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Res."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Febuxostat (FBX), a potent xanthine oxidase inhibitor, is widely used as a blood uric acid-reducing agent and has recently shown a promising repurposing outcome as an anti-cancer. FBX is known for its poor water solubility, which is the main cause of its weak oral bioavailability. In a previous study, we developed a binary system complex between FBX and sulfobutylether-\u03b2-cyclodextrin (SBE7-\u03b2CD) with improved dissolution behavior. The aim of the current study was to investigate the effect of incorporating a water-soluble polymer with a binary system forming a ternary one, on further enhancement of FBX solubility and dissolution rate. In vivo oral bioavailability was also studied using LC\u2013MS\/MS chromatography. The polymer screening study revealed a marked increment in the solubility of FBX with SBE7-\u03b2CD in the presence of 5% w\/v polyethylene glycol (PEG 6000). In vitro release profile showed a significant increase in the dissolution rate of FBX from FBX ternary complex (FTC). Oral in vivo bioavailability of prepared FTC showed more than threefold enhancement in <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> value (17.05\u2009\u00b1\u20092.6\u00a0\u00b5g\/mL) compared to pure FBX C<jats:sub>max<\/jats:sub> value (5.013\u2009\u00b1\u20090.417\u00a0\u00b5g\/mL) with 257% rise in bioavailability. In conclusion, the association of water-soluble polymers with FBX and SBE7-\u03b2CD system could significantly improve therapeutic applications of the drug.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s13346-023-01496-4","type":"journal-article","created":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T17:01:13Z","timestamp":1704646873000},"page":"1909-1922","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Febuxostat ternary inclusion complex using SBE7-\u03b2CD in presence of a water-soluble polymer: physicochemical characterization, in vitro dissolution, and in vivo evaluation"],"prefix":"10.1007","volume":"14","author":[{"given":"Wedad","family":"Sakran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Abdel-Hakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-4036","authenticated-orcid":false,"given":"Mohammed S.","family":"Teiama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania S.","family":"Abdel-Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,7]]},"reference":[{"key":"1496_CR1","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1016\/j.clinthera.2009.11.033","volume":"31","author":"ME Ernst","year":"2009","unstructured":"Ernst ME, Fravel MA. 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