{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:39:54Z","timestamp":1793579994126,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["32172208"],"award-info":[{"award-number":["32172208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Central Funds Guiding the Local Science and Technology Development of China","award":["2020JH6\/10500002"],"award-info":[{"award-number":["2020JH6\/10500002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s13346-023-01428-2","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T15:02:59Z","timestamp":1695913379000},"page":"757-772","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes"],"prefix":"10.1007","volume":"14","author":[{"given":"Si-hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-jia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Ning","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"1428_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.fct.2014.06.010","volume":"71","author":"A Arya","year":"2014","unstructured":"Arya A, Jamil Al-Obaidi M, Shahid N, Bin Noordin M, Looi C, Wong W, et al. Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: a mechanistic study. Food Chem Toxicol. 2014;71:183\u201396. https:\/\/doi.org\/10.1016\/j.fct.2014.06.010.","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"1428_CR2","doi-asserted-by":"publisher","first-page":"43212","DOI":"10.1038\/srep43212","volume":"7","author":"M Liu","year":"2017","unstructured":"Liu M, Song X, Zhang J, Zhang C, Gao Z, Li S, et al. Protective effects on liver, kidney and pancreas of enzymatic-and acidic-hydrolysis of polysaccharides by spent mushroom compost (Hypsizigus marmoreus). Sci Rep-UK. 2017;7(1):43212. https:\/\/doi.org\/10.1038\/srep43212.","journal-title":"Sci Rep-UK"},{"key":"1428_CR3","doi-asserted-by":"publisher","unstructured":"Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan B, et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pr. 2022;183:109119. https:\/\/doi.org\/10.1016\/j.diabres.2021.109119.","DOI":"10.1016\/j.diabres.2021.109119"},{"issue":"27","key":"1428_CR4","doi-asserted-by":"publisher","first-page":"30607","DOI":"10.1021\/acsami.2c07488","volume":"14","author":"M Fan","year":"2022","unstructured":"Fan M, Zhang X, Zhao Y, Zhi J, Xu W, Yang Y, et al. Mn (II)-mediated self-assembly of tea polysaccharide nanoparticles and their functional role in mice with type 2 diabetes. ACS Appl Mater Interfaces. 2022;14(27):30607\u201317. https:\/\/doi.org\/10.1021\/acsami.2c07488.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"6","key":"1428_CR5","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/j.1463-1326.2006.00686.x","volume":"9","author":"D Russell-Jones","year":"2007","unstructured":"Russell-Jones D, Khan R. Insulin-associated weight gain in diabetes\u2013causes, effects and coping strategies. Diabetes Obes Metab. 2007;9(6):799\u2013812. https:\/\/doi.org\/10.1111\/j.1463-1326.2006.00686.x.","journal-title":"Diabetes Obes Metab"},{"key":"1428_CR6","doi-asserted-by":"publisher","unstructured":"Madi\u0107 V, Petrovi\u0107 A, Ju\u0161kovi\u0107 M, Jugovi\u0107 D, Djordjevi\u0107 L, Stojanovi\u0107 G, et al. Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes. J Ethnopharmacol. 2021;265:113210. https:\/\/doi.org\/10.1016\/j.jep.2020.113210.","DOI":"10.1016\/j.jep.2020.113210"},{"issue":"17","key":"1428_CR7","doi-asserted-by":"publisher","first-page":"19648","DOI":"10.1021\/acsami.1c01943","volume":"13","author":"M He","year":"2021","unstructured":"He M, Yu P, Hu Y, Zhang J, He M, Nie C, et al. Erythrocyte-membrane-enveloped biomineralized metal\u2013organic framework nanoparticles enable intravenous glucose-responsive insulin delivery. ACS Appl Mater Interfaces. 2021;13(17):19648\u201359. https:\/\/doi.org\/10.1021\/acsami.1c01943.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1428_CR8","doi-asserted-by":"publisher","unstructured":"Marton L, Pescinini-e-Salzedas L, Camargo M, Barbalho S, Haber J, Sinatora R, et al. The effects of curcumin on diabetes mellitus: a systematic review. Front Endocrinol. 2021;12:669448. https:\/\/doi.org\/10.3389\/fendo.2021.669448.","DOI":"10.3389\/fendo.2021.669448"},{"key":"1428_CR9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.biopha.2017.08.070","volume":"95","author":"E \u00d6zt\u00fcrk","year":"2017","unstructured":"\u00d6zt\u00fcrk E, Arslan A, Yerer M, Bishayee A. Resveratrol and diabetes: a critical review of clinical studies. Biomed Pharmacother. 2017;95:230\u20134. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.070.","journal-title":"Biomed Pharmacother"},{"key":"1428_CR10","doi-asserted-by":"publisher","unstructured":"Wang Y, Liu H, Zheng M, Yang Y, Ren H, Kong Y, et al. Berberine slows the progression of prediabetes to diabetes in zucker diabetic fatty rats by enhancing intestinal secretion of glucagon-like peptide-2 and improving the gut microbiota. Front Endocrinol. 2021;12:609134. https:\/\/doi.org\/10.3389\/fendo.2021.609134.","DOI":"10.3389\/fendo.2021.609134"},{"key":"1428_CR11","doi-asserted-by":"publisher","unstructured":"Noh J, Yang H, Jun M, Lee B. Puerarin attenuates obesity-induced inflammation and dyslipidemia by regulating macrophages and TNF-Alpha in obese mice. biomedicine. 2022;10(1):175. https:\/\/doi.org\/10.3390\/biomedicines10010175.","DOI":"10.3390\/biomedicines10010175"},{"issue":"8","key":"1428_CR12","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1142\/s0192415x185","volume":"46","author":"X Chen","year":"2018","unstructured":"Chen X, Yu J, Shi J. Management of diabetes mellitus with puerarin, a natural isoflavone from pueraria lobata. Am J Chinese Med. 2018;46(8):1771\u201389. https:\/\/doi.org\/10.1142\/s0192415x185.","journal-title":"Am J Chinese Med"},{"key":"1428_CR13","doi-asserted-by":"publisher","unstructured":"Deng X, Zhang H, Wang G, Xu D, Zhang W, Wang Q, et al. Colon-specific microspheres loaded with puerarin reduce tumorigenesis and metastasis in colitis-associated colorectal cancer. Int J Pharmaceut. 2019;570(C):118644. https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118644.","DOI":"10.1016\/j.ijpharm.2019.118644"},{"issue":"1","key":"1428_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ijpharm.2011.04.005","volume":"412","author":"A Bohr","year":"2011","unstructured":"Bohr A, Kristensen J, Stride E, Dyas M, Edirisinghe M. Preparation of microspheres containing low solubility drug compound by electrohydrodynamic spraying. Int J Pharmaceut. 2011;412(1):59\u201367. https:\/\/doi.org\/10.1016\/j.ijpharm.2011.04.005.","journal-title":"Int J Pharmaceut"},{"issue":"1","key":"1428_CR15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ijpharm.2006.05.054","volume":"323","author":"G Pasparakis","year":"2006","unstructured":"Pasparakis G, Bouropoulos N. Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate\u2013chitosan beads. Int J Pharmaceut. 2006;323(1):34\u201342. https:\/\/doi.org\/10.1016\/j.ijpharm.2006.05.054.","journal-title":"Int J Pharmaceut"},{"issue":"1\u20132","key":"1428_CR16","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ijpharm.2016.10.002","volume":"515","author":"Q Wang","year":"2016","unstructured":"Wang Q, Wang G, Zhou J, Gao L, Cui Y. Colon targeted oral drug delivery system based on alginate-chitosan microspheres loaded with icariin in the treatment of ulcerative colitis. Int J Pharmaceut. 2016;515(1\u20132):176\u201385. https:\/\/doi.org\/10.1016\/j.ijpharm.2016.10.002.","journal-title":"Int J Pharmaceut"},{"key":"1428_CR17","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.msec.2019.03.040","volume":"100","author":"Y Bi","year":"2019","unstructured":"Bi Y, Lin Z, Deng S. Fabrication and characterization of hydroxyapatite\/sodium alginate\/chitosan composite microspheres for drug delivery and bone tissue engineering. Mat Sci Eng C. 2019;100:576\u201383. https:\/\/doi.org\/10.1016\/j.msec.2019.03.040.","journal-title":"Mat Sci Eng C"},{"key":"1428_CR18","doi-asserted-by":"publisher","unstructured":"Sheng Y, Gao J, Yin Z, Kang J, Kong Y. Dual-drug delivery system based on the hydrogels of alginate and sodium carboxymethyl cellulose for colorectal cancer treatment. Carbohyd Polym. 2021;269:118325. https:\/\/doi.org\/10.1016\/j.carbpol.2021.118325.","DOI":"10.1016\/j.carbpol.2021.118325"},{"issue":"12","key":"1428_CR19","doi-asserted-by":"publisher","first-page":"5764","DOI":"10.3390\/md12125764","volume":"12","author":"J Hou","year":"2014","unstructured":"Hou J, Gao L, Meng F, Cui Y. Mucoadhesive microparticles for gastroretentive delivery: preparation, biodistribution and targeting evaluation. Mar Drugs. 2014;12(12):5764\u201387. https:\/\/doi.org\/10.3390\/md12125764.","journal-title":"Mar Drugs"},{"issue":"78","key":"1428_CR20","doi-asserted-by":"publisher","first-page":"10831","DOI":"10.1039\/C7CC05710E","volume":"53","author":"Y Long","year":"2017","unstructured":"Long Y, Xiao L, Cao Q, Shi X, Wang Y. Efficient incorporation of diverse components into metal organic frameworks via metal phenolic networks. Chem Commun. 2017;53(78):10831\u20134. https:\/\/doi.org\/10.1039\/C7CC05710E.","journal-title":"Chem Commun"},{"issue":"22","key":"1428_CR21","doi-asserted-by":"publisher","first-page":"3975","DOI":"10.1002\/cssc.201801546","volume":"11","author":"E Bartzoka","year":"2018","unstructured":"Bartzoka E, Lange H, Poce G, Crestini C. Stimuli-responsive tannin\u2013FeIII hybrid microcapsules demonstrated by the active release of an anti-tuberculosis agent. Chemsuschem. 2018;11(22):3975\u201391. https:\/\/doi.org\/10.1002\/cssc.201801546.","journal-title":"Chemsuschem"},{"issue":"4","key":"1428_CR22","doi-asserted-by":"publisher","first-page":"C560","DOI":"10.1111\/j.1750-3841.2011.02116.x","volume":"76","author":"C Kunyanga","year":"2011","unstructured":"Kunyanga C, Imungi J, Okoth M, Momanyi C, Biesalski H, Vadivel V. Antioxidant and antidiabetic properties of condensed tannins in acetonic extract of selected raw and processed indigenous food ingredients from kenya. J Food Sci. 2011;76(4):C560\u20137. https:\/\/doi.org\/10.1111\/j.1750-3841.2011.02116.x.","journal-title":"J Food Sci"},{"issue":"22","key":"1428_CR23","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1002\/anie.201311136","volume":"53","author":"J Guo","year":"2014","unstructured":"Guo J, Ping Y, Ejima H, Alt K, Meissner M, Richardson J, et al. Engineering multifunctional capsules through the assembly of metal-phenolic networks. Angew Chem Int Ed Engl. 2014;53(22):5546\u201351. https:\/\/doi.org\/10.1002\/anie.201311136.","journal-title":"Angew Chem Int Ed Engl"},{"issue":"45","key":"1428_CR24","doi-asserted-by":"publisher","first-page":"18918","DOI":"10.1039\/C5NR05573C","volume":"7","author":"J Lee","year":"2015","unstructured":"Lee J, Cho H, Choi J, Kim D, Hong D, Park J, et al. Chemical sporulation and germination: cytoprotective nanocoating of individual mammalian cells with a degradable tannic acid\u2013FeIII complex. Nanoscale. 2015;7(45):18918\u201322. https:\/\/doi.org\/10.1039\/C5NR05573C.","journal-title":"Nanoscale"},{"key":"1428_CR25","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.nantod.2016.12.012","volume":"12","author":"H Ejima","year":"2017","unstructured":"Ejima H, Richardson J, Caruso F. Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces. Nano Today. 2017;12:136\u201348. https:\/\/doi.org\/10.1016\/j.nantod.2016.12.012.","journal-title":"Nano Today"},{"issue":"28","key":"1428_CR26","doi-asserted-by":"publisher","first-page":"1700784","DOI":"10.1002\/adma.201700784","volume":"29","author":"B Kim","year":"2017","unstructured":"Kim B, Han S, Lee K, Choi I. Biphasic supramolecular self-assembly of ferric ions and tannic acid across interfaces for nanofilm formation. Adv Mater. 2017;29(28):1700784. https:\/\/doi.org\/10.1002\/adma.201700784.","journal-title":"Adv Mater"},{"issue":"6142","key":"1428_CR27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1126\/science.1237265","volume":"341","author":"H Ejima","year":"2013","unstructured":"Ejima H, Richardson J, Liang K, Best J, van Koeverden M, Such G, et al. One-step assembly of coordination complexes for versatile film and particle engineering. Science. 2013;341(6142):154\u20137. https:\/\/doi.org\/10.1126\/science.1237265.","journal-title":"Science"},{"key":"1428_CR28","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jconrel.2019.11.001","volume":"316","author":"S Regmi","year":"2019","unstructured":"Regmi S, Pathak S, Nepal M, Shrestha P, Park J, Kim J, et al. Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1\/Th17 differentiation. J Control Release. 2019;316:138\u201349. https:\/\/doi.org\/10.1016\/j.jconrel.2019.11.001.","journal-title":"J Control Release"},{"issue":"29","key":"1428_CR29","doi-asserted-by":"publisher","first-page":"33948","DOI":"10.1021\/acsami.1c09804","volume":"13","author":"X Wang","year":"2021","unstructured":"Wang X, Gu H, Zhang H, Xian J, Li J, Fu C, et al. Oral core\u2013shell nanoparticles embedded in hydrogel microspheres for the efficient site-specific delivery of magnolol and enhanced antiulcerative colitis therapy. ACS Appl Mater Interfaces. 2021;13(29):33948\u201361. https:\/\/doi.org\/10.1021\/acsami.1c09804.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"9","key":"1428_CR30","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1039\/d2bm00344a","volume":"10","author":"M Halder","year":"2022","unstructured":"Halder M, Bhatia Y, Singh Y. Self-assembled di- and tripeptide gels for the passive entrapment and pH-responsive, sustained release of an antidiabetic drug, glimepiride. Biomater Sci-UK. 2022;10(9):2248\u201362. https:\/\/doi.org\/10.1039\/d2bm00344a.","journal-title":"Biomater Sci-UK"},{"issue":"1","key":"1428_CR31","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/jbm.a.36794","volume":"108","author":"R Rodr\u00edguez-Rodr\u00edguez","year":"2020","unstructured":"Rodr\u00edguez-Rodr\u00edguez R, Velasquillo-Mart\u00ednez C, Knauth P, L\u00f3pez Z, Moreno-Valtierra M, Bravo-Madrigal J, et al. Sterilized chitosan-based composite hydrogels: physicochemical characterization and in vitro cytotoxicity. J Biomed Mater Res A. 2020;108(1):81\u201393. https:\/\/doi.org\/10.1002\/jbm.a.36794.","journal-title":"J Biomed Mater Res A"},{"key":"1428_CR32","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.biopha.2018.07.090","volume":"106","author":"S Tekula","year":"2018","unstructured":"Tekula S, Khurana A, Anchi P, Godugu C. Withaferin-A attenuates multiple low doses of Streptozotocin (MLD-STZ) induced type 1 diabetes. Biomed Pharmacother. 2018;106:1428\u201340. https:\/\/doi.org\/10.1016\/j.biopha.2018.07.090.","journal-title":"Biomed Pharmacother"},{"key":"1428_CR33","doi-asserted-by":"publisher","unstructured":"Fan L, Niu H, Zhao L, Yao R, He X, Lu B, et al. Purendan alleviates non-alcoholic fatty liver disease in aged type 2 diabetic rats via regulating mTOR\/S6K1\/SREBP-1c signaling pathway. Biomed Pharmacother. 2022;148:112697. https:\/\/doi.org\/10.1016\/j.biopha.2022.112697.","DOI":"10.1016\/j.biopha.2022.112697"},{"issue":"44","key":"1428_CR34","doi-asserted-by":"publisher","first-page":"52385","DOI":"10.1021\/acsami.1c15503","volume":"13","author":"H Lee","year":"2021","unstructured":"Lee H, Nguyen D, Kim N, Han S, Hong Y, Yun G, et al. Enzyme-mediated kinetic control of Fe3+\u2013tannic acid complexation for interface engineering. ACS Appl Mater Interfaces. 2021;13(44):52385\u201394. https:\/\/doi.org\/10.1021\/acsami.1c15503.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"16","key":"1428_CR35","doi-asserted-by":"publisher","first-page":"19507","DOI":"10.1021\/acsami.1c04118","volume":"13","author":"J Dong","year":"2021","unstructured":"Dong J, Chen W, Feng J, Liu X, Xu Y, Wang C, et al. Facile, smart, and degradable metal\u2013organic framework nanopesticides gated with FeIII-tannic acid networks in response to seven biological and environmental stimuli. ACS Appl Mater Interfaces. 2021;13(16):19507\u201320. https:\/\/doi.org\/10.1021\/acsami.1c04118.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"15","key":"1428_CR36","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1039\/B927369G","volume":"6","author":"V Kozlovskaya","year":"2010","unstructured":"Kozlovskaya V, Kharlampieva E, Drachuk I, Cheng D, Tsukruk VV. Responsive microcapsule reactors based on hydrogen-bonded tannic acid layer-by-layer assemblies. Soft Matter. 2010;6(15):3596\u2013608. https:\/\/doi.org\/10.1039\/B927369G.","journal-title":"Soft Matter"},{"issue":"7","key":"1428_CR37","doi-asserted-by":"publisher","first-page":"51647","DOI":"10.1002\/app.51647","volume":"139","author":"Y Li","year":"2022","unstructured":"Li Y, Wang C, Luan Y, Liu W, Chen T, Liu P, et al. Preparation of pH-responsive cellulose nanofibril\/sodium alginate based hydrogels for drug release. J Appl Polym Sci. 2022;139(7):51647. https:\/\/doi.org\/10.1002\/app.51647.","journal-title":"J Appl Polym Sci"},{"issue":"10","key":"1428_CR38","doi-asserted-by":"publisher","first-page":"11653","DOI":"10.1021\/acsnano.9b05521","volume":"13","author":"J Chen","year":"2019","unstructured":"Chen J, Li J, Zhou J, Lin Z, Cavalieri F, Czuba-Wojnilowicz E, et al. Metal\u2013phenolic coatings as a platform to trigger endosomal escape of nanoparticles. ACS Nano. 2019;13(10):11653\u201364. https:\/\/doi.org\/10.1021\/acsnano.9b05521.","journal-title":"ACS Nano"},{"key":"1428_CR39","doi-asserted-by":"publisher","unstructured":"Zhang C, Peng S, Hong S, Chen Q, Zeng X, Rong L, et al. Biomimetic carbon monoxide nanogenerator ameliorates streptozotocin induced type 1 diabetes in mice. Biomaterials. 2020;245:119986. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.119986.","DOI":"10.1016\/j.biomaterials.2020.119986"},{"issue":"33","key":"1428_CR40","doi-asserted-by":"publisher","first-page":"29604","DOI":"10.1021\/acsami.9b10346","volume":"11","author":"Y Zhuang","year":"2019","unstructured":"Zhuang Y, Yang X, Li Y, Chen Y, Peng X, Yu L, et al. Sustained release strategy designed for lixisenatide delivery to synchronously treat diabetes and associated complications. ACS Appl Mater Interfaces. 2019;11(33):29604\u201318. https:\/\/doi.org\/10.1021\/acsami.9b10346.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"3","key":"1428_CR41","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.kint.2017.08.033","volume":"93","author":"Y Xie","year":"2018","unstructured":"Xie Y, Bowe B, Li T, Xian H, Yan Y, Al-Aly Z. Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus. Kidney Int. 2018;93(3):741\u201352. https:\/\/doi.org\/10.1016\/j.kint.2017.08.033.","journal-title":"Kidney Int"},{"issue":"6","key":"1428_CR42","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1136\/heartjnl-2016-310112","volume":"103","author":"Y Matsue","year":"2017","unstructured":"Matsue Y, van der Meer P, Damman K, Metra M, Connor C, Ponikowski P, et al. Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure. Heart. 2017;103(6):407\u201314. https:\/\/doi.org\/10.1136\/heartjnl-2016-310112.","journal-title":"Heart"},{"key":"1428_CR43","doi-asserted-by":"publisher","unstructured":"Lan Q, Zheng L, Zhou X, Wu H, Buys N, Liu Z, et al. The value of blood urea nitrogen in the prediction of risks of cardiovascular disease in an older population. Front Cardiovasc Med. 2021;8:614117. https:\/\/doi.org\/10.3389\/fcvm.2021.614117.","DOI":"10.3389\/fcvm.2021.614117"},{"key":"1428_CR44","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2147\/clep.S107060","volume":"8","author":"C Schneider","year":"2016","unstructured":"Schneider C, Coll B, Jick S, Meier C. Doubling of serum creatinine and the risk of cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes mellitus: a cohort study. Clin Epidemiol. 2016;8:177\u201384. https:\/\/doi.org\/10.2147\/clep.S107060.","journal-title":"Clin Epidemiol"},{"key":"1428_CR45","doi-asserted-by":"publisher","unstructured":"Liu M, Wang Z, Feng D, Shang Y, Li X, Liu J, et al. An insulin-inspired supramolecular hydrogel for prevention of type 1 diabetes. Adv Sci. 2021;8(10):2003599. https:\/\/doi.org\/10.1002\/advs.202003599.","DOI":"10.1002\/advs.202003599"},{"issue":"6","key":"1428_CR46","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1039\/D0FO02761H","volume":"12","author":"D Xu","year":"2021","unstructured":"Xu D, Guo X, Zeng Z, Wang Y, Qiu J. Puerarin improves hepatic glucose and lipid homeostasis in vitro and in vivo by regulating the AMPK pathway. Food Funct. 2021;12(6):2726\u201340. https:\/\/doi.org\/10.1039\/D0FO02761H.","journal-title":"Food Funct"},{"key":"1428_CR47","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ejps.2016.06.018","volume":"92","author":"J Wu","year":"2016","unstructured":"Wu J, Williams G, Branford-White C, Li H, Li Y, Zhu L. Liraglutide-loaded poly (lactic-co-glycolic acid) microspheres: preparation and in vivo evaluation. Eur J of Pharm Sci. 2016;92:28\u201338. https:\/\/doi.org\/10.1016\/j.ejps.2016.06.018.","journal-title":"Eur J of Pharm Sci"},{"key":"1428_CR48","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbr.2017.11.015","volume":"339","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Huang N, Yan F, Jin H, Zhou S, Shi J, et al. Diabetes mellitus and Alzheimer\u2019s disease: GSK-3\u03b2 as a potential link. Behav Brain Res. 2018;339:57\u201365. https:\/\/doi.org\/10.1016\/j.bbr.2017.11.015.","journal-title":"Behav Brain Res"},{"issue":"9","key":"1428_CR49","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s00018-007-7006-1","volume":"64","author":"S Mandard","year":"2007","unstructured":"Mandard S, Stienstra R, Escher P, Tan N, Kim I, Gonzalez F, et al. Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. Cell Mol Life Sci. 2007;64(9):1145\u201357. https:\/\/doi.org\/10.1007\/s00018-007-7006-1.","journal-title":"Cell Mol Life Sci"},{"issue":"32","key":"1428_CR50","doi-asserted-by":"publisher","first-page":"9178","DOI":"10.1021\/acs.jafc.0c06831","volume":"69","author":"J Yang","year":"2021","unstructured":"Yang J, Zhang T, Dong Z, Shi H, Xu J, Mao X, et al. Dietary supplementation with exogenous sea-cucumber-derived ceramides and glucosylceramides alleviates insulin resistance in high-fructose-diet-fed rats by upregulating the IRS\/PI3K\/Akt signaling pathway. J Agric Food Chem. 2021;69(32):9178\u201387. https:\/\/doi.org\/10.1021\/acs.jafc.0c06831.","journal-title":"J Agric Food Chem"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-023-01428-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-023-01428-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-023-01428-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T14:12:57Z","timestamp":1706191977000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-023-01428-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["1428"],"URL":"https:\/\/doi.org\/10.1007\/s13346-023-01428-2","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]},"assertion":[{"value":"1 September 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures of this investigation were approved by the Experimental Animal Ethics Committee of National Engineering Research Center of Seafood of Dalian Polytechnic University (Dalian, China, Animal JN. No DLPU2022010).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors have read and agreed to the published version of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}