. Chitosan\/HPMC-based hydrogels containing essential oils for topical delivery of fluconazole: Preliminary studies. 2018;66(2):248\u201356.","journal-title":"Chitosan\/HPMC-based hydrogels containing essential oils for topical delivery of fluconazole: Preliminary studies"},{"key":"943_CR51","doi-asserted-by":"crossref","unstructured":"Corr\u00eaa JCR, Salgado HRN. Review of fluconazole properties and analytical methods for its determination. 2011;41(2):124\u2013132.","DOI":"10.1080\/10408347.2011.557980"},{"key":"943_CR52","doi-asserted-by":"crossref","unstructured":"Castelli MV, et al.\u00a0Novel antifungal agents: a patent review (2011\u2013present). 2014;24(3):323\u2013338.","DOI":"10.1517\/13543776.2014.876993"},{"issue":"11","key":"943_CR53","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1128\/AAC.47.11.3657-3659.2003","volume":"47","author":"SP Bachmann","year":"2003","unstructured":"Bachmann SP, et al. Antifungal combinations against Candida albicans biofilms in vitro. Antimicrob Agents Chemother. 2003;47(11):3657\u20139.","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"943_CR54","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1021\/cb400009f","volume":"8","author":"J You","year":"2013","unstructured":"You J, et al. Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates. ACS Chem Biol. 2013;8(4):840\u20138.","journal-title":"ACS Chem Biol"},{"issue":"9","key":"943_CR55","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.jiac.2015.05.007","volume":"21","author":"A Kawai","year":"2015","unstructured":"Kawai A, Yamagishi Y, Mikamo H. In vitro efficacy of liposomal amphotericin B, micafungin and fluconazole against non-albicans Candida species biofilms. J Infect Chemother. 2015;21(9):647\u201353.","journal-title":"J Infect Chemother"},{"issue":"4","key":"943_CR56","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3109\/1040841X.2010.489506","volume":"36","author":"LY Ann Chai","year":"2010","unstructured":"Ann Chai LY, Denning DW, Warn P. Candida tropicalis in human disease. Crit Rev Microbiol. 2010;36(4):282\u201398.","journal-title":"Crit Rev Microbiol"},{"issue":"8","key":"943_CR57","doi-asserted-by":"publisher","first-page":"7679","DOI":"10.1016\/j.actbio.2013.05.006","volume":"9","author":"YQ Yang","year":"2013","unstructured":"Yang YQ, et al. pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly (\u03b5-caprolactone)-b-poly (2-(diethylamino) ethyl methacrylate)-b-poly (poly (ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery. Acta Biomater. 2013;9(8):7679\u201390.","journal-title":"Acta Biomater"},{"issue":"1","key":"943_CR58","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/1556-276X-9-243","volume":"9","author":"W Lin","year":"2014","unstructured":"Lin W, et al. pH-responsive micelles based on (PCL) 2 (PDEA-b-PPEGMA) 2 miktoarm polymer: controlled synthesis, characterization, and application as anticancer drug carrier. Nanoscale Res Lett. 2014;9(1):243.","journal-title":"Nanoscale Res Lett"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-021-00943-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-021-00943-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-021-00943-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:14:23Z","timestamp":1675037663000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-021-00943-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,13]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["943"],"URL":"https:\/\/doi.org\/10.1007\/s13346-021-00943-4","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,13]]},"assertion":[{"value":"8 February 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have consented to the publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}