{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:37:27Z","timestamp":1789792647120,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hangzhou Medical and Health Science and Technology Project","award":["A20250256"],"award-info":[{"award-number":["A20250256"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"DOI":"10.1007\/s13346-026-02197-4","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:21:47Z","timestamp":1785774107000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Harnessing synergistic SN38\/quercetin nanomicelles via nebulized inhalation for enhanced lung cancer treatment"],"prefix":"10.1007","author":[{"given":"Xudong","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoQian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1841-6994","authenticated-orcid":false,"given":"Xinjun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2197_CR1","doi-asserted-by":"publisher","first-page":"102693","DOI":"10.1016\/j.canep.2024.102693","volume":"93","author":"J Zhou","year":"2024","unstructured":"Zhou J, Xu Y, Liu J, Feng L, Yu J, Chen D. Global burden of lung cancer in 2022 and projections to 2050: Incidence and mortality estimates from GLOBOCAN. Cancer Epidemiol. 2024;93:102693.","journal-title":"Cancer Epidemiol"},{"key":"2197_CR2","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229\u201363.","journal-title":"CA Cancer J Clin"},{"key":"2197_CR3","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/s41591-021-01450-2","volume":"27","author":"M Wang","year":"2021","unstructured":"Wang M, Herbst RS, Boshoff C. Toward personalized treatment approaches for non-small-cell lung cancer. Nat Med. 2021;27:1345\u201356.","journal-title":"Nat Med"},{"key":"2197_CR4","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.2174\/1389450117666160502151707","volume":"17","author":"K Gokduman","year":"2016","unstructured":"K Gokduman. Strategies Targeting DNA Topoisomerase I in Cancer Chemotherapy: Camptothecins, Nanocarriers for Camptothecins, Organic Non-Camptothecin Compounds and Metal Complexes. Curr Drug Targets. 2016;17:1928\u201339.","journal-title":"Curr Drug Targets"},{"key":"2197_CR5","doi-asserted-by":"publisher","first-page":"e1984","DOI":"10.1002\/wnan.1984","volume":"16","author":"M Molinaro","year":"2024","unstructured":"Molinaro M, Skrodzki D, Pan D. Chemoradiotherapy and nanomedicine: Drug mechanisms and delivery systems. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024;16:e1984.","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"2197_CR6","doi-asserted-by":"publisher","first-page":"109040","DOI":"10.1016\/j.bioorg.2025.109040","volume":"165","author":"G Shen","year":"2025","unstructured":"Shen G, Li S, Zhu Y, Xu Z, Liu X, Lv C, et al. Recent progress in topoisomerase inhibitors as anticancer agents: Research and design strategies for Topo I and II inhibitors via structural optimization. Bioorg Chem. 2025;165:109040.","journal-title":"Bioorg Chem"},{"key":"2197_CR7","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3390\/ijms26020796","volume":"26","author":"JY Jang","year":"2025","unstructured":"Jang JY, Kim D, Im E, Kim ND. Etoposide as a Key Therapeutic Agent in Lung Cancer: Mechanisms, Efficacy, and Emerging Strategies. Int J Mol Sci. 2025;26:796.","journal-title":"Int J Mol Sci"},{"key":"2197_CR8","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2147\/IJN.S435407","volume":"19","author":"QR Qi","year":"2024","unstructured":"Qi QR, Tian H, Yue BS, Zhai BT, Zhao F. Research Progress of SN38 Drug Delivery System in Cancer Treatment. Int J Nanomed. 2024;19:945\u201364.","journal-title":"Int J Nanomed"},{"key":"2197_CR9","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1002\/cmdc.202000753","volume":"16","author":"XY Yang","year":"2021","unstructured":"Yang XY, Zhao HY, Lei H, Yuan B, Mao S, Xin M, et al. Synthesis and Biological Evaluation of 10-Substituted Camptothecin Derivatives with Improved Water Solubility and Activity. ChemMedChem. 2021;16:1000\u201310.","journal-title":"ChemMedChem"},{"key":"2197_CR10","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1111\/cas.15377","volume":"113","author":"G Milano","year":"2022","unstructured":"Milano G, Innocenti F, Minami H. Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs. Cancer Sci. 2022;113:2224\u201331.","journal-title":"Cancer Sci"},{"key":"2197_CR11","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1007\/s11095-023-03622-w","volume":"40","author":"Z Su","year":"2023","unstructured":"Su Z, Li L, Hao F, Zhao J, Li M, Zhao X, et al. A Stable Irinotecan Liposome with Enhanced Antitumor Activity in a Range of Tumor Models. Pharm Res. 2023;40:3043\u201358.","journal-title":"Pharm Res"},{"key":"2197_CR12","doi-asserted-by":"publisher","first-page":"122573","DOI":"10.1016\/j.ijpharm.2022.122573","volume":"632","author":"FB Arslan","year":"2023","unstructured":"Arslan FB, \u00d6zt\u00fcrk K, Tavuk\u00e7uo\u011flu E, \u00d6zt\u00fcrk SC, Esenda\u011fl\u0131 G, \u00c7al\u0131\u015f S. A novel combination for the treatment of small cell lung cancer: Active targeted irinotecan and stattic co-loaded PLGA nanoparticles. Int J Pharm. 2023;632:122573.","journal-title":"Int J Pharm"},{"key":"2197_CR13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jcis.2024.05.046","volume":"670","author":"D Garc\u00eda-Soriano","year":"2024","unstructured":"Garc\u00eda-Soriano D, Mil\u00e1n-Rois P, Lafuente-G\u00f3mez N, Rodr\u00edguez-D\u00edaz C, Nav\u00edo C, Somoza \u00c1, et al. Multicore iron oxide nanoparticles for magnetic hyperthermia and combination therapy against cancer cells. J Colloid Interface Sci. 2024;670:73\u201385.","journal-title":"J Colloid Interface Sci"},{"key":"2197_CR14","doi-asserted-by":"publisher","first-page":"124420","DOI":"10.1016\/j.ijpharm.2024.124420","volume":"661","author":"C Chircov","year":"2024","unstructured":"Chircov C, Petcu MC, Vasile BS, Purc\u0103reanu B, Nicoar\u0103 AI, Oprea OC, et al. Irinotecan-loaded magnetite-silica core-shell systems for colorectal cancer treatment. Int J Pharm. 2024;661:124420.","journal-title":"Int J Pharm"},{"key":"2197_CR15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jcis.2024.04.013","volume":"667","author":"F Gao","year":"2024","unstructured":"Gao F, Guo J, Liu S, Zhang F, Zhang Y, Wang L. Empowering hydrophobic anticancer drugs by ultrashort peptides: General Co-assembly strategy for improved solubility, targeted efficacy, and clinical application. J Colloid Interface Sci. 2024;667:119\u201327.","journal-title":"J Colloid Interface Sci"},{"key":"2197_CR16","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1158\/2159-8290.CD-22-1368","volume":"13","author":"W Weng","year":"2023","unstructured":"Weng W, Meng T, Zhao Q, Shen Y, Fu G, Shi J, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023;13:950\u201373.","journal-title":"Cancer Discov"},{"key":"2197_CR17","doi-asserted-by":"publisher","first-page":"38022","DOI":"10.18632\/oncotarget.16723","volume":"8","author":"RB Mokhtari","year":"2017","unstructured":"Mokhtari RB, Homayouni TS, Baluch N, Morgatskaya E, Kumar S, Das B, et al. Combination therapy in combating cancer. Oncotarget. 2017;8:38022\u201343.","journal-title":"Oncotarget"},{"key":"2197_CR18","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.3390\/ijms20133177","volume":"20","author":"M Reyes-Farias","year":"2019","unstructured":"Reyes-Farias M, Carrasco-Pozo C. The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism. Int J Mol Sci. 2019;20:3177.","journal-title":"Int J Mol Sci"},{"key":"2197_CR19","doi-asserted-by":"publisher","first-page":"1547992","DOI":"10.3389\/fimmu.2025.1547992","volume":"16","author":"H Deng","year":"2025","unstructured":"Deng H, Wei F, Han W, Li Y, Xu X, Zhang L, et al. Synergistic chemotherapy and immunomodulatory effects of Quercetin in cancer: a review. Front Immunol. 2025;16:1547992.","journal-title":"Front Immunol"},{"key":"2197_CR20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/jcb.30162","volume":"123","author":"S Alam","year":"2022","unstructured":"Alam S, Mohammad T, Padder RA, Hassan MI, Husain M. Thymoquinone and quercetin induce enhanced apoptosis in non-small cell lung cancer in combination through the Bax\/Bcl2 cascade. J Cell Biochem. 2022;123:259\u201374.","journal-title":"J Cell Biochem"},{"key":"2197_CR21","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/mc.23408","volume":"61","author":"P Yang","year":"2022","unstructured":"Yang P, Li X, Wen Q, Zhao X. Quercetin attenuates the proliferation of arsenic-related lung cancer cells via a caspase-dependent DNA damage signaling. Mol Carcinog. 2022;61:655\u201363.","journal-title":"Mol Carcinog"},{"key":"2197_CR22","doi-asserted-by":"publisher","first-page":"109604","DOI":"10.1016\/j.biopha.2019.109604","volume":"121","author":"SM Tang","year":"2020","unstructured":"Tang SM, Deng XT, Zhou J, Li QP, Ge XX, Miao L. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomed Pharmacother. 2020;121:109604.","journal-title":"Biomed Pharmacother"},{"key":"2197_CR23","doi-asserted-by":"publisher","first-page":"1077531","DOI":"10.3389\/fimmu.2023.1077531","volume":"14","author":"N Lotfi","year":"2023","unstructured":"Lotfi N, Yousefi Z, Golabi M, Khalilian P, Ghezelbash B, Montazeri M, et al. The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update. Front Immunol. 2023;14:1077531.","journal-title":"Front Immunol"},{"key":"2197_CR24","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s44222-023-00138-1","volume":"2","author":"H Cabral","year":"2024","unstructured":"Cabral H, Li JJ, Miyata K, Kataoka K. Controlling the biodistribution and clearance of nanomedicines. Nat Reviews Bioeng. 2024;2:214\u201332.","journal-title":"Nat Reviews Bioeng"},{"key":"2197_CR25","doi-asserted-by":"publisher","first-page":"114641","DOI":"10.1016\/j.addr.2022.114641","volume":"192","author":"FC Man","year":"2023","unstructured":"Man FC, Tang J, Swedrowska M, Forbes B. R Rosales. Imaging drug delivery to the lungs: Methods and applications in oncology. Adv Drug Deliv Rev. 2023;192:114641.","journal-title":"Adv Drug Deliv Rev"},{"key":"2197_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev-bioeng-110122-010848","volume":"26","author":"IR Woodward","year":"2024","unstructured":"Woodward IR, Fromen CA. Recent Developments in Aerosol Pulmonary Drug Delivery: New Technologies, New Cargos, and New Targets. Annu Rev Biomed Eng. 2024;26:307\u201330.","journal-title":"Annu Rev Biomed Eng"},{"key":"2197_CR27","doi-asserted-by":"publisher","first-page":"100966","DOI":"10.1016\/j.mtbio.2024.100966","volume":"25","author":"B Wang","year":"2024","unstructured":"Wang B, Wang L, Yang Q, Zhang YM, Qinglai T, Yang XM, et al. Pulmonary inhalation for disease treatment: Basic research and clinical translations. Mater Today Bio. 2024;25:100966.","journal-title":"Mater Today Bio"},{"key":"2197_CR28","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.3390\/pharmaceutics15122777","volume":"15","author":"AO Al Khatib","year":"2023","unstructured":"Al Khatib AO, El-Tanani M, Al-Obaidi H. Inhaled Medicines for Targeting Non-Small Cell Lung Cancer. Pharmaceutics. 2023;15:2777.","journal-title":"Pharmaceutics"},{"key":"2197_CR29","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.3390\/ijms25094671","volume":"25","author":"LH Dong","year":"2024","unstructured":"Dong LH, Zhuang XM. Insights into Inhalation Drug Disposition: The Roles of Pulmonary Drug-Metabolizing Enzymes and Transporters. Int J Mol Sci. 2024;25:4671.","journal-title":"Int J Mol Sci"},{"key":"2197_CR30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"MJ Mitchell","year":"2021","unstructured":"Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20:101\u201324.","journal-title":"Nat Rev Drug Discov"},{"key":"2197_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.4155\/tde-2020-0101","volume":"12","author":"D Bardoliwala","year":"2021","unstructured":"Bardoliwala D, Javia A, Ghosh S, Misra A, Sawant K. Formulation and clinical perspectives of inhalation-based nanocarrier delivery: a new archetype in lung cancer treatment. Ther Deliv. 2021;12:397\u2013418.","journal-title":"Ther Deliv"},{"key":"2197_CR32","doi-asserted-by":"publisher","first-page":"e2007557","DOI":"10.1002\/adma.202007557","volume":"33","author":"Q Jin","year":"2021","unstructured":"Jin Q, Zhu W, Zhu J, Zhu J, Shen J, Liu Z, et al. Nanoparticle-Mediated Delivery of Inhaled Immunotherapeutics for Treating Lung Metastasis. Adv Mater. 2021;33:e2007557.","journal-title":"Adv Mater"},{"key":"2197_CR33","doi-asserted-by":"publisher","first-page":"5300","DOI":"10.1007\/s12274-022-5205-6","volume":"16","author":"Y Liu","year":"2023","unstructured":"Liu Y, Crowe WN, Wang L, Petty WJ, Habib AA, Zhao D. Aerosolized immunotherapeutic nanoparticle inhalation potentiates PD-L1 blockade for locally advanced lung cancer. Nano Res. 2023;16:5300\u201310.","journal-title":"Nano Res"},{"key":"2197_CR34","doi-asserted-by":"publisher","first-page":"555824","DOI":"10.2147\/IJN.S555824","volume":"21","author":"L Lin","year":"2026","unstructured":"Lin L, Wang G, Zhang J, Luo J, Fan X, Gao J, et al. Intratracheal Administration of pH-Responsive Nanomicelles: A More Effective Strategy for Enhanced Intracellular Drug Delivery in Lung Cancer Treatment. Int J Nanomed. 2026;21:555824.","journal-title":"Int J Nanomed"},{"key":"2197_CR35","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1039\/D5BM00670H","volume":"13","author":"J Li","year":"2025","unstructured":"Li J, Tian S, Zhang X, Deng X, Xu H, Yan L. Indocyanine green-based nanomedicine for theranostic applications. Biomater Sci. 2025;13:4321\u201357.","journal-title":"Biomater Sci"},{"key":"2197_CR36","first-page":"713","volume":"17","author":"X Fan","year":"2022","unstructured":"Fan X, Yue T, Liu A, Xie X, Fang W, Wei Y, et al. Lignin-assisted construction of sub-10 nm supramolecular self-assembly for photothermal immunotherapy and potentiating anti-PD-1 therapy against primary and distant breast tumors. Asian J Pharm Sci. 2022;17:713\u201327.","journal-title":"Asian J Pharm Sci"},{"key":"2197_CR37","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9:671\u20135.","journal-title":"Nat Methods"},{"key":"2197_CR38","doi-asserted-by":"publisher","first-page":"115111","DOI":"10.1016\/j.addr.2023.115111","volume":"202","author":"Z Jin","year":"2023","unstructured":"Jin Z, Gao Q, Wu K, Ouyang J, Guo W, Liang XJ. Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy. Adv Drug Deliv Rev. 2023;202:115111.","journal-title":"Adv Drug Deliv Rev"},{"key":"2197_CR39","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3892\/ijo.2024.5626","volume":"64","author":"L Xie","year":"2024","unstructured":"Xie L, Xie D, Du Z, Xue S, Wang K, Yu X, et al. A novel therapeutic outlook: Classification, applications and challenges of inhalable micron\/nanoparticle drug delivery systems in lung cancer (Review). Int J Oncol. 2024;64:38.","journal-title":"Int J Oncol"},{"key":"2197_CR40","doi-asserted-by":"publisher","first-page":"e1933","DOI":"10.1002\/wnan.1933","volume":"16","author":"RAZ Han","year":"2024","unstructured":"Han RAZ, Wang T, Zhu M, Zhou M, Sun X. Pulmonary delivery of nano-particles for lung cancer diagnosis and therapy: Recent advances and future prospects. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024;16:e1933.","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"2197_CR41","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1021\/acs.biomac.6b00164","volume":"17","author":"X Murgia","year":"2016","unstructured":"Murgia X, Pawelzyk P, Schaefer UF, Wagner C, Willenbacher N, Lehr CM. Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition. Biomacromolecules. 2016;17:1536\u201342.","journal-title":"Biomacromolecules"},{"key":"2197_CR42","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.3390\/pharmaceutics16121584","volume":"16","author":"R Fern\u00e1ndez-Garc\u00eda","year":"2024","unstructured":"Fern\u00e1ndez-Garc\u00eda R, Fraguas-S\u00e1nchez AI. Nanomedicines for Pulmonary Drug Delivery: Overcoming Barriers in the Treatment of Respiratory Infections and Lung Cancer. Pharmaceutics. 2024;16:1584.","journal-title":"Pharmaceutics"},{"key":"2197_CR43","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.jconrel.2013.09.013","volume":"172","author":"MJ Ernsting","year":"2013","unstructured":"Ernsting MJ, Murakami M, Roy A, Li SD. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. J Control Release. 2013;172:782\u201394.","journal-title":"J Control Release"},{"key":"2197_CR44","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jconrel.2011.09.063","volume":"161","author":"T Lammers","year":"2012","unstructured":"Lammers T, Kiessling F, Hennink WE, Storm G. Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release. 2012;161:175\u201387.","journal-title":"J Control Release"},{"key":"2197_CR45","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.biotechadv.2016.04.001","volume":"34","author":"EP Porcu","year":"2016","unstructured":"Porcu EP, Salis A, Gavini E, Rassu G, Maestri M, Giunchedi P. Indocyanine green delivery systems for tumour detection and treatments. Biotechnol Adv. 2016;34:768\u201389.","journal-title":"Biotechnol Adv"},{"key":"2197_CR46","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s40139-021-00227-z","volume":"9","author":"S Sharma","year":"2021","unstructured":"Sharma S, Parveen R, Chatterji BP. Toxicology of Nanoparticles in Drug Delivery. Curr Pathobiol Rep. 2021;9:133\u201344.","journal-title":"Curr Pathobiol Rep"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02197-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-026-02197-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02197-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:21:48Z","timestamp":1785774108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-026-02197-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":46,"alternative-id":["2197"],"URL":"https:\/\/doi.org\/10.1007\/s13346-026-02197-4","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"24 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}