{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:24:55Z","timestamp":1792783495981,"version":"4.5.0"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Brockhouse Institute for Materials Research Future Materials Innovators grant","id":[{"id":"https:\/\/ror.org\/033hdxa37","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant","award":["RGPIN-05500-2018"],"award-info":[{"award-number":["RGPIN-05500-2018"]}],"id":[{"id":"https:\/\/ror.org\/04mte1k06","id-type":"ROR","asserted-by":"crossref"}]},{"name":"New Frontiers in Research Fund","award":["NFRFE2018-00943"],"award-info":[{"award-number":["NFRFE2018-00943"]}]},{"name":"Canadian Institutes of Health Research (CIHR) Grant","award":["438050"],"award-info":[{"award-number":["438050"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Canada Foundation for Innovation: John R. Evans Leaders Fund","award":["34107"],"award-info":[{"award-number":["34107"]}],"id":[{"id":"https:\/\/ror.org\/000az4664","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ontario Research Fund - Research Infrastructure","award":["ORI-RI"],"award-info":[{"award-number":["ORI-RI"]}]},{"name":"Ontario Research Fund - Research Infrastructure","award":["34107"],"award-info":[{"award-number":["34107"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s13346-026-02060-6","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:32:59Z","timestamp":1770150779000},"page":"3658-3676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the dose: a clearance-enabled in vitro platform for evaluating local therapies"],"prefix":"10.1007","volume":"16","author":[{"given":"Mandeep K.","family":"Marway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahib K.","family":"Marway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Celejewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-9948","authenticated-orcid":false,"given":"Ryan G.","family":"Wylie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"2060_CR1","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1586\/14737140.2013.840090","volume":"13","author":"A Bregy","year":"2013","unstructured":"Bregy A, Shah AH, Diaz MV, Pierce HE, Ames PL, Diaz D, et al. The role of Gliadel wafers in the treatment of high-grade gliomas. Expert Rev Anticancer Ther. 2013;13:1453\u201361.","journal-title":"Expert Rev Anticancer Ther"},{"key":"2060_CR2","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.7150\/thno.18563","volume":"7","author":"JE Belz","year":"2017","unstructured":"Belz JE, Kumar R, Baldwin P, Ojo NC, Leal AS, Royce DB, et al. Sustained release talazoparib implants for localized treatment of Brca1-deficient breast cancer. Theranostics. 2017;7:4340\u20139.","journal-title":"Theranostics"},{"key":"2060_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-79663-7","volume":"11","author":"D Zhang","year":"2021","unstructured":"Zhang D, Singh B, Moerland J, Mitchell O, Lockwood L, Carapellucci S, et al. Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice. Sci Rep. 2021;11:1\u201310. https:\/\/doi.org\/10.1038\/s41598-020-79663-7.","journal-title":"Sci Rep"},{"key":"2060_CR4","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","volume":"355","author":"PJ Rosenfeld","year":"2006","unstructured":"Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419\u201331.","journal-title":"N Engl J Med"},{"key":"2060_CR5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.yaoo.2017.03.004","volume":"2","author":"AM Suelves","year":"2017","unstructured":"Suelves AM, Shulman JP. Anti-vascular endothelial growth factor medications in retinopathy of prematurity. Adv Ophthalmol Optom. 2017;2:75\u201386. https:\/\/doi.org\/10.1016\/j.yaoo.2017.03.004.","journal-title":"Adv Ophthalmol Optom"},{"key":"2060_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-023-02516-9","volume":"24","author":"S Ahmed","year":"2023","unstructured":"Ahmed S, Amin MM, Sayed S. Ocular drug delivery: a comprehensive review. AAPS PharmSciTech. 2023;24:1\u201329. https:\/\/doi.org\/10.1208\/s12249-023-02516-9.","journal-title":"AAPS PharmSciTech"},{"key":"2060_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-023-01992-2","volume":"21","author":"S Li","year":"2023","unstructured":"Li S, Chen L, Fu Y. Nanotechnology-based ocular drug delivery systems: recent advances and future prospects. J Nanobiotechnol. 2023;21:1\u201339. https:\/\/doi.org\/10.1186\/s12951-023-01992-2.","journal-title":"J Nanobiotechnol"},{"key":"2060_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-21438-3","volume":"12","author":"NC Brigham","year":"2021","unstructured":"Brigham NC, Ji RR, Becker ML. Degradable polymeric vehicles for postoperative pain management. Nat Commun. 2021;12:1\u201313. https:\/\/doi.org\/10.1038\/s41467-021-21438-3.","journal-title":"Nat Commun"},{"key":"2060_CR9","unstructured":"IMARC Group. Postoperative pain market size, epidemiology, in-market drugs sales, pipeline therapies, and regional outlook 2025\u20132035 [Internet]. 2025. Available from: https:\/\/www.imarcgroup.com\/postoperative-pain-market"},{"key":"2060_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph17101315","volume":"17","author":"S Adwan","year":"2024","unstructured":"Adwan S, Qasmieh M, Al-Akayleh F, Ali Agha ASA. Recent advances in ocular drug delivery: insights into lyotropic liquid crystals. Pharmaceuticals. 2024;17:1\u201326.","journal-title":"Pharmaceuticals"},{"key":"2060_CR11","unstructured":"Future Market Insights Inc. Ocular Drug Delivery System Market Outlook 2025 to 2035 [Internet]. 2025. Available from: https:\/\/www.futuremarketinsights.com\/reports\/ocular-drug-delivery-system-market"},{"key":"2060_CR12","unstructured":"Precedence Research. Cancer Therapeutics Market Growth Outlook and Future Trends [Internet]. 2025. Available from: https:\/\/www.precedenceresearch.com\/cancer-therapeutics-market"},{"key":"2060_CR13","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1021\/acsabm.2c00973","volume":"6","author":"RN Woodring","year":"2023","unstructured":"Woodring RN, Gurysh EG, Bachelder EM, Ainslie KM. Drug delivery systems for localized cancer combination therapy. ACS Appl Bio Mater. 2023;6:934\u201350.","journal-title":"ACS Appl Bio Mater"},{"key":"2060_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-35343-w","volume":"14","author":"P Bannigan","year":"2023","unstructured":"Bannigan P, Bao Z, Hickman RJ, Aldeghi M, H\u00e4se F, Aspuru-Guzik A, et al. Machine learning models to accelerate the design of polymeric long-acting injectables. Nat Commun. 2023;14:1\u201312.","journal-title":"Nat Commun"},{"key":"2060_CR15","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1039\/D0LC01010C","volume":"20","author":"L Abdul","year":"2020","unstructured":"Abdul L, Rajasekar S, Lin DSY, Venkatasubramania Raja S, Sotra A, Feng Y, et al. Deep-LUMEN assay-human lung epithelial spheroid classification from brightfield images using deep learning. Lab Chip. 2020;20:4623\u201331.","journal-title":"Lab Chip"},{"key":"2060_CR16","first-page":"1","volume":"12","author":"D Han","year":"2023","unstructured":"Han D, Huang Z, Rahimi E, Ardekani AM. Solute transport across the lymphatic vasculature in a soft skin tissue. Biology (Basel). 2023;12:1\u201327.","journal-title":"Biology (Basel)"},{"key":"2060_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11571-025-10298-y","volume":"19","author":"Z He","year":"2025","unstructured":"He Z, Sun J. Clearance mechanisms of the glymphatic\/lymphatic system in the brain: new therapeutic perspectives for cognitive impairment. Cogn Neurodyn. 2025;19:1\u201322.","journal-title":"Cogn Neurodyn"},{"key":"2060_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40495-025-00425-y","volume":"11","author":"A Ruiz","year":"2025","unstructured":"Ruiz A, DiCristina S. Absorption to excretion: the aging body\u2019s take on drugs \u2013 a review of pharmacokinetic changes and their impact on medication management. Curr Pharmacol Rep. 2025;11:1\u201312.","journal-title":"Curr Pharmacol Rep"},{"key":"2060_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-023-05216-z","volume":"6","author":"H Arakawa","year":"2023","unstructured":"Arakawa H, Nakazono Y, Matsuoka N, Hayashi M, Shirasaka Y, Hirao A, et al. Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion. Commun Biol. 2023;6:1\u201314.","journal-title":"Commun Biol"},{"key":"2060_CR20","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1016\/j.apsb.2022.02.015","volume":"12","author":"W Gao","year":"2022","unstructured":"Gao W, Hu H, Dai L, He M, Yuan H, Zhang H, et al. Structure-tissue exposure\/selectivity relationship (STR) correlates with clinical efficacy\/safety. Acta Pharm Sin B. 2022;12:2462\u201378. https:\/\/doi.org\/10.1016\/j.apsb.2022.02.015.","journal-title":"Acta Pharm Sin B"},{"key":"2060_CR21","first-page":"5","volume":"392","author":"R Langer","year":"1998","unstructured":"Langer R. Drug delivery and targeting. Nature. 1998;392:5\u201310.","journal-title":"Nature"},{"key":"2060_CR22","doi-asserted-by":"publisher","first-page":"114724","DOI":"10.1016\/j.addr.2023.114724","volume":"194","author":"C Pacheco","year":"2023","unstructured":"Pacheco C, Bai\u00e3o A, Ding T, Cui W, Sarmento B. Recent advances in long-acting drug delivery systems for anticancer drug. Adv Drug Deliv Rev. 2023;194:114724\u201336. https:\/\/doi.org\/10.1016\/j.addr.2023.114724.","journal-title":"Adv Drug Deliv Rev"},{"key":"2060_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.887402","volume":"13","author":"J McCright","year":"2022","unstructured":"McCright J, Naiknavare R, Yarmovsky J, Maisel K. Targeting lymphatics for nanoparticle drug delivery. Front Pharmacol. 2022;13:1\u201310.","journal-title":"Front Pharmacol"},{"key":"2060_CR24","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jsps.2014.04.002","volume":"23","author":"A Ghanemi","year":"2015","unstructured":"Ghanemi A. Cell cultures in drug development: applications, challenges and limitations. Saudi Pharm J. 2015;23:453\u20134.","journal-title":"Saudi Pharm J"},{"key":"2060_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.semcancer.2005.06.009","volume":"15","author":"A Birgersdotter","year":"2005","unstructured":"Birgersdotter A, Sandberg R, Ernberg I. Gene expression perturbation in vitro \u2014 a growing case for three-dimensional (3D ) culture systems. Semin Cancer Biol. 2005;15:405\u201312.","journal-title":"Semin Cancer Biol"},{"key":"2060_CR26","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1177\/2472555219830087","volume":"24","author":"TH Booij","year":"2019","unstructured":"Booij TH, Price LS, Danen EHJ. 3D cell-based assays for drug screens: challenges in imaging, image analysis, and high-content analysis. SLAS Discov. 2019;24:615\u201327.","journal-title":"SLAS Discov"},{"key":"2060_CR27","first-page":"3015","volume":"125","author":"BM Baker","year":"2012","unstructured":"Baker BM, Chen CS. Deconstructing the third dimension \u2013 how 3D culture microenvironments alter cellular cues. J Cell Sci. 2012;125:3015\u201324.","journal-title":"J Cell Sci"},{"key":"2060_CR28","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jacbts.2019.10.008","volume":"4","author":"NGA Van","year":"2019","unstructured":"Van NGA. Limitations of animal studies for predicting toxicity in clinical trials. JACC Basic Transl Sci. 2019;4:845\u201354.","journal-title":"JACC Basic Transl Sci"},{"key":"2060_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciadv.aax4520","volume":"5","author":"Y Jun","year":"2019","unstructured":"Jun Y, Lee JS, Choi S, Yang JH, Sander M, Chung S, et al. In vivo\u2013mimicking microfluidic perfusion culture of pancreatic islet spheroids. Sci Adv. 2019;5:1\u201314.","journal-title":"Sci Adv"},{"key":"2060_CR30","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/aor.14503","volume":"47","author":"JJ Han","year":"2023","unstructured":"Han JJ. FDA modernization act 2. 0 allows for alternatives to animal testing. Artif Organs. 2023;47:449\u201350.","journal-title":"Artif Organs"},{"key":"2060_CR31","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41684-025-01619-z","volume":"54","author":"C Harrison","year":"2025","unstructured":"Harrison C. New approach methodologies gain momentum, providing human-relevant alternatives to animal models. Lab Anim. 2025;54:250\u20133. https:\/\/doi.org\/10.1038\/s41684-025-01619-z.","journal-title":"Lab Anim"},{"key":"2060_CR32","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1172\/JCI175824","volume":"133","author":"PJH Zushin","year":"2023","unstructured":"Zushin PJH, Mukherjee S, Wu JC. FDA modernization act 2.0: transitioning beyond animal models with human cells, organoids, and AI\/ML-based approaches. J Clin Invest. 2023;133:10\u20134.","journal-title":"J Clin Invest"},{"key":"2060_CR33","doi-asserted-by":"crossref","unstructured":"Berg A Van Den, Mummery CL, Passier R, Meer AD Van Der. Lab on a chip personalised organs-on-chips: functional testing for precision medicine. 2019;198\u2013205.","DOI":"10.1039\/C8LC00827B"},{"issue":"6","key":"2060_CR34","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.kint.2018.06.034","volume":"94","author":"N Ashammakhi","year":"2018","unstructured":"Ashammakhi N, Wesseling-Perry K, Hasan A, Elkhammas E, Zhang YS. Kidney-on-a-chip: untapped opportunities. Kidney Int. 2018;94:1073\u201386. https:\/\/doi.org\/10.1016\/j.kint.2018.06.034.","journal-title":"Kidney Int"},{"key":"2060_CR35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/jcp.24683","volume":"230","author":"M Ravi","year":"2015","unstructured":"Ravi M, Paramesh V, Kaviya SR, Anuradha E, Paul Solomon FD. 3d cell culture systems: advantages and applications. J Cell Physiol. 2015;230:16\u201326.","journal-title":"J Cell Physiol"},{"key":"2060_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2023.122408","volume":"304","author":"R Xie","year":"2024","unstructured":"Xie R, Pal V, Yu Y, Lu X, Gao M, Liang S, et al. A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications. Biomaterials. 2024;304:1\u201326. https:\/\/doi.org\/10.1016\/j.biomaterials.2023.122408.","journal-title":"Biomaterials"},{"key":"2060_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-023-45144-w","volume":"13","author":"ZN Abbas","year":"2023","unstructured":"Abbas ZN, Al-Saffar AZ, Jasim SM, Sulaiman GM. Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations. Sci Rep. 2023;13:1\u201316. https:\/\/doi.org\/10.1038\/s41598-023-45144-w.","journal-title":"Sci Rep"},{"key":"2060_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11033-024-09669-1","volume":"51","author":"M Alwahsh","year":"2024","unstructured":"Alwahsh M, Al-Doridee A, Jasim S, Awwad O, Hergenr\u00f6der R, Hamadneh L. Cytotoxic and molecular differences of anticancer agents on 2D and 3D cell culture. Mol Biol Rep. 2024;51:1\u201314. https:\/\/doi.org\/10.1007\/s11033-024-09669-1.","journal-title":"Mol Biol Rep"},{"issue":"11","key":"2060_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cam4.7318","volume":"13","author":"TR Tidwell","year":"2024","unstructured":"Tidwell TR, R\u00f8sland G, Tronstad KJ, S\u00f8reide K, Hagland HR. Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D cell models: contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles. Cancer Med. 2024;13(11):1\u201311.","journal-title":"Cancer Med"},{"key":"2060_CR40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/03602532.2021.1922435","volume":"53","author":"J Yadav","year":"2021","unstructured":"Yadav J, El Hassani M, Sodhi J, Lauschke VM, Hartman JH, Russell LE. Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug Metab Rev. 2021;53:207\u201333.","journal-title":"Drug Metab Rev"},{"key":"2060_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12938-024-01226-y","volume":"23","author":"J Liu","year":"2024","unstructured":"Liu J, Du Y, Xiao X, Tan D, He Y, Qin L. Construction of in vitro liver-on-a-chip models and application progress. Biomed Eng Online. 2024;23:1\u201315. https:\/\/doi.org\/10.1186\/s12938-024-01226-y.","journal-title":"Biomed Eng Online"},{"key":"2060_CR42","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jiec.2018.11.041","volume":"71","author":"S Hun","year":"2019","unstructured":"Hun S, Jun B. Advances in dynamic microphysiological organ-on-a-chip: design principle and its biomedical application. J Ind Eng Chem. 2019;71:65\u201377. https:\/\/doi.org\/10.1016\/j.jiec.2018.11.041.","journal-title":"J Ind Eng Chem"},{"key":"2060_CR43","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1172\/JCI124615","volume":"129","author":"S Watanabe","year":"2019","unstructured":"Watanabe S, Alexander M, Misharin AV, Budinger GRS. The role of macrophages in the resolution of inflammation. J Clin Invest. 2019;129:2619\u201328.","journal-title":"J Clin Invest"},{"key":"2060_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-021-01156-z","volume":"9","author":"A Buonfiglioli","year":"2021","unstructured":"Buonfiglioli A, Hambardzumyan D. Macrophages and microglia: the cerberus of glioblastoma. Acta Neuropathol Commun. 2021;9:1\u201321. https:\/\/doi.org\/10.1186\/s40478-021-01156-z.","journal-title":"Acta Neuropathol Commun"},{"key":"2060_CR45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.addr.2019.12.001","volume":"165\u2013166","author":"W He","year":"2020","unstructured":"He W, Kapate N, Shields CW, Mitragotri S. Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases. Adv Drug Deliv Rev. 2020;165\u2013166:15\u201340. https:\/\/doi.org\/10.1016\/j.addr.2019.12.001.","journal-title":"Adv Drug Deliv Rev"},{"key":"2060_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00522-z","author":"S Wang","year":"2024","unstructured":"Wang S, Wang J, Chen Z, Luo J, Guo W, Sun L, et al. Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance. NPJ Precis Oncol. 2024. https:\/\/doi.org\/10.1038\/s41698-024-00522-z.","journal-title":"NPJ Precis Oncol"},{"key":"2060_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2020.566511","volume":"10","author":"I Larionova","year":"2020","unstructured":"Larionova I, Tuguzbaeva G, Ponomaryova A, Stakheyeva M, Cherdyntseva N, Pavlov V, et al. Tumor-associated macrophages in human breast, colorectal, lung, ovarian and prostate cancers. Front Oncol. 2020;10:1\u201334.","journal-title":"Front Oncol"},{"key":"2060_CR48","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/1759-7714.14268","volume":"13","author":"X Huang","year":"2022","unstructured":"Huang X, Zu X. Tumor-associated macrophages: an important player in breast cancer progression. Thorac Cancer. 2022;13:269\u201376.","journal-title":"Thorac Cancer"},{"key":"2060_CR49","first-page":"1","volume":"6","author":"Z Duan","year":"2021","unstructured":"Duan Z, Luo Y. Targeting macrophages in cancer immunotherapy. Signal Transduct Target Ther. 2021;6:1\u201321.","journal-title":"Signal Transduct Target Ther"},{"key":"2060_CR50","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028480","author":"E Alspach","year":"2019","unstructured":"Alspach E, Lussier DM, Schreiber RD. Interferon \u03b3 and its important roles in promoting and inhibiting spontaneous and therapeutic cancer immunity. Cold Spring Harb Perspect Biol. 2019. https:\/\/doi.org\/10.1101\/cshperspect.a028480.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2060_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2018.00071","volume":"9","author":"S Tedesco","year":"2018","unstructured":"Tedesco S, De Majo F, Kim J, Trenti A, Trevisi L, Fadini GP, et al. Convenience versus biological significance: are PMA-differentiated THP-1 cells a reliable substitute for blood-derived macrophages when studying in vitro polarization? Front Pharmacol. 2018;9:1\u201313.","journal-title":"Front Pharmacol"},{"key":"2060_CR52","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk7695","author":"L Niu","year":"2024","unstructured":"Niu L, Jang E, Chin AL, Huo Z, Wang W, Cai W, et al. Noncovalently particle-anchored cytokines with prolonged tumor retention safely elicit potent antitumor immunity. Sci Adv. 2024. https:\/\/doi.org\/10.1126\/sciadv.adk7695.","journal-title":"Sci Adv"},{"key":"2060_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2021.790821","volume":"11","author":"D Xu","year":"2022","unstructured":"Xu D, Zhou J, Mei H, Li H, Sun W, Xu H. Impediment of cerebrospinal fluid drainage through glymphatic system in glioma. Front Oncol. 2022;11:1\u201312.","journal-title":"Front Oncol"},{"key":"2060_CR54","first-page":"135","volume":"7","author":"Y Mei","year":"2021","unstructured":"Mei Y, He C, Gao C, Zhu P, Lu G, Li H. 3D-printed degradable anti-tumor scaffolds for controllable drug delivery. Int J Bioprinting. 2021;7:135\u201344.","journal-title":"Int J Bioprinting"},{"key":"2060_CR55","doi-asserted-by":"publisher","first-page":"20724","DOI":"10.1021\/acsomega.9b03694","volume":"5","author":"P Sengupta","year":"2020","unstructured":"Sengupta P, Agrawal V, Prasad BLV. Development of a smart scaffold for sequential cancer chemotherapy and tissue engineering. ACS Omega. 2020;5:20724\u201333.","journal-title":"ACS Omega"},{"key":"2060_CR56","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1172\/JCI90603","volume":"127","author":"A Louveau","year":"2017","unstructured":"Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. J Clin Invest. 2017;127:3210\u20139.","journal-title":"J Clin Invest"},{"key":"2060_CR57","doi-asserted-by":"crossref","unstructured":"Natale G, Limanaqi F, Busceti CL, Mastroiacovo F, Nicoletti F, Puglisi-allegra S, et al. Glymphatic system as a gateway to connect neurodegeneration from periphery to CNS. 2021;15:1\u201313","DOI":"10.3389\/fnins.2021.639140"},{"key":"2060_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics15020695","volume":"15","author":"A Mansour","year":"2023","unstructured":"Mansour A, Romani M, Acharya AB, Rahman B, Verron E, Badran Z. Drug delivery systems in regenerative medicine: an updated review. Pharmaceutics. 2023;15:1\u201323.","journal-title":"Pharmaceutics"},{"key":"2060_CR59","doi-asserted-by":"publisher","first-page":"5905","DOI":"10.3390\/molecules26195905","volume":"26","author":"S Adepu","year":"2021","unstructured":"Adepu S, Ramakrishna S. Controlled drug delivery systems: current status and future directions. Molecules. 2021;26:5905\u201349.","journal-title":"Molecules"},{"key":"2060_CR60","doi-asserted-by":"publisher","first-page":"10852","DOI":"10.1021\/acsomega.4c06984","volume":"10","author":"AJ Adeoye","year":"2025","unstructured":"Adeoye AJ, DeAlba E. A simple method to determine diffusion coefficients in soft hydrogels for drug delivery and biomedical applications. ACS Omega. 2025;10:10852\u201365.","journal-title":"ACS Omega"},{"key":"2060_CR61","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.3390\/molecules28155931","volume":"28","author":"FV Lavrentev","year":"2023","unstructured":"Lavrentev FV, Shilovskikh VV, Alabusheva VS, Yurova VY, Nikitina AA, Ulasevich SA, et al. Diffusion-limited processes in hydrogels with chosen applications from drug delivery to electronic components. Molecules. 2023;28:5931\u201364.","journal-title":"Molecules"},{"key":"2060_CR62","doi-asserted-by":"publisher","first-page":"5077","DOI":"10.1073\/pnas.1705757114","volume":"114","author":"N Mokarram","year":"2017","unstructured":"Mokarram N, Dymanus K, Srinivasan A, Lyon JG, Tipton J, Chu J, et al. Immunoengineering nerve repair. Proc Natl Acad Sci U S A. 2017;114:5077\u201384.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2060_CR63","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1021\/bm4005639","volume":"14","author":"N Jin","year":"2014","unstructured":"Jin N, Morin EA, Henn DM, Cao Y, Woodcock JW, Tang S, et al. Agarose hydrogels embedded with pH-responsive diblock copolymer micelles for triggered release of substances. Biomacromol. 2014;14:2713\u201323.","journal-title":"Biomacromol"},{"key":"2060_CR64","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1021\/acsbiomaterials.5c00783","volume":"11","author":"MK Marway","year":"2025","unstructured":"Marway MK, Bhagentsang D, Venugopal C, Singh SK, Wylie RG, Zhang B. Crossing barriers. In vitro cancer model for studying monocyte migration across endothelial barriers. ACS Biomater Sci Eng. 2025;11:5038\u201350.","journal-title":"ACS Biomater Sci Eng"},{"key":"2060_CR65","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00236","author":"DSY Lin","year":"2020","unstructured":"Lin DSY, Rajasekar S, Marway MK, Zhang B. From model system to therapy: scalable production of perfusable vascularized liver spheroids in \u201cOpen-Top\u201d 384-Well Plate. ACS Biomater Sci Eng. 2020. https:\/\/doi.org\/10.1021\/acsbiomaterials.0c00236.","journal-title":"ACS Biomater Sci Eng"},{"issue":"46","key":"2060_CR66","doi-asserted-by":"publisher","first-page":"2002974","DOI":"10.1002\/adma.202002974","volume":"32","author":"S Rajasekar","year":"2020","unstructured":"Rajasekar S, Lin DSY, Abdul L, Liu A, Sotra A, Zhang F, et al. IFlowPlate - a customized 384-well plate for the culture of perfusable vascularized colon organoids. Adv Mater. 2020;2002974:1\u201312.","journal-title":"Adv Mater"},{"key":"2060_CR67","doi-asserted-by":"publisher","unstructured":"Tapre RW, Thokal AG, Mandake MB, Jadhav SD, Vasantrao JS. Microscale fluid mechanics: A review of material-dependent flow characteristics and applications. Mater Today Proc. 2023;1\u20136. https:\/\/doi.org\/10.1016\/j.matpr.2023.03.097","DOI":"10.1016\/j.matpr.2023.03.097"},{"key":"2060_CR68","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1039\/C2LC20799K","volume":"12","author":"KW Oh","year":"2012","unstructured":"Oh KW, Lee K, Ahn B, Furlani EP. Design of pressure-driven microfluidic networks using electric circuit analogy. Lab Chip. 2012;12:515\u201345.","journal-title":"Lab Chip"},{"key":"2060_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2013.00044","volume":"3","author":"MJ Mitchell","year":"2013","unstructured":"Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress. Front Oncol. 2013;3:1\u201311.","journal-title":"Front Oncol"},{"key":"2060_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1088\/1758-5090\/acc09a","volume":"15","author":"H Jasuja","year":"2023","unstructured":"Jasuja H, Jaswandkar SV, Katti DR, Katti KS. Interstitial fluid flow contributes to prostate cancer invasion and migration to bone; study conducted using a novel horizontal flow bioreactor. Biofabrication. 2023;15:1\u201312. https:\/\/doi.org\/10.1088\/1758-5090\/acc09a.","journal-title":"Biofabrication"},{"key":"2060_CR71","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2147\/CMAR.S65444","volume":"6","author":"JM Munson","year":"2014","unstructured":"Munson JM, Shieh AC. Interstitial fluid flow in cancer: implications for disease progression and treatment. Cancer Manag Res. 2014;6:317\u201328.","journal-title":"Cancer Manag Res"},{"key":"2060_CR72","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.bpj.2020.12.020","volume":"120","author":"A Wolde-Kidan","year":"2021","unstructured":"Wolde-Kidan A, Herrmann A, Prause A, Gradzielski M, Haag R, Block S, et al. Particle diffusivity and free-energy profiles in hydrogels from time-resolved penetration data. Biophys J. 2021;120:463\u201375. https:\/\/doi.org\/10.1016\/j.bpj.2020.12.020.","journal-title":"Biophys J"},{"key":"2060_CR73","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0006-3495(99)76911-0","volume":"77","author":"A Pluen","year":"1999","unstructured":"Pluen A, Netti PA, Jain RK, Berk DA. Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations. Biophys J. 1999;77:542\u201352.","journal-title":"Biophys J"},{"key":"2060_CR74","doi-asserted-by":"publisher","first-page":"4628","DOI":"10.1073\/pnas.081626898","volume":"98","author":"A Pluen","year":"2001","unstructured":"Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, Di Tomaso E, et al. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A. 2001;98:4628\u201333.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2060_CR75","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/adma.201003963","volume":"23","author":"JA Burdick","year":"2011","unstructured":"Burdick JA, Prestwich GD. Hyaluronic acid hydrogels for biomedical applications. Adv Mater. 2011;23:41\u201356.","journal-title":"Adv Mater"},{"key":"2060_CR76","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.1073\/pnas.0509425103","volume":"103","author":"RG Thorne","year":"2006","unstructured":"Thorne RG, Nicholson C. In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. Proc Natl Acad Sci U S A. 2006;103:5567\u201372.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2060_CR77","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ultrasmedbio.2009.08.006","volume":"36","author":"JJ Choi","year":"2010","unstructured":"Choi JJ, Wang S, Tung YS, Morrison B, Konofagou EE. Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med Biol. 2010;36:58\u201367.","journal-title":"Ultrasound Med Biol"},{"key":"2060_CR78","first-page":"910","volume":"14","author":"M Kapa\u0142czy\u0144ska","year":"2018","unstructured":"Kapa\u0142czy\u0144ska M, Kolenda T, Przyby\u0142a W, Zaj\u0105czkowska M, Teresiak A, Filas V, et al. 2D and 3D cell cultures \u2013 a comparison of different types of cancer cell cultures. Arch Med Sci. 2018;14:910\u20139.","journal-title":"Arch Med Sci"},{"key":"2060_CR79","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.tcb.2011.09.005","volume":"21","author":"D Huh","year":"2011","unstructured":"Huh D, Hamilton GA, Ingber DE. From 3d cell culture to organs-on-chips. Trends Cell Biol. 2011;21:745\u201354. https:\/\/doi.org\/10.1016\/j.tcb.2011.09.005.","journal-title":"Trends Cell Biol"},{"key":"2060_CR80","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/adt.2014.573","volume":"12","author":"R Edmondson","year":"2014","unstructured":"Edmondson R, Broglie JJ, Adcock AF, Yang L. Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. Assay Drug Dev Technol. 2014;12:207\u201318.","journal-title":"Assay Drug Dev Technol"},{"key":"2060_CR81","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1177\/1087057117696795","volume":"22","author":"Y Fang","year":"2017","unstructured":"Fang Y, Eglen RM. Three-dimensional cell cultures in drug discovery and development. SLAS Discov. 2017;22:456\u201372. https:\/\/doi.org\/10.1177\/1087057117696795.","journal-title":"SLAS Discov"},{"key":"2060_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2023.1190333","volume":"14","author":"J Han","year":"2023","unstructured":"Han J, Wu M, Liu Z. Dysregulation in IFN-\u03b3 signaling and response: the barricade to tumor immunotherapy. Front Immunol. 2023;14:1\u201312.","journal-title":"Front Immunol"},{"key":"2060_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2022.113683","volume":"155","author":"H Ding","year":"2022","unstructured":"Ding H, Wang G, Yu Z, Sun H, Wang L. Role of interferon-gamma (IFN-\u03b3) and IFN-\u03b3 receptor 1\/2 (IFN\u03b3R1\/2) in regulation of immunity, infection, and cancer development: IFN-\u03b3-dependent or independent pathway. Biomed Pharmacother. 2022;155:1\u201315. https:\/\/doi.org\/10.1016\/j.biopha.2022.113683.","journal-title":"Biomed Pharmacother"},{"key":"2060_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40364-020-00228-x","volume":"8","author":"D Jorgovanovic","year":"2020","unstructured":"Jorgovanovic D, Song M, Wang L, Zhang Y. Roles of IFN-\u03b3 in tumor progression and regression: a review. Biomark Res. 2020;8:1\u201316.","journal-title":"Biomark Res"},{"key":"2060_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00432-024-05777-4","volume":"150","author":"R Huang","year":"2024","unstructured":"Huang R, Kang T, Chen S. The role of tumor-associated macrophages in tumor immune evasion. J Cancer Res Clin Oncol. 2024;150:1\u201324. https:\/\/doi.org\/10.1007\/s00432-024-05777-4.","journal-title":"J Cancer Res Clin Oncol"},{"key":"2060_CR86","first-page":"1","volume":"9","author":"C Anfray","year":"2020","unstructured":"Anfray C, Ummarino A, And\u00f3n FT, Allavena P. Current strategies to target tumor-associated-macrophages to improve anti-tumor immune responses. Cells. 2020;9:1\u201324.","journal-title":"Cells"},{"key":"2060_CR87","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.ymthe.2020.12.037","volume":"29","author":"Y Jia","year":"2021","unstructured":"Jia Y, Kodumudi KN, Ramamoorthi G, Basu A, Snyder C, Wiener D, et al. Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway. Mol Ther. 2021;29:1541\u201356. https:\/\/doi.org\/10.1016\/j.ymthe.2020.12.037.","journal-title":"Mol Ther"},{"issue":"1","key":"2060_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41523-020-0153-3","volume":"6","author":"RLB Costa","year":"2020","unstructured":"Costa RLB, Czerniecki BJ. Clinical development of immunotherapies for HER2+ breast cancer: a review of HER2-directed monoclonal antibodies and beyond. NPJ Breast Cancer. 2020;6(1):1\u201311.","journal-title":"NPJ Breast Cancer"},{"key":"2060_CR89","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1016\/j.celrep.2015.08.044","volume":"12","author":"Y Nagai","year":"2015","unstructured":"Nagai Y, Tsuchiya H, Runkle EA, Young PD, Ji MQ, Norton L, et al. Disabling of the erbB pathway followed by IFN-\u03b3 modifies phenotype and enhances genotoxic eradication of breast tumors. Cell Rep. 2015;12:2049\u201359. https:\/\/doi.org\/10.1016\/j.celrep.2015.08.044.","journal-title":"Cell Rep"},{"key":"2060_CR90","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1111\/bcp.14735","volume":"87","author":"CD Bruno","year":"2021","unstructured":"Bruno CD, Harmatz JS, Duan SX, Zhang Q, Chow CR, Greenblatt DJ. Effect of lipophilicity on drug distribution and elimination: influence of obesity. Br J Clin Pharmacol. 2021;87:3197\u2013205.","journal-title":"Br J Clin Pharmacol"},{"key":"2060_CR91","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1021\/acs.jmedchem.8b01263","volume":"62","author":"DA Smith","year":"2019","unstructured":"Smith DA, Beaumont K, Maurer TS, Di L. Clearance in drug design. J Med Chem. 2019;62:2245\u201355.","journal-title":"J Med Chem"},{"key":"2060_CR92","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s10928-021-09774-9","volume":"48","author":"M Vanhove","year":"2021","unstructured":"Vanhove M, Wagner JM, Noppen B, Jonckx B, Vermassen E, Stitt AW. Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687. J Pharmacokinet Pharmacodyn. 2021;48:837\u201349. https:\/\/doi.org\/10.1007\/s10928-021-09774-9.","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"2060_CR93","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.1039\/D4LC00512K","volume":"24","author":"E Pyne","year":"2024","unstructured":"Pyne E, Reardon M, Christensen M, Mateos R, Taylor S, Iles A, et al. Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer transcriptomes using a spheroid-on-chip perfusion system. Lab Chip. 2024;24:4609\u201322.","journal-title":"Lab Chip"},{"key":"2060_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells14100732","volume":"14","author":"S Shah","year":"2025","unstructured":"Shah S, D\u2019Souza GGM. Modeling tumor microenvironment complexity in vitro: spheroids as physiologically relevant tumor models and strategies for their analysis. Cells. 2025;14:1\u201335.","journal-title":"Cells"},{"key":"2060_CR95","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1182\/blood.V83.2.537.537","volume":"83","author":"M Bosco","year":"1994","unstructured":"Bosco M, Gusella G, Espinoza-Delgado I, Longo D, Varesio L. Interferon-gamma upregulates interleukin-8 gene expression in human monocytic cells by a posttranscriptional mechanism. Blood. 1994;83:537\u201342.","journal-title":"Blood"},{"key":"2060_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2018.00847","volume":"9","author":"F Castro","year":"2018","unstructured":"Castro F, Cardoso AP, Gon\u00e7alves RM, Serre K, Oliveira MJ. Interferon-gamma at the crossroads of tumor immune surveillance or evasion. Front Immunol. 2018;9:1\u201319.","journal-title":"Front Immunol"},{"key":"2060_CR97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms15207","volume":"8","author":"Y Liu","year":"2017","unstructured":"Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, et al. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-\u03b3-induced immunologic dormancy of tumor-repopulating cells. Nat Commun. 2017;8:1\u201315. https:\/\/doi.org\/10.1038\/ncomms15207.","journal-title":"Nat Commun"},{"key":"2060_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2025.01.001","author":"S Wu","year":"2025","unstructured":"Wu S, Cao Z, Lu R, Zhang Z, Sethi G, You Y. Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy. Cytokine Growth Factor Rev. 2025. https:\/\/doi.org\/10.1016\/j.cytogfr.2025.01.001.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"2060_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep31180","volume":"6","author":"MR Benakanakere","year":"2016","unstructured":"Benakanakere MR, Finoti LS, Tanaka U, Grant GR, Scarel-Caminaga RM, Kinane DF. Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR\/Cas9 mediated genome editing. Sci Rep. 2016;6(1):1\u201311.","journal-title":"Sci Rep"},{"key":"2060_CR100","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1215\/S1152851704001061","volume":"7","author":"DJ Brat","year":"2005","unstructured":"Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 2005;7:122\u201333.","journal-title":"Neuro Oncol"},{"key":"2060_CR101","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01019.2013","author":"DA Cuzzone","year":"2014","unstructured":"Cuzzone DA, Weitman ES, Albano NJ, Ghanta S, Savetsky IL, Gardenier JC, et al. IL-6 regulates adipose deposition and homeostasis in lymphedema. Am J Physiol Heart Circ Physiol. 2014. https:\/\/doi.org\/10.1152\/ajpheart.01019.2013.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2060_CR102","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/nrc2734","volume":"9","author":"H Yu","year":"2009","unstructured":"Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9:798\u2013809.","journal-title":"Nat Rev Cancer"},{"key":"2060_CR103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers16152676","volume":"16","author":"SU Reddy","year":"2024","unstructured":"Reddy SU, Sadia FZ, Vancura A, Vancurova I. IFN\u03b3-induced Bcl3, PD-L1 and IL-8 signaling in ovarian cancer: mechanisms and clinical significance. Cancers (Basel). 2024;16:1\u201323.","journal-title":"Cancers (Basel)"},{"key":"2060_CR104","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1182\/blood.V86.7.2767.2767","volume":"86","author":"NW Lukacs","year":"1995","unstructured":"Lukacs NW, Strieter RM, Elner V, Evanoff HL, Burdick MD, Kunkel SL. Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte:endothelial cell interactions. Blood. 1995;86:2767\u201373. https:\/\/doi.org\/10.1182\/blood.V86.7.2767.2767.","journal-title":"Blood"},{"key":"2060_CR105","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s13139-019-00598-7","volume":"53","author":"H Kim","year":"2019","unstructured":"Kim H, Yu AR, Lee JJ, Lee YJ, Lim SM, Kim JS. Measurement of tumor pressure and strategies of imaging tumor pressure for radioimmunotherapy. Nucl Med Mol Imaging (2010). 2019;53:235\u201341.","journal-title":"Nucl Med Mol Imaging (2010)"},{"key":"2060_CR106","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.molonc.2014.10.008","volume":"9","author":"MD Basson","year":"2015","unstructured":"Basson MD, Zeng B, Downey C, Sirivelu MP, Tepe JJ. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-\u03b2. Mol Oncol. 2015;9:513\u201326.","journal-title":"Mol Oncol"},{"key":"2060_CR107","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.trecan.2018.02.005","volume":"4","author":"T Stylianopoulos","year":"2018","unstructured":"Stylianopoulos T, Munn LL, Jain RK. Reengineering the physical microenvironment of tumors to improve drug delivery and efficacy: from mathematical modeling to bench to bedside. Trends Cancer. 2018;4:292\u2013319. https:\/\/doi.org\/10.1016\/j.trecan.2018.02.005.","journal-title":"Trends Cancer"},{"key":"2060_CR108","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/neuonc\/5.2.79","volume":"5","author":"M Westphal","year":"2003","unstructured":"Westphal M, Hilt DC, Bortey E, Delavault P, Olivares R, Warnke PC, et al. A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro Oncol. 2003;5:79\u201388.","journal-title":"Neuro Oncol"},{"key":"2060_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0197177","volume":"13","author":"DM Riddy","year":"2018","unstructured":"Riddy DM, Goy E, Delerive P, Summers RJ, Sexton PM, Langmead CJ. Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease. PLoS One. 2018;13:1\u201319.","journal-title":"PLoS One"},{"key":"2060_CR110","doi-asserted-by":"crossref","unstructured":"Oliveda PM, Cesca B, B\u00fchler EM, Ibarra LE. Exploring monocytes-macrophages in immune microenvironment of glioblastoma for the design of novel therapeutic strategies. Brain Sci. 2023;13.","DOI":"10.3390\/brainsci13040542"},{"issue":"25","key":"2060_CR111","doi-asserted-by":"publisher","first-page":"5631","DOI":"10.1016\/j.febslet.2005.09.032","volume":"579","author":"W Khazen","year":"2005","unstructured":"Khazen W, M\u2019Bika JP, Tomkiewicz C, Benelli C, Chany C, Achour A, et al. Expression of macrophage-selective markers in human and rodent adipocytes. FEBS Lett. 2005;579:5631\u20134.","journal-title":"FEBS Lett"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02060-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-026-02060-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02060-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:03:24Z","timestamp":1790607804000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-026-02060-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":111,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2060"],"URL":"https:\/\/doi.org\/10.1007\/s13346-026-02060-6","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]},"assertion":[{"value":"3 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study did not involve human participants, human data, or animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MKM, SKM, MBC, ADD, and RW declare that they have no conflict of interest. BZ holds equities in OrganoBiotech, Inc., which commercialize the IFlowPlate\u2122 platform.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}