{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:26:55Z","timestamp":1787574415348,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Keynote Project of National Natural Science Foundation of China"},{"name":"Open Fund of Henan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Projects in Guangzhou"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"DOI":"10.1007\/s13346-026-02206-6","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:59:21Z","timestamp":1787572761000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vivo spatiotemporal fate of nanoparticle-incorporated dissolving microneedles: nanoparticle size effects"],"prefix":"10.1007","author":[{"given":"Ting","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6106-592X","authenticated-orcid":false,"given":"Guilan","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"3","key":"2206_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1021\/acsmaterialslett.3c01317","volume":"6","author":"Y Xue","year":"2024","unstructured":"Xue Y, Chen C, Mi X, et al. Transdermal drug delivery system: current status and clinical application of microneedles. ACS Mater Lett. 2024;6(3):801\u201321. https:\/\/doi.org\/10.1021\/acsmaterialslett.3c01317","journal-title":"ACS Mater Lett"},{"key":"2206_CR2","doi-asserted-by":"publisher","first-page":"117219","DOI":"10.1016\/j.biopha.2024.117219","volume":"178","author":"W Yao","year":"2024","unstructured":"Yao W, Yan X, Xie X, et al. Nanoformulation-assisted microneedle transdermal drug delivery system: an innovative platform enhancing rheumatoid arthritis treatment. Biomed Pharmacother. 2024;178:117219. https:\/\/doi.org\/10.1016\/j.biopha.2024.117219","journal-title":"Biomed Pharmacother"},{"key":"2206_CR3","doi-asserted-by":"publisher","first-page":"119673","DOI":"10.1016\/j.ijpharm.2020.119673","volume":"587","author":"KAS AL-Japairai","year":"2020","unstructured":"AL-Japairai KAS, Mahmood S, Almurisi SH, et al. Current trends in polymer microneedle for transdermal drug delivery. Int J Pharm. 2020;587:119673. https:\/\/doi.org\/10.1016\/j.ijpharm.2020.119673","journal-title":"Int J Pharm"},{"key":"2206_CR4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jconrel.2023.07.011","volume":"360","author":"B Newell","year":"2023","unstructured":"Newell B, Zhan W. Mathematical modelling of microneedle-mediated transdermal delivery of drug nanocarriers into skin tissue and circulatory system. J Controlled Release. 2023;360:447\u2013467. https:\/\/doi.org\/10.1016\/j.jconrel.2023.07.011","journal-title":"J Controlled Release"},{"issue":"8","key":"2206_CR5","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.3390\/pharmaceutics15082165","volume":"15","author":"T Cheng","year":"2023","unstructured":"Cheng T, Tai Z, Shen M, et al. Advance and challenges in the treatment of skin diseases with the transdermal drug delivery system. Pharmaceutics. 2023;15(8):2165. https:\/\/doi.org\/10.3390\/pharmaceutics15082165.","journal-title":"Pharmaceutics"},{"issue":"4","key":"2206_CR6","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1007\/s13346-021-00909-6","volume":"12","author":"D Ramadon","year":"2022","unstructured":"Ramadon D, McCrudden MTC, Courtenay AJ, et al. Enhancement strategies for transdermal drug delivery systems: current trends and applications. Drug Delivery Translational Res. 2022;12(4):758\u201391. https:\/\/doi.org\/10.1007\/s13346-021-00909-6","journal-title":"Drug Delivery Translational Res"},{"key":"2206_CR7","doi-asserted-by":"publisher","first-page":"113302","DOI":"10.1016\/j.colsurfb.2023.113302","volume":"226","author":"R Zhang","year":"2023","unstructured":"Zhang R, Miao Q, Deng D, et al. Research progress of advanced microneedle drug delivery system and its application in biomedicine. Colloids Surf B: Biointerfaces. 2023;226:113302. https:\/\/doi.org\/10.1016\/j.colsurfb.2023.113302.","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"11","key":"2206_CR8","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1007\/s13346-024-01531-y","volume":"14","author":"T Su","year":"2024","unstructured":"Su T, Tang Z, Hu J, et al. Innovative freeze-drying technique in the fabrication of dissolving microneedle patch: enhancing transdermal drug delivery efficiency. Drug Delivery Translational Res. 2024;14(11):3112\u201327. https:\/\/doi.org\/10.1007\/s13346-024-01531-y.","journal-title":"Drug Delivery Translational Res"},{"issue":"1","key":"2206_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40486-024-00204-2","volume":"12","author":"R Dave","year":"2024","unstructured":"Dave R, Shinde S, Kalayil N, et al. Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function. Micro Nano Syst Lett. 2024;12(1):14. https:\/\/doi.org\/10.1186\/s40486-024-00204-2.","journal-title":"Micro Nano Syst Lett"},{"issue":"1","key":"2206_CR10","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.3762\/bjnano.12.77","volume":"12","author":"ZF Rad","year":"2021","unstructured":"Rad ZF, Prewett PD, Davies GJ. An overview of microneedle applications, materials, and fabrication methods. Beilstein J Nanotechnol. 2021;12(1):1034\u201346. https:\/\/doi.org\/10.3762\/bjnano.12.77.","journal-title":"Beilstein J Nanotechnol"},{"issue":"10","key":"2206_CR11","doi-asserted-by":"publisher","first-page":"5104","DOI":"10.1021\/acs.molpharmaceut.4c00492","volume":"21","author":"PR Yadav","year":"2024","unstructured":"Yadav PR, Hingonia P, Das DB, et al. Modeling of dissolving microneedle-based transdermal drug delivery: effects of dynamics of polymers in solution. Mol Pharm. 2024;21(10):5104\u201314. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.4c00492.","journal-title":"Mol Pharm"},{"key":"2206_CR12","doi-asserted-by":"publisher","first-page":"125064","DOI":"10.1016\/j.ijpharm.2024.125064","volume":"669","author":"JL Paris","year":"2025","unstructured":"Paris JL, Vora LK, Perez-Moreno AM, et al. Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform. Int J Pharm. 2025;669:125064. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.125064.","journal-title":"Int J Pharm"},{"issue":"8","key":"2206_CR13","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1080\/09205063.2024.2320948","volume":"35","author":"AN Aisyah","year":"2024","unstructured":"Aisyah AN, Permana AD, Wahyudin E, et al. Formulation and evaluation of dissolving microneedle for transdermal delivery of piperine: the effect of polymers concentration. J Biomater Sci Polym Ed. 2024;35(8):1177\u201396. https:\/\/doi.org\/10.1080\/09205063.2024.2320948.","journal-title":"J Biomater Sci Polym Ed"},{"key":"2206_CR14","doi-asserted-by":"publisher","first-page":"120749","DOI":"10.1016\/j.ijpharm.2021.120749","volume":"604","author":"L Zhang","year":"2021","unstructured":"Zhang L, Guo R, Wang S, et al. Fabrication, evaluation and applications of dissolving microneedles. Int J Pharm. 2021;604:120749. https:\/\/doi.org\/10.1016\/j.ijpharm.2021.120749.","journal-title":"Int J Pharm"},{"issue":"1\u20132","key":"2206_CR15","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ijpharm.2017.10.035","volume":"534","author":"G Yao","year":"2017","unstructured":"Yao G, Quan G, Lin S, et al. Novel dissolving microneedles for enhanced transdermal delivery of levonorgestrel: in vitro and in vivo characterization. Int J Pharm. 2017;534(1\u20132):378\u201386. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.10.035.","journal-title":"Int J Pharm"},{"key":"2206_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jconrel.2020.06.039","volume":"325","author":"M Chen","year":"2020","unstructured":"Chen M, Quan G, Sun Y, et al. Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery. J Controlled Release. 2020;325:163\u201375. https:\/\/doi.org\/10.1016\/j.jconrel.2020.06.039.","journal-title":"J Controlled Release"},{"key":"2206_CR17","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.2147\/IJN.S452207","volume":"19","author":"A Cheng","year":"2024","unstructured":"Cheng A, Zhang S, Meng F, et al. Nanosuspension-loaded dissolving microneedle patches for enhanced transdermal delivery of a highly lipophilic cannabidiol. Int J Nanomed. 2024;19:4061\u201379. https:\/\/doi.org\/10.2147\/IJN.S452207.","journal-title":"Int J Nanomed"},{"key":"2206_CR18","doi-asserted-by":"publisher","first-page":"103110","DOI":"10.1016\/j.jddst.2022.103110","volume":"68","author":"TC De Oliveira","year":"2022","unstructured":"De Oliveira TC, Tavares ME, Soares-Sobrinho JL, et al. The role of nanocarriers for transdermal application targeted to lymphatic drug delivery: opportunities and challenges. J Drug Deliv Sci Technol. 2022;68:103110. https:\/\/doi.org\/10.1016\/j.jddst.2022.103110.","journal-title":"J Drug Deliv Sci Technol"},{"key":"2206_CR19","doi-asserted-by":"publisher","first-page":"106836","DOI":"10.1016\/j.jddst.2025.106836","volume":"107","author":"A Kheirieh","year":"2025","unstructured":"Kheirieh A, Abbasi A, Malaekeh-Nikouei B, et al. Delivery of nanocarriers with dissolvable microneedles for skin treatments: approaches and challenges. J Drug Deliv Sci Technol. 2025;107:106836. https:\/\/doi.org\/10.1016\/j.jddst.2025.106836.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"4","key":"2206_CR20","doi-asserted-by":"publisher","first-page":"2300142","DOI":"10.1002\/anbr.202300142","volume":"4","author":"R Xie","year":"2024","unstructured":"Xie R, Li W, Shi K, et al. Versatile platforms of microneedle patches loaded with responsive nanoparticles: synthesis and promising biomedical applications. Adv NanoBiomed Res. 2024;4(4):2300142. https:\/\/doi.org\/10.1002\/anbr.202300142.","journal-title":"Adv NanoBiomed Res"},{"issue":"9","key":"2206_CR21","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.1021\/acs.molpharmaceut.4c00435","volume":"21","author":"Z Chang","year":"2024","unstructured":"Chang Z, Wu Y, Chen Y, et al. Biological fate tracking of nitric oxide-propelled microneedle delivery system using an aggregation-caused quenching probe. Mol Pharm. 2024;21(9):4541\u201352. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.4c00435.","journal-title":"Mol Pharm"},{"issue":"2","key":"2206_CR22","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3390\/ph18020176","volume":"18","author":"X Wang","year":"2025","unstructured":"Wang X, Huang J, Guo M, et al. Aggregation-caused quenching dyes as potent tools to track the integrity of antitumor nanocarriers: a mini-review. Pharmaceuticals. 2025;18(2):176. https:\/\/doi.org\/10.3390\/ph18020176.","journal-title":"Pharmaceuticals"},{"issue":"3","key":"2206_CR23","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.cclet.2019.07.016","volume":"31","author":"J Yang","year":"2020","unstructured":"Yang J, Dong Z, Liu W, et al. Discriminating against injectable fat emulsions with similar formulation based on water quenching fluorescent probe. Chin Chem Lett. 2020;31(3):875\u20139. https:\/\/doi.org\/10.1016\/j.cclet.2019.07.016.","journal-title":"Chin Chem Lett"},{"issue":"4","key":"2206_CR24","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s12247-021-09576-z","volume":"17","author":"W Wang","year":"2022","unstructured":"Wang W, Yang B, Huang Z, et al. Investigating the effect of particle size on cellular uptake by aggregation-caused quenching probe\u2013encapsulating solid lipid nanoparticles, inhaled. J Pharm Innov. 2022;17(4):1109\u201315. https:\/\/doi.org\/10.1007\/s12247-021-09576-z.","journal-title":"J Pharm Innov"},{"key":"2206_CR25","doi-asserted-by":"publisher","first-page":"100124","DOI":"10.1016\/j.medidd.2022.100124","volume":"14","author":"C Shi","year":"2022","unstructured":"Shi C, Yang D, Zhao Y, et al. The spatial-dimensional and temporal-dimensional fate of nanocarrier-loaded dissolving microneedles with different lengths of needles. Med Drug Discovery. 2022;14:100124. https:\/\/doi.org\/10.1016\/j.medidd.2022.100124.","journal-title":"Med Drug Discovery"},{"issue":"1","key":"2206_CR26","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3390\/pharmaceutics15010169","volume":"15","author":"Y Fu","year":"2023","unstructured":"Fu Y, Shi C, Li X, et al. Demonstrating biological fate of nanoparticle-loaded dissolving microneedles with aggregation-caused quenching probes: influence of application sites. Pharmaceutics. 2023;15(1):169. https:\/\/doi.org\/10.3390\/pharmaceutics15010169.","journal-title":"Pharmaceutics"},{"issue":"6","key":"2206_CR27","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1080\/17425247.2024.2375385","volume":"21","author":"J Cong","year":"2024","unstructured":"Cong J, Zheng Z, Fu Y, et al. Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate. Expert Opin Drug Deliv. 2024;21(6):965\u201374. https:\/\/doi.org\/10.1080\/17425247.2024.2375385.","journal-title":"Expert Opin Drug Deliv"},{"issue":"31","key":"2206_CR28","doi-asserted-by":"publisher","first-page":"e2302314","DOI":"10.1002\/adhm.202302314","volume":"12","author":"F Qu","year":"2023","unstructured":"Qu F, Sun Y, Bi D, et al. Regulating size and charge of liposomes in microneedles to enhance intracellular drug delivery efficiency in skin for psoriasis therapy. Adv Healthc Mater. 2023;12(31):e2302314. https:\/\/doi.org\/10.1002\/adhm.202302314","journal-title":"Adv Healthc Mater"},{"issue":"26","key":"2206_CR29","doi-asserted-by":"publisher","first-page":"21660","DOI":"10.1021\/acsami.7b04916","volume":"9","author":"F Xia","year":"2017","unstructured":"Xia F, Fan W, Jiang S, et al. Size-dependent translocation of nanoemulsions via oral delivery. ACS Appl Mater Interfaces. 2017;9(26):21660\u201372. https:\/\/doi.org\/10.1021\/acsami.7b04916","journal-title":"ACS Appl Mater Interfaces"},{"key":"2206_CR30","doi-asserted-by":"publisher","first-page":"1479464","DOI":"10.3389\/fnano.2025.1479464","volume":"7","author":"WS Mota","year":"2025","unstructured":"Mota WS, Severino P, Kadian V, et al. Nanometrology: particle sizing and influence on the toxicological profile. Front Nanatechnol. 2025;7:1479464. https:\/\/doi.org\/10.3389\/fnano.2025.1479464","journal-title":"Front Nanatechnol"},{"key":"2206_CR31","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.msec.2017.05.143","volume":"80","author":"W Yu","year":"2017","unstructured":"Yu W, Jiang G, Zhang Y, et al. Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin. Mater Sci Eng C Mater Biol Appl. 2017;80:187\u201396. https:\/\/doi.org\/10.1016\/j.msec.2017.05.143.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"2","key":"2206_CR32","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3390\/pharmaceutics16020286","volume":"16","author":"Z Chang","year":"2024","unstructured":"Chang Z, Wu Y, Hu P, et al. The necessity to investigate in vivo fate of nanoparticle-loaded dissolving microneedles. Pharmaceutics. 2024;16(2):286. https:\/\/doi.org\/10.3390\/pharmaceutics16020286.","journal-title":"Pharmaceutics"},{"key":"2206_CR33","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.addr.2019.05.009","volume":"143","author":"J Qi","year":"2019","unstructured":"Qi J, Hu X, Dong X, et al. Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool. Adv Drug Deliv Rev. 2019;143:206\u201325. https:\/\/doi.org\/10.1016\/j.addr.2019.05.009.","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"2206_CR34","doi-asserted-by":"publisher","first-page":"e277","DOI":"10.1002\/agt2.277","volume":"4","author":"Y Cai","year":"2023","unstructured":"Cai Y, Ji X, Zhang Y, et al. Near-infrared fluorophores with absolute aggregation-caused quenching and negligible fluorescence re-illumination for in vivo bioimaging of nanocarriers. Aggregate. 2023;4(2):e277. https:\/\/doi.org\/10.1002\/agt2.277.","journal-title":"Aggregate"},{"issue":"1","key":"2206_CR35","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1186\/s12951-024-02761-5","volume":"22","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Liu C, Lu Y, et al. In vivo fluorescence imaging of nanocarriers in near-infrared window II based on aggregation-caused quenching. J Nanobiotechnol. 2024;22(1):488. https:\/\/doi.org\/10.1186\/s12951-024-02761-5.","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"2206_CR36","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1186\/s12951-024-02930-6","volume":"22","author":"Y Wang","year":"2024","unstructured":"Wang Y, Mo Y, Sun Y, et al. Intestinal nanoparticle delivery and cellular response: a review of the bidirectional nanoparticle-cell interplay in mucosa based on physiochemical properties. J Nanobiotechnol. 2024;22(1):669. https:\/\/doi.org\/10.1186\/s12951-024-02930-6.","journal-title":"J Nanobiotechnol"},{"key":"2206_CR37","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.jconrel.2024.04.047","volume":"370","author":"R Han","year":"2024","unstructured":"Han R, He H, Lu Y, et al. Oral targeted drug delivery to post-gastrointestinal sites. J Controlled Release. 2024;370:256\u201376. https:\/\/doi.org\/10.1016\/j.jconrel.2024.04.047.","journal-title":"J Controlled Release"},{"issue":"11","key":"2206_CR38","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.1016\/j.apsb.2023.05.018","volume":"13","author":"Q Liu","year":"2023","unstructured":"Liu Q, Zou J, Chen Z, et al. Current research trends of nanomedicines. Acta Pharm Sinica B. 2023;13(11):4391\u2013416. https:\/\/doi.org\/10.1016\/j.apsb.2023.05.018.","journal-title":"Acta Pharm Sinica B"},{"issue":"9","key":"2206_CR39","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1016\/j.xphs.2023.07.002","volume":"112","author":"HW Chan","year":"2023","unstructured":"Chan HW, Chow S, Zhang X, et al. Role of particle size in translational research of nanomedicines for successful drug delivery: discrepancies and inadequacies. J Pharm Sci. 2023;112(9):2371\u201384. https:\/\/doi.org\/10.1016\/j.xphs.2023.07.002.","journal-title":"J Pharm Sci"},{"issue":"4","key":"2206_CR40","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3390\/ma11040623","volume":"11","author":"P Zhang","year":"2018","unstructured":"Zhang P, Xia J, Luo S. Generation of well-defined micro\/nanoparticles via advanced manufacturing techniques for therapeutic delivery. Materials. 2018;11(4):623. https:\/\/doi.org\/10.3390\/ma11040623.","journal-title":"Materials"},{"key":"2206_CR41","doi-asserted-by":"publisher","first-page":"111303","DOI":"10.1016\/j.colsurfb.2020.111303","volume":"196","author":"C Li","year":"2020","unstructured":"Li C, Guan H, Li Z, et al. Study on different particle sizes of DOX-loaded mixed micelles for cancer therapy. Colloids Surf B: Biointerfaces. 2020;196:111303. https:\/\/doi.org\/10.1016\/j.colsurfb.2020.111303.","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"2206_CR42","doi-asserted-by":"publisher","first-page":"106931","DOI":"10.1016\/j.fbio.2025.106931","volume":"69","author":"Y Pan","year":"2025","unstructured":"Pan Y, Li R, Jing N, et al. Isorhamnetin-lignin nanoparticles: green preparation, characterization, remarkable bioavailability and long-lasting bioactivity in vivo. Food Bioscience. 2025;69:106931. https:\/\/doi.org\/10.1016\/j.fbio.2025.106931.","journal-title":"Food Bioscience"},{"issue":"6","key":"2206_CR43","doi-asserted-by":"publisher","first-page":"5205","DOI":"10.3390\/ijms24065205","volume":"24","author":"P Yang","year":"2023","unstructured":"Yang P, Ren J, Yang L. Nanoparticles in the new era of cardiovascular therapeutics: challenges and opportunities. Int J Mol Sci. 2023;24(6):5205. https:\/\/doi.org\/10.3390\/ijms24065205.","journal-title":"Int J Mol Sci"},{"key":"2206_CR44","doi-asserted-by":"publisher","first-page":"122793","DOI":"10.1016\/j.ijpharm.2023.122793","volume":"636","author":"M Qin","year":"2023","unstructured":"Qin M, Ye G, Xin J, et al. Comparison of in vivo behaviors of intramuscularly long-acting celecoxib nanosuspensions with different particle sizes for the postoperative pain treatment. Int J Pharm. 2023;636:122793. https:\/\/doi.org\/10.1016\/j.ijpharm.2023.122793.","journal-title":"Int J Pharm"},{"key":"2206_CR45","doi-asserted-by":"publisher","DOI":"10.1080\/01932691.2025.2556726","author":"CEM Dcruz","year":"2025","unstructured":"Dcruz CEM, Kumar L, Shirodkar RK. Nano-in-micro drug delivery: glycerospanlastic polymeric microneedle patch for hypertension. J Dispers Sci Technol. 2025. https:\/\/doi.org\/10.1080\/01932691.2025.2556726.","journal-title":"J Dispers Sci Technol"},{"key":"2206_CR46","doi-asserted-by":"publisher","first-page":"125128","DOI":"10.1016\/j.ijpharm.2024.125128","volume":"670","author":"B Xu","year":"2025","unstructured":"Xu B, Liu H, Yang G, et al. Novel double-layered PLGA microparticles-dissolving microneedle (MPs-DMN) system for peptide drugs sustained release by transdermal delivery. Int J Pharm. 2025;670:125128. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.125128.","journal-title":"Int J Pharm"},{"issue":"7","key":"2206_CR47","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1080\/17425247.2025.2505758","volume":"22","author":"L Morici","year":"2025","unstructured":"Morici L, Jordan O, Allemann E, et al. Recent advances in nanocrystals for arthritis drug delivery. Expert Opin Drug Deliv. 2025;22(7):1031\u201342. https:\/\/doi.org\/10.1080\/17425247.2025.2505758.","journal-title":"Expert Opin Drug Deliv"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02206-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-026-02206-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-026-02206-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:59:22Z","timestamp":1787572762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-026-02206-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":47,"alternative-id":["2206"],"URL":"https:\/\/doi.org\/10.1007\/s13346-026-02206-6","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"20 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the School of Pharmaceutical Sciences, Sun Yat-Sen University (Protocol approval number SYSU-IACUC-2025-002720).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}