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The in vitro tear replenishment was achieved via intermittent flow of a tear solution over the CCM at a rate of 1\u00a0mL\/hour. A zero-order kinetic was observed for basal drug concentration over the 12\u00a0h period. Similar basal and apical drug concentrations were observed with monolayer and multilayer CCM, except for the etafilcon A material. The apical release of latanoprost was significantly lower under replenishment compared to no-replenishment conditions. These results demonstrate the role that a dynamic release model will have in predicting the amount of drug that can be released from a contact lens into the tear film and the critical role of a cell monolayer in in vitro drug delivery studies.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s13346-024-01746-z","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T14:58:23Z","timestamp":1733410703000},"page":"2509-2521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In vitro tear replenishment system: assessing drug delivery from contact lens biomaterials through corneal epithelial monolayer and multilayer under replenishment conditions"],"prefix":"10.1007","volume":"15","author":[{"given":"Saman","family":"Mohammadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahabedin","family":"Eslami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndon","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-2522","authenticated-orcid":false,"given":"Maud","family":"Gorbet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"1746_CR1","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jconrel.2022.02.014","volume":"343","author":"AF Pereira-da-Mota","year":"2022","unstructured":"Pereira-da-Mota AF, Phan C-M, Concheiro A, Jones L, Alvarez-Lorenzo C. 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