{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:14:01Z","timestamp":1793718841175,"version":"4.6.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"DOI":"10.1007\/s13346-026-02143-4","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:39:25Z","timestamp":1778002765000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Engineered ATP-loaded extracellular vesicles: a dual-functional strategy for improving myocardial infarction therapy"],"prefix":"10.1007","author":[{"given":"Farshid Jaberi","family":"Ansari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Behroozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Chamanara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Shahrezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shakerimoghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Mousavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Amanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Shokrgozar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Ahmadi","family":"Tafti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Greening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-8396","authenticated-orcid":false,"given":"Reza","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"issue":"1","key":"2143_CR1","first-page":"83","volume":"3","author":"Y Raziani","year":"2021","unstructured":"Raziani Y, Raziani S. The effect of air pollution on myocardial infarction. J Chem Reviews. 2021;3(1):83\u201396.","journal-title":"J Chem Reviews"},{"issue":"14","key":"2143_CR2","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1056\/NEJMoa1406656","volume":"372","author":"GA Roth","year":"2015","unstructured":"Roth GA, et al. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015;372(14):1333\u201341.","journal-title":"N Engl J Med"},{"key":"2143_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.actbio.2021.08.031","volume":"139","author":"H Esmaeili","year":"2022","unstructured":"Esmaeili H, et al. Electroconductive biomaterials for cardiac tissue engineering. Acta Biomater. 2022;139:118\u201340.","journal-title":"Acta Biomater"},{"issue":"18","key":"2143_CR4","doi-asserted-by":"publisher","first-page":"10314","DOI":"10.3390\/ijms231810314","volume":"23","author":"M Csobonyeiova","year":"2022","unstructured":"Csobonyeiova M, et al. Cell-Based and Selected Cell-Free Therapies for Myocardial Infarction: How Do They Compare to the Current Treatment Options? Int J Mol Sci. 2022;23(18):10314.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2143_CR5","doi-asserted-by":"publisher","first-page":"644","DOI":"10.2174\/1574888X18666230417085117","volume":"19","author":"F Heidari","year":"2024","unstructured":"Heidari F, et al. Menstrual Blood-Derived Mesenchymal Stem Cell Therapy for Severe COVID-19 Patients. Curr Stem Cell Res Ther. 2024;19(5):644\u201352.","journal-title":"Curr Stem Cell Res Ther"},{"issue":"7","key":"2143_CR6","first-page":"353","volume":"24","author":"N Daneshi","year":"2022","unstructured":"Daneshi N, Bahmaie N, Esmaeilzadeh A. Cell-Free Treatments: A New Generation of Targeted Therapies for Treatment of Ischemic Heart Disease. Cell J. 2022;24(7):353\u201363.","journal-title":"Cell J"},{"issue":"4","key":"2143_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/ncrna9040044","volume":"9","author":"H Baghdadi","year":"2023","unstructured":"Baghdadi H, et al. Long Non-Coding RNA Signatures in Lymphopoiesis and Lymphoid Malignancies. Non-Coding RNA. 2023;9(4):44.","journal-title":"Non-Coding RNA"},{"issue":"9","key":"2143_CR8","first-page":"532","volume":"13","author":"M Shahrezaee","year":"2025","unstructured":"Shahrezaee M, Heidari R. Cartilage Repair in 2025: Hope, Hype, or Horizon? Archives Bone Joint Surg. 2025;13(9):532\u20134.","journal-title":"Archives Bone Joint Surg"},{"issue":"2","key":"2143_CR9","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1161\/01.RES.56.2.262","volume":"56","author":"RB Jennings","year":"1985","unstructured":"Jennings RB, et al. Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure. Circul Res. 1985;56(2):262\u201378.","journal-title":"Circul Res"},{"issue":"1","key":"2143_CR10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13098-023-00980-8","volume":"15","author":"M Karami","year":"2023","unstructured":"Karami M, et al. Biochemical and molecular biomarkers: unraveling their role in gestational diabetes mellitus. Diabetol Metab Syndr. 2023;15(1):5.","journal-title":"Diabetol Metab Syndr"},{"key":"2143_CR11","first-page":"101668","volume":"38","author":"FJ Ansari","year":"2024","unstructured":"Ansari FJ, et al. Comparison of the efficiency of ultrafiltration, precipitation, and ultracentrifugation methods for exosome isolation. Biochem Biophys Rep. 2024;38:101668.","journal-title":"Biochem Biophys Rep"},{"issue":"1","key":"2143_CR12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s13287-024-03868-0","volume":"15","author":"M Akhlaghpasand","year":"2024","unstructured":"Akhlaghpasand M, et al. Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial. Stem Cell Res Ther. 2024;15(1):264.","journal-title":"Stem Cell Res Ther"},{"issue":"11","key":"2143_CR13","doi-asserted-by":"publisher","first-page":"e0165926","DOI":"10.1371\/journal.pone.0165926","volume":"11","author":"JK Lang","year":"2016","unstructured":"Lang JK, et al. Inhibiting extracellular vesicle release from human cardiosphere derived cells with lentiviral knockdown of nSMase2 differentially effects proliferation and apoptosis in cardiomyocytes, fibroblasts and endothelial cells in vitro. PLoS ONE. 2016;11(11):e0165926.","journal-title":"PLoS ONE"},{"issue":"9","key":"2143_CR14","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1161\/CIRCULATIONAHA.123.065005","volume":"150","author":"J Li","year":"2024","unstructured":"Li J, et al. Inhalable stem cell exosomes promote Heart Repair after myocardial infarction. Circulation. 2024;150(9):710\u201323.","journal-title":"Circulation"},{"issue":"1","key":"2143_CR15","doi-asserted-by":"publisher","first-page":"15885","DOI":"10.1038\/s41598-018-34357-z","volume":"8","author":"SM Davidson","year":"2018","unstructured":"Davidson SM, et al. Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning. Sci Rep. 2018;8(1):15885.","journal-title":"Sci Rep"},{"issue":"4","key":"2143_CR16","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1007\/s11010-020-04029-6","volume":"476","author":"RA Kore","year":"2021","unstructured":"Kore RA, et al. MSC exosome-mediated cardioprotection in ischemic mouse heart comparative proteomics of infarct and peri-infarct areas. Mol Cell Biochem. 2021;476(4):1691\u2013704.","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"2143_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bja.2022.08.040","volume":"130","author":"Z Luo","year":"2023","unstructured":"Luo Z, et al. Plasma exosomes generated by ischaemic preconditioning are cardioprotective in a rat heart failure model. Br J Anaesth. 2023;130(1):29\u201338.","journal-title":"Br J Anaesth"},{"key":"2143_CR18","doi-asserted-by":"crossref","unstructured":"Haider KH, Najimi M. Exosome-Based Cell-Free Therapy in Regenerative Medicine for Myocardial Repair, in Handbook of Stem Cell Therapy. Springer; 2022. pp. 1\u201329.","DOI":"10.1007\/978-981-16-6016-0_42-1"},{"issue":"1","key":"2143_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1567201043480063","volume":"1","author":"W Liang","year":"2004","unstructured":"Liang W, et al. ATP-containing immunoliposomes specific for cardiac myosin. Curr Drug Deliv. 2004;1(1):1\u20137.","journal-title":"Curr Drug Deliv"},{"issue":"12","key":"2143_CR20","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.5966\/sctm.2015-0285","volume":"5","author":"T Furuta","year":"2016","unstructured":"Furuta T, et al. Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model. Stem Cells Transl Med. 2016;5(12):1620\u201330.","journal-title":"Stem Cells Transl Med"},{"issue":"5","key":"2143_CR21","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.bbamcr.2008.01.024","volume":"1783","author":"GG Yegutkin","year":"2008","unstructured":"Yegutkin GG. Nucleotide-and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim Biophys Acta. 2008;1783(5):673\u201394.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"2143_CR22","doi-asserted-by":"publisher","first-page":"e88685","DOI":"10.1371\/journal.pone.0088685","volume":"9","author":"Y Feng","year":"2014","unstructured":"Feng Y, et al. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS ONE. 2014;9(2):e88685.","journal-title":"PLoS ONE"},{"issue":"1","key":"2143_CR23","first-page":"1","volume":"10","author":"M Cheng","year":"2019","unstructured":"Cheng M, et al. Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Commun. 2019;10(1):1\u20139.","journal-title":"Nat Commun"},{"issue":"1","key":"2143_CR24","doi-asserted-by":"publisher","first-page":"1422674","DOI":"10.1080\/20013078.2017.1422674","volume":"7","author":"R Kornilov","year":"2018","unstructured":"Kornilov R, et al. Efficient ultrafiltration-based protocol to deplete extracellular vesicles from fetal bovine serum. J Extracell vesicles. 2018;7(1):1422674.","journal-title":"J Extracell vesicles"},{"issue":"493","key":"2143_CR25","doi-asserted-by":"publisher","first-page":"eaau1168","DOI":"10.1126\/scitranslmed.aau1168","volume":"11","author":"P Saha","year":"2019","unstructured":"Saha P, et al. Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium. Sci Transl Med. 2019;11(493):eaau1168.","journal-title":"Sci Transl Med"},{"key":"2143_CR26","doi-asserted-by":"publisher","first-page":"101210","DOI":"10.1016\/j.nantod.2021.101210","volume":"39","author":"S Hu","year":"2021","unstructured":"Hu S, et al. Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury. Nano Today. 2021;39:101210.","journal-title":"Nano Today"},{"issue":"3","key":"2143_CR27","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/ar.22641","volume":"296","author":"EC Jensen","year":"2013","unstructured":"Jensen EC. Quantitative analysis of histological staining and fluorescence using ImageJ. Anat Rec. 2013;296(3):378\u201381.","journal-title":"Anat Rec"},{"issue":"7","key":"2143_CR28","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.7150\/thno.20524","volume":"8","author":"A Vandergriff","year":"2018","unstructured":"Vandergriff A, et al. Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide. Theranostics. 2018;8(7):1869.","journal-title":"Theranostics"},{"issue":"12","key":"2143_CR29","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.3390\/pharmaceutics13122153","volume":"13","author":"I Van Zundert","year":"2021","unstructured":"Van Zundert I, et al. Versatile and robust method for antibody conjugation to nanoparticles with high targeting efficiency. Pharmaceutics. 2021;13(12):2153.","journal-title":"Pharmaceutics"},{"issue":"1","key":"2143_CR30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13578-022-00784-9","volume":"12","author":"B Dumontel","year":"2022","unstructured":"Dumontel B, et al. Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices. Cell Bioscience. 2022;12(1):61.","journal-title":"Cell Bioscience"},{"issue":"8","key":"2143_CR31","doi-asserted-by":"publisher","first-page":"12352","DOI":"10.1002\/jev2.12352","volume":"12","author":"Y Fan","year":"2023","unstructured":"Fan Y, et al. Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles. J Extracell Vesicles. 2023;12(8):12352.","journal-title":"J Extracell Vesicles"},{"issue":"9","key":"2143_CR32","doi-asserted-by":"publisher","first-page":"e73790","DOI":"10.1371\/journal.pone.0073790","volume":"8","author":"L Camacho","year":"2013","unstructured":"Camacho L, Guerrero P, Marchetti D. MicroRNA and protein profiling of brain metastasis competent cell-derived exosomes. PLoS ONE. 2013;8(9):e73790.","journal-title":"PLoS ONE"},{"issue":"11","key":"2143_CR33","doi-asserted-by":"publisher","first-page":"e78505","DOI":"10.1371\/journal.pone.0078505","volume":"8","author":"MMH Sohel","year":"2013","unstructured":"Sohel MMH, et al. Exosomal and non-exosomal transport of extra-cellular microRNAs in follicular fluid: implications for bovine oocyte developmental competence. PLoS ONE. 2013;8(11):e78505.","journal-title":"PLoS ONE"},{"issue":"19","key":"2143_CR34","first-page":"3997","volume":"121","author":"BW van Balkom","year":"2013","unstructured":"van Balkom BW, et al. Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells. Blood. J Am Soc Hematol. 2013;121(19):3997\u20134006.","journal-title":"J Am Soc Hematol"},{"key":"2143_CR35","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jconrel.2014.07.047","volume":"195","author":"C Wischke","year":"2014","unstructured":"Wischke C, et al. Sustained release carrier for adenosine triphosphate as signaling molecule. J Controlled Release. 2014;195:86\u201391.","journal-title":"J Controlled Release"},{"issue":"1","key":"2143_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/imr.12528","volume":"276","author":"B Allard","year":"2017","unstructured":"Allard B, et al. The ectonucleotidases CD 39 and CD 73: novel checkpoint inhibitor targets. Immunol Rev. 2017;276(1):121\u201344.","journal-title":"Immunol Rev"},{"issue":"2","key":"2143_CR37","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/jcp.1041190211","volume":"119","author":"GA Weisman","year":"1984","unstructured":"Weisman GA, et al. Cellular responses to external ATP which precede an increase in nucleotide permeability in transformed cells. J Cell Physiol. 1984;119(2):211\u20139.","journal-title":"J Cell Physiol"},{"key":"2143_CR38","doi-asserted-by":"crossref","unstructured":"Nejatollahi F, Bayat P, Moazen B. Cell growth inhibition and apoptotic effects of a specific anti-RTFscFv antibody on prostate cancer, but not glioblastoma, cells. F1000Res, 2017. 6.","DOI":"10.12688\/f1000research.10803.1"},{"issue":"2","key":"2143_CR39","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1161\/CIRCRESAHA.116.304360","volume":"116","author":"WD Gray","year":"2015","unstructured":"Gray WD, et al. Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology. Circ Res. 2015;116(2):255\u201363.","journal-title":"Circ Res"},{"issue":"7","key":"2143_CR40","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/j.biomaterials.2013.11.083","volume":"35","author":"Y Tian","year":"2014","unstructured":"Tian Y, et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials. 2014;35(7):2383\u201390.","journal-title":"Biomaterials"},{"issue":"2","key":"2143_CR41","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.amjsurg.2006.08.069","volume":"193","author":"B Chiang","year":"2007","unstructured":"Chiang B, et al. Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Am J Surg. 2007;193(2):213\u20138.","journal-title":"Am J Surg"},{"issue":"8","key":"2143_CR42","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0031-6989(88)80117-6","volume":"20","author":"A Laham","year":"1988","unstructured":"Laham A, et al. Intracarotidal administration of liposomally-entrapped ATP: improved efficiency against experimental brain ischemia. Pharmacol Res Commun. 1988;20(8):699\u2013705.","journal-title":"Pharmacol Res Commun"},{"issue":"1","key":"2143_CR43","doi-asserted-by":"publisher","first-page":"218","DOI":"10.7150\/thno.38198","volume":"10","author":"Z Wan","year":"2020","unstructured":"Wan Z, et al. Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium. Theranostics. 2020;10(1):218.","journal-title":"Theranostics"},{"key":"2143_CR44","doi-asserted-by":"crossref","unstructured":"Kang K et al. Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction. Stem Cells Int, 2015. 2015.","DOI":"10.1155\/2015\/659890"},{"issue":"1","key":"2143_CR45","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ymthe.2016.09.001","volume":"25","author":"C Wang","year":"2017","unstructured":"Wang C, et al. Macrophage-derived mir-155-containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury. Mol Ther. 2017;25(1):192\u2013204.","journal-title":"Mol Ther"},{"issue":"4","key":"2143_CR46","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.numecd.2021.10.022","volume":"32","author":"A Petrelli","year":"2022","unstructured":"Petrelli A, et al. Education inequalities in cardiovascular and coronary heart disease in Italy and the role of behavioral and biological risk factors. Nutr Metab Cardiovasc Dis. 2022;32(4):918\u201328.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2143_CR47","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1007\/s11095-005-8354-x","volume":"22","author":"DD Verma","year":"2005","unstructured":"Verma DD, et al. ATP-loaded liposomes effectively protect the myocardium in rabbits with an acute experimental myocardial infarction. Pharm Res. 2005;22:2115\u201320.","journal-title":"Pharm Res"},{"issue":"6","key":"2143_CR48","doi-asserted-by":"publisher","first-page":"e371","DOI":"10.1016\/j.jtcvs.2021.07.062","volume":"164","author":"A Aboulgheit","year":"2022","unstructured":"Aboulgheit A, et al. Extracellular vesicles improve diastolic function and substructure in normal and high-fat diet models of chronic myocardial ischemia. J Thorac Cardiovasc Surg. 2022;164(6):e371\u201384.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"12","key":"2143_CR49","doi-asserted-by":"publisher","first-page":"e008344","DOI":"10.1161\/JAHA.117.008344","volume":"7","author":"BA Potz","year":"2018","unstructured":"Potz BA, et al. Extracellular vesicle injection improves myocardial function and increases angiogenesis in a swine model of chronic ischemia. J Am Heart Association. 2018;7(12):e008344.","journal-title":"J Am Heart Association"},{"issue":"9","key":"2143_CR50","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.3390\/life12091448","volume":"12","author":"AM Chaulin","year":"2022","unstructured":"Chaulin AM. Cardiac Troponins as Biomarkers of Cardiac Myocytes Damage in Case of Arterial Hypertension: From Pathological Mechanisms to Predictive Significance. Life. 2022;12(9):1448.","journal-title":"Life"},{"issue":"10","key":"2143_CR51","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1161\/01.RES.85.10.e51","volume":"85","author":"S Cl\u00e9ment","year":"1999","unstructured":"Cl\u00e9ment S, Chaponnier C, Gabbiani G. A subpopulation of cardiomyocytes expressing \u03b1-skeletal actin is identified by a specific polyclonal antibody. Circ Res. 1999;85(10):e51\u20138.","journal-title":"Circ Res"},{"issue":"3","key":"2143_CR52","first-page":"1711","volume":"11","author":"J Huang","year":"2019","unstructured":"Huang J, et al. Cancer cell-derived exosomes promote cell proliferation and inhibit cell apoptosis of both normal lung fibroblasts and non-small cell lung cancer cell through delivering alpha-smooth muscle actin. Am J Transl Res. 2019;11(3):1711.","journal-title":"Am J Transl Res"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02143-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-026-02143-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02143-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:02:41Z","timestamp":1778058161000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-026-02143-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":52,"alternative-id":["2143"],"URL":"https:\/\/doi.org\/10.1007\/s13346-026-02143-4","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"10 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable since study did not include humans.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Approval for animal ethics was conducted according to guidelines provided by the Guide for the Care and Use of Laboratory Animals and approved by the Institutional Animal Care and Use Committee of Aja University of Medical Sciences (IR.AJAUMS.REC.1401.167).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no financial, institutional, or personal relationships that could be perceived as influencing the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}