{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:45:53Z","timestamp":1773837953248,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673363"],"award-info":[{"award-number":["81673363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s13346-021-00976-9","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T03:27:38Z","timestamp":1619321258000},"page":"1080-1095","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Construction of mannose-modified polyethyleneimine-block-polycaprolactone cationic polymer micelles and its application in acute lung injury"],"prefix":"10.1007","volume":"12","author":[{"given":"Meiling","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongning","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"976_CR1","doi-asserted-by":"crossref","unstructured":"Valderrama AP, Kaynar AM. The basic science and molecular mechanisms of lung injury and acute respiratory distress syndrome.\u00a0Int Anesthesiol Clin.\u00a02018;56(1): 1\u201325.","DOI":"10.1097\/AIA.0000000000000177"},{"issue":"10058","key":"976_CR2","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1016\/S0140-6736(16)00578-X","volume":"388","author":"M Sweeney","year":"2016","unstructured":"Sweeney M. Acute respiratory distress syndrome. The Lancet. 2016;388(10058):2416\u201330.","journal-title":"The Lancet"},{"key":"976_CR3","doi-asserted-by":"crossref","unstructured":"Yasmeen B, Kurdowska A, Allen TC. Acute lung injury: a clinical and molecular review. Arch Pathol Lab Med.\u00a02016;140(4): 345\u201350.","DOI":"10.5858\/arpa.2015-0519-RA"},{"key":"976_CR4","doi-asserted-by":"crossref","unstructured":"Anil S, Flori H, Quasney MW, Dahmer MK, Jouvet et al. Pathobiology of acute respiratory distress syndrome.\u00a0Pediatric Critical Care Medicine: A Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.\u00a02015;16(5 Suppl 1): S6\u201322.","DOI":"10.1097\/PCC.0000000000000431"},{"issue":"2","key":"976_CR5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.21037\/atm.2017.12.18","volume":"6","author":"R Herrero","year":"2018","unstructured":"Herrero R, Sanchez G, Lorente JA. New insights into the mechanisms of pulmonary edema in acute lung injury. Ann Transl Med. 2018;6(2):32.","journal-title":"Annals of translational medicine"},{"key":"976_CR6","doi-asserted-by":"crossref","unstructured":"Zhang J, Feng C, Chen W. A study of noninvasive positive-pressure mechanical ventilation in the treatment of acute lung injury with a complex critical care ventilator. J Int Med Res. 2014;42 (3): 788\u201398.","DOI":"10.1177\/0300060514522205"},{"issue":"6","key":"976_CR7","first-page":"448","volume":"76","author":"L Gattinoni","year":"2010","unstructured":"Gattinoni L, Carlesso E, Taccone P, Polli F, Gu\u00e9rin C, Mancebo J. Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis. Minerva Anestesiol. 2010;76(6):448\u201354.","journal-title":"Minerva Anestesiol"},{"key":"976_CR8","doi-asserted-by":"crossref","unstructured":"Goulet R, Sessler EH. Severe hypoxemic respiratory failure: part 2\u2014nonventilatory strategies: part 2\u2014nonventilatory strategies.\u00a0Chest.\u00a02010;137(6): 1437\u2013448.","DOI":"10.1378\/chest.09-2416"},{"key":"976_CR9","doi-asserted-by":"crossref","unstructured":"Masclans S, Chacon S, Planas S, et al. Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS): a prospective, randomized, double-blind, parallel group study.\u00a0Nutrition & Metabolism.\u00a02011;8(1): 22.","DOI":"10.1186\/1743-7075-8-22"},{"key":"976_CR10","doi-asserted-by":"crossref","unstructured":"Matthay MA, Rachel LZ. The acute respiratory distress syndrome: pathogenesis and treatment. Annual Review of Pathology: Mech Dis. 6(1): 147\u2013163.","DOI":"10.1146\/annurev-pathol-011110-130158"},{"key":"976_CR11","unstructured":"Weng D, Huiping L. Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone demonstrate high lung targeting and therapeutic effect for acute lung injury. B31. Acute Lung Injury and Ards: Translational and Mechanistic Studies. Am Thoracic Soc, 2018; A2984-A2984."},{"key":"976_CR12","doi-asserted-by":"crossref","unstructured":"Song LC, Xu XC, Meng JG, Hu, MJ, Huan B, et al. Effects of different corticosteroid doses and durations on smoke inhalation-induced acute lung injury and pulmonary fibrosis in the rat.\u00a0Int Immunopharm.\u00a02019;71: 392\u2013403.","DOI":"10.1016\/j.intimp.2019.03.051"},{"key":"976_CR13","doi-asserted-by":"publisher","unstructured":"Villar J, Ferrando C, Mart\u00ednez, Ambr\u00f3s, Mu\u00f1oz, Soler,\u00a0et al. Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial.\u00a0Lancet Respir Med. 2020;8(3):267\u2013276.https:\/\/doi.org\/10.1016\/S2213-2600(19)30417-5","DOI":"10.1016\/S2213-2600(19)30417-5"},{"issue":"4","key":"976_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1517\/14740338.2016.1140743","volume":"15","author":"M Oray","year":"2016","unstructured":"Oray M, Abu Samra K, Ebrahimiadib N, Meese H, Foster C. Long-term side effects of glucocorticoids. Expert Opin Drug Saf. 2016;15(4):457\u201365.","journal-title":"Expert Opin Drug Saf"},{"key":"976_CR15","doi-asserted-by":"crossref","unstructured":"Jae WL, Kyeong HS, Hyung WR, Heung JY, Hyun AP, et al. Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264. 7 macrophages and LPS-induced murine model of acute lung injury.\u00a0J ethnopharmacol.\u00a02018;210: 23\u201330.","DOI":"10.1016\/j.jep.2017.08.028"},{"key":"976_CR16","doi-asserted-by":"crossref","unstructured":"Zou R, Gui X, Zhang J, et al. Association of serum macrophage-mannose receptor CD206 with mortality in idiopathic pulmonary fibrosis. Int Immunopharmacol. 2020;86: 106732.","DOI":"10.1016\/j.intimp.2020.106732"},{"key":"976_CR17","doi-asserted-by":"crossref","unstructured":"Erica F, Jie KYF. Regulation of alveolar macrophage death in acute lung inflammation.\u00a0Resp res.\u00a02018;19(1): 50.","DOI":"10.1186\/s12931-018-0756-5"},{"key":"976_CR18","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cellimm.2018.01.005","volume":"330","author":"N Joshi","year":"2018","unstructured":"Joshi N, Walter JM, Misharin AV. Alveolar macrophages. Cell Immunol. 2018;330:86\u201390.","journal-title":"Cell Immunol"},{"issue":"3","key":"976_CR19","doi-asserted-by":"publisher","first-page":"107384","DOI":"10.1016\/j.jsb.2019.09.001","volume":"208","author":"Z Hu","year":"2019","unstructured":"Hu Z, Wang Y, Cheng C, He Y. Structural basis of the PH-dependent conformational change of the N-terminal region of human mannose receptor\/CD206. J Struct Biol. 2019;208(3):107384.","journal-title":"J Struct Biol"},{"key":"976_CR20","doi-asserted-by":"crossref","unstructured":"Kenta K, Ohashi W, Tomita K, Takashina M, Fujisaka S, et al. In vivo depletion of CD206 M2 macrophages exaggerates lung injury in endotoxemic mice. Am J Pathol.\u00a02015;185 (1): 162\u201371.","DOI":"10.1016\/j.ajpath.2014.09.005"},{"key":"976_CR21","doi-asserted-by":"crossref","unstructured":"Kazuo T, Suzuki Y, Yoshimura K, Yasui H, Karayama M, et al. Macrophage mannose receptor CD206 predicts prognosis in community-acquired pneumonia. Scientific Reports. 2019;9 (1): 18750.","DOI":"10.1038\/s41598-019-55289-2"},{"key":"976_CR22","unstructured":"Xuan LX, Zhang P, Yi HS, He QL, Yue HW, et al. Mannose prevents acute lung injury through mannose receptor pathway and contributes to regulate PPAR. and TGF-beta 1 Level. Int J of Clin And Exper Pathol. 2015; 8(6): 6214\u2013224."},{"key":"976_CR23","doi-asserted-by":"crossref","unstructured":"Xu X, Shen L, Chen Y, et al. Involvement of mannose receptor in the preventive effects of mannose in lipopolysaccharide-induced acute lung injury.\u00a0Eur J Pharmacol.\u00a02010;641(2\u20133): 229\u201337.","DOI":"10.1016\/j.ejphar.2010.05.021"},{"key":"976_CR24","doi-asserted-by":"crossref","unstructured":"Ohashi K, Takashina T, Hayashi F, et al. In\u00a0vivo depletion of CD206 M2 macrophages exaggerates lung injury in endotoxemic mice. Am J Pathol.\u00a02015;185 (1): 162\u201371.","DOI":"10.1016\/j.ajpath.2014.09.005"},{"key":"976_CR25","doi-asserted-by":"crossref","unstructured":"Zhang WF, Li ZT ,  Fang J J, Wang GB, Yu Y, et al. Effect of mannose on the lung function of rats with acute pancreatitis. J Biological Regulators and Homeostatic Agents. 2018;32 (3): 627\u201333.","DOI":"10.1002\/jbt.22211"},{"issue":"4","key":"976_CR26","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1021\/mp800049w","volume":"5","author":"S-D Li","year":"2008","unstructured":"Li S-D, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm. 2008;5(4):496\u2013504.","journal-title":"Mol Pharm"},{"key":"976_CR27","doi-asserted-by":"crossref","unstructured":"Feng S et al.\u00a0\u00a0Review on smart gas sensing technology. Sensors, 19(17), pp. Sensors, 2019, Vol.19(17).","DOI":"10.3390\/s19173760"},{"key":"976_CR28","doi-asserted-by":"crossref","unstructured":"Koji I, Chuan Y, Lakshmi C, et al. Cooperative orthogonal macromolecular assemblies with broad spectrum antiviral activity, high selectivity, and resistance mitigation.\u00a0Macromole. 2016\u00a049 (7): 2618\u20132629.","DOI":"10.1021\/acs.macromol.6b00091"},{"key":"976_CR29","unstructured":"Wei C, Hedrick Jl, Williams Df, et al. Delivery of a granzyme B inhibitor gene using carbamate-mannose modified PEI protects against cytotoxic lymphocyte killing.\u00a0Biomaterials.\u00a0201334 (14): 3697\u20133705."},{"issue":"11","key":"976_CR30","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1039\/C4PY01623H","volume":"6","author":"H Li","year":"2015","unstructured":"Li H, et al. Intracellular redox potential-responsive micelles based on polyethylenimine \u2013 cystamine \u2013 poly (epsilon -caprolactone) block copolymer for enhanced miR-34a delivery. Polym Chem. 2015;6(11):1952\u201360.","journal-title":"Polym Chem"},{"key":"976_CR31","doi-asserted-by":"crossref","unstructured":"Wang Y. et al. Functionalized polymeric hybrid micelles as an efficient nanotheranostic agent for thrombus imaging and thrombolysis. Acta biomaterialia, pp. Acta biomaterialia.2020","DOI":"10.1016\/j.actbio.2020.10.015"},{"issue":"3","key":"976_CR32","doi-asserted-by":"publisher","first-page":"192092","DOI":"10.1098\/rsos.192092","volume":"7","author":"H Li","year":"2020","unstructured":"Li H, Danna Hu, Liang F, Huang X, Zhu Q. Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples. Royal Soc Open Sci. 2020;7(3):192092.","journal-title":"Royal Society Open Science"},{"key":"976_CR33","doi-asserted-by":"crossref","unstructured":"Benjamin B, Colombo M, Sahle FF, Zoubari G, Staufenbiel S, et al. Comparison of different in vitro release methods used to investigate nanocarriers intended for dermal application. Int J Pharm. 2016;513 (1\u20132): 247\u201354.","DOI":"10.1016\/j.ijpharm.2016.09.033"},{"key":"976_CR34","doi-asserted-by":"crossref","unstructured":"Tao Z, Zhang W, Feng SJ, Yu HP. Emodin Suppresses LPS-induced Inflammation in RAW264.7 Cells through a PPAR\u03b3-dependent Pathway. Int Immunopharm. 2016;34: 16\u201324.","DOI":"10.1016\/j.intimp.2016.02.014"},{"issue":"1","key":"976_CR35","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s10753-017-0675-5","volume":"41","author":"M Rabelo","year":"2018","unstructured":"Rabelo M, et al. Acute lung injury in response to intratracheal instillation of lipopolysaccharide in an animal model of emphysema induced by Elastase. Inflammation. 2018;41(1):174\u201382.","journal-title":"Inflammation"},{"key":"976_CR36","doi-asserted-by":"crossref","unstructured":"Kang JL, Lee HW, Lee HS, HW, Lee, HS, et al. Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. Am j respiratory and crit care med. 2001;164(12): 2206\u20132212.","DOI":"10.1164\/ajrccm.164.12.2104017"},{"key":"976_CR37","doi-asserted-by":"crossref","unstructured":"Daoshu Y, Li P, Liu X, Hu J, Yang L. New side chain liquid crystal aliphatic polycarbonate with pendant functionalized diosgenyl groups: I. Synthesis and mesomorphism.\u00a0Colloid and Polymer Sci. 2015;293(10): 3049\u20133059.","DOI":"10.1007\/s00396-015-3750-1"},{"issue":"10","key":"976_CR38","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1021\/bm100561v","volume":"11","author":"F Li","year":"2010","unstructured":"Li F, Danquah M, Mahato RI. Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery. Biomacromol. 2010;11(10):2610\u201320.","journal-title":"Biomacromol"},{"key":"976_CR39","doi-asserted-by":"crossref","unstructured":"Rodney TA, Aerken X, Fuchs A, Bettencourt DAD. Sensitization of LnIII (Ln= Eu, Tb, Tm) Ion luminescence by functionalized polycarbonate\u2010based materials and white light generation. Eur J of Inorganic Chem.\u00a02017;44 (2017): 5310\u20135317.","DOI":"10.1002\/ejic.201700655"},{"key":"976_CR40","doi-asserted-by":"crossref","unstructured":"Koji I, Chuan Y, Lakshmi C, et al. Cooperative orthogonal macromolecular assemblies with broad spectrum antiviral activity, high selectivity, and resistance mitigation.\u00a0Macromole.\u00a02016;49 (7): 2618\u20132629.","DOI":"10.1021\/acs.macromol.6b00091"},{"key":"976_CR41","doi-asserted-by":"crossref","unstructured":"Hanmei L, Yao F, Ting Z, et al. Rational design of polymeric hybrid micelles with highly tunable properties to co-deliver MicroRNA-34a and Vismodegib for melanoma therapy. Adv Funct Materials. 2015;25 (48): 7457\u2013469.","DOI":"10.1002\/adfm.201503115"},{"key":"976_CR42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jcis.2016.07.020","volume":"481","author":"N Soni","year":"2016","unstructured":"Soni N, Soni N, Pandey H, Maheshwari R, Kesharwani P, Tekade RK. Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles. J Colloid Interface Sci. 2016;481:107\u201316.","journal-title":"J Colloid Interface Sci"},{"issue":"7","key":"976_CR43","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/S0142-9612(02)00445-3","volume":"24","author":"D Fischer","year":"2003","unstructured":"Fischer D, Li Y, Ahlemeyer B, Krieglstein J, Kissel T. In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis. Biomaterials. 2003;24(7):1121\u201331.","journal-title":"Biomaterials"},{"issue":"4","key":"976_CR44","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.carbpol.2004.06.033","volume":"58","author":"D Lee","year":"2004","unstructured":"Lee D, Powers K, Baney R. Physicochemical properties and blood compatibility of acylated chitosan nanoparticles. Carbohyd Polym. 2004;58(4):371\u20137.","journal-title":"Carbohyd Polym"},{"issue":"1","key":"976_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2013.01.016","volume":"167","author":"G Sharma","year":"2013","unstructured":"Sharma G, Modgil A, Layek B, Arora K, Sun C, Law B, Singh J. Cell penetrating peptide tethered bi-ligand liposomes for delivery to brain in vivo: biodistribution and transfection. J Control Release. 2013;167(1):1\u201310.","journal-title":"J Control Release"},{"issue":"2","key":"976_CR46","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ajps.2018.03.004","volume":"14","author":"Y Pan","year":"2019","unstructured":"Pan Y, Wang X, Yin Z. Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis. Asian J Pharm Sci. 2019;14(2):144\u201353.","journal-title":"Asian Journal of Pharmceutical Sciences"},{"issue":"28","key":"976_CR47","doi-asserted-by":"publisher","first-page":"12038","DOI":"10.1039\/C5NR01407G","volume":"7","author":"W Han","year":"2015","unstructured":"Han W, Macewan S, Chilkoti A, Lpez G. Bio-inspired synthesis of hybrid silica nanoparticles templated from elastin-like polypeptide micelles. Nanoscale. 2015;7(28):12038\u201344.","journal-title":"Nanoscale"},{"issue":"1","key":"976_CR48","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/molecules14010210","volume":"14","author":"B Wagner","year":"2009","unstructured":"Wagner B. The use of coumarins as environmentally-sensitive fluorescent probes of heterogeneous inclusion systems. Molecules. 2009;14(1):210\u201337.","journal-title":"Molecules"},{"issue":"10","key":"976_CR49","doi-asserted-by":"publisher","first-page":"19343","DOI":"10.3390\/molecules201019343","volume":"20","author":"H Ruiz","year":"2015","unstructured":"Ruiz H, Molina-Bolivar CR, Hierrezuelo M, Molina-Bolivar A. Analysis of the photophysical behavior and rotational-relaxation dynamics of coumarin 6 in nonionic micellar environments: the effect of temperature. Molecules. 2015;20(10):19343\u201360.","journal-title":"Molecules"},{"issue":"30","key":"976_CR50","doi-asserted-by":"publisher","first-page":"3810","DOI":"10.1039\/C9AY00577C","volume":"11","author":"A Fluksman","year":"2019","unstructured":"Fluksman A, Benny O. A robust method for critical micelle concentration determination using coumarin-6 as a fluorescent probe. Anal Methods. 2019;11(30):3810\u20138.","journal-title":"Anal Methods"},{"key":"976_CR51","doi-asserted-by":"crossref","unstructured":"Smith J, Purr E.\u00a0\u00a0Preparation of PLGA nanoparticles encapsulated with fluorescent probe coumarin-6. BioRxiv, pp.BioRxiv, Apr 23, 2019.2019","DOI":"10.1101\/614875"},{"issue":"6927","key":"976_CR52","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nature01451","volume":"422","author":"SD Conner","year":"2003","unstructured":"Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature. 2003;422(6927):37\u201344.","journal-title":"Nature"},{"issue":"2","key":"976_CR53","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.nantod.2011.02.003","volume":"6","author":"T-G Iversen","year":"2011","unstructured":"Iversen T-G, Skotland T, Sandvig K. Endocytosis and intracellular transport of nanoparticles: present knowledge and need for future studies. Nano Today. 2011;6(2):176\u201385.","journal-title":"Nano Today"},{"key":"976_CR54","doi-asserted-by":"crossref","unstructured":"Dagmar KA, Vanhecke D, Michen B, Blank F, Gehr P, et al. Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages. Beilstein J Nanotechno. 2014;5 (1): 1625\u2013636.","DOI":"10.3762\/bjnano.5.174"},{"key":"976_CR55","doi-asserted-by":"crossref","unstructured":"Youta DC, Kroubi M, Zibouche R, Matran R, Betbeder D. Characterization of endocytosis and exocytosis of cationic nanoparticles in airway epithelium cells. Nanotechno. 2010;21(35): 355102.","DOI":"10.1088\/0957-4484\/21\/35\/355102"},{"key":"976_CR56","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0074-7696(03)01006-4","volume":"226","author":"A Regnier-Vigouroux","year":"2003","unstructured":"Regnier-Vigouroux A. The mannose receptor in the brain. Int Rev Cytol. 2003;226:321\u201342.","journal-title":"Int Rev Cytol"},{"key":"976_CR57","first-page":"1","volume":"479","author":"S Linehan","year":"2000","unstructured":"Linehan S, Martinez-Pomares L, Gordon S. Mannose receptor and scavenger receptor: two macrophage pattern recognition receptors with diverse functions in tissue homeostasis and host defense. Adv Exp Med Biol. 2000;479:1\u201314.","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"976_CR58","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1007\/s10753-018-0773-z","volume":"41","author":"X Jiang","year":"2018","unstructured":"Jiang X, Chen L, Zhang Z, et al. Protective and therapeutic effects of engeletin on LPS-induced acute lung injury. Inflammation. 2018;41(4):1259\u201365.","journal-title":"Inflammation"},{"key":"976_CR59","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.imlet.2020.12.015","volume":"231","author":"R Xu","year":"2021","unstructured":"Xu R, Shao Z, Cao Q. MicroRNA-144-3p enhances LPS induced septic acute lung injury in mice through downregulating Caveolin-2. Immunol Lett. 2021;231:18\u201325.","journal-title":"Immunol Lett"},{"key":"976_CR60","doi-asserted-by":"crossref","unstructured":"Asti C, Ruggieri V, Porzio S, Chiusaroli R, Melillo G, & Caselli G. Lipopolysaccharide-induced Lung Injury in Mice. I. Concomitant evaluation of inflammatory cells and haemorrhagic lung damage. Pulmon Pharmaco & Therap, 2000;13(2), 61\u201369.","DOI":"10.1006\/pupt.2000.0231"},{"issue":"4","key":"976_CR61","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1016\/j.bbrc.2018.08.072","volume":"503","author":"L Liu","year":"2018","unstructured":"Liu L, Xu D, Liu P, Liu F, Dai L, Yan H, Wen F. Effects of calcium gluconate on lipopolysaccharide-induced acute lung injury in mice. Biochem Biophys Res Commun. 2018;503(4):2931\u20135.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"976_CR62","first-page":"L579","volume":"312","author":"CM Hendriekson","year":"2017","unstructured":"Hendriekson CM, Zhuo JA, Hanjing L, Kathleen D, Calfee CS, Matthay MA. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. Am J Physiol (Consolidated). 2017;312(5):L579\u201385.","journal-title":"American Journal of Physiology (Consolidated)"},{"key":"976_CR63","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.micpath.2018.11.048","volume":"127","author":"X Hu","year":"2019","unstructured":"Hu X, Li H, Fu L, Liu, et al. The protective effect of hyperin on LPS-induced acute lung injury in mice. Microb Pathog. 2019;127:116\u201320.","journal-title":"Microb Pathog"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-021-00976-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-021-00976-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-021-00976-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T18:02:04Z","timestamp":1648058524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-021-00976-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,23]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["976"],"URL":"https:\/\/doi.org\/10.1007\/s13346-021-00976-9","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,23]]},"assertion":[{"value":"1 April 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal care and experimental protocols were conducted in accordance with the guidelines of Sichuan University and approved by the ethics committee of Sichuan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"My co-authors and I agree to publish this manuscript in <i>Drug Delivery and Translational Research<\/i>.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}