{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:54:59Z","timestamp":1788897299273,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s13346-021-00979-6","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:02:37Z","timestamp":1618358557000},"page":"925-930","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Budesonide transnasal pulsating nebulization after surgery in chronic rhinosinusitis with nasal polyps"],"prefix":"10.1007","volume":"12","author":[{"given":"Thomas","family":"Bourhis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Mouawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Szymanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-1625","authenticated-orcid":false,"given":"Geoffrey","family":"Mortuaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"979_CR1","unstructured":"Fokkens WJ, Lund VJ, Hopkins C, et al. European Position Paper on Rhinosinusitis and Nasal Polyps. Rhinology.2020; 58(Suppl S29):1\u2013464."},{"key":"979_CR2","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2500\/ajra.2016.30.4297","volume":"30","author":"AS DeConde","year":"2016","unstructured":"DeConde AS, Soler ZM. Chronic rhinosinusitis: epidemiology and burden of disease. Am J Rhinol Allergy. 2016;30:134\u20139.","journal-title":"Am J Rhinol Allergy"},{"key":"979_CR3","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1111\/j.1398-9995.2008.01750.x","volume":"63","author":"H Derendorf","year":"2008","unstructured":"Derendorf H, Meltzer EO. Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy. 2008;63:1292\u2013300.","journal-title":"Allergy"},{"key":"979_CR4","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.2500\/ajra.2013.27.3950","volume":"27","author":"M Fandi\u00f1o","year":"2013","unstructured":"Fandi\u00f1o M, Macdonald KI, Lee J, et al. The use of postoperative topical corticosteroids in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis. Am J Rhinol Allergy. 2013;27:e146\u201357.","journal-title":"Am J Rhinol Allergy"},{"key":"979_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.otohns.2008.04.020","volume":"139","author":"RJ Harvey","year":"2008","unstructured":"Harvey RJ, Goddard JC, Wise SK, et al. Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation. Otolaryngol-Head Neck Surg. 2008;139:137\u201342.","journal-title":"Otolaryngol-Head Neck Surg"},{"key":"979_CR6","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1365-2362.2006.01654.x","volume":"36","author":"M Maniscalco","year":"2006","unstructured":"Maniscalco M, Sofia M, Weitzberg E, et al. Sounding airflow enhances aerosol delivery into the paranasal sinuses. Eur J Clin Invest. 2006;36:509\u201313.","journal-title":"Eur J Clin Invest"},{"key":"979_CR7","doi-asserted-by":"publisher","first-page":"e74991","DOI":"10.1371\/journal.pone.0074991","volume":"8","author":"W M\u00f6ller","year":"2013","unstructured":"M\u00f6ller W, Schuschnig U, Celik G, et al. Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols. PLoS One. 2013;8:e74991.","journal-title":"PLoS ONE"},{"key":"979_CR8","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1007\/s11095-014-1330-6","volume":"31","author":"L Leclerc","year":"2014","unstructured":"Leclerc L, Pourchez J, Aubert G, et al. Impact of airborne particle size, acoustic airflow and breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human nasal replica. Pharm Res. 2014;31:2335\u201343.","journal-title":"Pharm Res"},{"issue":"922\u201329","key":"979_CR9","first-page":"e6","volume":"135","author":"C Wang","year":"2015","unstructured":"Wang C, Lou H, Wang X, et al. Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2015;135(922\u201329):e6.","journal-title":"J Allergy Clin Immunol"},{"key":"979_CR10","doi-asserted-by":"crossref","unstructured":"Lildholdt T, Fogstrup J, Gammelgaard N, et al. Surgical versus medical treatment of nasal polyps. Acta Otolaryngol (Stockh).1988; 105:140\u20133.","DOI":"10.3109\/00016488809119457"},{"key":"979_CR11","first-page":"183","volume":"31","author":"VJ Lund","year":"1993","unstructured":"Lund VJ, Mackay IS. Staging in rhinosinusitus. Rhinology. 1993;31:183\u20134.","journal-title":"Rhinology"},{"key":"979_CR12","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1002\/lary.24654","volume":"124","author":"AJ Psaltis","year":"2014","unstructured":"Psaltis AJ, Li G, Vaezeafshar R, et al. Modification of the Lund-Kennedy endoscopic scoring system improves its reliability and correlation with patient-reported outcome measures. Laryngoscope. 2014;124:2216\u201323.","journal-title":"Laryngoscope"},{"key":"979_CR13","unstructured":"Committee on Nebulization in Rhinology, https:\/\/www.orlfrance.org\/wp-content\/uploads\/2017\/06\/Recommandation_nebulisation_2014.pdf. Accessed 22 Dec\u00a02020."},{"key":"979_CR14","doi-asserted-by":"publisher","first-page":"286","DOI":"10.4193\/Rhino10.268","volume":"49","author":"W Moller","year":"2011","unstructured":"Moller W, Saba GK, Haussinger K, et al. Nasally inhaled pulsating aerosols: lung, sinus and nose deposition. Rhinology. 2011;49:286\u201391.","journal-title":"Rhinology"},{"key":"979_CR15","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00405-018-5232-9","volume":"276","author":"L de Gabory","year":"2019","unstructured":"de Gabory L, Escabasse V, Boudard P, et al. Prospective, randomized, controlled, open-label study to compare efficacy of a mineral-rich solution vs normal saline after complete ethmoidectomy. Eur Arch Oto-Rhino-Laryngol. 2019;276:447\u201357.","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"979_CR16","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1398-9995.2008.01870.x","volume":"64","author":"A Ehnhage","year":"2009","unstructured":"Ehnhage A, Olsson P, K\u00f6lbeck KG, et al. Functional endoscopic sinus surgery improved asthma symptoms as well as PEFR and olfaction in patients with nasal polyposis. Allergy. 2009;64:762\u20139.","journal-title":"Allergy"},{"key":"979_CR17","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/coa.13015","volume":"43","author":"HY Yoon","year":"2018","unstructured":"Yoon HY, Lee HS, Kim IH, et al. Post-operative corticosteroid irrigation for chronic rhinosinusitis after endoscopic sinus surgery: a meta-analysis. Clin Otolaryngol. 2018;43:525\u201332.","journal-title":"Clin Otolaryngol"},{"key":"979_CR18","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4193\/Rhino14.196","volume":"53","author":"RB Rawal","year":"2015","unstructured":"Rawal RB, Deal AM, Ebert CS, et al. Post-operative budesonide irrigations for patients with polyposis: a blinded, randomized controlled trial. Rhinology. 2015;53:227\u201334.","journal-title":"Rhinology"},{"key":"979_CR19","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/j.1365-2273.1993.tb00628.x","volume":"18","author":"L Vendelo Johansen","year":"1993","unstructured":"Vendelo Johansen L, Illum P, Kristensen S, et al. The effect of budesonide (Rhinocort) in the treatment of small and medium-sized nasal polyps. Clin Otolaryngol Allied Sci. 1993;18:524\u20137.","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"979_CR20","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/alr.22324","volume":"9","author":"Z Farzal","year":"2019","unstructured":"Farzal Z, Basu S, Burke A, et al. Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients. Int Forum Allergy Rhinol. 2019;9:746\u201358.","journal-title":"Int Forum Allergy Rhinol"},{"key":"979_CR21","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1177\/0194599811400686","volume":"144","author":"M Marro","year":"2011","unstructured":"Marro M, Mondina M, Stoll D, et al. French validation of the NOSE and RhinoQOL questionnaires in the management of nasal obstruction. Otolaryngol-Head Neck Surg. 2011;144:988\u201393.","journal-title":"Otolaryngol-Head Neck Surg"},{"key":"979_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/coa.12315","volume":"40","author":"C de Dorlodot","year":"2015","unstructured":"de Dorlodot C, Horoi M, Lefebvre P, et al. French adaptation and validation of the sino-nasal outcome test-22: a prospective cohort study on quality of life among 422 subjects. Clin Otolaryngol. 2015;40:29\u201335.","journal-title":"Clin Otolaryngol"},{"key":"979_CR23","doi-asserted-by":"crossref","unstructured":"Tzelnick S, Alkan U, Leshno M, et al. Sinonasal debridement versus no debridement for the postoperative care of patients undergoing endoscopic sinus surgery. Cochrane Database Syst Rev. 2018;11:CD011988.","DOI":"10.1002\/14651858.CD011988.pub2"},{"key":"979_CR24","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/17425247.2016.1214563","volume":"14","author":"R Varshney","year":"2017","unstructured":"Varshney R, Lee JT. Current trends in topical therapies for chronic rhinosinusitis: update and literature review. Expert Opin Drug Deliv. 2017;14:257\u201371.","journal-title":"Expert Opin Drug Deliv"},{"key":"979_CR25","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/lary.26880","volume":"128","author":"Y Cai","year":"2018","unstructured":"Cai Y, Gudis DA. Is topical high-volume budesonide sinus irrigation safe? Laryngoscope. 2018;128:781\u20132.","journal-title":"Laryngoscope"},{"key":"979_CR26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1046\/j.1365-2125.1999.00956.x","volume":"47","author":"L Thorsson","year":"1999","unstructured":"Thorsson L, Borg\u00e2 O, Edsb\u00e4cker S. Systemic availability of budesonide after nasal administration of three different formulations: pressurized aerosol, aqueous pump spray, and powder. Br J Clin Pharmacol. 1999;47:619\u201324.","journal-title":"Br J Clin Pharmacol"},{"key":"979_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1745-6215-9-34","volume":"9","author":"J Algorta","year":"2008","unstructured":"Algorta J, Pena MA, Francisco S, Abajo Z, Sanz E. Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations. Trials. 2008;9:34.","journal-title":"Trials"},{"key":"979_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2165\/00002018-200023010-00002","volume":"23","author":"BJ Lipworth","year":"2000","unstructured":"Lipworth BJ, Jackson CM. Safety of inhaled and intranasal corticosteroids: lessons for the new millennium. Drug Saf. 2000;23:11\u201333.","journal-title":"Drug Saf"},{"key":"979_CR29","doi-asserted-by":"crossref","unstructured":"Luong A, Ow RA, Singh A, et al. Safety and effectiveness of a bioabsorbable steroid-releasing implant for the paranasal sinus ostia: a randomized clinical trial. JAMA Otolaryngol-- Head Neck Surg.2018; 144:28\u201335.","DOI":"10.1001\/jamaoto.2017.1859"},{"key":"979_CR30","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1002\/alr.22340","volume":"9","author":"EC Kuan","year":"2019","unstructured":"Kuan EC, Kovacs AJ, Workman AD, et al. Efficacy of fluticasone exhalation delivery system in the management of chronic rhinosinusitis: what is the evidence? Int Forum Allergy Rhinol. 2019;9:S16\u201321.","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-021-00979-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-021-00979-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-021-00979-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T14:28:28Z","timestamp":1646144908000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-021-00979-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["979"],"URL":"https:\/\/doi.org\/10.1007\/s13346-021-00979-6","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"assertion":[{"value":"5 April 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was carried out according to the Institutional Review Board recommendations as an exploratory protocol for 2 therapeutic options used routinely in our institution.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Consent form was obtained from each participant before enrolment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}