{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:09:03Z","timestamp":1779358143530,"version":"3.51.4"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s13346-024-01664-0","type":"journal-article","created":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T17:01:35Z","timestamp":1720371695000},"page":"1221-1234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of a Zn-based metalorganic framework doped with benznidazole on acute experimental Trypanosoma cruzi infection"],"prefix":"10.1007","volume":"15","author":[{"given":"Anah\u00ed","family":"Sosa-Arroniz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aracely","family":"L\u00f3pez-Monteon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Pe\u00f1a-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Rivera-Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Torres-Montero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Ramos-Ligonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,7]]},"reference":[{"issue":"1","key":"1664_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.idc.2018.10.015","volume":"33","author":"LE Echeverria","year":"2019","unstructured":"Echeverria LE, Morillo CA. American Trypanosomiasis (Chagas Disease). Infect Dis Clin North Am. 2019;33(1):119\u201334. https:\/\/doi.org\/10.1016\/j.idc.2018.10.015","journal-title":"Infect Dis Clin North Am"},{"issue":"2","key":"1664_CR2","doi-asserted-by":"publisher","first-page":"e0015221","DOI":"10.1128\/cmr.00152-21","volume":"35","author":"A Abras","year":"2022","unstructured":"Abras A, Ballart C, Fern\u00e1ndez-Ar\u00e9valo A, Pinazo MJ, Gasc\u00f3n J, Mu\u00f1oz C, G\u00e1llego M. Worldwide Control and Management of Chagas Disease in a new era of globalization: a close look at Congenital Trypanosoma Cruzi Infection. Clin Microbiol Rev. 2022;35(2):e0015221. https:\/\/doi.org\/10.1128\/cmr.00152-21","journal-title":"Clin Microbiol Rev"},{"issue":"10115","key":"1664_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","volume":"391","author":"JA P\u00e9rez-Molina","year":"2018","unstructured":"P\u00e9rez-Molina JA, Molina I. Chagas disease. Lancet. 2018;391(10115):82\u201394. https:\/\/doi.org\/10.1016\/S0140-6736(17)31612-4","journal-title":"Lancet"},{"issue":"11","key":"1664_CR4","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.amjmed.2020.05.022","volume":"133","author":"RM Mills","year":"2020","unstructured":"Mills RM. Chagas Disease: epidemiology and barriers to treatment. Am J Med. 2020;133(11):1262\u20135. https:\/\/doi.org\/10.1016\/j.amjmed.2020.05.022","journal-title":"Am J Med"},{"key":"1664_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ijpddr.2019.11.004","volume":"12","author":"V Ribeiro","year":"2020","unstructured":"Ribeiro V, Dias N, Paiva T, Hagstr\u00f6m-Bex L, Nitz N, Pratesi R, Hecht M. Current trends in the pharmacological management of Chagas disease. Int J Parasitol Drugs Drug Resist. 2020;12:7\u201317. https:\/\/doi.org\/10.1016\/j.ijpddr.2019.11.004","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"1664_CR6","doi-asserted-by":"publisher","first-page":"6407","DOI":"10.2147\/IJN.S206109","volume":"14","author":"C Quijia Quezada","year":"2019","unstructured":"Quijia Quezada C, Azevedo CS, Charneau S, Santana JM, Chorilli M, Carneiro MB, Bastos IMD. Advances in nanocarriers as drug delivery systems in Chagas disease. Int J Nanomed. 2019;14:6407\u201324. https:\/\/doi.org\/10.2147\/IJN.S206109","journal-title":"Int J Nanomed"},{"issue":"26","key":"1664_CR7","doi-asserted-by":"publisher","first-page":"9950","DOI":"10.1039\/d2dt00994c","volume":"51","author":"D De","year":"2022","unstructured":"De D, Sahoo P. The impact of MOFs in pH-dependent drug delivery systems: progress in the last decade. Dalton Trans. 2022;51(26):9950\u201365. https:\/\/doi.org\/10.1039\/d2dt00994c","journal-title":"Dalton Trans"},{"key":"1664_CR8","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.matchemphys.2018.11.017","volume":"223","author":"R Pe\u00f1a-Rodr\u00edguez","year":"2019","unstructured":"Pe\u00f1a-Rodr\u00edguez R, Molina-Gonz\u00e1lez J, Desirena-Enrriquez H, Rivera JM, Castillo-Blum SE. Tunable luminescence modulation and warm light emission of ZN-MOF (4,4\u2032-bipyridyl and zinc acetate) doped with EU3\u2009+\u2009and TB3+. Mater Chem Phys. 2019;223:494\u2013502. https:\/\/doi.org\/10.1016\/j.matchemphys.2018.11.017","journal-title":"Mater Chem Phys"},{"key":"1664_CR9","doi-asserted-by":"crossref","unstructured":"Morales-Baez M, Rivera-Villanueva JM, L\u00f3pez-Monteon A, Pe\u00f1a-Rodr\u00edguez R, Trigos \u00c1, Ramos-Ligonio A. Trypanocidal Effect of Nano MOFs-EP on circulating forms of Trypanosoma Cruzi. Iran J Parasitol. 2020 Jan-Mar;15(1):115\u201323.","DOI":"10.18502\/ijpa.v15i1.2534"},{"issue":"6","key":"1664_CR10","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/ptr.3653","volume":"26","author":"A Ramos-Ligonio","year":"2012","unstructured":"Ramos-Ligonio A, L\u00f3pez-Monteon A, Trigos A. Trypanocidal activity of ergosterol peroxide from Pleurotus Ostreatus. Phytother Res. 2012;26(6):938\u201343. https:\/\/doi.org\/10.1002\/ptr.3653","journal-title":"Phytother Res"},{"issue":"1","key":"1664_CR11","doi-asserted-by":"publisher","first-page":"16815","DOI":"10.1038\/s41598-020-73848-w","volume":"10","author":"LR de Moura Ferraz","year":"2020","unstructured":"de Moura Ferraz LR, Tabosa A\u00c9GA, da Silva Nascimento DDS, Ferreira AS, de Albuquerque Wanderley Sales V, Silva JYR, J\u00fanior SA, Rolim LA, de Souza Pereira JJ, Rolim-Neto PJ. ZIF-8 as a promising drug delivery system for benznidazole: development, characterization, in vitro dialysis release and cytotoxicity. Sci Rep. 2020;10(1):16815. https:\/\/doi.org\/10.1038\/s41598-020-73848-w","journal-title":"Sci Rep"},{"key":"1664_CR12","doi-asserted-by":"publisher","unstructured":"Ortiz-Islas E, Sosa-Arr\u00f3niz A, Manr\u00edquez-Ram\u00edrez ME, Rodr\u00edguez-P\u00e9rez CE, Tzompantzi F, Padilla J. Mesoporous silica nanoparticles functionalized with folic acid for targeted release CIS-PT to glioblastoma cells. Reviews on Advanced Materials Science, 2021; 60(1), 25\u201337. https:\/\/doi.org\/10.1515\/rams-2021-0009) e.","DOI":"10.1515\/rams-2021-0009"},{"key":"1664_CR13","unstructured":"Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 2010 May-Jun;67(3):217\u201323."},{"issue":"6","key":"1664_CR14","doi-asserted-by":"publisher","first-page":"838","DOI":"10.3390\/pathogens12060838.)","volume":"12","author":"G Kr\u00f3l","year":"2023","unstructured":"Kr\u00f3l G, Fortunka K, Majchrzak M, Piktel E, Paprocka P, Ma\u0144kowska A, Lesiak A, Karasi\u0144ski M, Strzelecka A, Durna\u015b B, Bucki R. Metallic nanoparticles and Core-Shell Nanosystems in the treatment, diagnosis, and Prevention of Parasitic diseases. Pathogens. 2023;12(6):838. https:\/\/doi.org\/10.3390\/pathogens12060838.)","journal-title":"Pathogens"},{"issue":"5","key":"1664_CR15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/14787210.2021.1834849","volume":"19","author":"I Losada Galv\u00e1n","year":"2021","unstructured":"Losada Galv\u00e1n I, Alonso-Padilla J, Cort\u00e9s-Serra N, Alonso-Vega C, Gasc\u00f3n J, Pinazo MJ. Benznidazole for the treatment of Chagas disease. Expert Rev Anti Infect Ther. 2021;19(5):547\u201356. https:\/\/doi.org\/10.1080\/14787210.2021.1834849","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"8","key":"1664_CR16","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3390\/ph16081163","volume":"16","author":"DF Paiva","year":"2023","unstructured":"Paiva DF, Matos APDS, Gar\u00f3falo DA, do Nascimento T, Monteiro MSSB, Santos-Oliveira R, Ricci-Junior E. Use of Nanocarriers containing antitrypanosomal drugs for the treatment of Chagas Disease. Pharmaceuticals (Basel). 2023;16(8):1163. https:\/\/doi.org\/10.3390\/ph16081163","journal-title":"Pharmaceuticals (Basel)"},{"issue":"4","key":"1664_CR17","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.3390\/molecules19044145","volume":"19","author":"EM Bezerra","year":"2014","unstructured":"Bezerra EM, Bezerra-Neto JR, Sales FA, dos Santos RP, Martins AM, de Lima-Neto P, Caetano EW, Albuquerque EL, Freire VN. Optical absorption of the antitrypanocidal drug benznidazole in water. Molecules. 2014;19(4):4145\u201356. https:\/\/doi.org\/10.3390\/molecules19044145","journal-title":"Molecules"},{"key":"1664_CR18","doi-asserted-by":"publisher","first-page":"782","DOI":"10.5829\/idosi.mejsr.2013.16.06.75176","volume":"16","author":"G Yadav","year":"2013","unstructured":"Yadav G, Bansal M, Thakur N, Khare S, Khare P. Multilayer tablets and their drug release kinetic models for oral controlled drug delivery system. Middle-East J Sci Res. 2013;16:782\u201395. https:\/\/doi.org\/10.5829\/idosi.mejsr.2013.16.06.75176","journal-title":"Middle-East J Sci Res"},{"issue":"2\u2013s","key":"1664_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.22270\/jddt.v9i2-s.2471","volume":"9","author":"N Rayakwar","year":"2019","unstructured":"Rayakwar N, Dangi YS. Development and characterization of controlled release bilayered tablets of citicoline sodium. J Drug Delivery Ther. 2019;9(2\u2013s):125\u201331. https:\/\/jddtonline.info\/index.php\/jddt\/article\/view\/2471","journal-title":"J Drug Delivery Ther"},{"issue":"3","key":"1664_CR20","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/anie.201906755","volume":"59","author":"T Fri\u0161\u010di\u0107","year":"2020","unstructured":"Fri\u0161\u010di\u0107 T, Mottillo C, Titi HM. Mechanochemistry for Synthesis. Angew Chem Int Ed Engl. 2020;59(3):1018\u201329. https:\/\/doi.org\/10.1002\/anie.201906755","journal-title":"Angew Chem Int Ed Engl"},{"issue":"1","key":"1664_CR21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3390\/molecules27010100","volume":"27","author":"R Safdar Ali","year":"2021","unstructured":"Safdar Ali R, Meng H, Li Z. Zinc-based Metal-Organic frameworks in Drug Delivery, Cell Imaging, and sensing. Molecules. 2021;27(1):100. https:\/\/doi.org\/10.3390\/molecules27010100","journal-title":"Molecules"},{"issue":"3","key":"1664_CR22","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1080\/03602532.2019.1632887","volume":"51","author":"S Bahrani","year":"2019","unstructured":"Bahrani S, Hashemi SA, Mousavi SM, Azhdari R. Zinc-based metal\u2013organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study. Drug Metab Rev. 2019;51(3):356\u201377. https:\/\/doi.org\/10.1080\/03602532.2019.1632887","journal-title":"Drug Metab Rev"},{"key":"1664_CR23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.trac.2019.06.007","volume":"118","author":"M Safaei","year":"2019","unstructured":"Safaei M, Foroughi MM, Ebrahimpoor N, Jahani S, Omidi A, Khatami M. A review on metal-organic frameworks: synthesis and applications. Trends Anal Chem. 2019;118:401\u201325. https:\/\/doi.org\/10.1016\/j.trac.2019.06.007","journal-title":"Trends Anal Chem"},{"issue":"30","key":"1664_CR24","doi-asserted-by":"publisher","first-page":"5925","DOI":"10.1039\/d1tb01044a","volume":"9","author":"N Singh","year":"2021","unstructured":"Singh N, Qutub S, Khashab NM. Biocompatibility and biodegradability of metal organic frameworks for biomedical applications. J Mater Chem B. 2021;9(30):5925\u201334. https:\/\/doi.org\/10.1039\/d1tb01044a","journal-title":"J Mater Chem B"},{"key":"1664_CR25","doi-asserted-by":"publisher","unstructured":"Keskin S, K\u0131z\u0131lel S, Biomedical Applications of Metal Organic Frameworks. Ind Eng Chem Res. 2011;50:1799\u2013812. https:\/\/doi.org\/10.1021\/ie101312k","DOI":"10.1021\/ie101312k"},{"issue":"2","key":"1664_CR26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3390\/nano12020277","volume":"12","author":"M Al Sharabati","year":"2022","unstructured":"Al Sharabati M, Sabouni R, Husseini GA. Biomedical Applications of Metal-Organic frameworks for Disease diagnosis and drug delivery: a review. Nanomaterials (Basel). 2022;12(2):277. https:\/\/doi.org\/10.3390\/nano12020277","journal-title":"Nanomaterials (Basel)"},{"issue":"10","key":"1664_CR27","doi-asserted-by":"publisher","first-page":"e1906846","DOI":"10.1002\/smll.201906846","volume":"16","author":"J Yang","year":"2020","unstructured":"Yang J, Yang YW. Metal-Organic frameworks for Biomedical Applications. Small. 2020;16(10):e1906846. https:\/\/doi.org\/10.1002\/smll.201906846","journal-title":"Small"},{"issue":"21","key":"1664_CR28","doi-asserted-by":"publisher","first-page":"23697","DOI":"10.1021\/acsami.0c04363","volume":"12","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Wang J, Cai X, Ding P, Lv H, Pei R. Metal-Organic frameworks with enhanced photodynamic therapy: synthesis, erythrocyte membrane camouflage, and aptamer-targeted aggregation. ACS Appl Mater Interfaces. 2020;12(21):23697\u2013706. https:\/\/doi.org\/10.1021\/acsami.0c04363","journal-title":"ACS Appl Mater Interfaces"},{"issue":"18","key":"1664_CR29","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.3390\/ma16186143","volume":"16","author":"C P\u0103un","year":"2023","unstructured":"P\u0103un C, Motelic\u0103 L, Ficai D, Ficai A, Andronescu E. Metal-Organic frameworks: versatile platforms for Biomedical innovations. Mater (Basel). 2023;16(18):6143. https:\/\/doi.org\/10.3390\/ma16186143","journal-title":"Mater (Basel)"},{"issue":"21","key":"1664_CR30","doi-asserted-by":"publisher","first-page":"13364","DOI":"10.1021\/acs.inorgchem.8b01955","volume":"57","author":"R Abazari","year":"2018","unstructured":"Abazari R, Ataei F, Morsali A, Carpenter-Warren CL, Mehdizadeh K, Slawin AMZ. Chitosan Immobilization on Bio-MOF nanostructures: a Biocompatible PH-Responsive nanocarrier for doxorubicin release on MCF-7 cell lines of human breast cancer. Inorg Chem. 2018;57(21):13364\u201379. https:\/\/doi.org\/10.1021\/acs.inorgchem.8b01955","journal-title":"Inorg Chem"},{"issue":"8","key":"1664_CR31","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1039\/c3cc47666a","volume":"50","author":"H Ren","year":"2014","unstructured":"Ren H, Zhang L, An J, Wang T, Li L, Si X, He L, Wu X, Wang C, Su Z. Polyacrylic acid@Zeolitic Imidazolate Framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release. Chem Commun. 2014;50(8):1000\u20132. https:\/\/doi.org\/10.1039\/c3cc47666a","journal-title":"Chem Commun"},{"issue":"6","key":"1664_CR32","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1002\/chem.201405380","volume":"21","author":"A Ruyra","year":"2014","unstructured":"Ruyra A, Yazdi A, Esp\u00edn J, Carn\u00e9-S\u00e1nchez A, Roher N, Lorenzo J, Imaz I, Maspoch D. Synthesis, culture medium stability, and in vitro and in vivo zebrafish embryo toxicity of Metal-Organic framework nanoparticles. Chemistry: Eur J. 2014;21(6):2508\u201318. https:\/\/doi.org\/10.1002\/chem.201405380","journal-title":"Chemistry: Eur J"},{"key":"1664_CR33","doi-asserted-by":"publisher","unstructured":"L\u00e1zaro A, Haddad S, Sacca S, Orellana-Tavra C, Fairen-Jimenez D, Forgan RS. Selective surface PEGylation of UIO-66 nanoparticles for enhanced stability, cell uptake, and PH-Responsive drug delivery Chem. 2017; 2(4):561\u201378. https:\/\/doi.org\/10.1016\/j.chempr.2017.02.005","DOI":"10.1016\/j.chempr.2017.02.005"},{"issue":"2","key":"1664_CR34","doi-asserted-by":"publisher","first-page":"e1852","DOI":"10.1002\/wnan.1852","volume":"15","author":"AC Mengarda","year":"2023","unstructured":"Mengarda AC, Iles B, Longo JPF, de Moraes J. Recent approaches in nanocarrier-based therapies for neglected tropical diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023;15(2):e1852. https:\/\/doi.org\/10.1002\/wnan.1852","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"12","key":"1664_CR35","doi-asserted-by":"publisher","first-page":"e0006119","DOI":"10.1371\/journal.pntd.0006119","volume":"11","author":"MS Rial","year":"2017","unstructured":"Rial MS, Scalise ML, Arrua EC, Esteva M, Salomon CJ, Fichera LE. Elucidating the impact of low doses of nano-formulated benznidazole in acute experimental Chagas disease. PLoS Negl Trop Dis. 2017;11(12):e0006119. https:\/\/doi.org\/10.1371\/journal.pntd.0006119","journal-title":"PLoS Negl Trop Dis"},{"key":"1664_CR36","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.actatropica.2018.02.008.)","volume":"185","author":"LRM Ferraz","year":"2018","unstructured":"Ferraz LRM, Alves A\u00c9G, Nascimento DDSDS, Amariz IAE, Ferreira AS, Costa SPM, Rolim LA, Lima \u00c1AN, Rolim Neto PJ. Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole. Acta Trop. 2018;185:127\u201332. https:\/\/doi.org\/10.1016\/j.actatropica.2018.02.008.)","journal-title":"Acta Trop"},{"key":"1664_CR37","unstructured":"LiverTox. Clinical and Research Information on Drug Induced Liver Injury [Internet]. Bethesda (MD). Benznidazole: National Institute of Diabetes and Digestive and Kidney Diseases; 2012-."},{"issue":"1","key":"1664_CR38","first-page":"69","volume":"1","author":"JA\u00c1 Illanes","year":"2013","unstructured":"Illanes JA\u00c1, Choquehuanca BM, Pinell GR. Determinaci\u00f3n De valores de referencia hematol\u00f3gicos y bioqu\u00edmicos en ratones albinos Swiss criados y reproducidos en El Bioterio De La Facultad De Ciencias Farmac\u00e9uticas Y Bioqu\u00edmicas. La Paz - Bolivia Revista CON-CIENCIA. 2013;1(1):69\u201383. http:\/\/www.scielo.org.bo\/pdf\/rcfb\/v1n1\/v1n1_a09.pdf","journal-title":"La Paz - Bolivia Revista CON-CIENCIA"},{"key":"1664_CR39","unstructured":"Morales-Baez M, Rivera-Villanueva JM, L\u00f3pez-Monteon A, Pe\u00f1a-Rodr\u00edguez R, Trigos \u00c1, Ramos-Ligonio A. Oral administration of EP@Zn-MOF reduces parasitemia in mice infected with Trypanosoma Cruzi 2024; in preparation."},{"issue":"2","key":"1664_CR40","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/pharmaceutics14020378","volume":"14","author":"I Han","year":"2022","unstructured":"Han I, Choi SA, Lee DN. Therapeutic application of Metal-Organic frameworks composed of copper, Cobalt, and zinc: their anticancer activity and mechanism. Pharmaceutics. 2022;14(2):378. https:\/\/doi.org\/10.3390\/pharmaceutics14020378. PMID: 35214110; PMCID: PMC8877445.","journal-title":"Pharmaceutics"},{"key":"1664_CR41","doi-asserted-by":"publisher","first-page":"123272","DOI":"10.1016\/j.ijbiomac.2023.123272","volume":"230","author":"ACJ Oliveira","year":"2023","unstructured":"Oliveira ACJ, Silva EB, Oliveira TC, Ribeiro FOS, Nadvorny D, Oliveira JWF, Borrego-S\u00e1nchez A, Rodrigues KADF, Silva MS, Rolim-Neto PJ, Viseras C, Silva-Filho EC, Silva DAD, Chaves LL, Soares MFR, Soares-Sobrinho JL. pH-responsive phthalate cashew gum nanoparticles for improving drugs delivery and anti-trypanosoma cruzi efficacy. Int J Biol Macromol. 2023;230:123272. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.123272. Epub 2023 Jan 14. PMID: 36649864.","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"1664_CR42","doi-asserted-by":"publisher","first-page":"388","DOI":"10.4269\/ajtmh.15-0889","volume":"95","author":"ML Scalise","year":"2016","unstructured":"Scalise ML, Arr\u00faa EC, Rial MS, Esteva MI, Salomon CJ, Fichera LE. Promising efficacy of Benznidazole nanoparticles in Acute Trypanosoma Cruzi Murine Model: In-Vitro and In-Vivo studies. Am J Trop Med Hyg. 2016;95(2):388\u201393. https:\/\/doi.org\/10.4269\/ajtmh.15-0889. Epub 2016 May 31. PMID: 27246447; PMCID: PMC4973187.","journal-title":"Am J Trop Med Hyg"},{"key":"1664_CR43","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3762\/bjnano.14.66","volume":"14","author":"G Muraca","year":"2023","unstructured":"Muraca G, Ruiz ME, Gambaro RC, Scioli-Montoto S, Sbaraglini ML, Padula G, Cisneros JS, Chain CY, \u00c1lvarez VA, Huck-Iriart C, Castro GR, Pi\u00f1ero MB, Marchetto MI, Alba Soto C, Islan GA, Talevi A. Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies. Beilstein J Nanotechnol. 2023;14:804\u201318. https:\/\/doi.org\/10.3762\/bjnano.14.66. PMID: 37533841; PMCID: PMC10390827.","journal-title":"Beilstein J Nanotechnol"},{"key":"1664_CR44","doi-asserted-by":"publisher","first-page":"123120","DOI":"10.1016\/j.ijpharm.2023.123120","volume":"642","author":"EC Arrua","year":"2023","unstructured":"Arrua EC, Hartwig O, Loretz B, Murgia X, Ho DK, Bastiat G, Lehr CM, Salomon CJ. Formulation of benznidazole-lipid nanocapsules: drug release, permeability, biocompatibility, and stability studies. Int J Pharm. 2023;642:123120. https:\/\/doi.org\/10.1016\/j.ijpharm.2023.123120. Epub 2023 Jun 10. PMID: 37307960.","journal-title":"Int J Pharm"},{"key":"1664_CR45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.colsurfb.2019.01.039","volume":"177","author":"KP Seremeta","year":"2019","unstructured":"Seremeta KP, Arr\u00faa EC, Okulik NB, Salomon CJ. Development and characterization of benznidazole nano- and microparticles: a new tool for pediatric treatment of Chagas disease? Colloids Surf B Biointerfaces. 2019;177:169\u201377. https:\/\/doi.org\/10.1016\/j.colsurfb.2019.01.039. Epub 2019 Jan 23. PMID: 30731393.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"2","key":"1664_CR46","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1590\/s0074-02762010000200022","volume":"105","author":"AJ Romanha","year":"2010","unstructured":"Romanha AJ, Castro SL, Soeiro Mde N, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade Zde A. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz. 2010;105(2):233\u20138. https:\/\/doi.org\/10.1590\/s0074-02762010000200022","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"6","key":"1664_CR47","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/jac\/45.6.819","volume":"45","author":"MS Ara\u00fajo","year":"2000","unstructured":"Ara\u00fajo MS, Martins-Filho OA, Pereira ME, Brener Z. A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas\u2019 disease. J Antimicrob Chemother. 2000;45(6):819\u201324. https:\/\/doi.org\/10.1093\/jac\/45.6.819","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"1664_CR48","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/infdis\/jit420","volume":"209","author":"JM Bustamante","year":"2014","unstructured":"Bustamante JM, Craft JM, Crowe BD, Ketchie SA, Tarleton RL. New, combined, and reduced dosing treatment protocols cure Trypanosoma Cruzi infection in mice. J Infect Dis. 2014;209(1):150\u201362. https:\/\/doi.org\/10.1093\/infdis\/jit420","journal-title":"J Infect Dis"},{"issue":"1","key":"1664_CR49","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ijpddr.2015.12.001","volume":"6","author":"\u00c1C Cevey","year":"2015","unstructured":"Cevey \u00c1C, Mirkin GA, Penas FN, Goren NB. Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma Cruzi strain. Int J Parasitol Drugs Drug Resist. 2015;6(1):12\u201322. https:\/\/doi.org\/10.1016\/j.ijpddr.2015.12.001","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"1664_CR50","doi-asserted-by":"publisher","unstructured":"Scalise ML, Arr\u00faa EC, Rial MS, Esteva MI, Salomon CJ, Fichera LE. Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies. Am J Trop Med Hyg. 2016;95(2):388\u2013\u200993. https:\/\/doi.org\/10.4269\/ajtmh.15-0889","DOI":"10.4269\/ajtmh.15-0889"},{"issue":"12","key":"1664_CR51","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1111\/tmi.12980","volume":"22","author":"HF Santos Souza","year":"2017","unstructured":"Santos Souza HF, Real D, Leonardi D, Rocha SC, Alonso V, Serra E, Silber AM, Salomon CJ. Development and in vitro\/in vivo evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach. Trop Med Int Health. 2017;22(12):1514\u201322. https:\/\/doi.org\/10.1111\/tmi.12980","journal-title":"Trop Med Int Health"},{"issue":"7","key":"1664_CR52","doi-asserted-by":"publisher","first-page":"e0200707","DOI":"10.1371\/journal.pone.0200707","volume":"13","author":"TBS Pavan","year":"2018","unstructured":"Pavan TBS, Silva JWD, Martins LC, Costa SCB, Almeida EA. Hepatic changes by benznidazole in a specific treatment for Chagas disease. PLoS ONE. 2018;13(7):e0200707. https:\/\/doi.org\/10.1371\/journal.pone.0200707","journal-title":"PLoS ONE"},{"issue":"11","key":"1664_CR53","doi-asserted-by":"publisher","first-page":"e0011519","DOI":"10.1371\/journal.pntd.0011519","volume":"17","author":"DM Nguyen","year":"2023","unstructured":"Nguyen DM, Poveda C, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma Cruzi infection. PLoS Negl Trop Dis. 2023;17(11):e0011519. https:\/\/doi.org\/10.1371\/journal.pntd.0011519","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"1664_CR54","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1080\/21505594.2022.2132776","volume":"13","author":"J San Francisco","year":"2022","unstructured":"San Francisco J, Astudillo C, Vega JL, Catal\u00e1n A, Guti\u00e9rrez B, Araya JE, Zailberger A, Marina A, Garc\u00eda C, Sanchez N, Osuna A, Vilchez S, Ram\u00edrez MI, Macedo J, Feijoli VS, Palmisano G, Gonz\u00e1lez J. Trypanosoma Cruzi pathogenicity involves virulence factor expression and upregulation of bioenergetic and biosynthetic pathways. Virulence. 2022;13(1):1827\u201348. https:\/\/doi.org\/10.1080\/21505594.2022.2132776","journal-title":"Virulence"},{"issue":"21","key":"1664_CR55","doi-asserted-by":"publisher","first-page":"7795","DOI":"10.1039\/c4dt00219a","volume":"43","author":"A Karmakar","year":"2014","unstructured":"Karmakar A, Guedes da Silva MF, Pombeiro AJ. Zinc metal-organic frameworks: efficient catalysts for the diastereoselective Henry reaction and transesterification. Dalton Trans. 2014;43(21):7795\u2013810. https:\/\/doi.org\/10.1039\/c4dt00219a","journal-title":"Dalton Trans"},{"issue":"11","key":"1664_CR56","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.7150\/thno.31918","volume":"9","author":"Y Liu","year":"2019","unstructured":"Liu Y, Zhao Y, Chen X. Bioengineering of metal-organic frameworks for Nanomedicine. Theragnostic. 2019;9(11):3122\u201333. https:\/\/doi.org\/10.7150\/thno.31918","journal-title":"Theragnostic"},{"key":"1664_CR57","doi-asserted-by":"publisher","unstructured":"Wang Y, Gao N, Li X, Ling G, Zhang P. Metal organic framework-based variable-size nanoparticles for tumor microenvironment-responsive drug delivery. Drug Deliv Transl Res. 2024 Feb 8. https:\/\/doi.org\/10.1007\/s13346-023-01500-x","DOI":"10.1007\/s13346-023-01500-x"},{"key":"1664_CR58","doi-asserted-by":"publisher","first-page":"113266","DOI":"10.1016\/j.colsurfb.2023.113266","volume":"225","author":"SF Fatima","year":"2023","unstructured":"Fatima SF, Sabouni R, Garg R, Gomaa H. Recent advances in Metal-Organic frameworks as nanocarriers for triggered release of anticancer drugs: brief history, biomedical applications, challenges and future perspective. Colloids Surf B Biointerfaces. 2023;225:113266. https:\/\/doi.org\/10.1016\/j.colsurfb.2023.113266","journal-title":"Colloids Surf B Biointerfaces"},{"key":"1664_CR59","doi-asserted-by":"publisher","first-page":"119619","DOI":"10.1016\/j.biomaterials.2019.119619","volume":"230","author":"Y Wang","year":"2019","unstructured":"Wang Y, Jianhua Y, Nachuan W, Hongjie X, Cai S, Qunye H, Yaqin H, Dongming P, Zhenbao L, Liu Yanfei. Metal-organic frameworks for stimuli-responsive drug delivery. Biomaterials. 2019;230:119619. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119619","journal-title":"Biomaterials"},{"key":"1664_CR60","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/bs.ai.2019.11.007","volume":"145","author":"C Wang","year":"2020","unstructured":"Wang C, Zhang R, Wei X, Lv M, Jiang Z. Metalloimmunology: the metal ion-controlled immunity. Adv Immunol. 2020;145:187\u2013241. https:\/\/doi.org\/10.1016\/bs.ai.2019.11.007","journal-title":"Adv Immunol"},{"key":"1664_CR61","doi-asserted-by":"crossref","unstructured":"Cubillas P, Anderson MW. In: Cejka J, Corma A, Zones S, editors. Synthesis mechanism: crystal growth and nucleation. In zeolites and Catalysis, synthesis, reactions and applications. Verlag GmbH & Co. KGaA; 2010. pp. 1\u201355.","DOI":"10.1002\/9783527630295.ch1"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-024-01664-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-024-01664-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-024-01664-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:13:46Z","timestamp":1740748426000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-024-01664-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,7]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["1664"],"URL":"https:\/\/doi.org\/10.1007\/s13346-024-01664-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3970600\/v1","asserted-by":"object"}]},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,7]]},"assertion":[{"value":"28 June 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki. The approval of this work was granted by the Ethics Committee of the Faculty of Chemical Sciences-UV, Orizaba campus (No. CEFCQO-017-2023).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors agreed with the final version of this manuscript and with the current submission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal studies"}}]}}