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Res."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cerebrovascular impairment represents one of the main causes of death worldwide with a mortality rate of 5.5 million per year. The disability of 50% of surviving patients has high social impacts and costs in long period treatment for national healthcare systems. For these reasons, the efficacious clinical treatment of patients, with brain ischemic stroke, remains a medical need. To this aim, a liposome nanomedicine, with monosialic ganglioside type 1 (GM1), OX26 (an anti-transferrin receptor antibody), and CDP-choline (a neurotrophic drug) (CDP-choline\/OX26Lip) was prepared. CDP-choline\/OX26Lip were prepared by a freeze and thaw method and then extruded through polycarbonate filters, to have narrow size distributed liposomes of\u2009~80\u00a0nm. CDP-choline\/OX26Lip were stable in human serum, they had suitable pharmacokinetic properties, and 30.0\u2009\u00b1\u20094.2% of the injected drug was still present in the blood stream 12\u00a0h after its systemic injection. The post-ischemic therapeutic effect of CDP-choline\/OX26Lip is higher than CDP-choline\/Lip, thus showing a significantly high survival rate of the re-perfused post-ischemic rats, i.e. 96% and 78% after 8\u00a0days. The treatment with CDP-choline\/OX26Lip significantly decreased the peroxidation rate of\u2009~5-times compared to CDP-choline\/Lip; and the resulting conjugated dienes, that was 13.9\u2009\u00b1\u20091.1\u00a0mmol\/mg proteins for CDP-choline\/Lip and 3.1\u2009\u00b1\u20090.8 for CDP-choline\/OX26Lip. OX26 increased the accumulation of GM1-liposomes in the brain tissues and thus the efficacious of CDP-choline. Therefore, this nanomedicine may represent a strategy for the reassessment of CDP-choline to treat post-ischemic events caused by brain stroke, and respond to a significant clinical need.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s13346-024-01556-3","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T16:33:14Z","timestamp":1710347594000},"page":"2771-2787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-6653","authenticated-orcid":false,"given":"Nicola","family":"d\u2019Avanzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-9879","authenticated-orcid":false,"given":"Donatella","family":"Paolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-8610","authenticated-orcid":false,"given":"Antonella","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-1750","authenticated-orcid":false,"given":"Luigi","family":"Ciriolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-8643","authenticated-orcid":false,"given":"Antonia","family":"Mancuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5510-7599","authenticated-orcid":false,"given":"Maria Chiara","family":"Christiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-0845","authenticated-orcid":false,"given":"Anna Maria","family":"Tolomeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-5429","authenticated-orcid":false,"given":"Christian","family":"Celia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-7050","authenticated-orcid":false,"given":"Xiaoyong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-817X","authenticated-orcid":false,"given":"Massimo","family":"Fresta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"1556_CR1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","volume":"20","author":"VL Feigin","year":"2021","unstructured":"Feigin VL, Stark BA, Johnson CO, et al. 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